Lentiviral Vector Mediated Thymidine Kinase Expression in Pluripotent Stem Cells Enables Removal of Tumorigenic Cells

PLoS ONE

Volumn 8, Issue 7, 2013, Pages

  Lim, Tiong Ti ^a,b   Geisen, Caroline ^a   Hesse, Michael ^a   Fleischmann, Bernd K ^a,b   Zimmermann, Katrin ^a,b   Pfeifer, Alexander ^a,b  

^a UNIVERSITY OF BONN   (Germany)

^b PharmaCenter Bonn   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

GANCICLOVIR; HYGROMYCIN; LENTIVIRUS VECTOR; THYMIDINE KINASE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CANCER INHIBITION; CANCER RISK; CARCINOGENESIS; CELL KILLING; CELL POPULATION; CELL SELECTION; CELL TRANSPLANTATION; CONTROLLED STUDY; DNA MODIFICATION; DRUG RESISTANCE; DRUG SENSITIVITY; EMBRYONIC STEM CELL; EOS C3 GENE; EOS S4 GENE; GENE; GENE CASSETTE; GENE CONTROL; GENETIC TRANSDUCTION; HERPES SIMPLEX VIRUS; HUMAN; HUMAN TISSUE; IN VITRO STUDY; IN VIVO STUDY; INSERTIONAL MUTAGENESIS; MOUSE; MUTAGENESIS; NANOG GENE; NONHUMAN; OCT3 GENE; PLURIPOTENT STEM CELL; PROMOTER REGION; PROTEIN EXPRESSION; RISK ASSESSMENT; TERATOMA; TUMOR CELL; VIRAL GENE DELIVERY SYSTEM;

ANIMALS; BYSTANDER EFFECT; CELL LINE; DISEASE MODELS, ANIMAL; EMBRYONIC STEM CELLS; GANCICLOVIR; GENE EXPRESSION REGULATION; GENE ORDER; GENES, TRANSGENIC, SUICIDE; GENETIC THERAPY; GENETIC VECTORS; LENTIVIRUS; MICE; PLURIPOTENT STEM CELLS; PRODRUGS; PROMOTER REGIONS, GENETIC; SIMPLEXVIRUS; STEM CELL TRANSPLANTATION; TERATOMA; THYMIDINE KINASE; TRANSDUCTION, GENETIC;

EID: 84880806153     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0070543     Document Type: Article

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