Association of vitamin B12 with obesity, overweight, insulin resistance and metabolic syndrome, and body fat composition; primary care-based study

Medicinski Glasnik

Volumn 10, Issue 2, 2013, Pages 203-210

  Baltaci, Davut ^a   Kutlucan, Ali ^a   Turker, Yasemin ^a   Yilmaz, Aylin ^a   Karacam, Serkan ^a   Deler, Harun ^a   Ucgun, Taner ^a   Kara, Ismail Hamdi ^a  

^a DUZCE UNIVERSITY   (Turkey)

Author keywords

Bioelectric impedance analysis; Insulin resistance; Obesity; Vitamin B12

Indexed keywords

CYANOCOBALAMIN; FERRITIN; FOLIC ACID; INSULIN;

ADULT; AGE; ANTHROPOMETRIC PARAMETERS; ARTICLE; BLOOD PRESSURE; BODY MASS; CASE CONTROL STUDY; CONTROLLED STUDY; CORRELATIONAL STUDY; CROSS-SECTIONAL STUDY; CYANOCOBALAMIN DEFICIENCY; FEMALE; HUMAN; INSULIN RESISTANCE; IRON BINDING CAPACITY; IRON BLOOD LEVEL; LIPID ANALYSIS; LIPID COMPOSITION; MAJOR CLINICAL STUDY; MALE; METABOLIC SYNDROME X; OBESITY; PRIMARY MEDICAL CARE; RISK FACTOR; ADIPOSE TISSUE; BLOOD; PRIMARY HEALTH CARE;

ADIPOSE TISSUE; BODY MASS INDEX; CROSS-SECTIONAL STUDIES; HUMANS; INSULIN RESISTANCE; METABOLIC SYNDROME X; OBESITY; OVERWEIGHT; PRIMARY HEALTH CARE; VITAMIN B 12;

EID: 84880736760     PISSN: 18400132     EISSN: 18402445     Source Type: Journal    
DOI: None     Document Type: Article

References (41)

1. Rebecca MP, Chealsea AH. Stigmata of obesity: review and update. Obes Res 2009; 17: 941-64.
2. Kopelman PG. Obesity as a medical problem. Nature 2000; 404:635-3.
3. Katherina MF, Margaret MC. Brain KK, Cynthia LO. Prevalence of obesity and trends in the distribution of body mass index among US adults, 199-2010. JAMA 2012; 307:491-7.
4. Hill JO, Wyatt H. Outpatient management of obesity: a primary care perspective. Obes Res 2002; 10(Suppl):124-30.
5. Finucane MM Stevens GA, Cowan MJ, Danaei G, Lin JK, Paciorek CJ, Singh GM, Gutierrez HR, Lu Y, Bahalim AN, Farzadfar F, Riley LM, Ezzati M; Global Burden of Metabolic Risk Factors of Chronic Diseases Collaborating Group (Body Mass Index). National, regional, and global trends in body-mass index since 1980: systematic analysis of health examination surveys and epidemiological studies with 960 country-years and 9·1 million participants. Lancet 2011; 377:557-67.
6. Wang YC, McPherson K, Marsh T, Gortmaker SL, Brown M. Health and economic burden of the projected obesity trends in the USA and the UK. Lancet 2011; 378:815-25.
7. Kral JG. Morbid obesity and related health risks. Ann Intern Med 1985; 103:1043-47.
8. Allen LH. How common is vitamin B-12 deficiency? Am J Clin Nutr 2009; 89:693-6.
9. Tucker KL, Rich S, Rosenberg I, Jacques P, Dallal G, Wilson PWF, Selhub J. Plasma vitamin B-12 concentrations relate to intake source in the Framingham Offspring Study. Am J Clin Nutr 2000; 71:514-22.
10. Herrmann W, Obeid R. Causes and early diagnosis of vitamin B12 deficiency. Dtsch Arztebl Int 2008; 105:680-5.
11. Allen LH. How common is vitamin B-12 deficiency? Am J Clin Nutr 2009; 89: 69396.
12. Goraya JS. Vitamin B12 deficiency in childhood and adolescence. J Pediatr 2002; 140:636.
13. El-Serag H. Role of obesity in GORD-related disorders. Gut 2008; 57:281-4.
14. Uehara SK, Rosa G. Association of homocysteinemia with high concentrations of serum insulin and uric acid in Brazilian subjects with metabolic syndrome genotyped for C677T polymorphism in the methylenetetrahydrofolate reductase gene. Nutr Res 2008; 28:760-6.
15. Kant AK. Reported consumption of low-nutrientdensity foods by American children and adolescents: nutritional and health correlates, NHANES III, 1988 to 1994 Arch Pediatr Adolesc Med. 2003; 157:789-96.
16. Tungtrongchitr R, Pongpaew P, Tongboonchoo C, Vudhivai N, Changbumrung S, Tungtrongchitr A, Phonrat B, Viroonudomphol D, Pooudong S, Schelp FP. Serum homocysteine, B12 and folic acid concentration in Thai overweight and obese subjects. Int J Vitam Nutr Res 2003; 73:8-14.
17. Karatela RA, Sainani GS. Plasma homocysteine in obese, overweight and normal weight hypertensives and normotensives. Indian Heart J 2009; 61:156-9.
18. Brasileiro RS, Escrivão MA, Taddei JA, D'Almeida V, Ancona-Lopez F, Carvalhaes JT. Plasma total homocysteine in Brazilian overweight and nonoverweight adolescents: a case-control study. Nutr Hosp 2005; 20:313-9.
19. Demir D, Erten Bucaktepe G, Kara IH. The Comparing of the sociodemographic features, anthropometric and biochemical parameters of the cases with Metabolic Syndrome, Type 2 Diabetes Mellitus and healthy controls. Konuralp Ti{dotless}p Dergisi [Konuralp Medical Journal] 2010; 2:12-9.
20. Lindenbaum J, Healton EB, Savage DG, Brust JC, Garrett TJ, Podell ER, Marcell PD, Stabler SP, Allen RH. Neuropsychiatric disorders caused by cobalamin deficiency in the absence of anemia or macrocytosis. N Engl J Med 1988; 318:1720-28.
21. International Obesity Task Force. Managing the Global Epidemic of Obesity. Report of the WHO Consultation on Obesity, Geneva 5-7 June, 1998. WHO: Geneva. [http://www.who.int/whr/1998/en/whr98_en.pdf] (05 June 2011)
22. International Diabetes Federation. The IDF consensus worldwide definition of metabolic syndrome. Brussels, 2006. http://www.idf.org/webdata/docs/MetSyndrome_FINAL.pdf (10 May 2011)
23. Executive summary of the Third Report on the National Cholesterol Education Program (NCEP) Expert Panel ob Detection, Evaluation and Treatment of High Blood Cholesterol in Adults (Adult Treatment Panel III). JAMA 2001; 265:2486-7.
24. Stabler SP, Allwn RH, Savage DG, Lindenbaum J. Clinical spectrum and diagnosis of cobalamin deficiency. Blood 1990; 76:871-1.
25. Guven A, Inanc F, Kilinc M, Ekerbicer H. Plasma homocysteine and lipoprotein (a) levels in Turkish patients with metabolic syndrome. Heart Vessels 2005; 20:290-95.
26. Setola E, Monti LD, Galluccio E, Palloshi A, Fragasso G, Paroni R, Magni F, Sandoli EP, Lucotti P, Costa S, Fermo I, Galli-Kienle M, Origgi A, Margonato A, Piatti P. Insulin resistance and endothelial function are improved after folate and vitamin B12 therapy in patients with metabolic syndrome: relationship between homocysteine levels and hyperinsulinemia. Eur J Endocrinol 2004; 151:483-9.
27. Gargari BP, Aghamohammadi V, Aliasgharzadeh A. Effect of folic acid supplementation on biochemical indices in overweight and obese men with type 2 diabetes. Diabetes Res Clin Pract 2011; 94:33-8.
28. Kaya C, Cengiz SD, Satiroǧlu H. Obesity and insulin resistance associated with lower plasma vitamin B12 in PCOS. Reprod Biomed Online 2009; 19:721-6.
29. Baltaci D, Kutlucan A, Ozturk S, Karabulut I, Yildirim HA, Celer G, Celbek G, Kara IH. Evaluation of vitamin B12 level in middle-aged obese women with metabolic syndrome and non-metabolic syndrome: case-control study. Turk J Med Sci 2012; 42:802-9.
30. Pinhas-Hamiel O, Doron-Panush N, Reichman B, Nitzan-Kaluski D, Shalitin S, Geva-Lerner L. Obese children and adolescents: a risk group for low vitamin B12 concentration. Arch Pediatr Adolesc Med 2006; 160:933-6.
31. Bates CJ, Schneede J, Mishra G, Prentice A, Mansoor MA. Relationship between methylmalonic acid, homocysteine, vitamin B12 intake and status and socio-economic indices, in a subset of participants in the British National Diet and Nutrition Survey of people aged 65 y and over. Eur J Clin Nutr 2003; 57:349-57.
32. Carmel R, Green R, Jacobsen DW, Rasmussen K, Florea M, Azen C. Serum cobalamin, homocysteine, and methylmalonic acid concentrations in a multiethnic elderly population: ethnic and sex differences in cobalamin and metabolite abnormalities. Am J Clin Nutr 1999; 70:904-10.
33. Rasmussen K, Møller J, Lyngbak M, Pedersen AM, Dybkjaer L. Age-and gender-specific reference intervals for total homocysteine and methylmalonic acid in plasma before and after vitamin supplementation. Clin Chem 1996; 42:630-6.
34. Hirschowitz BI, Worthington J, Mohnen J. Vitamin B12 deficiency in hypersecretors during long-term acid suppression with proton pump inhibitors. Aliment Pharmacol Ther 2008; 27:1110-21.
35. Pongchaidecha M, Srikusalanukul V, Chattananon A, Tanjariyaporn S. Effect of metformin on plasma homocysteine, vitamin B12 and folic acid: a crosssectional study in patients with type 2 diabetes mellitus. J Med Assoc Thai 2004; 87: 780-7.
36. El-Serag H. The association between obesity and GERD: a review of the epidemiological evidence. Dig Dis Sci 2008; 53:2307-12.
37. Yamamoto S, Watabe K, Takehara T. Is obesity a new risk factor for gastritis? Digestion 2012; 85:108-10
38. Pi-Sunyer FX. The obesity epidemic: pathophysiology and consequences of obesity. Obes Res 2002; 10 (Suppl 2):97-104.
39. Béchade D, Blondon H, Sekkach Y, Desramé J, Algayres JP. Review of the association between obesity and gastroesophageal reflux and its complications. Gastroenterol Clin Biol 2009; 33:155-66.
40. Biccas BN, Lemme EM, Abrahão LJ Jr, Aguero GC, Alvariz A, Schechter RB. Higher prevalence of obesity in erosive gastroesophageal reflux disease. Arq Gastroenterol 2009; 46:15-9.
41. van Oijen MG, Josemanders DF, Laheij RJ, van Rossum LG, Tan AC, Jansen JB. Gastrointestinal disorders and symptoms: does body mass index matter? Neth J Med 2006; 64:45-9.