Apathy is associated with a single-nucleotide polymorphism in a dopamine-related gene

Neuroscience Letters

Volumn 549, Issue , 2013, Pages 87-91

  Mitaki, Shingo ^a   Isomura, Minoru ^a   Maniwa, Kyohei ^a   Yamasaki, Masayuki ^a   Nagai, Atsushi ^a   Nabika, Toru ^a   Yamaguchi, Shuhei ^a  

^a SHIMANE UNIVERSITY FACULTY OF MEDICINE   (Japan)

Author keywords

Apathy; Catechol O methyltransferase; Dopamine; General population; Polymorphism; Prefrontal cortex

Indexed keywords

CATECHOL METHYLTRANSFERASE; DOPAMINE; DOPAMINE 2 RECEPTOR; DOPAMINE 3 RECEPTOR; DOPAMINE 4 RECEPTOR; METHIONINE;

ADULT; AGED; ALLELE; APATHY; ARTICLE; COGNITION; CONTROLLED STUDY; DEPRESSION; DOPAMINERGIC ACTIVITY; DOPAMINERGIC TRANSMISSION; ENZYME ACTIVITY; FEMALE; GENE FREQUENCY; GENE FUNCTION; GENE SEQUENCE; GENETIC ASSOCIATION; GENETIC RISK; GENOTYPE; HUMAN; MAJOR CLINICAL STUDY; MALE; PATHOGENESIS; PREFRONTAL CORTEX; PRIORITY JOURNAL; SINGLE NUCLEOTIDE POLYMORPHISM;

APATHY; CATECHOL-O-METHYLTRANSFERASE; DOPAMINE; GENERAL POPULATION; POLYMORPHISM; PREFRONTAL CORTEX;

AGED; ALLELES; APATHY; CATECHOL O-METHYLTRANSFERASE; FEMALE; GENE FREQUENCY; GENETIC ASSOCIATION STUDIES; GENOTYPE; HUMANS; MALE; MIDDLE AGED; POLYMORPHISM, SINGLE NUCLEOTIDE;

EID: 84880718281     PISSN: 03043940     EISSN: 18727972     Source Type: Journal    
DOI: 10.1016/j.neulet.2013.05.075     Document Type: Article

References (48)

1. Aarsland D., Litvan I., Larsen J.P. Neuropsychiatric symptoms of patients with progressive supranuclear palsy and Parkinson's disease. J. Neuropsychiatry Clin. Neurosci. 2001, 13:42-49.
2. Comparing the Emotional Brains of Humans and others animals 2003, 25-51. Oxford University Press, Oxford. K.C. Berridge (Ed.).
3. Bhatia K.P., Marsden C.D. The behavioural and motor consequences of focal lesions of the basal ganglia in man. Brain 1994, 117(Pt 4):859-876.
4. Briand L.A., Gritton H., Howe W.M., Young D.A., Sarter M. Modulators in concert for cognition: modulator interactions in the prefrontal cortex. Prog. Neurobiol. 2007, 83:69-91.
5. Brown R.G., Pluck G. Negative symptoms: the 'pathology' of motivation and goal-directed behaviour. Trends Neurosci. 2000, 23:412-417.
6. Chen J., Lipska B.K., Halim N., Ma Q.D., Matsumoto M., Melhem S., Kolachana B.S., Hyde T.M., Herman M.M., Apud J., Egan M.F., Kleinman J.E., Weinberger D.R. Functional analysis of genetic variation in catechol-O-methyltransferase (COMT): effects on mRNA, protein, and enzyme activity in postmortem human brain. Am. J. Hum. Genet. 2004, 75:807-821.
7. Craig A.H., Cummings J.L., Fairbanks L., Itti L., Miller B.L., Li J., Mena I. Cerebral blood flow correlates of apathy in Alzheimer disease. Arch. Neurol. 1996, 53:1116-1120.
8. Craufurd D., Thompson J.C., Snowden J.S. Behavioral changes in Huntington Disease. Neuropsychiatry Neuropsychol. Behav. Neurol. 2001, 14:219-226.
9. Czernecki V., Pillon B., Houeto J.L., Pochon J.B., Levy R., Dubois B. Motivation, reward, and Parkinson's disease: influence of dopatherapy. Neuropsychologia 2002, 40:2257-2267.
10. David R., Koulibaly M., Benoit M., Garcia R., Caci H., Darcourt J., Robert P. Striatal dopamine transporter levels correlate with apathy in neurodegenerative diseases A SPECT study with partial volume effect correction. Clin. Neurol. Neurosurg. 2008, 110:19-24.
11. Delgado M.R. Reward-related responses in the human striatum. Ann. N. Y. Acad. Sci. 2007, 1104:70-88.
12. Duan J., Wainwright M.S., Comeron J.M., Saitou N., Sanders A.R., Gelernter J., Gejman P.V. Synonymous mutations in the human dopamine receptor D2 (DRD2) affect mRNA stability and synthesis of the receptor. Hum. Mol. Genet. 2003, 12:205-216.
13. Duffy J.D. The neural substrates of motivation. Psychiat. Ann. 1997, 27:24-29.
14. Engelborghs S., Marien P., Pickut B.A., Verstraeten S., De Deyn P.P. Loss of psychic self-activation after paramedian bithalamic infarction. Stroke 2000, 31:1762-1765.
15. Eslinger P.J., Damasio A.R. Severe disturbance of higher cognition after bilateral frontal lobe ablation: patient EVR. Neurology 1985, 35:1731-1741.
16. Fukunishi I., Okabe S., Nakagawa T., Hosokawa K. The assessment of intelligence function of aged chronic schizophrenia. Jpn. J. Psychiatry Neurol. 1990, 44:503-509.
17. Girault J.A., Greengard P. The neurobiology of dopamine signaling. Arch. Neurol. 2004, 61:641-644.
18. Ishii S., Weintraub N., Mervis J.R. Apathy: a common psychiatric syndrome in the elderly. J. Am. Med. Dir. Assoc. 2009, 10:381-393.
19. Koob G.F. Hedonic valence, dopamine and motivation. Mol. Psychiatry 1996, 1:186-189.
20. Krack P., Batir A., Van Blercom N., Chabardes S., Fraix V., Ardouin C., Koudsie A., Limousin P.D., Benazzouz A., LeBas J.F., Benabid A.L., Pollak P. Five-year follow-up of bilateral stimulation of the subthalamic nucleus in advanced Parkinson's disease. N. Engl. J. Med. 2003, 349:1925-1934.
21. Kuzis G., Sabe L., Tiberti C., Dorrego F., Starkstein S.E. Neuropsychological correlates of apathy and depression in patients with dementia. Neurology 1999, 52:1403-1407.
22. Levy M.L., Cummings J.L., Fairbanks L.A., Masterman D., Miller B.L., Craig A.H., Paulsen J.S., Litvan I. Apathy is not depression. J. Neuropsychiatry Clin. Neurosci. 1998, 10:314-319.
23. Levy R., Dubois B. Apathy and the functional anatomy of the prefrontal cortex-basal ganglia circuits. Cereb. Cortex 2006, 16:916-928.
24. Lundstrom K., Turpin M.P. Proposed schizophrenia-related gene polymorphism: expression of the Ser9Gly mutant human dopamine D3 receptor with the Semliki Forest virus system. Biochem. Biophys. Res. Commun. 1996, 225:1068-1072.
25. Marin R.S. Apathy: concept, syndrome, neural mechanisms, and treatment. Semin. Clin. Neuropsychiatry 1996, 1:304-314.
26. Marin R.S., Fogel B.S., Hawkins J., Duffy J., Krupp B. Apathy: a treatable syndrome. J. Neuropsychiatry Clin. Neurosci. 1995, 7:23-30.
27. McKhann G., Drachman D., Folstein M., Katzman R., Price D., Stadlan E.M. Clinical diagnosis of Alzheimer's disease: report of the NINCDS-ADRDA Work Group under the auspices of Department of Health and Human Services Task Force on Alzheimer's Disease. Neurology 1984, 34:939-944.
28. Mendez M.F., Adams N.L., Lewandowski K.S. Neurobehavioral changes associated with caudate lesions. Neurology 1989, 39:349-354.
29. Meyer-Lindenberg A., Nichols T., Callicott J.H., Ding J., Kolachana B., Buckholtz J., Mattay V.S., Egan M., Weinberger D.R. Impact of complex genetic variation in COMT on human brain function. Mol. Psychiatry 2006, 11:867-877. 797.
30. Migneco O., Benoit M., Koulibaly P.M., Dygai I., Bertogliati C., Desvignes P., Robert P.H., Malandain G., Bussiere F., Darcourt J. Perfusion brain SPECT and statistical parametric mapping analysis indicate that apathy is a cingulate syndrome: a study in Alzheimer's disease and nondemented patients. Neuroimage 2001, 13:896-902.
31. Okabe S. Simple intelligence assessment scale (in Japanese). Jpn. J. Clin. Psychiat. 1988, 17:55-61.
32. Okada K., Kobayashi S., Aoki K., Suyama N., Yamagata S. Assessment of motivational loss in poststroke patients using the Japanese version of Starkstein's Apathy Scale (in Japanese). Jpn. J. Stroke 1998, 20:318-327.
33. Okuyama Y., Ishiguro H., Toru M., Arinami T. A genetic polymorphism in the promoter region of DRD4 associated with expression and schizophrenia. Biochem. Biophys. Res. Commun. 1999, 258:292-295.
34. Pluck G.C., Brown R.G. Apathy in Parkinson's disease. J. Neurol. Neurosurg. Psychiatry 2002, 73:636-642.
35. Roman G.C., Tatemichi T.K., Erkinjuntti T., Cummings J.L., Masdeu J.C., Garcia J.H., Amaducci L., Orgogozo J.-M., Brun A., Hofman A., Moody D.M., O'Brien M.D., Yamaguchi T., Grafman J., Drayer B.P., Bennett D.A., Fisher M., Ogata J., Kokmen E., Berejo F., Wolf P.A., Gorelick P.B., Bick K.L., Pajeau A.K., Bell M.A., DeCarli C., Culebras A., Korczyn A.D., Bogousslavsky J., Hartmenn A., Scheinberg P. Vascular dementia: diagnostic criteria for research studies. Report of the NINDS-AIREN International Workshop. Neurology 1993, 43:250-260.
36. Roselli F., Pisciotta N.M., Perneczky R., Pennelli M., Aniello M.S., De Caro M.F., Ferrannini E., Tartaglione B., Defazio G., Rubini G., Livrea P. Severity of neuropsychiatric symptoms and dopamine transporter levels in dementia with Lewy bodies: a 123I-FP-CIT SPECT study. Mov. Disord. 2009, 24:2097-2103.
37. Rushworth M.F., Behrens T.E., Rudebeck P.H., Walton M.E. Contrasting roles for cingulate and orbitofrontal cortex in decisions and social behaviour. Trends Cogn. Sci. 2007, 11:168-176.
38. Schultz W. Dopamine neurons and their role in reward mechanisms. Curr. Opin. Neurobiol. 1997, 7:191-197.
39. Starkstein S.E., Mayberg H.S., Preziosi T.J., Andrezejewski P., Leiguarda R., Robinson R.G. Reliability, validity, and clinical correlates of apathy in Parkinson's disease. J. Neuropsychiatry Clin. Neurosci. 1992, 4:134-139.
40. Starkstein S.E., Merello M., Jorge R., Brockman S., Bruce D., Power B. The syndromal validity and nosological position of apathy in Parkinson's disease. Mov. Disord. 2009, 24:1211-1216.
41. Differentiation of States and Causes of Apathy 2000, 340-363. Oxford University Press, Oxford. D. Stuss, R. Van Reekum, K. Murphy (Eds.).
42. van Eimeren T., Ballanger B., Pellecchia G., Miyasaki J.M., Lang A.E., Strafella A.P. Dopamine agonists diminish value sensitivity of the orbitofrontal cortex: a trigger for pathological gambling in Parkinson's disease?. Neuropsychopharmacology 2009, 34:2758-2766.
43. van Reekum R., Stuss D.T., Ostrander L. Apathy: why care?. J. Neuropsychiatry Clin. Neurosci. 2005, 17:7-19.
44. Wang Y., Fang Y., Shen Y., Xu Q. Analysis of association between the catechol-O-methyltransferase (COMT) gene and negative symptoms in chronic schizophrenia. Psychiat. Res. 2010, 179:147-150.
45. Zhang L., Zhou F.M., Dani J.A. Cholinergic drugs for Alzheimer's disease enhance in vitro dopamine release. Mol. Pharmacol. 2004, 66:538-544.
46. Zung W.W. A cross-cultural survey of symptoms in depression. Am. J. Psychiatry 1969, 126:116-121.
47. Zung W.W. A Self-Rating Depression Scale. Arch. Gen. Psychiatry 1965, 12:63-70.
48. Zung W.W., Richards C.B., Short M.J. Self-rating depression scale in an outpatient clinic. Further validation of the SDS. Arch. Gen. Psychiatry 1965, 13:508-515.