Very Long-Chain Acyl-CoA Synthetase 3: Overexpression and Growth Dependence in Lung Cancer

PLoS ONE

Volumn 8, Issue 7, 2013, Pages

  Pei, Zhengtong ^a,b,e   Fraisl, Peter ^c,d   Shi, Xiaohai ^a,b   Gabrielson, Edward ^b   Forss Petter, Sonja ^c   Berger, Johannes ^c   Watkins, Paul A ^a,b  

^a KENNEDY KRIEGER INSTITUTE   (United States)

^b JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c MEDICAL UNIVERSITY OF VIENNA   (Austria)

^d UNIVERSITY OF LEUVEN   (Belgium)

^e SAINT BARNABAS MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

COENZYME A; LONG CHAIN FATTY ACID COENZYME A LIGASE; LONG CHAIN MONOUNSATURATED FATTY ACID; MESSENGER RNA; POLYUNSATURATED FATTY ACID; UNCLASSIFIED DRUG; VERY LONG CHAIN FATTY ACID;

ADENOCARCINOMA; ARTICLE; CANCER CELL CULTURE; CANCER GROWTH; CELL COMPARTMENTALIZATION; CELL FRACTIONATION; CELLULAR DISTRIBUTION; COLONY FORMATION; CONFOCAL MICROSCOPY; CONTROLLED STUDY; ENZYME ACTIVATION; ENZYME ACTIVITY; GENE OVEREXPRESSION; GENE SILENCING; HUMAN; HUMAN CELL; HUMAN TISSUE; HUMAN VERSUS ANIMAL COMPARISON; IMMUNOFLUORESCENCE; IMMUNOHISTOCHEMISTRY; LARGE CELL CARCINOMA; LUNG CANCER; MOLECULAR CLONING; NONHUMAN; NUCLEOTIDE SEQUENCE; PROTEIN DEPLETION; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; RNA INTERFERENCE; SMALL CELL CARCINOMA; SQUAMOUS CELL CARCINOMA; TISSUE SECTION; WESTERN BLOTTING;

ANIMALS; BRONCHI; CELL ADHESION; CELL LINE, TUMOR; CELL PROLIFERATION; COENZYME A LIGASES; EPITHELIAL CELLS; FATTY ACIDS; FLUORESCENT ANTIBODY TECHNIQUE; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION, ENZYMOLOGIC; GENE KNOCKDOWN TECHNIQUES; HUMANS; LUNG NEOPLASMS; MICE; PROTEIN TRANSPORT; RNA, MESSENGER; SUBCELLULAR FRACTIONS;

EID: 84880709693     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0069392     Document Type: Article

References (42)

1. Watkins PA, Maiguel D, Jia Z, Pevsner J, (2007) Evidence for 26 distinct acyl-coenzyme A synthetase genes in the human genome. J Lipid Res 48: 2736-2750.
2. Watkins PA, (2008) Very-long-chain Acyl-CoA Synthetases. J Biol Chem 283: 1773-1777.
3. Gimeno RE, (2007) Fatty acid transport proteins. Curr Opin Lipidol 18: 271-276.
4. DiRusso CC, Li H, Darwis D, Watkins PA, Berger J, et al. (2005) Comparative biochemical studies of the murine fatty acid transport proteins (FATP) expressed in yeast. J Biol Chem 280: 16829-16837.
5. Pei Z, Fraisl P, Berger J, Jia Z, Forss-Petter S, et al. (2004) Mouse very long-chain Acyl-CoA synthetase 3/fatty acid transport protein 3 catalyzes fatty acid activation but not fatty acid transport in MA-10 cells. J Biol Chem 279: 54454-54462.
6. Pei Z, Sun P, Huang P, Lal B, Laterra J, et al. (2009) Acyl-CoA synthetase VL3 knockdown inhibits human glioma cell proliferation and tumorigenicity. Cancer Res 69: 9175-9182.
7. Siegel R, Naishadham D, Jemal A, (2012) Cancer statistics, 2012. CA Cancer J Clin 62: 10-29.
8. Shibata Y, Carninci P, Watahiki A, Shiraki T, Konno H, et al. (2001) Cloning full-length, cap-trapper-selected cDNAs by using the single-strand linker ligation method. Biotechniques 30: 1250-1254.
9. Ramirez RD, Sheridan S, Girard L, Sato M, Kim Y, et al. (2004) Immortalization of human bronchial epithelial cells in the absence of viral oncoproteins. Cancer Res 64: 9027-9034.
10. Steinberg SJ, Wang SJ, McGuinness MC, Watkins PA, (1999) Human liver-specific very-long-chain acyl-coenzyme A synthetase: cDNA cloning and characterization of a second enzymatically active protein. Mol Genet Metab 68: 32-42.
11. Fraisl P, Tanaka H, Forss-Petter S, Lassmann H, Nishimune Y, et al. (2006) A novel mammalian bubblegum-related acyl-CoA synthetase restricted to testes and possibly involved in spermatogenesis. Arch Biochem Biophys 451: 23-33.
12. Pei Z, Oey NA, Zuidervaart MM, Jia Z, Li Y, et al. (2003) The acyl-CoA synthetase "bubblegum" (lipidosin): further characterization and role in neuronal fatty acid beta-oxidation. J Biol Chem 278: 47070-47078.
13. Fraisl P, Forss-Petter S, Zigman M, Berger J, (2004) Murine bubblegum orthologue is a microsomal very long-chain acyl-CoA synthetase. Biochem J 377: 85-93.
14. Watkins PA, Gould SJ, Smith MA, Braiterman LT, Wei HM, et al. (1995) Altered expression of ALDP in X-linked adrenoleukodystrophy. Am J Hum Genet 57: 292-301.
15. Steinberg SJ, Wang SJ, Kim DG, Mihalik SJ, Watkins PA, (1999) Human very-long-chain acyl-CoA synthetase: cloning, topography, and relevance to branched-chain fatty acid metabolism. Biochem Biophys Res Commun 257: 615-621.
16. Lagerstedt SA, Hinrichs DR, Batt SM, Magera MJ, Rinaldo P, et al. (2001) Quantitative determination of plasma c8-c26 total fatty acids for the biochemical diagnosis of nutritional and metabolic disorders. Mol Genet Metab 73: 38-45.
17. Steinberg SJ, Morgenthaler J, Heinzer AK, Smith KD, Watkins PA, (2000) Very long-chain acyl-CoA synthetases. Human "bubblegum" represents a new family of proteins capable of activating very long-chain fatty acids. J Biol Chem 275: 35162-35169.
18. Steinberg SJ, Wang SJ, McGuinness MC, Watkins PA, (1999) Human liver-specific very-long-chain acyl-coenzyme A synthetase: cDNA cloning and characterization of a second enzymatically active protein. Mol Genet Metab 68: 32-42.
19. Vance JE, (1990) Phospholipid synthesis in a membrane fraction associated with mitochondria. J Biol Chem 265: 7248-7256.
20. Lechner JF, Haugen A, McClendon IA, Pettis EW, (1982) Clonal growth of normal adult human bronchial epithelial cells in a serum-free medium. In Vitro 18: 633-642.
21. Ellis JM, Frahm JL, Li LO, Coleman RA, (2010) Acyl-coenzyme A synthetases in metabolic control. Curr Opin Lipidol 21: 212-217.
22. Heinzer AK, Watkins PA, Lu JF, Kemp S, Moser AB, et al. (2003) A very long-chain acyl-CoA synthetase-deficient mouse and its relevance to X-linked adrenoleukodystrophy. Hum Mol Genet 12: 1145-1154.
23. Chiu HC, Kovacs A, Blanton RM, Han X, Courtois M, et al. (2005) Transgenic expression of fatty acid transport protein 1 in the heart causes lipotoxic cardiomyopathy. Circ Res 96: 225-233.
24. Kim JK, Gimeno RE, Higashimori T, Kim HJ, Choi H, et al. (2004) Inactivation of fatty acid transport protein 1 prevents fat-induced insulin resistance in skeletal muscle. J Clin Invest 113: 756-763.
25. Wu Q, Ortegon AM, Tsang B, Doege H, Feingold KR, et al. (2006) FATP1 is an insulin-sensitive fatty acid transporter involved in diet-induced obesity. Mol Cell Biol 26: 3455-3467.
26. Herrmann T, Van Der Hoeven F, Grone HJ, Stewart AF, Langbein L, et al. (2003) Mice with targeted disruption of the fatty acid transport protein 4 (Fatp 4, Slc27a4) gene show features of lethal restrictive dermopathy. J Cell Biol 161: 1105-1115.
27. Moulson CL, Martin DR, Lugus JJ, Schaffer JE, Lind AC, et al. (2003) Cloning of wrinkle-free, a previously uncharacterized mouse mutation, reveals crucial roles for fatty acid transport protein 4 in skin and hair development. Proc Natl Acad Sci U S A 100: 5274-5279.
28. Klar J, Schweiger M, Zimmerman R, Zechner R, Li H, et al. (2009) Mutations in the fatty acid transport protein 4 gene cause the ichthyosis prematurity syndrome. Am J Hum Genet 85: 248-253.
29. Mihalik SJ, Steinberg SJ, Pei Z, Park J, Kim DG, et al. (2002) Participation of two members of the very long-chain acyl-CoA synthetase family in bile acid synthesis and recycling. J Biol Chem 277: 24771-24779.
30. Steinberg SJ, Mihalik SJ, Kim DG, Cuebas DA, Watkins PA, (2000) The Human Liver-specific Homolog of Very Long-chain Acyl-CoA Synthetase Is Cholate:CoA Ligase. J Biol Chem 275: 15605-15608.
31. Hubbard B, Doege H, Punreddy S, Wu H, Huang X, et al. (2006) Mice deleted for fatty acid transport protein 5 have defective bile acid conjugation and are protected from obesity. Gastroenterology 130: 1259-1269.
32. Chong CP, Mills PB, McClean P, Gissen P, Bruce C, et al. (2011) Bile acid-CoA ligase deficiency-a new inborn error of bile acid metabolism. J Inherit Metab Dis 35: 521-530.
33. Doege H, Baillie RA, Ortegon AM, Tsang B, Wu Q, et al. (2006) Targeted deletion of FATP5 reveals multiple functions in liver metabolism: alterations in hepatic lipid homeostasis. Gastroenterology 130: 1245-1258.
34. Cao Y, Dave KB, Doan TP, Prescott SM, (2001) Fatty acid CoA ligase 4 is up-regulated in colon adenocarcinoma. Cancer Res 61: 8429-8434.
35. Sung YK, Hwang SY, Park MK, Bae HI, Kim WH, et al. (2003) Fatty acid-CoA ligase 4 is overexpressed in human hepatocellular carcinoma. Cancer Sci 94: 421-424.
36. Monaco ME, Creighton CJ, Lee P, Zou X, Topham MK, et al. (2010) Expression of Long-chain Fatty Acyl-CoA Synthetase 4 in Breast and Prostate Cancers Is Associated with Sex Steroid Hormone Receptor Negativity. Transl Oncol 3: 91-98.
37. Yamashita Y, Kumabe T, Cho YY, Watanabe M, Kawagishi J, et al. (2000) Fatty acid induced glioma cell growth is mediated by the acyl-CoA synthetase 5 gene located on chromosome 10q25.1-q25.2, a region frequently deleted in malignant gliomas. Oncogene 19: 5919-5925.
38. Gaisa NT, Reinartz A, Schneider U, Klaus C, Heidenreich A,et al. Levels of acyl-coenzyme A synthetase 5 in urothelial cells and corresponding neoplasias reflect cellular differentiation. Histol Histopathol 28: 353-364.
39. Hagberg CE, Falkevall A, Wang X, Larsson E, Huusko J, et al. (2010) Vascular endothelial growth factor B controls endothelial fatty acid uptake. Nature 464: 917-921.
40. Orita H, Coulter J, Lemmon C, Tully E, Vadlamudi A, et al. (2007) Selective inhibition of fatty acid synthase for lung cancer treatment. Clin Cancer Res 13: 7139-7145.
41. Visca P, Sebastiani V, Botti C, Diodoro MG, Lasagni RP, et al. (2004) Fatty acid synthase (FAS) is a marker of increased risk of recurrence in lung carcinoma. Anticancer Res 24: 4169-4173.
42. Zaugg K, Yao Y, Reilly PT, Kannan K, Kiarash R, et al. (2011) Carnitine palmitoyltransferase 1C promotes cell survival and tumor growth under conditions of metabolic stress. Genes Dev 25: 1041-1051.