Succinate receptor GPR91, a Gαi coupled receptor that increases intracellular calcium concentrations through PLCβ

FEBS Letters

Volumn 587, Issue 15, 2013, Pages 2399-2404

  Sundström, Linda ^a   Greasley, Peter J ^a   Engberg, Susanna ^a   Wallander, Malin ^a   Ryberg, Erik ^a  

^a ASTRAZENECA R AND D   (Sweden)

Author keywords

GPCR; GPR91; PLC ; PTX; Succinate

Indexed keywords

1 [[6 (3 METHOXYESTRA 1,3,5(10) TRIEN 17BETA YL)AMINO]HEXYL] 1H PYRROLE 2,5 DIONE; CALCIUM ION; CYCLIC AMP; EDELFOSINE; G PROTEIN COUPLED RECEPTOR; G PROTEIN COUPLED RECEPTOR 91; GUANINE NUCLEOTIDE BINDING PROTEIN ALPHA SUBUNIT; GUANINE NUCLEOTIDE BINDING PROTEIN ALPHA SUBUNIT Q; INHIBITORY GUANINE NUCLEOTIDE BINDING PROTEIN; INOSITOL PHOSPHATE; PERTUSSIS TOXIN; PHOSPHOLIPASE C; PHOSPHOLIPASE C BETA; SUCCINIC ACID; UNCLASSIFIED DRUG;

ARTICLE; CALCIUM CELL LEVEL; CALCIUM TRANSPORT; CELL STRAIN HEK293; CONTROLLED STUDY; EXTRACELLULAR CALCIUM; HUMAN; HUMAN CELL; PRIORITY JOURNAL; SIGNAL TRANSDUCTION;

3′-5′-CYCLIC ADENOSINE MONOPHOSPHATE; BOVINE SERUM ALBUMIN; BSA; CAMP; DMR; DYNAMIC MASS REDISTRIBUTION; ERK; EXTRACELLULAR-SIGNAL-REGULATED KINASE; FACS; FLIPR; FLUORESCENCE-ACTIVATED CELL SORTING; FLUORESCENT IMAGING PLATE READER; GPCR; GPR91; GTPΓS; GUANOSINE 5′-[Γ-(35)S]-TRIPHOSPHATE; HOMOGENEOUS TIME RESOLVED FLUORESCENCE; HTRF; INOSITOL-1-PHOSPHATE; IP(1); MAPK; MITOGEN-ACTIVATED PROTEIN KINASE; PERTUSSIS TOXIN; PLCΒ; PTX; SUCCINATE; SUCCINATE RECEPTOR 1; SUCNR1;

CALCIUM; CYCLIC AMP; HEK293 CELLS; HUMANS; PHOSPHOLIPASE C BETA; RECEPTORS, G-PROTEIN-COUPLED; SIGNAL TRANSDUCTION; SUCCINATES;

EID: 84880703514     PISSN: 00145793     EISSN: 18733468     Source Type: Journal    
DOI: 10.1016/j.febslet.2013.05.067     Document Type: Article

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