Ribosomal protein S6 phosphorylation is associated with epithelial dysplasia and squamous cell carcinoma of the oral cavity

Pathology and Oncology Research

Volumn 19, Issue 2, 2013, Pages 189-193

  Chaisuparat, Risa ^a   Rojanawatsirivej, Somsri ^a   Yodsanga, Somchai ^a  

^a CHULALONGKORN UNIVERSITY   (Thailand)

Author keywords

Epithelial dysplasia; Oral squamous cell carcinoma; Ribosomal protein S6; Tumor progression

Indexed keywords

PROTEIN S6;

AGED; ARTICLE; CANCER CLASSIFICATION; CANCER LOCALIZATION; CELL DIFFERENTIATION; CONTROLLED STUDY; DISEASE ASSOCIATION; DISEASE MARKER; DISEASE SEVERITY; EPITHELIUM DYSPLASIA; FEMALE; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; MAJOR CLINICAL STUDY; MALE; MOUTH SQUAMOUS CELL CARCINOMA; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; PROTEIN PHOSPHORYLATION; TISSUE MICROARRAY; TUMOR CELL; TUMOR GROWTH;

ADULT; AGED; AGED, 80 AND OVER; CARCINOMA, SQUAMOUS CELL; DISEASE PROGRESSION; EARLY DETECTION OF CANCER; FEMALE; HUMANS; MALE; MIDDLE AGED; MOUTH MUCOSA; MOUTH NEOPLASMS; PHOSPHORYLATION; PRECANCEROUS CONDITIONS; RIBOSOMAL PROTEIN S6; TUMOR MARKERS, BIOLOGICAL; YOUNG ADULT;

EID: 84880697736     PISSN: 12194956     EISSN: 15322807     Source Type: Journal    
DOI: 10.1007/s12253-012-9568-y     Document Type: Article

References (26)

1. Johnson NW, Jayasekara P, Amarasinghe AA (2011) Squamous cell carcinoma and precursor lesions of the oral cavity: epidemiology and aetiology. Periodontol 2000 57(1):19-37
2. Warnakulasuriya S (2009) Global epidemiology of oral and oropharyngeal cancer. Oral Oncol 45:309-316
3. Napier SS, Speight PM (2008) Natural history of potentially malignant oral lesions and conditions: an overview of the literature. J Oral Pathol Med 37:1-10
4. Mithani SK, Mydlarz WK, Grumbine FL et al (2007) Molecular genetics of premalignant oral lesions. Oral Dis 13:126-133
5. Ruvinsky I, Meyuhas O (2006) Ribosomal protein S6 phosphorylation: from protein synthesis to cell size. Trends Biochem Sci 31:342-348
6. Vivanco I, Sawyers CL (2002) The phosphatidylinositol 3-Kinase AKT pathway in human cancer. Nat Rev Cancer 2:489-501
7. Ruvinsky I, Katz M, Dreazen A et al (2009) Mice deficient in ribosomal protein S6 phosphorylation suffer from muscle weakness that reflects a growth defect and energy deficit. PLoS One 4:e5618
8. Ruvinsky I, Sharon N, Lerer T, Cohen H, Stolovich-Rain M, Nir T, Dor Y, Zisman P, Meyuhas O (2005) Ribosomal protein S6 phosphorylation is a determinant of cell size and glucose homeostasis. Genes Dev 19(18):2199-2211
9. Clark C, Shah S, Herman-Ferdinandez L et al (2010) Teasing out the best molecular marker in the AKT/mTOR pathway in head and neck squamous cell cancer patients. Laryngoscope 120:1159-1165
10. Molinolo AA, Hewitt SM, Amornphimoltham P et al (2007) Dissecting the Akt/mammalian target of rapamycin signaling network: emerging results from the head and neck cancer tissue array initiative. Clin Cancer Res 13:4964-4973
11. Kononen J, Bubendorf L, Kallioniemi A et al (1998) Tissue microarrays for high-throughput molecular profiling of tumor specimens. Nat Med 4:844-847
12. Bose S, Chandran S, Mirocha JM et al (2006) The Akt pathway in human breast cancer: a tissue-array-based analysis. Mod Pathol 19:238-245
13. Pantuck AJ, Seligson DB, Klatte T et al (2007) Prognostic relevance of the mTOR pathway in renal cell carcinoma: implications for molecular patient selection for targeted therapy. Cancer 109:2257-2267
14. Bjornsti MA, Houghton PJ (2004) The TOR pathway: a target for cancer therapy. Nat Rev Cancer 4:335-348
15. Scheper MA, Chaisuparat R, Nikitakis NG et al (2008) Expression and alterations of the PTEN/AKT/mTOR pathway in ameloblastomas. Oral Dis 14:561-568
16. Amornphimoltham P, Patel V, Sodhi A et al (2005) Mammalian target of rapamycin, a molecular target in squamous cell carcinomas of the head and neck. Cancer Res 65:9953-9961
17. Liu Y, Hidayat S, Su WH et al (2007) Expression and activity of mTOR and its substrates in different cell cycle phases and in oral squamous cell carcinomas of different malignant grade. Cell Biochem Funct 25:45-53
18. Garnis C, Buys TP, Lam WL (2004) Genetic alteration and gene expression modulation during cancer progression. Mol Cancer 3:9
19. Vitale-Cross L, Czerninski R, Amornphimoltham P et al (2009) Chemical carcinogenesis models for evaluating molecular-targeted prevention and treatment of oral cancer. Cancer Prev Res (Phila) 2:419-422
20. Feng CJ, Li HJ, Li JN et al (2008) Expression of Mcm7 and Cdc6 in oral squamous cell carcinoma and precancerous lesions. Anticancer Res 28:3763-3769
21. Inoue H, Miyazaki Y, Kikuchi K et al (2012) Podoplanin expression during dysplasia-carcinoma sequence in the oral cavity. Tumour Biol 33:183-194
22. Jham BC, Costa NL, Silva JM et al (2012) Midkine expression in oral squamous cell carcinoma and leukoplakia. J Oral Pathol Med 41:21-26
23. Kato Y, Uzawa K, Yamamoto N et al (2007) Overexpression of Septin1: possible contribution to the development of oral cancer. Int J Oncol 31:1021-1028
24. Montebugnoli L, Cervellati F, Cocchi R et al (2010) Immunohistochemical expression of p16(INK4A) protein as a helpful marker of a subset of potentially malignant oral epithelial lesions: study on a series with long-term follow-up. Histopathology 57:528-534
25. Nomura H, Uzawa K, Yamano Y et al (2009) Down-regulation of plasma membranous Annexin A1 protein expression in premalignant and malignant lesions of the oral cavity: correlation with epithelial differentiation. J Cancer Res Clin Oncol 135:943-949
26. Torres-Rendon A, Roy S, Craig GT et al (2009) Expression of Mcm2, geminin and Ki67 in normal oral mucosa, oral epithelial dysplasias and their corresponding squamous-cell carcinomas. Br J Cancer 100:1128-1134