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Volumn 57, Issue 4, 2010, Pages 528-534

Immunohistochemical expression of p16INK4A protein as a helpful marker of a subset of potentially malignant oral epithelial lesions: Study on a series with long-term follow-up

Author keywords

Immunohistochemistry; Oral lesions; OSCC; P16INK4A

Indexed keywords

CYCLIN DEPENDENT KINASE INHIBITOR 2A;

EID: 78650453792     PISSN: 03090167     EISSN: 13652559     Source Type: Journal    
DOI: 10.1111/j.1365-2559.2010.03671.x     Document Type: Article
Times cited : (14)

References (47)
  • 1
    • 9344247476 scopus 로고    scopus 로고
    • Genetic progression model for head and neck cancer: implications for field cancerization
    • Califano J, Van Der Riet P, Westra W et al. Genetic progression model for head and neck cancer: implications for field cancerization. Cancer Res. 1996; 6; 2488-2492.
    • (1996) Cancer Res. , vol.6 , pp. 2488-2492
    • Califano, J.1    Van Der Riet, P.2    Westra, W.3
  • 3
    • 0029061585 scopus 로고
    • Sequential loss of heterozygosity at microsatellite motifs in preinvasive and invasive head and neck squamous carcinoma
    • El-Naggar AK, Hurr K, Batsakis JG, Luna MA, Goepfert H, Huff V. Sequential loss of heterozygosity at microsatellite motifs in preinvasive and invasive head and neck squamous carcinoma. Cancer Res. 1995; 55; 2656-2659.
    • (1995) Cancer Res. , vol.55 , pp. 2656-2659
    • El-Naggar, A.K.1    Hurr, K.2    Batsakis, J.G.3    Luna, M.A.4    Goepfert, H.5    Huff, V.6
  • 4
    • 0028278720 scopus 로고
    • Frequent loss of chromosome 9p21-22 early in head and neck cancer progression
    • Van Der Riet P, Nawroz H, Hruban RH et al. Frequent loss of chromosome 9p21-22 early in head and neck cancer progression. Cancer Res. 1994; 54; 1156-1158.
    • (1994) Cancer Res. , vol.54 , pp. 1156-1158
    • Van Der Riet, P.1    Nawroz, H.2    Hruban, R.H.3
  • 7
    • 33745887525 scopus 로고    scopus 로고
    • Correlation of clinicopathological features with immunohistochemical expression of cell cycle regulatory proteins p16 and retinoblastoma: distinct association with keratinisation and differentiation in oral cavity squamous cell carcinoma
    • Muirhead DM, Hoffman HT, Robinson RA. Correlation of clinicopathological features with immunohistochemical expression of cell cycle regulatory proteins p16 and retinoblastoma: distinct association with keratinisation and differentiation in oral cavity squamous cell carcinoma. J. Clin. Pathol. 2006; 59; 711-715.
    • (2006) J. Clin. Pathol. , vol.59 , pp. 711-715
    • Muirhead, D.M.1    Hoffman, H.T.2    Robinson, R.A.3
  • 8
    • 0032517341 scopus 로고    scopus 로고
    • The p16INK4a/CDKN2A tumor suppressor and its relatives
    • Ruas M, Peters G. The p16INK4a/CDKN2A tumor suppressor and its relatives. Biochim. Biophys. Acta 1998; 1378; F115-F177.
    • (1998) Biochim. Biophys. Acta , vol.1378
    • Ruas, M.1    Peters, G.2
  • 9
    • 0037399861 scopus 로고    scopus 로고
    • Oral cancer: reviewing the present understanding of its molecular mechanism and exploring the future directions for its effective management
    • Nagpal JK, Das BR. Oral cancer: reviewing the present understanding of its molecular mechanism and exploring the future directions for its effective management. Oral Oncol. 2003; 39; 213-221.
    • (2003) Oral Oncol. , vol.39 , pp. 213-221
    • Nagpal, J.K.1    Das, B.R.2
  • 10
    • 0036141797 scopus 로고    scopus 로고
    • Clinicopathological significance of p16 gene expression in the surgical treatment of head and neck squamous cell carcinomas
    • Yuen PW, Man M, Lam KY, Kwong YL. Clinicopathological significance of p16 gene expression in the surgical treatment of head and neck squamous cell carcinomas. J. Clin. Pathol. 2002; 55; 58-60.
    • (2002) J. Clin. Pathol. , vol.55 , pp. 58-60
    • Yuen, P.W.1    Man, M.2    Lam, K.Y.3    Kwong, Y.L.4
  • 11
    • 0141519075 scopus 로고    scopus 로고
    • The p16 (CDKN2a/INK4a) tumor-suppressor gene in head and neck squamous cell carcinoma: a promoter methylation and protein expression study in 100 cases
    • Ai L, Stephenson KK, Ling W et al. The p16 (CDKN2a/INK4a) tumor-suppressor gene in head and neck squamous cell carcinoma: a promoter methylation and protein expression study in 100 cases. Mod. Pathol. 2003; 16; 944-950.
    • (2003) Mod. Pathol. , vol.16 , pp. 944-950
    • Ai, L.1    Stephenson, K.K.2    Ling, W.3
  • 12
    • 0035835818 scopus 로고    scopus 로고
    • p16(MTS-1/CDKN2/INK4a) in cancer progression
    • Rocco JW, Sidransky D. p16(MTS-1/CDKN2/INK4a) in cancer progression. Exp. Cell Res. 2001; 264; 42-55.
    • (2001) Exp. Cell Res. , vol.264 , pp. 42-55
    • Rocco, J.W.1    Sidransky, D.2
  • 13
    • 4444288693 scopus 로고    scopus 로고
    • Prognostic significance of p16 protein levels in oropharyngeal squamous cell cancer
    • Weinberger PM, Yu Z, Haffty BG et al. Prognostic significance of p16 protein levels in oropharyngeal squamous cell cancer. Clin. Cancer Res. 2004; 10; 5684-5691.
    • (2004) Clin. Cancer Res. , vol.10 , pp. 5684-5691
    • Weinberger, P.M.1    Yu, Z.2    Haffty, B.G.3
  • 14
    • 0036126045 scopus 로고    scopus 로고
    • Cyclin D1 amplification and p16(MTS1/CDK4I) deletion correlate with poor prognosis in head and neck tumors
    • Namazie A, Alavi S, Olopade OI et al. Cyclin D1 amplification and p16(MTS1/CDK4I) deletion correlate with poor prognosis in head and neck tumors. Laryngoscope 2002; 112; 472-481.
    • (2002) Laryngoscope , vol.112 , pp. 472-481
    • Namazie, A.1    Alavi, S.2    Olopade, O.I.3
  • 15
    • 33846646536 scopus 로고    scopus 로고
    • Comparison of p16(INK4a) expression with p53 alterations in head and neck cancer by tissue microarray analysis
    • Karsai S, Abel U, Roesch-Ely M et al. Comparison of p16(INK4a) expression with p53 alterations in head and neck cancer by tissue microarray analysis. J. Pathol. 2007; 211; 314-322.
    • (2007) J. Pathol. , vol.211 , pp. 314-322
    • Karsai, S.1    Abel, U.2    Roesch-Ely, M.3
  • 16
    • 4043054432 scopus 로고    scopus 로고
    • Altered p16INK4a and Fhit expression in carcinogenesis and progression of human oral cancer
    • Paradiso A, Ranieri G, Stea B et al. Altered p16INK4a and Fhit expression in carcinogenesis and progression of human oral cancer. Int. J. Oncol. 2004; 24; 249-255.
    • (2004) Int. J. Oncol. , vol.24 , pp. 249-255
    • Paradiso, A.1    Ranieri, G.2    Stea, B.3
  • 17
    • 33747168283 scopus 로고    scopus 로고
    • Expression of p16(INK4A), p53, and Rb proteins are independent from the presence of human papillomavirus genes in oral squamous cell carcinoma
    • Nemes JA, Deli L, Nemes Z, Márton IJ. Expression of p16(INK4A), p53, and Rb proteins are independent from the presence of human papillomavirus genes in oral squamous cell carcinoma. Oral. Surg. Oral Med. Oral Pathol.Oral Radiol. Endod. 2006; 102; 344-352.
    • (2006) Oral. Surg. Oral Med. Oral Pathol.Oral Radiol. Endod. , vol.102 , pp. 344-352
    • Nemes, J.A.1    Deli, L.2    Nemes, Z.3    Márton, I.J.4
  • 19
    • 0035871985 scopus 로고    scopus 로고
    • Overexpression of p16(INK4A) as a specific marker for dysplastic and neoplastic epithelial cells of the cervix uteri
    • Klaes R, Friedrich T, Spitkovsky D et al. Overexpression of p16(INK4A) as a specific marker for dysplastic and neoplastic epithelial cells of the cervix uteri. Int. J. Cancer 2001; 92; 276-284.
    • (2001) Int. J. Cancer , vol.92 , pp. 276-284
    • Klaes, R.1    Friedrich, T.2    Spitkovsky, D.3
  • 20
    • 0036826860 scopus 로고    scopus 로고
    • p16INK4a immunohistochemistry improves interobserver agreement in the diagnosis of cervical intraepithelial neoplasia
    • Klaes R, Benner A, Friedrich T et al. p16INK4a immunohistochemistry improves interobserver agreement in the diagnosis of cervical intraepithelial neoplasia. Am. J. Surg. Pathol. 2002; 26; 1389-1399.
    • (2002) Am. J. Surg. Pathol. , vol.26 , pp. 1389-1399
    • Klaes, R.1    Benner, A.2    Friedrich, T.3
  • 21
    • 0036019563 scopus 로고    scopus 로고
    • Overexpression of p16 and p14ARF is associated with human papillomavirus infection in cervical squamous cell carcinoma and dysplasia
    • Sano T, Masuda N, Oyama T, Nakajima T. Overexpression of p16 and p14ARF is associated with human papillomavirus infection in cervical squamous cell carcinoma and dysplasia. Pathol. Int. 2002; 52; 375-383.
    • (2002) Pathol. Int. , vol.52 , pp. 375-383
    • Sano, T.1    Masuda, N.2    Oyama, T.3    Nakajima, T.4
  • 22
    • 20844443130 scopus 로고    scopus 로고
    • p16INK4A, CDC6, and MCM5: predictive biomarkers in cervical preinvasive neoplasia and cervical cancer
    • Murphy N, Ring M, Heffron CC et al. p16INK4A, CDC6, and MCM5: predictive biomarkers in cervical preinvasive neoplasia and cervical cancer. J. Clin. Pathol. 2005; 58; 525-534.
    • (2005) J. Clin. Pathol. , vol.58 , pp. 525-534
    • Murphy, N.1    Ring, M.2    Heffron, C.C.3
  • 23
    • 33947670404 scopus 로고    scopus 로고
    • CK17 and p16 expression patterns distinguish (atypical) immature squamous metaplasia from high-grade cervical intraepithelial neoplasia (CIN III)
    • Regauer S, Reich O. CK17 and p16 expression patterns distinguish (atypical) immature squamous metaplasia from high-grade cervical intraepithelial neoplasia (CIN III). Histopathology 2007; 50; 629-635.
    • (2007) Histopathology , vol.50 , pp. 629-635
    • Regauer, S.1    Reich, O.2
  • 24
    • 0030612712 scopus 로고    scopus 로고
    • Frequent inactivation of p16INK4a in oral premalignant lesions
    • Papadimitrakopoulou V, Izzo J, Lippman SM et al. Frequent inactivation of p16INK4a in oral premalignant lesions. Oncogene 1997; 14; 1799-1803.
    • (1997) Oncogene , vol.14 , pp. 1799-1803
    • Papadimitrakopoulou, V.1    Izzo, J.2    Lippman, S.M.3
  • 25
    • 0037105785 scopus 로고    scopus 로고
    • Alterations of p16(INK4a) and p14(ARF) in patients with severe oral epithelial dysplasia
    • Kresty LA, Mallery SR, Knobloch TJ et al. Alterations of p16(INK4a) and p14(ARF) in patients with severe oral epithelial dysplasia. Cancer Res. 2002; 62; 5295-5300.
    • (2002) Cancer Res. , vol.62 , pp. 5295-5300
    • Kresty, L.A.1    Mallery, S.R.2    Knobloch, T.J.3
  • 26
    • 19544374893 scopus 로고    scopus 로고
    • Potential diagnostic use of p16INK4A, a new marker that correlates with dysplasia in oral squamoproliferative lesions
    • Gologan O, Barnes EL, Hunt JL. Potential diagnostic use of p16INK4A, a new marker that correlates with dysplasia in oral squamoproliferative lesions. Am. J. Surg. Pathol. 2005; 29; 792-796.
    • (2005) Am. J. Surg. Pathol. , vol.29 , pp. 792-796
    • Gologan, O.1    Barnes, E.L.2    Hunt, J.L.3
  • 27
    • 33745740651 scopus 로고    scopus 로고
    • Overexpression of p16INK4 is a reliable marker of human papillomavirus-induced oral high-grade squamous dysplasia
    • Cunningham LL Jr, Pagano GM, Li M et al. Overexpression of p16INK4 is a reliable marker of human papillomavirus-induced oral high-grade squamous dysplasia. Oral Surg. Oral Med. Oral Pathol. Oral Radiol. Endod. 2006; 102; 77-81.
    • (2006) Oral Surg. Oral Med. Oral Pathol. Oral Radiol. Endod. , vol.102 , pp. 77-81
    • Cunningham Jr, L.L.1    Pagano, G.M.2    Li, M.3
  • 28
    • 33748860116 scopus 로고    scopus 로고
    • Immunohistochemical detection of p16INK4a in dysplastic lesions of the oral cavity
    • Bradley KT, Budnick SD, Logani S. Immunohistochemical detection of p16INK4a in dysplastic lesions of the oral cavity. Mod. Pathol. 2006; 19; 1310-1316.
    • (2006) Mod. Pathol. , vol.19 , pp. 1310-1316
    • Bradley, K.T.1    Budnick, S.D.2    Logani, S.3
  • 29
    • 33646399282 scopus 로고    scopus 로고
    • Pathology and genetics head and neck tumour
    • Barnes L, Eveson JW, Reichart P, Sidranski D, eds. Lyon: World Health Classification of Tumours.
    • El Naggar AK, Reichart PA. Proliferative verrucous leukoplakia and precancerous conditions. In Barnes L, Eveson JW, Reichart P, Sidranski D eds. Pathology and genetics head and neck tumour. Lyon: World Health Classification of Tumours, 2005; 180-181.
    • (2005) Proliferative verrucous leukoplakia and precancerous conditions , pp. 180-181
    • El Naggar, A.K.1    Reichart, P.A.2
  • 30
    • 0034634752 scopus 로고    scopus 로고
    • Alterations of Rb, p16INK4a and cyclin D1 in the tumorigenesis of oral squamous cell carcinomas
    • Nakahara Y, Shintani S, Mihara A, Ueyama Y, Matsamura T. Alterations of Rb, p16INK4a and cyclin D1 in the tumorigenesis of oral squamous cell carcinomas. Cancer Lett. 2000; 160; 3-8.
    • (2000) Cancer Lett. , vol.160 , pp. 3-8
    • Nakahara, Y.1    Shintani, S.2    Mihara, A.3    Ueyama, Y.4    Matsamura, T.5
  • 31
    • 0028034775 scopus 로고
    • Transcriptional repression of the D-type cyclin-dependent kinase inhibitor p16 by the retinoblastoma susceptibility gene product pRb
    • Li Y, Nichols MA, Shay JW, Xiong Y. Transcriptional repression of the D-type cyclin-dependent kinase inhibitor p16 by the retinoblastoma susceptibility gene product pRb. Cancer Res. 1994; 54; 6078-6682.
    • (1994) Cancer Res. , vol.54 , pp. 6078-6682
    • Li, Y.1    Nichols, M.A.2    Shay, J.W.3    Xiong, Y.4
  • 32
    • 0029091503 scopus 로고
    • Frequency of homozygous deletion at p16/CDKN2 in primary human tumours
    • Cairns P, Polascik TJ, Eby Y et al. Frequency of homozygous deletion at p16/CDKN2 in primary human tumours. Nat. Genet. 1995; 11; 210-212.
    • (1995) Nat. Genet. , vol.11 , pp. 210-212
    • Cairns, P.1    Polascik, T.J.2    Eby, Y.3
  • 33
    • 0028138707 scopus 로고
    • Higher frequency of alterations in the p16/CDKN2 gene in squamous cell carcinoma cell lines than in primary tumors of the head and neck
    • Zhang SY, Klein-Szanto AJ, Sauter ER et al. Higher frequency of alterations in the p16/CDKN2 gene in squamous cell carcinoma cell lines than in primary tumors of the head and neck. Cancer Res. 1994; 54; 5050-5053.
    • (1994) Cancer Res. , vol.54 , pp. 5050-5053
    • Zhang, S.Y.1    Klein-Szanto, A.J.2    Sauter, E.R.3
  • 34
    • 0029011539 scopus 로고
    • 5' CpG island methylation is associated with transcriptional silencing of the tumour suppressor p16/CDKN2/MTS1 in human cancers
    • Merlo A, Herman JG, Mao L et al. 5' CpG island methylation is associated with transcriptional silencing of the tumour suppressor p16/CDKN2/MTS1 in human cancers. Nat. Med. 1995; 1; 686-692.
    • (1995) Nat. Med. , vol.1 , pp. 686-692
    • Merlo, A.1    Herman, J.G.2    Mao, L.3
  • 35
    • 34247850954 scopus 로고    scopus 로고
    • Human papillomavirus: its identity and controversial role in oral oncogenesis, premalignant and malignant lesions (review)
    • Campisi G, Panzarella V, Giuliani M et al. Human papillomavirus: its identity and controversial role in oral oncogenesis, premalignant and malignant lesions (review). Int. J. Oncol. 2007; 30; 813-823.
    • (2007) Int. J. Oncol. , vol.30 , pp. 813-823
    • Campisi, G.1    Panzarella, V.2    Giuliani, M.3
  • 36
    • 0142058246 scopus 로고    scopus 로고
    • The study of p16 and p15 gene methylation in head and neck squamous cell carcinoma and their quantitative evaluation in plasma by real-time PCR
    • Wong TS, Man MW, Lam AK, Wei WI, Kwong YL, Yuen AP. The study of p16 and p15 gene methylation in head and neck squamous cell carcinoma and their quantitative evaluation in plasma by real-time PCR. Eur. J. Cancer 2003; 39; 1881-1887.
    • (2003) Eur. J. Cancer , vol.39 , pp. 1881-1887
    • Wong, T.S.1    Man, M.W.2    Lam, A.K.3    Wei, W.I.4    Kwong, Y.L.5    Yuen, A.P.6
  • 37
    • 0029067843 scopus 로고
    • Human papillomaviruses in 91 oral cancers from Indian betel quid chewers - high prevalence and multiplicity of infections
    • Balaram P, Nalinakumari KR, Abraham E et al. Human papillomaviruses in 91 oral cancers from Indian betel quid chewers - high prevalence and multiplicity of infections. Int. J. Cancer 1995; 61; 450-454.
    • (1995) Int. J. Cancer , vol.61 , pp. 450-454
    • Balaram, P.1    Nalinakumari, K.R.2    Abraham, E.3
  • 38
    • 0032215461 scopus 로고    scopus 로고
    • Low prevalence of human papillomavirus in a geographic region with a high incidence of head and neck cancer
    • Miguel RE, Villa LL, Cordeiro AC, Prado JC, Sobrinho JS, Kowalski LP. Low prevalence of human papillomavirus in a geographic region with a high incidence of head and neck cancer. Am. J. Surg. 1998; 176; 428-429.
    • (1998) Am. J. Surg. , vol.176 , pp. 428-429
    • Miguel, R.E.1    Villa, L.L.2    Cordeiro, A.C.3    Prado, J.C.4    Sobrinho, J.S.5    Kowalski, L.P.6
  • 39
    • 3242670907 scopus 로고    scopus 로고
    • Genetic patterns in head and neck cancers that contain or lack transcriptionally active human papillomavirus
    • Braakhuis BJ, Snijders PJ, Keune WJ et al. Genetic patterns in head and neck cancers that contain or lack transcriptionally active human papillomavirus. J. Natl Cancer Inst. 2004; 96; 998-1006.
    • (2004) J. Natl Cancer Inst. , vol.96 , pp. 998-1006
    • Braakhuis, B.J.1    Snijders, P.J.2    Keune, W.J.3
  • 40
    • 85047700479 scopus 로고    scopus 로고
    • Involvement of intact HPV16 E6/E7 gene expression in head and neck cancers with unaltered p53 status and perturbed pRb cell cycle control
    • Wiest T, Schwarz E, Enders C, Flechtenmacher C, Bosch FX. Involvement of intact HPV16 E6/E7 gene expression in head and neck cancers with unaltered p53 status and perturbed pRb cell cycle control. Oncogene 2002; 21; 1510-1517.
    • (2002) Oncogene , vol.21 , pp. 1510-1517
    • Wiest, T.1    Schwarz, E.2    Enders, C.3    Flechtenmacher, C.4    Bosch, F.X.5
  • 41
    • 0142122353 scopus 로고    scopus 로고
    • A subset of head and neck squamous cell carcinomas exhibits integration of HPV 16/18 DNA and overexpression of p16INK4A and p53 in the absence of mutations in p53 exons 5-8
    • Hafkamp HC, Speel EJ, Haesevoets A et al. A subset of head and neck squamous cell carcinomas exhibits integration of HPV 16/18 DNA and overexpression of p16INK4A and p53 in the absence of mutations in p53 exons 5-8. Int. J. Cancer 2003; 107; 394-400.
    • (2003) Int. J. Cancer , vol.107 , pp. 394-400
    • Hafkamp, H.C.1    Speel, E.J.2    Haesevoets, A.3
  • 42
    • 0141731157 scopus 로고    scopus 로고
    • p16(INK4A) immunohistochemical overexpression in premalignant and malignant oral lesions infected with human papillomavirus
    • Fregonesi PA, Teresa DB, Duarte RA, Neto CB, De Oliveira MR, Soares CP. p16(INK4A) immunohistochemical overexpression in premalignant and malignant oral lesions infected with human papillomavirus. J. Histochem. Cytochem. 2003; 51; 1291-1297.
    • (2003) J. Histochem. Cytochem. , vol.51 , pp. 1291-1297
    • Fregonesi, P.A.1    Teresa, D.B.2    Duarte, R.A.3    Neto, C.B.4    De Oliveira, M.R.5    Soares, C.P.6
  • 43
    • 0029851041 scopus 로고    scopus 로고
    • Mutations and polymorphisms in the p53, p21 and p16 genes in oral carcinomas of Indian betel quid chewers
    • Heinzel PA, Balaram P, Bernard HU. Mutations and polymorphisms in the p53, p21 and p16 genes in oral carcinomas of Indian betel quid chewers. Int. J. Cancer 1996; 68; 420-423.
    • (1996) Int. J. Cancer , vol.68 , pp. 420-423
    • Heinzel, P.A.1    Balaram, P.2    Bernard, H.U.3
  • 44
    • 65449133543 scopus 로고    scopus 로고
    • Scoring mechanisms of p16INK4a immunohistochemistry based on either independent nucleic stain or mixed cytoplasmic with nucleic expression can significantly signal to distinguish between endocervical and endometrial adenocarcinomas in a tissue microarray study
    • Koo CL, Kok LF, Lee MY et al. Scoring mechanisms of p16INK4a immunohistochemistry based on either independent nucleic stain or mixed cytoplasmic with nucleic expression can significantly signal to distinguish between endocervical and endometrial adenocarcinomas in a tissue microarray study. J. Transl. Med. 2009; 14; 7-25.
    • (2009) J. Transl. Med. , vol.14 , pp. 7-25
    • Koo, C.L.1    Kok, L.F.2    Lee, M.Y.3
  • 45
    • 54049086674 scopus 로고    scopus 로고
    • P16 promoter hypermethylation is a potential predictor of malignant transformation in oral epithelial dysplasia
    • Hall GL, Shaw RJ, Field EA et al. P16 promoter hypermethylation is a potential predictor of malignant transformation in oral epithelial dysplasia. Cancer Epidemiol. Biomarkers Prev. 2008; 17; 2174-2179.
    • (2008) Cancer Epidemiol. Biomarkers Prev. , vol.17 , pp. 2174-2179
    • Hall, G.L.1    Shaw, R.J.2    Field, E.A.3
  • 46
    • 0034937638 scopus 로고    scopus 로고
    • Detailed gene expression analysis but not microsatellite marker analysis of 9p21 reveals differential defects in the INK4a gene locus in the majority of head and neck cancers
    • Grüttgen A, Reichenzeller M, Jünger M, Schlien S, Affolter A, Bosch FX. Detailed gene expression analysis but not microsatellite marker analysis of 9p21 reveals differential defects in the INK4a gene locus in the majority of head and neck cancers. J. Pathol. 2001; 194; 311-317.
    • (2001) J. Pathol. , vol.194 , pp. 311-317
    • Grüttgen, A.1    Reichenzeller, M.2    Jünger, M.3    Schlien, S.4    Affolter, A.5    Bosch, F.X.6
  • 47
    • 0032167474 scopus 로고    scopus 로고
    • pRb and p16 protein alterations in human oral tumorigenesis
    • Pande P, Mathur M, Shukla NK, Ralhan R. pRb and p16 protein alterations in human oral tumorigenesis. Oral Oncol. 1998; 34; 396-403.
    • (1998) Oral Oncol. , vol.34 , pp. 396-403
    • Pande, P.1    Mathur, M.2    Shukla, N.K.3    Ralhan, R.4


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