Toxicological mechanism of endocrine disrupting chemicals: Is estrogen receptor involved?

Toxicological Research

Volumn 26, Issue 4, 2013, Pages 237-243

  Jeung, Eui Bae ^a   Choi, Kyung Chul ^a  

^a Chungbuk National University   (South Korea)

Author keywords

Endocrine disrupting chemicals; Estrogen receptor; Toxicological mechanism

Indexed keywords

EID: 84880645930     PISSN: 19768257     EISSN: 22342753     Source Type: Journal    
DOI: 10.5487/TR.2010.26.4.237     Document Type: Article

References (71)

1. Abney, T.O. and Myers, R.B. (1991). 17 beta-estradiol inhibition of Leydig cell regeneration in the ethane dimethylsulfonatetreated mature rat. J. Androl., 12, 295-304.
2. Allen, D.L., Mitchner, N.A., Uveges, T.E., Nephew, K.P., Khan, S. and Ben-Jonathan, N. (1997). Cell-specific induction of c-fos expression in the pituitary gland by estrogen. Endocrinology, 138, 2128-2135.
3. An, B.S., Choi, K.C., Kang, S.K., Hwang, W.S. and Jeung, E.B. (2003). Novel Calbindin-D(9k) protein as a useful biomarker for environmental estrogenic compounds in the uterus of immature rats. Reprod Toxicol., 17, 311-319.
4. Aranda, A. and Pascual, A. (2001). Nuclear hormone receptors and gene expression. Physiol. Rev., 81, 1269-1304.
5. Arnold, A.P. and Gorski, R.A. (1984). Gonadal steroid induction of structural sex differences in the central nervous system. Annu. Rev. Neurosci., 7, 413-442.
6. Bulayeva, N.N., Gametchu, B. and Watson, C.S. (2004). Quantitative measurement of estrogen-induced ERK 1 and 2 activation via multiple membrane-initiated signaling pathways. Steroids, 69, 181-192.
7. Bulayeva, N.N., Wozniak, A.L., Lash, L.L. and Watson, C.S. (2005). Mechanisms of membrane estrogen receptor-alphamediated rapid stimulation of Ca2+ levels and prolactin release in a pituitary cell line. Am. J. Physiol. Endocrinol. Metab., 288, E388-397.
8. Charpentier, A.H., Bednarek, A.K., Daniel, R.L., Hawkins, K.A., Laflin, K.J., Gaddis, S., MacLeod, M.C. and Aldaz, C.M. (2000). Effects of estrogen on global gene expression: identification of novel targets of estrogen action. Cancer Res., 60, 5977-5983.
9. Choi, K.C. and Jeung, E.B. (2003). The biomarker and endocrine disruptors in mammals. J. Reprod. Dev., 49, 337-345.
10. Cobb, M.H. and Goldsmith, E.J. (1995). How MAP kinases are regulated. J. Biol. Chem., 270, 14843-14846.
11. Couse, J.F., Lindzey, J., Grandien, K., Gustafsson, J.A. and Korach, K.S. (1997). Tissue distribution and quantitative analysis of estrogen receptor-alpha (ERalpha) and estrogen receptorbeta (ERbeta) messenger ribonucleic acid in the wild-type and ERalpha-knockout mouse. Endocrinology, 138, 4613-4621.
12. Crisp, T.M., Clegg, E.D., Cooper, R.L., Wood, W.P., Anderson, D.G., Baetcke, K.P., Hoffmann, J.L., Morrow, M.S., Rodier, D.J., Schaeffer, J.E., Touart, L.W., Zeeman, M.G. and Patel, Y.M. (1998). Environmental endocrine disruption: an effects assessment and analysis. Environ. Health Perspect, 106 Suppl 1, 11-56.
13. Dang, V.H., Choi, K.C., Hyun, S.H. and Jeung, E.B. (2007a). Analysis of gene expression profiles in the offspring of rats following maternal exposure to xenoestrogens. Reprod. Toxicol., 23, 42-54.
14. Dang, V.H., Choi, K.C., Hyun, S.H. and Jeung, E.B. (2007b). Induction of uterine calbindin-D9k through an estrogen receptor- dependent pathway following single injection with xenobiotic agents in immature rats. J. Toxicol. Environ. Health A, 70, 171-182.
15. Dang, V.H., Choi, K.C. and Jeung, E.B. (2007c). Tetrabromodiphenyl ether (BDE 47) evokes estrogenicity and calbindin- D9k expression through an estrogen receptor-mediated pathway in the uterus of immature rats. Toxicol. Sci., 97, 504-511.
16. Dang, V.H., Nguyen, T.H., Choi, K.C. and Jeung, E.B. (2007d). A calcium-binding protein, calbindin-D9k, is regulated through an estrogen-receptor mediated mechanism following xenoestrogen exposure in the GH3 cell line. Toxicol. Sci., 98, 408-415.
17. Dang, V.H., Choi, K.C. and Jeung, E.B. (2009a). Estrogen receptors are involved in xenoestrogen induction of growth hormone in the rat pituitary gland. J. Reprod. Dev., 55, 206-213.
18. Dang, V.H., Nguyen, T.H., Lee, G.S., Choi, K.C. and Jeung, E.B. (2009b). In vitro exposure to xenoestrogens induces growth hormone transcription and release via estrogen receptor-dependent pathways in rat pituitary GH3 cells. Steroids, 74, 707-714.
19. Dang, V.H., Choi, K.C. and Jeung, E.B. (2010). Membrane-impermeable estrogen is involved in regulation of calbindin-D9k expression via non-genomic pathways in a rat pituitary cell line, GH3 cells. Toxicol. In Vitro, In press.
20. Daston, G.P., Cook, J.C. and Kavlock, R.J. (2003). Uncertainties for endocrine disrupters: our view on progress. Toxicol. Sci., 74, 245-252.
21. Dos Santos, E.G., Dieudonne, M.N., Pecquery, R., Le Moal, V., Giudicelli, Y. and Lacasa, D. (2002). Rapid nongenomic E2 effects on p42/p44 MAPK, activator protein-1, and cAMP response element binding protein in rat white adipocytes. Endocrinology, 143, 930-940.
22. Ellerkmann, E., Nagy, G.M. and Frawley, L.S. (1991). Rapid augmentation of prolactin cell number and secretory capacity by an estrogen-induced factor released from the neurointermediate lobe. Endocrinology, 129, 838-842.
23. Filardo, E.J. (2002). Epidermal growth factor receptor (EGFR) transactivation by estrogen via the G-protein-coupled receptor, GPR30: a novel signaling pathway with potential significance for breast cancer. J. Steroid. Biochem. Mol. Biol., 80, 231-238.
24. Filardo, E.J., Quinn, J.A., Frackelton, A.R., Jr. and Bland, K.I. (2002). Estrogen action via the G protein-coupled receptor, GPR30: stimulation of adenylyl cyclase and cAMP-mediated attenuation of the epidermal growth factor receptor-to-MAPK signaling axis. Mol. Endocrinol., 16, 70-84.
25. Frasor, J., Barnett, D.H., Danes, J.M., Hess, R., Parlow, A.F. and Katzenellenbogen, B.S. (2003). Response-specific and ligand dose-dependent modulation of estrogen receptor (ER) alpha activity by ERbeta in the uterus. Endocrinology, 144, 3159- 3166.
26. Hall, J.M. and McDonnell, D.P. (2005). Coregulators in nuclear estrogen receptor action: from concept to therapeutic targeting. Mol. Interv., 5, 343-357.
27. Hess, R.A., Bunick, D., Lee, K.H., Bahr, J., Taylor, J.A., Korach, K.S. and Lubahn, D.B. (1997). A role for oestrogens in the male reproductive system. Nature, 390, 509-512.
28. Hong, E., Choi, K.-C. and Jeung, E.-B. (2003). Maternal-fetal transfer of endocrine disruptors in the induction of Calbindin- D9k mRNA and protein during pregnancy in rat model. Mol. Cell. Endocrinol., 212, 63-72.
29. Hoyer, P.B. (2001). Reproductive toxicology: current and future directions. Biochem. Pharmacol., 62, 1557-1564.
30. Katzenellenbogen, J.A. and Katzenellenbogen, B.S. (1996). Nuclear hormone receptors: ligand-activated regulators of transcription and diverse cell responses. Chem. Biol., 3, 529-536.
31. Keefer, D.A., Stumpf, W.E. and Petrusz, P. (1976). Quantitative autoradiographic assessment of 3H-estradiol uptake in immunocytochemically characterized pituitary cells. Cell. Tissue. Res., 166, 25-35.
32. Kelly, M.J. and Levin, E.R. (2001). Rapid actions of plasma membrane estrogen receptors. Trends Endocrinol. Metab., 12, 152- 156.
33. Kuiper, G.G., Enmark, E., Pelto-Huikko, M., Nilsson, S. and Gustafsson, J.A. (1996). Cloning of a novel receptor expressed in rat prostate and ovary. Proc. Natl. Acad. Sci. USA, 93, 5925- 5930.
34. Laws, S.C., Carey, S.A., Ferrell, J.M., Bodman, G.J. and Cooper, R.L. (2000). Estrogenic activity of octylphenol, nonylphenol, bisphenol A and methoxychlor in rats. Toxicol. Sci., 54, 154- 167.
35. Leung, K.C., Johannsson, G., Leong, G.M. and Ho, K.K. (2004). Estrogen regulation of growth hormone action. Endocr. Rev., 25, 693-721.
36. Levin, E.R. (2005). Integration of the extranuclear and nuclear actions of estrogen. Mol. Endocrinol., 19, 1951-1959.
37. Levine, J.E. (1997). New concepts of the neuroendocrine regulation of gonadotropin surges in rats. Biol. Reprod., 56, 293-302.
38. Lieberman, M.E., Maurer, R.A., Claude, P. and Gorski, J. (1982). Prolactin synthesis in primary cultures of pituitary cells: regulation by estradiol. Mol. Cell. Endocrinol., 25, 277-294.
39. MacLusky, N.J. and Naftolin, F. (1981). Sexual differentiation of the central nervous system. Science, 211, 1294-1302.
40. Marino, M., Acconcia, F. and Ascenzi, P. (2005). Estrogen receptor signalling: bases for drug actions. Curr. Drug. Targets. Immune. Endocr. Metabol. Disord., 5, 305-314.
41. Marino, M., Galluzzo, P. and Ascenzi, P. (2006). Estrogen signaling multiple pathways to impact gene transcription. Curr. Genomics, 7, 497-508.
42. Micevych, P.E. and Mermelstein, P.G. (2008). Membrane estrogen receptors acting through metabotropic glutamate receptors: an emerging mechanism of estrogen action in brain. Mol. Neurobiol., 38, 66-77.
43. Mitchner, N.A., Garlick, C., Steinmetz, R.W. and Ben-Jonathan, N. (1999). Differential regulation and action of estrogen receptors alpha and beta in GH3 cells. Endocrinology, 140, 2651- 2658.
44. Mosselman, S., Polman, J. and Dijkema, R. (1996). ER beta: identification and characterization of a novel human estrogen receptor. FEBS Lett., 392, 49-53.
45. Nilsson, S., Makela, S., Treuter, E., Tujague, M., Thomsen, J., Andersson, G., Enmark, E., Pettersson, K., Warner, M. and Gustafsson, J.A. (2001). Mechanisms of estrogen action. Physiol. Rev., 81, 1535-1565.
46. Nishihara, E., Nagayama, Y., Inoue, S., Hiroi, H., Muramatsu, M., Yamashita, S. and Koji, T. (2000). Ontogenetic changes in the expression of estrogen receptor alpha and beta in rat pituitary gland detected by immunohistochemistry. Endocrinology, 141, 615-620.
47. Paech, K., Webb, P., Kuiper, G.G., Nilsson, S., Gustafsson, J., Kushner, P.J. and Scanlan, T.S. (1997). Differential ligand activation of estrogen receptors ERalpha and ERbeta at AP1 sites. Science, 277, 1508-1510.
48. Park, S.H., Kim, K.Y., An, B.S., Choi, J.H., Jeung, E.B., Leung, P.C. and Choi, K.C. (2009). Cell growth of ovarian cancer cells is stimulated by xenoestrogens through an estrogen-dependent pathway, but their stimulation of cell growth appears not to be involved in the activation of the mitogen-activated protein kinases ERK-1 and p38. J. Reprod. Dev., 55, 23-29.
49. Pelletier, G., Liao, N., Follea, N. and Govindan, M.V. (1988). Distribution of estrogen receptors in the rat pituitary as studied by in situ hybridization. Mol. Cell. Endocrinol., 56, 29-33.
50. Pujol, P., Rey, J.M., Nirde, P., Roger, P., Gastaldi, M., Laffargue, F., Rochefort, H. and Maudelonde, T. (1998). Differential expression of estrogen receptor-alpha and -beta messenger RNAs as a potential marker of ovarian carcinogenesis. Cancer. Res., 58, 5367-5373.
51. Qin, C., Samudio, I., Ngwenya, S. and Safe, S. (2004). Estrogendependent regulation of ornithine decarboxylase in breast cancer cells through activation of nongenomic cAMP-dependent pathways. Mol. Carcinog., 40, 160-170.
52. Revelli, A., Massobrio, M. and Tesarik, J. (1998). Nongenomic actions of steroid hormones in reproductive tissues. Endocr. Rev., 19, 3-17.
53. Roy, D., Angelini, N.L. and Belsham, D.D. (1999). Estrogen directly respresses gonadotropin-releasing hormone (GnRH) gene expression in estrogen receptor-alpha (ERalpha)- and ERbeta-expressing GT1-7 GnRH neurons. Endocrinology, 140, 5045-5053.
54. Sarkar, D.K., Kim, K.H. and Minami, S. (1992). Transforming growth factor-beta 1 messenger RNA and protein expression in the pituitary gland: its action on prolactin secretion and lactotropic growth. Mol. Endocrinol., 6, 1825-1833.
55. Sharpe. (1998a). The roles of oestrogen in male. Trends Endocrinol. Metab., 9, 371-377.
56. Sharpe. (1998b). Environmental oestrogen and male infertility. Pure. Appl. Chem., 70, 1685-1701.
57. Steinmetz, R., Brown, N.G., Allen, D.L., Bigsby, R.M. and Ben-Jonathan, N. (1997). The environmental estrogen bisphenol A stimulates prolactin release in vitro and in vivo. Endocrinology, 138, 1780-1786.
58. Tinnanooru, P., Dang, V.H., Nguyen, T.H., Lee, G.S., Choi, K.C. and Jeung, E.B. (2008). Estrogen regulates the localization and expression of calbindin-D9k in the pituitary gland of immature male rats via the ERalpha-pathway. Mol. Cell. Endocrinol., 285, 26-33.
59. Tokunaga, E., Kimura, Y., Mashino, K., Oki, E., Kataoka, A., Ohno, S., Morita, M., Kakeji, Y., Baba, H. and Maehara, Y. (2006). Activation of PI3K/Akt signaling and hormone resistance in breast cancer. Breast Cancer, 13, 137-144.
60. Toppari, J., Larsen, J.C., Christiansen, P., Giwercman, A., Grandjean, P., Guillette, L.J., Jr., Jegou, B., Jensen, T.K., Jouannet, P., Keiding, N., Leffers, H., McLachlan, J.A., Meyer, O., Muller, J., Rajpert-De Meyts, E., Scheike, T., Sharpe, R., Sumpter, J. and Skakkebaek, N.E. (1996). Male reproductive health and environmental xenoestrogens. Environ. Health Perspect, 104 Suppl 4, 741-803.
61. Treeck, O., Pfeiler, G., Mitter, D., Lattrich, C., Piendl, G. and Ortmann, O. (2007). Estrogen receptor {beta}1 exerts antitumoral effects on SK-OV-3 ovarian cancer cells. J. Endocrinol., 193, 421-433.
62. Turgeon, J.L. and Waring, D.W. (1981). Acute progesterone and 17 beta-estradiol modulation of luteinizing hormone secretion by pituitaries of cycling rats superfused in vitro. Endocrinology, 108, 413-419.
63. Turner, R.T., Riggs, B.L. and Spelsberg, T.C. (1994). Skeletal effects of estrogen. Endocr. Rev., 15, 275-300.
64. Vo, T.T., Jung, E.M., Dang, V.H., Jung, K., Baek, J., Choi, K.C. and Jeung, E.B. (2009a). Differential effects of flutamide and di-(2-ethylhexyl) phthalate on male reproductive organs in a rat model. J. Reprod. Dev., 55, 400-411.
65. Vo, T.T., Jung, E.M., Dang, V.H., Yoo, Y.M., Choi, K.C., Yu, F.H. and Jeung, E.B. (2009b). Di-(2 ethylhexyl) phthalate and flutamide alter gene expression in the testis of immature male rats. Reprod. Biol. Endocrinol., 7, 104.
66. Waring, R.H. and Harris, R.M. (2005). Endocrine disrupters: a human risk? Mol. Cell. Endocrinol., 244, 2-9.
67. Watanabe, H., Suzuki, A., Kobayashi, M., Takahashi, E., Itamoto, M., Lubahn, D.B., Handa, H. and Iguchi, T. (2003). Analysis of temporal changes in the expression of estrogen-regulated genes in the uterus. J. Mol. Endocrinol., 30, 347-358.
68. Watson, C.S., Bulayeva, N.N., Wozniak, A.L. and Alyea, R.A. (2007). Xenoestrogens are potent activators of nongenomic estrogenic responses. Steroids, 72, 124-134.
69. Watters, J.J., Chun, T.Y., Kim, Y.N., Bertics, P.J. and Gorski, J. (2000). Estrogen modulation of prolactin gene expression requires an intact mitogen-activated protein kinase signal transduction pathway in cultured rat pituitary cells. Mol. Endocrinol., 14, 1872-1881.
70. Williams, K., McKinnell, C., Saunders, P.T., Walker, M., Fisher, J.S., Turner, K.J., Atanassova, N. and Sharpe, M. (2001). Neonatal exposure to potent and environmental oestrogens and abnormalities of the male reproductive system in the rat: evidence for importance of the androgen-oestrogen balance and assessment of the relevance to man. Hum. Reprod. Update, 7, 236-247.
71. Wilson, M.E., Price, R.H., Jr. and Handa, R.J. (1998). Estrogen receptor-beta messenger ribonucleic acid expression in the pituitary gland. Endocrinology, 139, 5151-5156.