Histone deacetylase 4 mediates SMAD family member 4 deacetylation and induces 5-fluorouracil resistance in breast cancer cells

Oncology Reports

Volumn 30, Issue 3, 2013, Pages 1293-1300

  Yu, Seong Lan ^a   Lee, Dong Chul ^b   Son, Ji Woong ^c   Park, Chang Gyo ^a   Lee, Hoi Young ^a   Kang, Jaeku ^a  

^a Konyang University   (South Korea)

^b Korea Research Institute of Bioscience and Biotechnology (KRIBB)   (South Korea)

^c Konyang University College of Medicine   (South Korea)

Author keywords

5 fluorouracil; Breast cancer cells; Chemoresistance; Histone deacetylase 4; SMAD family member 4

Indexed keywords

BONE MORPHOGENETIC PROTEIN 6; CISPLATIN; FLUOROURACIL; GEMCITABINE; HISTONE DEACETYLASE 4; HISTONE H3; INHIBITOR OF DIFFERENTIATION 1; PACLITAXEL; SMAD4 PROTEIN; SMAD6 PROTEIN; TRANSFORMING GROWTH FACTOR BETA2;

ARTICLE; BREAST CANCER; CANCER CELL CULTURE; CANCER RESISTANCE; CELLULAR DISTRIBUTION; CONCENTRATION RESPONSE; CONTROLLED STUDY; DEACETYLATION; DOWN REGULATION; DRUG CYTOTOXICITY; DRUG SENSITIVITY; GENE FUNCTION; GENE INTERACTION; GENE LOCATION; GENE OVEREXPRESSION; GENE SILENCING; GENE TARGETING; HDAC4 GENE; HUMAN; HUMAN CELL; MICROARRAY ANALYSIS; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN DETERMINATION; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN LOCALIZATION; PROTEIN PROTEIN INTERACTION; PROTEIN TARGETING; SIGNAL TRANSDUCTION; UPREGULATION;

ACETYLATION; ANTIMETABOLITES, ANTINEOPLASTIC; BREAST NEOPLASMS; CELL PROLIFERATION; CHROMATIN IMMUNOPRECIPITATION; DRUG RESISTANCE, NEOPLASM; FEMALE; FLUOROURACIL; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION, NEOPLASTIC; HISTONE DEACETYLASES; HISTONES; HUMANS; MCF-7 CELLS; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; PROMOTER REGIONS, GENETIC; REAL-TIME POLYMERASE CHAIN REACTION; REPRESSOR PROTEINS; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; SIGNAL TRANSDUCTION; SMAD4 PROTEIN; TRANSFORMING GROWTH FACTOR BETA; TUMOR MARKERS, BIOLOGICAL;

EID: 84880645239     PISSN: 1021335X     EISSN: 17912431     Source Type: Journal    
DOI: 10.3892/or.2013.2578     Document Type: Article

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