메뉴 건너뛰기




Volumn 18, Issue 5, 2013, Pages 449-461

Iron in multiple myeloma

Author keywords

Bone morphogenetic protein; Hepcidin; Interleukin 6; Multiple myeloma; Transferrin receptors

Indexed keywords

ANTIANEMIC AGENT; BONE MORPHOGENETIC PROTEIN; BONE MORPHOGENETIC PROTEIN 2; BONE MORPHOGENETIC PROTEIN 4; BONE MORPHOGENETIC PROTEIN 6; BONE MORPHOGENETIC PROTEIN 9; DEFEROXAMINE; DI 2 PYRIDYLKETONE 4,4 DIMETHYL 3 THIOSEMICARBAZONE; GALLIUM; HEMOGLOBIN; HEPCIDIN; IMMUNOMODULATING AGENT; INTERLEUKIN 1BETA; INTERLEUKIN 6; INTERLEUKIN 6 RECEPTOR; IRON; JANUS KINASE; NOVEL ERYTHROPOIESIS STIMULATING PROTEIN; PROTEIN MCL 1; RECOMBINANT BONE MORPHOGENETIC PROTEIN 2; RECOMBINANT ERYTHROPOIETIN; RECOMBINANT INTERLEUKIN 6; SMAD PROTEIN; STAT PROTEIN; STAT3 PROTEIN; THIOSEMICARBAZONE DERIVATIVE; TRANSFERRIN; TRANSFERRIN RECEPTOR; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG; UNINDEXED DRUG;

EID: 84880631247     PISSN: 08939675     EISSN: 21626448     Source Type: Journal    
DOI: 10.1615/CritRevOncog.2013007934     Document Type: Article
Times cited : (22)

References (73)
  • 3
    • 67449161589 scopus 로고    scopus 로고
    • Autologous hematopoietic stem-cell transplantation for multiple myeloma
    • Harrousseau JL, Moreau P. Autologous hematopoietic stem-cell transplantation for multiple myeloma. N Engl J Med. 2009;360:2645-54.
    • (2009) N Engl J Med , vol.360 , pp. 2645-2654
    • Harrousseau, J.L.1    Moreau, P.2
  • 6
    • 0016431708 scopus 로고
    • Multiple myeloma: Review of 869 cases
    • Kyle RA. Multiple myeloma: Review of 869 cases. Mayo Clin Proc. 1975;50:29-40.
    • (1975) Mayo Clin Proc , vol.50 , pp. 29-40
    • Kyle, R.A.1
  • 7
    • 8544272477 scopus 로고    scopus 로고
    • Clinical results of recombinant erythropoietin in transfusion-dependent patients with refractory multiple myeloma: Role of cytokines and monitoring of erythropoiesis
    • Musto P, Falcone A, D'Arena G. Clinical results of recombinant erythropoietin in transfusion-dependent patients with refractory multiple myeloma: role of cytokines and monitoring of erythropoiesis. Eur J Hematol. 1997;58:314-9.
    • (1997) Eur J Hematol , vol.58 , pp. 314-319
    • Musto, P.1    Falcone, A.2    D'Arena, G.3
  • 8
    • 0030755786 scopus 로고    scopus 로고
    • The Functional Assessment of Cancer TherapyAnemia (FACT-An) Scale: A new tool for the assessment of outcomes in cancer anemia and fatigue
    • Cella, D. The Functional Assessment of Cancer TherapyAnemia (FACT-An) Scale: a new tool for the assessment of outcomes in cancer anemia and fatigue. Semin Hematol. 1997;34: 13-9.
    • (1997) Semin Hematol , vol.34 , pp. 13-19
    • Cella, D.1
  • 9
    • 0035875880 scopus 로고    scopus 로고
    • Anemia as an independent prognostic factor for survival in patients with cacner: A systemic, quantitative review
    • Caro J, Salas M, Ward A, Gross G. Anemia as an independent prognostic factor for survival in patients with cacner: a systemic, quantitative review. Cancer. 2001;91:2214-21.
    • (2001) Cancer , vol.91 , pp. 2214-2221
    • Caro, J.1    Salas, M.2    Ward, A.3    Gross, G.4
  • 10
    • 0035675491 scopus 로고    scopus 로고
    • Guideline: Diagnosis and management of multiple myeloma
    • Samson D. Guideline: diagnosis and management of multiple myeloma. Br J Haematol. 2001;155:522-40.
    • (2001) Br J Haematol , vol.155 , pp. 522-540
    • Samson, D.1
  • 11
    • 0017813724 scopus 로고
    • Monoclonal Gammopathy of Undetermined Significance: Natural history in 241 cases
    • Kyle RA. Monoclonal Gammopathy of Undetermined Significance: Natural history in 241 cases. Amer J of Med. 1978;64:814-26.
    • (1978) Amer J of Med , vol.64 , pp. 814-826
    • Kyle, R.A.1
  • 12
    • 0019181628 scopus 로고
    • Localized and indolent myeloma
    • Alexanian R. Localized and indolent myeloma. Blood. 1980;56:521-5.
    • (1980) Blood , vol.56 , pp. 521-525
    • Alexanian, R.1
  • 14
    • 0142124313 scopus 로고    scopus 로고
    • The implications of anemia in multiple myeloma
    • Mittelman, M. The implications of anemia in multiple myeloma. Clinical Lymphoma. 2003; 4:S23-S29.
    • (2003) Clinical Lymphoma , vol.4
    • Mittelman, M.1
  • 15
    • 77954872334 scopus 로고    scopus 로고
    • Favaloro EJ.Thrombotic complications of erythropoiesis-stimulating agents
    • Lippi G, Franchini M, Favaloro EJ.Thrombotic complications of erythropoiesis-stimulating agents. Sem Thromb Hemost. 2010;36:537-49.
    • (2010) Sem Thromb Hemost , vol.36 , pp. 537-549
    • Lippi, G.1    Franchini, M.2
  • 19
    • 78549286047 scopus 로고    scopus 로고
    • American Society of Clinical Oncology/American Society of Hematology Clinical Practice Guideline Update on the Use of Epoetin and Darbepoetin in Adult Patients With Cancer
    • Rizzo JD, Brouwers M, Hurley P, Seidenfeld J, Bennett CL, Goode MJ, Regan DH, Somerfield MR. American Society of Clinical Oncology/American Society of Hematology Clinical Practice Guideline Update on the Use of Epoetin and Darbepoetin in Adult Patients With Cancer. Blood. 2010;116:4045-4059.
    • (2010) Blood , vol.116 , pp. 4045-4059
    • Rizzo, J.D.1    Brouwers, M.2    Hurley, P.3    Seidenfeld, J.4    Bennett, C.L.5    Goode, M.J.6    Regan, D.H.7    Somerfield, M.R.8
  • 20
    • 78650408078 scopus 로고    scopus 로고
    • Multiple myeloma: 2011 update on diagnosis, risk-stratification, and management
    • Rajkumar SV. Multiple myeloma: 2011 update on diagnosis, risk-stratification, and management. Am J Hematol. 2011;86:57-65.
    • (2011) Am J Hematol , vol.86 , pp. 57-65
    • Rajkumar, S.V.1
  • 22
    • 0027076489 scopus 로고
    • Erythropoiesis in multiple myeloma: Defective red cell production due to inappropriate erythropoietin production
    • Beguin Y, Yerna M, Loo M, Weber M, Fillet G. Erythropoiesis in multiple myeloma: defective red cell production due to inappropriate erythropoietin production. Brit J of Hemat. 1992; 82:648-53.
    • (1992) Brit J of Hemat , vol.82 , pp. 648-653
    • Beguin, Y.1    Yerna, M.2    Loo, M.3    Weber, M.4    Fillet, G.5
  • 23
    • 0037082473 scopus 로고    scopus 로고
    • Negative regulation of erythroblast maturation by Fas-L(+)/ TRAIL(+) highly malignant plasma cells: A major pathogenetic mechanism of anemia in multiple myeloma
    • Silvestris F, Cafforio P, Tucci M, Dammacco F. Negative regulation of erythroblast maturation by Fas-L(+)/ TRAIL(+) highly malignant plasma cells: a major pathogenetic mechanism of anemia in multiple myeloma. Blood. 2002; 99:1305-13.
    • (2002) Blood , vol.99 , pp. 1305-1313
    • Silvestris, F.1    Cafforio, P.2    Tucci, M.3    Dammacco, F.4
  • 24
    • 13544252463 scopus 로고    scopus 로고
    • Hepcidin excess induces the sequestration of iron and exacerbates tumor-associated anemia
    • Rivera S, Liu L, Nemeth E, Gabayan V, Sorensen OE, Ganz T. Hepcidin excess induces the sequestration of iron and exacerbates tumor-associated anemia. Blood. 2005;105:1797-802.
    • (2005) Blood , vol.105 , pp. 1797-1802
    • Rivera, S.1    Liu, L.2    Nemeth, E.3    Gabayan, V.4    Sorensen, O.E.5    Ganz, T.6
  • 26
    • 33645314044 scopus 로고    scopus 로고
    • Molecular pathogenesis of anemia of chronic disease
    • Ganz T. Molecular pathogenesis of anemia of chronic disease. Pediatr Blood Cancer. 2006; 46:554-7.
    • (2006) Pediatr Blood Cancer , vol.46 , pp. 554-557
    • Ganz, T.1
  • 27
    • 0038662619 scopus 로고    scopus 로고
    • Hepcidin, a putative mediator of anemia of inflammation, is a type II acute-phase protein
    • Nemeth E, Valore EV, Territo M, Schiller G, Lichtenstein A, Ganz T. Hepcidin, a putative mediator of anemia of inflammation, is a type II acute-phase protein. Blood. 2003;101:2461-13.
    • (2003) Blood , vol.101 , pp. 2461-2513
    • Nemeth, E.1    Valore, E.V.2    Territo, M.3    Schiller, G.4    Lichtenstein, A.5    Ganz, T.6
  • 28
    • 2342510407 scopus 로고    scopus 로고
    • IL-6 mediates hypoferremia of inflammation by inducing the synthesis of the iron regulatory hormone hepcidin
    • Nemeth E, Rivera S, Gabayan V, Keller C, Taudorf S, Pedersen BK, Ganz T. IL-6 mediates hypoferremia of inflammation by inducing the synthesis of the iron regulatory hormone hepcidin. J of Clin Invest. 2004;113:1271-6.
    • (2004) J of Clin Invest , vol.113 , pp. 1271-1276
    • Nemeth, E.1    Rivera, S.2    Gabayan, V.3    Keller, C.4    Taudorf, S.5    Pedersen, B.K.6    Ganz, T.7
  • 30
    • 0025853227 scopus 로고
    • Serum levels of IL-6 in multiple myeloma and other disorders: Correlation with disease activity and other prognostic parameters
    • Nachbaur DM, Herold M, manescheg A, Huber H. Serum levels of IL-6 in multiple myeloma and other disorders: correlation with disease activity and other prognostic parameters. Ann Hematol. 1991;62:54-8.
    • (1991) Ann Hematol , vol.62 , pp. 54-58
    • Nachbaur, D.M.1    Herold, M.2    Manescheg, A.3    Huber, H.4
  • 32
    • 33845245942 scopus 로고    scopus 로고
    • Suppression of hepcidin during anemia requires erythropoietic activity
    • Pak M, Lopez MA, Gabayan V, Ganz T, Rivera S. Suppression of hepcidin during anemia requires erythropoietic activity. Blood. 2006;108:3730-5.
    • (2006) Blood , vol.108 , pp. 3730-3735
    • Pak, M.1    Lopez, M.A.2    Gabayan, V.3    Ganz, T.4    Rivera, S.5
  • 35
    • 67749091257 scopus 로고    scopus 로고
    • Sequential evaluation of serum hepcidin in anemic myeloma patients: Study of correlations with myeloma treatment, disease variables and anemia response
    • Katodritou E, Ganz T, Terpos E, Verrou E, Olbina G, Varthaliti M, Westerman M, Zervas K. Sequential evaluation of serum hepcidin in anemic myeloma patients: study of correlations with myeloma treatment, disease variables and anemia response. Amer J Hemat. 2009; 84:524-6.
    • (2009) Amer J Hemat , vol.84 , pp. 524-526
    • Katodritou, E.1    Ganz, T.2    Terpos, E.3    Verrou, E.4    Olbina, G.5    Varthaliti, M.6    Westerman, M.7    Zervas, K.8
  • 40
    • 77952095269 scopus 로고    scopus 로고
    • Bone morphogenetic proteins and receptors are over-expressed in bone marrow cells of multiple myeloma patients and support myeloma cells by inducing ID genes
    • Grcevic D, Kusec R, Kovacic N, Lukic A, Lukic IK, Nemet D, Ostojic SK, Croucher PI, Marusic A. Bone morphogenetic proteins and receptors are over-expressed in bone marrow cells of multiple myeloma patients and support myeloma cells by inducing ID genes. Oncogene. 2010;34:742-51.
    • (2010) Oncogene , vol.34 , pp. 742-751
    • Grcevic, D.1    Kusec, R.2    Kovacic, N.3    Lukic, A.4    Lukic, I.K.5    Nemet, D.6    Ostojic, S.K.7    Croucher, P.I.8    Marusic, A.9
  • 41
    • 33751175421 scopus 로고    scopus 로고
    • IL-6 induces hepcidin expression through STAT3
    • Wrighting DM, Andrews NC. IL-6 induces hepcidin expression through STAT3. Blood. 2006;108:3204-9.
    • (2006) Blood , vol.108 , pp. 3204-3209
    • Wrighting, D.M.1    Andrews, N.C.2
  • 42
    • 60249095353 scopus 로고    scopus 로고
    • Two BMP responsive ele ments, STAT and bZIP/HNF4/COUP motifs of the hepcidin promoter are critical for BMP, SMAD1 and HJV responsiveness
    • Truksa J, Lee P, Beutler E. Two BMP responsive ele ments, STAT and bZIP/HNF4/COUP motifs of the hepcidin promoter are critical for BMP, SMAD1 and HJV responsiveness. Blood. 2009;113:688-95.
    • (2009) Blood , vol.113 , pp. 688-695
    • Truksa, J.1    Lee, P.2    Beutler, E.3
  • 44
    • 33750008791 scopus 로고    scopus 로고
    • The transferrin receptor part I: Biology and targeting with cytotoxic antibodies for the treatment of cancer
    • Daniels TR, Delgado T, Rodriguez JA, Helguera G, Penichet ML. The transferrin receptor part I: Biology and targeting with cytotoxic antibodies for the treatment of cancer. Clin Immunol. 2006;121:144-58.
    • (2006) Clin Immunol , vol.121 , pp. 144-158
    • Daniels, T.R.1    Delgado, T.2    Rodriguez, J.A.3    Helguera, G.4    Penichet, M.L.5
  • 45
    • 29844457587 scopus 로고    scopus 로고
    • The evolution of iron chelators for the treatment of iron overload disease and cancer
    • Kalinowski DS, Richardson DR. The evolution of iron chelators for the treatment of iron overload disease and cancer. Pharmacol Rev. 2005;57:547-83.
    • (2005) Pharmacol Rev , vol.57 , pp. 547-583
    • Kalinowski, D.S.1    Richardson, D.R.2
  • 46
    • 33749515083 scopus 로고    scopus 로고
    • A class of iron chelators with a wide spectrum of potent antitumor activity that overcomes resistance to chemotherapeutics
    • Whitnall M, Howard J, Ponka P, Richardson DR. A class of iron chelators with a wide spectrum of potent antitumor activity that overcomes resistance to chemotherapeutics. Proc Natl Acad Sci U S A. 2006;103:14901-6.
    • (2006) Proc Natl Acad Sci U S A , vol.103 , pp. 14901-14906
    • Whitnall, M.1    Howard, J.2    Ponka, P.3    Richardson, D.R.4
  • 47
    • 4444248453 scopus 로고    scopus 로고
    • Novel di-2-pyridylderived iron chelators with marked and selective antitumor activity: In vitro and in vivo assessment
    • Yuan J, Lovejoy DB, Richardson DR. Novel di-2-pyridylderived iron chelators with marked and selective antitumor activity: in vitro and in vivo assessment. Blood. 2004;104:1450-8.
    • (2004) Blood , vol.104 , pp. 1450-1458
    • Yuan, J.1    Lovejoy, D.B.2    Richardson, D.R.3
  • 49
    • 77954789725 scopus 로고    scopus 로고
    • Medical applications and toxicities of gallium compounds
    • Chitambar CR. Medical applications and toxicities of gallium compounds. Int J Environ Res Public Health. 2010;7:2337-61.
    • (2010) Int J Environ Res Public Health , vol.7 , pp. 2337-2361
    • Chitambar, C.R.1
  • 50
    • 0021107162 scopus 로고
    • Thermodynamic binding constants for gallium transferrin
    • Harris WR, Pecoraro VL. Thermodynamic binding constants for gallium transferrin. Biochemistry. 1983;22:292-9.
    • (1983) Biochemistry , vol.22 , pp. 292-299
    • Harris, W.R.1    Pecoraro, V.L.2
  • 51
    • 0027360938 scopus 로고
    • Low dose gallium nitrate for prevention of osteolysis in myeloma: Results of a pilot randomized study
    • Warrell RP, Jr., Lovett D, Dilmanian FA, Schneider R, Heelan RT. Low dose gallium nitrate for prevention of osteolysis in myeloma: results of a pilot randomized study. J Clin Oncol. 1993;11:2443-50.
    • (1993) J Clin Oncol , vol.11 , pp. 2443-2450
    • Warrell Jr., R.P.1    Lovett, D.2    Dilmanian, F.A.3    Schneider, R.4    Heelan, R.T.5
  • 52
    • 0037809787 scopus 로고    scopus 로고
    • Gallium nitrate in multiple myeloma: Prolonged survival in a cohort of patients with advanced-stage disease
    • Niesvizky R. Gallium nitrate in multiple myeloma: prolonged survival in a cohort of patients with advanced-stage disease. Semin Oncol. 2003;30:20-4.
    • (2003) Semin Oncol , vol.30 , pp. 20-24
    • Niesvizky, R.1
  • 54
    • 0037305821 scopus 로고    scopus 로고
    • Curcumin down-regulates NF-kB in human multiple myeloma cells leading to suppression of proliferation and induction of apoptosis
    • Bharti AC, Donato N, Singh S, Aggarwal BB. Curcumin down-regulates NF-kB in human multiple myeloma cells leading to suppression of proliferation and induction of apoptosis. Blood. 2003;101:1053-62.
    • (2003) Blood , vol.101 , pp. 1053-1062
    • Bharti, A.C.1    Donato, N.2    Singh, S.3    Aggarwal, B.B.4
  • 59
    • 33750019824 scopus 로고    scopus 로고
    • The transferrin receptor part II: Targeted delivery of therapeutic agents into cancer cells
    • Daniels TR, Delgado T, Helguera G, Penichet ML. The transferrin receptor part II: targeted delivery of therapeutic agents into cancer cells. Clin Immunol. 2006;121:159-76.
    • (2006) Clin Immunol , vol.121 , pp. 159-176
    • Daniels, T.R.1    Delgado, T.2    Helguera, G.3    Penichet, M.L.4
  • 60
    • 0019968268 scopus 로고
    • Murine cell surface transferrin receptor: Studies with an anti-receptor monoclonal antibody
    • Trowbridge IS, Lesley J, Schulte R. Murine cell surface transferrin receptor: studies with an anti-receptor monoclonal antibody. J Cell Physiol. 1982;112:403-10.
    • (1982) J Cell Physiol , vol.112 , pp. 403-410
    • Trowbridge, I.S.1    Lesley, J.2    Schulte, R.3
  • 62
    • 0022616986 scopus 로고
    • Mechanisms of growth inhibition by anti-transferrin receptor monoclonal antibodies
    • Taetle R, Castagnola J, Mendelsohn J. Mechanisms of growth inhibition by anti-transferrin receptor monoclonal antibodies. Cancer Res. 1986;46:1759-63.
    • (1986) Cancer Res , vol.46 , pp. 1759-1763
    • Taetle, R.1    Castagnola, J.2    Mendelsohn, J.3
  • 65
    • 0036678172 scopus 로고    scopus 로고
    • An antitransferrin receptor-avidin fusion protein exhibits both strong proapoptotic activity and the ability to deliver various molecules into cancer cells
    • Ng PP, Dela Cruz JS, Sorour DN, Stinebaugh JM, Shin SU, Shin DS, Morrison SL, Penichet ML. An antitransferrin receptor-avidin fusion protein exhibits both strong proapoptotic activity and the ability to deliver various molecules into cancer cells. Proc Natl Acad Sci U S A. 2002;99:10706-11.
    • (2002) Proc Natl Acad Sci U S A , vol.99 , pp. 10706-10711
    • Ng, P.P.1    Dela Cruz, J.S.2    Sorour, D.N.3    Stinebaugh, J.M.4    Shin, S.U.5    Shin, D.S.6    Morrison, S.L.7    Penichet, M.L.8
  • 66
    • 33750631022 scopus 로고    scopus 로고
    • Molecular events contributing to cell death in malignant human hematopoietic cells elicited by an IgG3-avidin fusion protein targeting the transferrin receptor
    • Ng PP, Helguera G, Daniels TR, Lomas SZ, Rodriguez JA, Schiller G, Bonavida B, Morrison SL, Penichet ML. Molecular events contributing to cell death in malignant human hematopoietic cells elicited by an IgG3-avidin fusion protein targeting the transferrin receptor. Blood. 2006;108:2745-54.
    • (2006) Blood , vol.108 , pp. 2745-2754
    • Ng, P.P.1    Helguera, G.2    Daniels, T.R.3    Lomas, S.Z.4    Rodriguez, J.A.5    Schiller, G.6    Bonavida, B.7    Morrison, S.L.8    Penichet, M.L.9
  • 67
    • 58249123414 scopus 로고    scopus 로고
    • Enhanced cytotoxicity of an anti-transferrin receptor IgG3-avidin fusion protein in combination with gambogic acid against human malignant hematopoietic cells: Functional relevance of iron, the receptor, and reactive oxygen species
    • Ortiz-Sanchez E, Daniels TR, Helguera G, MartinezMaza O, Bonavida B, Penichet ML. Enhanced cytotoxicity of an anti-transferrin receptor IgG3-avidin fusion protein in combination with gambogic acid against human malignant hematopoietic cells: functional relevance of iron, the receptor, and reactive oxygen species. Leukemia. 2009;23:59-70
    • (2009) Leukemia , vol.23 , pp. 59-70
    • Ortiz-Sanchez, E.1    Daniels, T.R.2    Helguera, G.3    Martinezmaza, O.4    Bonavida, B.5    Penichet, M.L.6
  • 69
    • 36749004368 scopus 로고    scopus 로고
    • Conjugation of an anti transferrin receptor IgG3-avidin fusion protein with biotinylated saporin results in significant enhancement of its cytotoxicity against malignant hematopoietic cells
    • Daniels TR, Ng PP, Delgado T, Lynch MR, Schiller G, Helguera G, Penichet ML. Conjugation of an anti transferrin receptor IgG3-avidin fusion protein with biotinylated saporin results in significant enhancement of its cytotoxicity against malignant hematopoietic cells. Mol Cancer Ther. 2007;6:2995-3008.
    • (2007) Mol Cancer Ther , vol.6 , pp. 2995-3008
    • Daniels, T.R.1    Ng, P.P.2    Delgado, T.3    Lynch, M.R.4    Schiller, G.5    Helguera, G.6    Penichet, M.L.7
  • 71
    • 0030781105 scopus 로고    scopus 로고
    • Characterization and phenotypic analysis of differentiating CD34+ human bone marrow cells in liquid culture
    • Gross S, Helm K, Gruntmeir JJ, Stillman WS, Pyatt DW, Irons RD. Characterization and phenotypic analysis of differentiating CD34+ human bone marrow cells in liquid culture. Eur J Haematol. 1997;59:318-26.
    • (1997) Eur J Haematol , vol.59 , pp. 318-326
    • Gross, S.1    Helm, K.2    Gruntmeir, J.J.3    Stillman, W.S.4    Pyatt, D.W.5    Irons, R.D.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.