The osmolyte betaine promotes protein misfolding and disruption of protein aggregates

Proteins: Structure, Function and Bioinformatics

Volumn 75, Issue 2, 2009, Pages 509-517

  Natalello, Antonino ^a,b   Liu, Jing ^c   Ami, Diletta ^d   Doglia, Silvia Maria ^a,b   De Marco, Ario ^d,e  

^a UNIVERSITY OF MILANO BICOCCA   (Italy)

^b INFM   (Italy)

^c INSTITUTE OF GEOLOGY AND GEOPHYSICS   (China)

^d COGENTECH ^*  (Italy)

^e Campus for Oncogenomics ^*  (Italy)

Author keywords

Aggregation; Circular dichroism; Disaggregation; Dynamic light scattering; Fourier transform infrared spectroscopy; Oligomers; Osmolytes; Protein destabilization; Protein stability

Indexed keywords

BETAINE; GLUTATHIONE TRANSFERASE; GREEN FLUORESCENT PROTEIN; HYBRID PROTEIN; THIOFLAVINE; PEPTIDE HYDROLASE;

ARTICLE; BETA SHEET; CIRCULAR DICHROISM; ELECTRON MICROSCOPY; HYDRODYNAMICS; INFRARED SPECTROSCOPY; LIGHT SCATTERING; PRIORITY JOURNAL; PROTEIN AGGREGATION; PROTEIN FOLDING; PROTEIN SECONDARY STRUCTURE; PROTEIN STABILITY; PROTEIN STRUCTURE; PROTEIN TERTIARY STRUCTURE; TURBIDITY; CHEMISTRY; METABOLISM; TEMPERATURE;

BETAINE; CIRCULAR DICHROISM; GREEN FLUORESCENT PROTEINS; PEPTIDE HYDROLASES; PROTEIN FOLDING; PROTEIN STABILITY; SPECTROSCOPY, FOURIER TRANSFORM INFRARED; TEMPERATURE;

EID: 66149143156     PISSN: 08873585     EISSN: 10970134     Source Type: Journal    
DOI: 10.1002/prot.22266     Document Type: Article

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