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Volumn 84, Issue 2, 2013, Pages 218-226

Inflammatory mediators increase SUMOylation of retinoid X receptor α in a c-Jun N-terminal kinase-dependent manner in human hepatocellular carcinoma cells

Author keywords

[No Author keywords available]

Indexed keywords

ALITRETINOIN; CELL NUCLEUS RECEPTOR; INTERLEUKIN 1BETA; LIPOPOLYSACCHARIDE; RETINOID X RECEPTOR ALPHA; STRESS ACTIVATED PROTEIN KINASE; STRESS ACTIVATED PROTEIN KINASE INHIBITOR; TUMOR NECROSIS FACTOR ALPHA;

EID: 84880611926     PISSN: 0026895X     EISSN: 15210111     Source Type: Journal    
DOI: 10.1124/mol.113.085555     Document Type: Article
Times cited : (20)

References (54)
  • 1
    • 0033516462 scopus 로고    scopus 로고
    • Hyperphosphorylation of the retinoid X receptor alpha by activated c-Jun NH2-terminal kinases
    • Adam-Stitah S, Penna L, Chambon P, and Rochette-Egly C (1999) Hyperphosphorylation of the retinoid X receptor alpha by activated c-Jun NH2-terminal kinases. J Biol Chem 274:18932-18941.
    • (1999) J Biol Chem , vol.274 , pp. 18932-18941
    • Adam-Stitah, S.1    Penna, L.2    Chambon, P.3    Rochette-Egly, C.4
  • 2
    • 0035800772 scopus 로고    scopus 로고
    • Human bile salt export pump promoter is transactivated by the farnesoid X receptor/bile acid receptor
    • Ananthanarayanan M, Balasubramanian N, Makishima M, Mangelsdorf DJ, and Suchy FJ (2001) Human bile salt export pump promoter is transactivated by the farnesoid X receptor/bile acid receptor. J Biol Chem 276:28857-28865.
    • (2001) J Biol Chem , vol.276 , pp. 28857-28865
    • Ananthanarayanan, M.1    Balasubramanian, N.2    Makishima, M.3    Mangelsdorf, D.J.4    Suchy, F.J.5
  • 3
    • 47249140920 scopus 로고    scopus 로고
    • Growth factor-induced phosphorylation of sterol regulatory element-binding proteins inhibits sumoylation, thereby stimulating the expression of their target genes, low density lipoprotein uptake, and lipid synthesis
    • Arito M, Horiba T, Hachimura S, Inoue J, and Sato R (2008) Growth factor-induced phosphorylation of sterol regulatory element-binding proteins inhibits sumoylation, thereby stimulating the expression of their target genes, low density lipoprotein uptake, and lipid synthesis. J Biol Chem 283:15224-15231.
    • (2008) J Biol Chem , vol.283 , pp. 15224-15231
    • Arito, M.1    Horiba, T.2    Hachimura, S.3    Inoue, J.4    Sato, R.5
  • 4
    • 0034717067 scopus 로고    scopus 로고
    • The acute phase response is associated with retinoid X receptor repression in rodent liver
    • Beigneux AP, Moser AH, Shigenaga JK, Grunfeld C, and Feingold KR (2000) The acute phase response is associated with retinoid X receptor repression in rodent liver. J Biol Chem 275:16390-16399.
    • (2000) J Biol Chem , vol.275 , pp. 16390-16399
    • Beigneux, A.P.1    Moser, A.H.2    Shigenaga, J.K.3    Grunfeld, C.4    Feingold, K.R.5
  • 5
    • 3042644131 scopus 로고    scopus 로고
    • A M55V polymorphism in a novel SUMO gene (SUMO-4) differentially activates heat shock transcription factors and is associated with susceptibility to type i diabetes mellitus
    • Bohren KM, Nadkarni V, Song JH, Gabbay KH, and Owerbach D (2004) A M55V polymorphism in a novel SUMO gene (SUMO-4) differentially activates heat shock transcription factors and is associated with susceptibility to type I diabetes mellitus. J Biol Chem 279:27233-27238.
    • (2004) J Biol Chem , vol.279 , pp. 27233-27238
    • Bohren, K.M.1    Nadkarni, V.2    Song, J.H.3    Gabbay, K.H.4    Owerbach, D.5
  • 6
    • 3042599451 scopus 로고    scopus 로고
    • Lipopolysaccharidemediated regulation of hepatic transporter mRNA levels in rats
    • Cherrington NJ, Slitt AL, Li N, and Klaassen CD (2004) Lipopolysaccharidemediated regulation of hepatic transporter mRNA levels in rats. Drug Metab Dispos 32:734-741.
    • (2004) Drug Metab Dispos , vol.32 , pp. 734-741
    • Cherrington, N.J.1    Slitt, A.L.2    Li, N.3    Klaassen, C.D.4
  • 7
    • 33750089739 scopus 로고    scopus 로고
    • Negative modulation of RXRalpha transcriptional activity by small ubiquitin-related modifier (SUMO) modification and its reversal by SUMOspecific protease SUSP1
    • Choi SJ, Chung SS, Rho EJ, Lee HW, Lee MH, Choi HS, Seol JH, Baek SH, Bang OS, and Chung CH (2006) Negative modulation of RXRalpha transcriptional activity by small ubiquitin-related modifier (SUMO) modification and its reversal by SUMO specific protease SUSP1. J Biol Chem 281:30669-30677.
    • (2006) J Biol Chem , vol.281 , pp. 30669-30677
    • Choi, S.J.1    Chung, S.S.2    Rho, E.J.3    Lee, H.W.4    Lee, M.H.5    Choi, H.S.6    Seol, J.H.7    Baek, S.H.8    Bang, O.S.9    Chung, C.H.10
  • 8
    • 75749145045 scopus 로고    scopus 로고
    • MicroRNAs of the immune system: Roles in inflammation and cancer
    • Davidson-Moncada J, Papavasiliou FN, and Tam W (2010) MicroRNAs of the immune system: roles in inflammation and cancer. Ann N Y Acad Sci 1183:183-194.
    • (2010) Ann N y Acad Sci , vol.1183 , pp. 183-194
    • Davidson-Moncada, J.1    Papavasiliou, F.N.2    Tam, W.3
  • 13
    • 18144387309 scopus 로고    scopus 로고
    • Endotoxin leads to rapid subcellular re-localization of hepatic RXRalpha: A novel mechanism for reduced hepatic gene expression in inflammation
    • Ghose R, Zimmerman TL, Thevananther S, and Karpen SJ (2004) Endotoxin leads to rapid subcellular re-localization of hepatic RXRalpha: A novel mechanism for reduced hepatic gene expression in inflammation. Nucl Recept 2:4.
    • (2004) Nucl Recept , vol.2 , pp. 4
    • Ghose, R.1    Zimmerman, T.L.2    Thevananther, S.3    Karpen, S.J.4
  • 15
    • 33646812194 scopus 로고    scopus 로고
    • Environmental obesogens: Organotins and endocrine disruption via nuclear receptor signaling
    • Grün F and Blumberg B (2006) Environmental obesogens: organotins and endocrine disruption via nuclear receptor signaling. Endocrinology 147(6, Suppl)S50-S55.
    • (2006) Endocrinology , vol.147 , Issue.6 SUPPL.
    • Grün, F.1    Blumberg, B.2
  • 16
    • 66349136233 scopus 로고    scopus 로고
    • Extracellular signal-regulated kinase mitogenactivated protein kinase signaling initiates a dynamic interplay between sumoylation and ubiquitination to regulate the activity of the transcriptional activator PEA3
    • Guo B and Sharrocks AD (2009) Extracellular signal-regulated kinase mitogenactivated protein kinase signaling initiates a dynamic interplay between sumoylation and ubiquitination to regulate the activity of the transcriptional activator PEA3. Mol Cell Biol 29:3204-3218.
    • (2009) Mol Cell Biol , vol.29 , pp. 3204-3218
    • Guo, B.1    Sharrocks, A.D.2
  • 18
    • 78149263436 scopus 로고    scopus 로고
    • Pregnane X receptor is SUMOylated to repress the inflammatory response
    • Hu G, Xu C, and Staudinger JL (2010) Pregnane X receptor is SUMOylated to repress the inflammatory response. J Pharmacol Exp Ther 335:342-350.
    • (2010) J Pharmacol Exp Ther , vol.335 , pp. 342-350
    • Hu, G.1    Xu, C.2    Staudinger, J.L.3
  • 19
    • 0141533155 scopus 로고    scopus 로고
    • Functional genetic dissection of nuclear receptor signalling in obesity, diabetes and liver regeneration using spatiotemporally controlled somatic mutagenesis in the mouse
    • Imai T (2003) Functional genetic dissection of nuclear receptor signalling in obesity, diabetes and liver regeneration using spatiotemporally controlled somatic mutagenesis in the mouse. Keio J Med 52:198-203.
    • (2003) Keio J Med , vol.52 , pp. 198-203
    • Imai, T.1
  • 20
    • 3943099375 scopus 로고    scopus 로고
    • Protein modification by SUMO
    • Johnson ES (2004) Protein modification by SUMO. Annu Rev Biochem 73:355-382.
    • (2004) Annu Rev Biochem , vol.73 , pp. 355-382
    • Johnson, E.S.1
  • 21
    • 33846174641 scopus 로고    scopus 로고
    • Tumor necrosis factor and interleukin 1 decrease RXRalpha, PPARalpha, PPARgamma, LXRalpha, and the coactivators SRC-1, PGC-1alpha, and PGC-1beta in liver cells
    • Kim MS, Sweeney TR, Shigenaga JK, Chui LG, Moser A, Grunfeld C, and Feingold KR (2007) Tumor necrosis factor and interleukin 1 decrease RXRalpha, PPARalpha, PPARgamma, LXRalpha, and the coactivators SRC-1, PGC-1alpha, and PGC-1beta in liver cells. Metabolism 56:267-279.
    • (2007) Metabolism , vol.56 , pp. 267-279
    • Kim, M.S.1    Sweeney, T.R.2    Shigenaga, J.K.3    Chui, L.G.4    Moser, A.5    Grunfeld, C.6    Feingold, K.R.7
  • 22
    • 48749087514 scopus 로고    scopus 로고
    • Bile acid transporters in health and disease
    • Kosters A and Karpen SJ (2008) Bile acid transporters in health and disease. Xenobiotica 38:1043-1071.
    • (2008) Xenobiotica , vol.38 , pp. 1043-1071
    • Kosters, A.1    Karpen, S.J.2
  • 23
    • 77951522428 scopus 로고    scopus 로고
    • The role of inflammation in cholestasis: Clinical and basic aspects
    • Kosters A and Karpen SJ (2010) The role of inflammation in cholestasis: clinical and basic aspects. Semin Liver Dis 30:186-194.
    • (2010) Semin Liver Dis , vol.30 , pp. 186-194
    • Kosters, A.1    Karpen, S.J.2
  • 24
    • 70349741297 scopus 로고    scopus 로고
    • Redundant roles for cJun-N-terminal kinase 1 and 2 in interleukin-1beta-mediated reduction and modification of murine hepatic nuclear retinoid X receptor alpha
    • Kosters A, White DD, Sun H, Thevananther S, and Karpen SJ (2009) Redundant roles for cJun-N-terminal kinase 1 and 2 in interleukin-1beta-mediated reduction and modification of murine hepatic nuclear retinoid X receptor alpha. J Hepatol 51:898-908.
    • (2009) J Hepatol , vol.51 , pp. 898-908
    • Kosters, A.1    White, D.D.2    Sun, H.3    Thevananther, S.4    Karpen, S.J.5
  • 25
    • 8844258035 scopus 로고    scopus 로고
    • Retinoid receptors in inflammatory responses: A potential target for pharmacology
    • Kuenzli S, Tran C, and Saurat JH (2004) Retinoid receptors in inflammatory responses: a potential target for pharmacology. Curr Drug Targets Inflamm Allergy 3:355-360.
    • (2004) Curr Drug Targets Inflamm Allergy , vol.3 , pp. 355-360
    • Kuenzli, S.1    Tran, C.2    Saurat, J.H.3
  • 26
    • 38749136631 scopus 로고    scopus 로고
    • Down-regulation of organic anion transporter expression in human hepatocytes exposed to the proinflammatory cytokine interleukin 1beta
    • Le Vee M, Gripon P, Stieger B, and Fardel O (2008) Down-regulation of organic anion transporter expression in human hepatocytes exposed to the proinflammatory cytokine interleukin 1beta. Drug Metab Dispos 36:217-222.
    • (2008) Drug Metab Dispos , vol.36 , pp. 217-222
    • Le Vee, M.1    Gripon, P.2    Stieger, B.3    Fardel, O.4
  • 27
    • 78049278719 scopus 로고    scopus 로고
    • Retinoid X receptors: Common heterodimerization partners with distinct functions
    • Lefebvre P, Benomar Y, and Staels B (2010) Retinoid X receptors: common heterodimerization partners with distinct functions. Trends Endocrinol Metab 21: 676-683.
    • (2010) Trends Endocrinol Metab , vol.21 , pp. 676-683
    • Lefebvre, P.1    Benomar, Y.2    Staels, B.3
  • 28
    • 77952309664 scopus 로고    scopus 로고
    • Silencing of the JNK pathway maintains progesterone receptor activity in decidualizing human endometrial stromal cells exposed to oxidative stress signals
    • Leitao B, Jones MC, Fusi L, Higham J, Lee Y, Takano M, Goto T, Christian M, Lam EW, and Brosens JJ (2010) Silencing of the JNK pathway maintains progesterone receptor activity in decidualizing human endometrial stromal cells exposed to oxidative stress signals. FASEB J 24:1541-1551.
    • (2010) FASEB J , vol.24 , pp. 1541-1551
    • Leitao, B.1    Jones, M.C.2    Fusi, L.3    Higham, J.4    Lee, Y.5    Takano, M.6    Goto, T.7    Christian, M.8    Lam, E.W.9    Brosens, J.J.10
  • 29
    • 70349659645 scopus 로고    scopus 로고
    • Sumoylated PPARalpha mediates sex-specific gene repression and protects the liver from estrogen-induced toxicity in mice
    • Leuenberger N, Pradervand S, and Wahli W (2009) Sumoylated PPARalpha mediates sex-specific gene repression and protects the liver from estrogen-induced toxicity in mice. J Clin Invest 119:3138-3148.
    • (2009) J Clin Invest , vol.119 , pp. 3138-3148
    • Leuenberger, N.1    Pradervand, S.2    Wahli, W.3
  • 30
    • 41949117824 scopus 로고    scopus 로고
    • Phosphorylation of the human retinoid X receptor alpha at serine 260 impairs coactivator(s) recruitment and induces hormone resistance to multiple ligands
    • Macoritto M, Nguyen-Yamamoto L, Huang DC, Samuel S, Yang XF, Wang TT, White JH, and Kremer R (2008) Phosphorylation of the human retinoid X receptor alpha at serine 260 impairs coactivator(s) recruitment and induces hormone resistance to multiple ligands. J Biol Chem 283:4943-4956.
    • (2008) J Biol Chem , vol.283 , pp. 4943-4956
    • MacOritto, M.1    Nguyen-Yamamoto, L.2    Huang, D.C.3    Samuel, S.4    Yang, X.F.5    Wang, T.T.6    White, J.H.7    Kremer, R.8
  • 32
    • 66849101522 scopus 로고    scopus 로고
    • Function of retinoic acid receptors during embryonic development
    • Mark M, Ghyselinck NB, and Chambon P (2009) Function of retinoic acid receptors during embryonic development. Nucl Recept Signal 7:e002.
    • (2009) Nucl Recept Signal , vol.7
    • Mark, M.1    Ghyselinck, N.B.2    Chambon, P.3
  • 33
    • 63849332390 scopus 로고    scopus 로고
    • Nuclear receptors: Mediators and modifiers of inflammation-induced cholestasis
    • Mulder J, Karpen SJ, Tietge UJ, and Kuipers F (2009) Nuclear receptors: mediators and modifiers of inflammation-induced cholestasis. Front Biosci 14:2599-2630.
    • (2009) Front Biosci , vol.14 , pp. 2599-2630
    • Mulder, J.1    Karpen, S.J.2    Tietge, U.J.3    Kuipers, F.4
  • 36
    • 76549099044 scopus 로고    scopus 로고
    • Involvement of pregnane X receptor in the regulation of CYP2B6 gene expression by oltipraz in human hepatocytes
    • Piton A, Rauch C, Langouet S, Guillouzo A, and Morel F (2010) Involvement of pregnane X receptor in the regulation of CYP2B6 gene expression by oltipraz in human hepatocytes. Toxicol In Vitro 24:452-459.
    • (2010) Toxicol in Vitro , vol.24 , pp. 452-459
    • Piton, A.1    Rauch, C.2    Langouet, S.3    Guillouzo, A.4    Morel, F.5
  • 37
    • 0036186337 scopus 로고    scopus 로고
    • Farnesoid X receptor and bile salts are involved in transcriptional regulation of the gene encoding the human bile salt export pump
    • Plass JR, Mol O, Heegsma J, Geuken M, Faber KN, Jansen PL, and Müller M (2002) Farnesoid X receptor and bile salts are involved in transcriptional regulation of the gene encoding the human bile salt export pump. Hepatology 35:589-596.
    • (2002) Hepatology , vol.35 , pp. 589-596
    • Plass, J.R.1    Mol, O.2    Heegsma, J.3    Geuken, M.4    Faber, K.N.5    Jansen, P.L.6    Müller, M.7
  • 38
    • 0034887798 scopus 로고    scopus 로고
    • Gene transcription in hepatocytes during the acute phase of a systemic inflammation: From transcription factors to target genes
    • Ruminy P, Gangneux C, Claeyssens S, Scotte M, Daveau M, and Salier JP (2001) Gene transcription in hepatocytes during the acute phase of a systemic inflammation: from transcription factors to target genes. Inflamm Res 50:383-390.
    • (2001) Inflamm Res , vol.50 , pp. 383-390
    • Ruminy, P.1    Gangneux, C.2    Claeyssens, S.3    Scotte, M.4    Daveau, M.5    Salier, J.P.6
  • 40
    • 1642304065 scopus 로고    scopus 로고
    • Structural determinants of allosteric ligand activation in RXR heterodimers
    • Shulman AI, Larson C, Mangelsdorf DJ, and Ranganathan R (2004) Structural determinants of allosteric ligand activation in RXR heterodimers. Cell 116: 417-429.
    • (2004) Cell , vol.116 , pp. 417-429
    • Shulman, A.I.1    Larson, C.2    Mangelsdorf, D.J.3    Ranganathan, R.4
  • 41
    • 23444431623 scopus 로고    scopus 로고
    • Retinoid x receptor heterodimers in the metabolic syndrome
    • Shulman AI and Mangelsdorf DJ (2005) Retinoid x receptor heterodimers in the metabolic syndrome. N Engl J Med 353:604-615.
    • (2005) N Engl J Med , vol.353 , pp. 604-615
    • Shulman, A.1    Mangelsdorf, D.J.2
  • 42
    • 0032695358 scopus 로고    scopus 로고
    • Mitogen-activated protein kinase inhibits 1,25-dihydroxyvitamin D3-dependent signal transduction by phosphorylating human retinoid X receptor alpha
    • Solomon C, White JH, and Kremer R (1999) Mitogen-activated protein kinase inhibits 1,25-dihydroxyvitamin D3-dependent signal transduction by phosphorylating human retinoid X receptor alpha. J Clin Invest 103:1729-1735.
    • (1999) J Clin Invest , vol.103 , pp. 1729-1735
    • Solomon, C.1    White, J.H.2    Kremer, R.3
  • 43
    • 79957729535 scopus 로고    scopus 로고
    • Post-translational modification of pregnane x receptor
    • Staudinger JL, Xu C, Biswas A, and Mani S (2011) Post-translational modification of pregnane x receptor. Pharmacol Res 64:4-10.
    • (2011) Pharmacol Res , vol.64 , pp. 4-10
    • Staudinger, J.L.1    Xu, C.2    Biswas, A.3    Mani, S.4
  • 44
    • 36048938333 scopus 로고    scopus 로고
    • Mechanisms of cytochrome P450 induction
    • Tompkins LM and Wallace AD (2007) Mechanisms of cytochrome P450 induction. J Biochem Mol Toxicol 21:176-181.
    • (2007) J Biochem Mol Toxicol , vol.21 , pp. 176-181
    • Tompkins, L.1    Wallace, A.D.2
  • 45
    • 79958244237 scopus 로고    scopus 로고
    • Transcriptional control of metabolic and inflammatory pathways by nuclear receptor SUMOylation
    • Treuter E and Venteclef N (2011) Transcriptional control of metabolic and inflammatory pathways by nuclear receptor SUMOylation. Biochim Biophys Acta 1812:909-918.
    • (2011) Biochim Biophys Acta , vol.1812 , pp. 909-918
    • Treuter, E.1    Venteclef, N.2
  • 48
    • 77951561501 scopus 로고    scopus 로고
    • Nuclear receptor regulation of the adaptive response of bile acid transporters in cholestasis
    • Wagner M, Zollner G, and Trauner M (2010) Nuclear receptor regulation of the adaptive response of bile acid transporters in cholestasis. Semin Liver Dis 30: 160-177.
    • (2010) Semin Liver Dis , vol.30 , pp. 160-177
    • Wagner, M.1    Zollner, G.2    Trauner, M.3
  • 49
    • 3142764845 scopus 로고    scopus 로고
    • Human constitutive androstane receptor mediates induction of CYP2B6 gene expression by phenytoin
    • Wang H, Faucette S, Moore R, Sueyoshi T, Negishi M, and LeCluyse E (2004) Human constitutive androstane receptor mediates induction of CYP2B6 gene expression by phenytoin. J Biol Chem 279:29295-29301.
    • (2004) J Biol Chem , vol.279 , pp. 29295-29301
    • Wang, H.1    Faucette, S.2    Moore, R.3    Sueyoshi, T.4    Negishi, M.5    Lecluyse, E.6
  • 50
    • 79953791507 scopus 로고    scopus 로고
    • ABC transporters, bile acids, and inflammatory stress in liver cancer
    • Wang R, Sheps JA, and Ling V (2011) ABC transporters, bile acids, and inflammatory stress in liver cancer. Curr Pharm Biotechnol 12:636-646.
    • (2011) Curr Pharm Biotechnol , vol.12 , pp. 636-646
    • Wang, R.1    Sheps, J.A.2    Ling, V.3
  • 52
    • 11144340951 scopus 로고    scopus 로고
    • Il-1 beta mediated modification and nucleo-cytoplasmic translocation of RXR alpha involves JNK
    • Zimmerman TL, Ghose R, Thevananther S, and Karpen SJ (2003) Il-1 beta mediated modification and nucleo-cytoplasmic translocation of RXR alpha involves JNK. Hepatology 38:391A-391A.
    • (2003) Hepatology , vol.38
    • Zimmerman, T.L.1    Ghose, R.2    Thevananther, S.3    Karpen, S.J.4
  • 53
    • 84894896350 scopus 로고    scopus 로고
    • IL-1 beta induced RXR alpha nuclear export requires JNK activated cell signaling and involves serine
    • Zimmerman TL, Ghose R, Thevananther S, and Karpen SJ (2004) IL-1 beta induced RXR alpha nuclear export requires JNK activated cell signaling and involves serine. Hepatology 40:213A-213A.
    • (2004) Hepatology , vol.40
    • Zimmerman, T.L.1    Ghose, R.2    Thevananther, S.3    Karpen, S.J.4
  • 54
    • 33744957050 scopus 로고    scopus 로고
    • Nuclear export of retinoid X receptor alpha in response to interleukin-1beta-mediated cell signaling: Roles for JNK and SER260
    • Zimmerman TL, Thevananther S, Ghose R, Burns AR, and Karpen SJ (2006) Nuclear export of retinoid X receptor alpha in response to interleukin-1beta- mediated cell signaling: roles for JNK and SER260. J Biol Chem 281:15434-15440. Digestive and Kidney Diseases
    • (2006) J Biol Chem , vol.281 , pp. 15434-15440
    • Zimmerman, T.L.1    Thevananther, S.2    Ghose, R.3    Burns, A.R.4    Karpen, S.J.5


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