Inhibition of CCR7/CCL19 axis in lesional skin is a critical event for clinical remission induced by TNF blockade in patients with psoriasis

American Journal of Pathology

Volumn 183, Issue 2, 2013, Pages 413-421

  Bosè, Francesca ^a   Petti, Luciana ^a   Diani, Marco ^b   Moscheni, Claudia ^c   Molteni, Silvia ^a   Altomare, Andrea ^b   Rossi, Riccardo L ^d   Talarico, Daniela ^e   Fontana, Raffaella ^e   Russo, Vincenzo ^e   Altomare, Gianfranco ^b   Reali, Eva ^a,d  

^a IRCCS ISTITUTO ORTOPEDICO GALEAZZI   (Italy)

^b UNIVERSITY OF MILAN   (Italy)

^c UNIVERSITY OF MILAN   (Italy)

^d National Institute of Molecular Genetics (INGM)   (Italy)

^e SAN RAFFAELE HOSPITAL   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

ADALIMUMAB; CHEMOKINE RECEPTOR CCR7; ETANERCEPT; IMMUNOGLOBULIN; INFLIXIMAB; LIGAND; MACROPHAGE INFLAMMATORY PROTEIN 3BETA; TUMOR NECROSIS FACTOR ALPHA; TUMOR NECROSIS FACTOR INHIBITOR; VASCULOTROPIN;

ADULT; AGED; ARTICLE; CELL MATURATION; CLINICAL ARTICLE; CONTROLLED STUDY; CORRELATION ANALYSIS; DATA ANALYSIS; DENDRITIC CELL; FEMALE; GENE EXPRESSION; HUMAN; MALE; PRIORITY JOURNAL; PSORIASIS; PSORIASIS AREA AND SEVERITY INDEX; REMISSION; SKIN BIOPSY; SKIN DEFECT;

ADULT; AGED; AGED, 80 AND OVER; ANTI-INFLAMMATORY AGENTS; ANTIBODIES, MONOCLONAL; ANTIBODIES, MONOCLONAL, HUMANIZED; ANTIGENS, CD4; CELL AGING; CHEMOKINE CCL19; FEMALE; HUMANS; IMMUNOGLOBULIN G; LANGERHANS CELLS; LYMPHOCYTE ACTIVATION; MALE; MIDDLE AGED; PSORIASIS; RECEPTORS, CCR7; RECEPTORS, TUMOR NECROSIS FACTOR; REMISSION INDUCTION; SKIN; T-LYMPHOCYTES; TUMOR NECROSIS FACTOR-ALPHA;

EID: 84880608647     PISSN: 00029440     EISSN: 15252191     Source Type: Journal    
DOI: 10.1016/j.ajpath.2013.04.021     Document Type: Article

References (30)

1. M.A. Lowes, A.M. Bowcock, and J.G. Krueger Pathogenesis and therapy of psoriasis Nature 445 2007 866 873
2. F.O. Nestle, D.H. Kaplan, and J. Barker Psoriasis N Engl J Med 361 2009 496 509
3. Y. Yao, L. Richman, C. Morehouse, M. de los Reyes, B.W. Higgs, A. Boutrin, B. White, A. Coyle, J. Krueger, P.A. Kiener, and B. Jallal Type I interferon: potential therapeutic target for psoriasis? PLoS One 3 2008 e2737
4. L.C. Zaba, J.G. Krueger, and M.A. Lowes Resident and " inflammatory" dendritic cells in human skin J Invest Dermatol 129 2009 302 308
5. X. Zhou, J.G. Krueger, M.C. Kao, E. Lee, F. Du, A. Menter, W.H. Wong, and A.M. Bowcock Novel mechanisms of T-cell and dendritic cell activation revealed by profiling of psoriasis on the 63,100-element oligonucleotide array Physiol Genomics 13 2003 69 78
6. A.B. Gottlieb, F. Chamian, S. Masud, I. Cardinale, M.V. Abello, M.A. Lowes, F. Chen, M. Magliocco, and J.G. Krueger TNF inhibition rapidly down-regulates multiple proinflammatory pathways in psoriasis plaques J Immunol 175 2005 2721 2729
7. L.C. Zaba, I. Cardinale, P. Gilleaudeau, M. Sullivan-Whalen, M. Suarez-Farinas, J. Fuentes-Duculan, I. Novitskaya, A. Khatcherian, M.J. Bluth, M.A. Lowes, and J.G. Krueger Amelioration of epidermal hyperplasia by TNF inhibition is associated with reduced Th17 responses J Exp Med 204 2007 3183 3194
8. E.T. Andreakos, B.M. Foxwell, F.M. Brennan, R.N. Maini, and M. Feldmann Cytokines and anti-cytokine biologicals in autoimmunity: present and future Cytokine Growth Factor Rev 13 2002 299 313
9. M. Feldmann, and R.N. Maini Anti-TNF alpha therapy of rheumatoid arthritis: what have we learned? Annu Rev Immunol 19 2001 163 196
10. F. Katou, H. Ohtani, T. Nakayama, H. Nagura, O. Yoshie, and K. Motegi Differential expression of CCL19 by DC-Lamp+ mature dendritic cells in human lymph node versus chronically inflamed skin J Pathol 199 2003 98 106
11. A. Yarilina, K.H. Park-Min, T. Antoniv, X. Hu, and L.B. Ivashkiv TNF activates an IRF1-dependent autocrine loop leading to sustained expression of chemokines and STAT1-dependent type I interferon-response genes Nat Immunol 9 2008 378 387
12. F. Bosè, L. Raeli, C. Garutti, E. Frigerio, A. Cozzi, M. Crimi, F. Caprioli, R. Scavelli, G. Altomare, J. Geginat, S. Abrignani, and E. Reali Dual role of anti-TNF therapy: enhancement of TCR-mediated T cell activation in peripheral blood and inhibition of inflammation in target tissues Clin Immunol 139 2011 164 176
13. L.C. Zaba, M. Suárez-Farinas, J. Fuentes-Duculan, K.E. Nograles, E. Guttman-Yassky, I. Cardinale, M.A. Lowes, and J.G. Krueger Effective treatment of psoriasis with etanercept is linked to suppression of IL-17 signaling, not immediate response TNF genes J Allergy Clin Immunol 124 2009 1022 1030.e395
14. F. Caprioli, F. Bosè, R. Rossi, L. Petti, C. Viganò, C. Ciafardini, L. Raeli, G. Basilisco, S. Ferrero, M. Pagani, D. Conte, G. Altomare, G. Monteleone, S. Abrignani, and E. Reali Reduction of CD68+ macrophages and decreased IL-17 expression in intestinal mucosa of patients with inflammatory bowel disease strongly correlate with endoscopic response and mucosal healing following infliximab therapy Inflamm Bowel Dis 19 2013 729 739
15. P.C. Taylor, A.M. Peters, E. Paleolog, P.T. Chapman, M.J. Elliott, R. McCloskey, M. Feldmann, and R.N. Maini Reduction of chemokine levels and leukocyte traffic to joints by tumor necrosis factor alpha blockade in patients with rheumatoid arthritis Arthritis Rheum 43 2000 38 47
16. D. Brown, J. Lydon, M. McLaughlin, A. Stuart-Tilley, R. Tyszkowski, and S. Alper Antigen retrieval in cryostat tissue sections and cultured cells by treatment with sodium dodecyl sulfate (SDS) Histochem Cell Biol 105 1996 261 267
17. P. Li, P. Liu, R.P. Xiong, X.Y. Chen, Y. Zhao, W.P. Lu, X. Liu, Y.L. Ning, N. Yang, and Y.G. Zhou Ski, a modulator of wound healing and scar formation in the rat skin and rabbit ear J Pathol 223 2011 659 671
18. J. Banchereau, F. Briere, C. Caux, J. Davoust, S. Lebecque, Y.J. Liu, B. Pulendran, and K. Palucka Immunobiology of dendritic cells Annu Rev Immunol 18 2000 767 811
19. C. van Kooten, and J. Banchereau Functions of CD40 on B cells, dendritic cells and other cells Curr Opin Immunol 9 1997 330 337
20. H. Mitsui, M. Suarez-Farinas, D.A. Belkin, N. Levenkova, J. Fuentes-Duculan, I. Coats, H. Fujita, and J.G. Krueger Combined use of laser capture microdissection and cDNA microarray analysis identifies locally expressed disease-related genes in focal regions of psoriasis vulgaris skin lesions J Invest Dermatol 132 2012 1645 1655
21. A.M. Bowcock, and J.G. Krueger Getting under the skin: the immunogenetics of psoriasis Nat Rev Immunol 5 2005 826
22. F. Aloisi, and R. Pujol-Borrell Lymphoid neogenesis in chronic inflammatory diseases Nat Rev Immunol 6 2006 205 217
23. M. Pasparakis, L. Alexopoulou, V. Episkopou, and G. Kollias Immune and inflammatory responses in TNF alpha-deficient mice: a critical requirement for TNF alpha in the formation of primary B cell follicles, follicular dendritic cell networks and germinal centers, and in the maturation of the humoral immune response J Exp Med 184 1996 1397 1411
24. T.D. Randall, D.M. Carragher, and J. Rangel-Moreno Development of secondary lymphoid organs Annu Rev Immunol 26 2008 627 650
25. R. Heidenreich, M. Rocken, and K. Ghoreschi Angiogenesis drives psoriasis pathogenesis Int J Exp Pathol 90 2009 232 248
26. W. Lew, A.M. Bowcock, and J.G. Krueger Psoriasis vulgaris: cutaneous lymphoid tissue supports T-cell activation and "Type 1" inflammatory gene expression Trends Immunol 25 2004 295 305
27. F. Geissmann, M.C. Dieu-Nosjean, C. Dezutter, J. Valladeau, S. Kayal, M. Leborgne, N. Brousse, S. Saeland, and J. Davoust Accumulation of immature Langerhans cells in human lymph nodes draining chronically inflamed skin J Exp Med 196 2002 417 430
28. A.W. van Lieshout, P. Barrera, R.L. Smeets, G.J. Pesman, P.L. van Riel, W.B. van den Berg, and T.R. Radstake Inhibition of TNF alpha during maturation of dendritic cells results in the development of semi-mature cells: a potential mechanism for the beneficial effects of TNF alpha blockade in rheumatoid arthritis Ann Rheum Dis 64 2005 408 414
29. R. Malaviya, Y. Sun, J.K. Tan, A. Wang, M. Magliocco, M. Yao, J.G. Krueger, and A.B. Gottlieb Etanercept induces apoptosis of dermal dendritic cells in psoriatic plaques of responding patients J Am Acad Dermatol 55 2006 590 597
30. F. Wang, N. Smith, L. Maier, W. Xia, C. Hammerberg, H. Chubb, C. Chen, M. Riblett, A. Johnston, J.E. Gudjonsson, Y. Helfrich, S. Kang, G.J. Fisher, and J.J. Voorhees Etanercept suppresses regenerative hyperplasia in psoriasis by acutely downregulating epidermal expression of interleukin (IL)-19, IL-20 and IL-24 Br J Dermatol 167 2012 92 102