Tetrazole and triazole as bioisosteres of carboxylic acid: Discovery of diketo tetrazoles and diketo triazoles as anti-HCV agents

Bioorganic and Medicinal Chemistry Letters

Volumn 23, Issue 16, 2013, Pages 4528-4531

  Song, Wu Hui ^a   Liu, Ming Ming ^a,b   Zhong, Dong Wei ^a   Zhu, Ye Lin ^a   Bosscher, Mike ^c   Zhou, Lu ^a   Ye, De Yong ^a   Yuan, Zheng Hong ^a  

^a FUDAN UNIVERSITY   (China)

^b FUDAN UNIVERSITY SHANGHAI CANCER CENTER   (China)

^c United States of America   (United States)

Author keywords

Anti HCV activity; Bioisosteres; Diketo tetrazoles; Diketo triazoles

Indexed keywords

1H TETRAZOL 5 ETHYL FORMATE; 4 (4 FLUOROBENZYLOXY)PHENYL DIKETO TRIAZOLE; ANTIVIRUS AGENT; TETRAZOLE DERIVATIVE; TRIAZOLE; TRIAZOLE DERIVATIVE; UNCLASSIFIED DRUG;

ANTIVIRAL ACTIVITY; ARTICLE; CELL VIABILITY; CYTOTOXICITY; DRUG SYNTHESIS; HEPATITIS C VIRUS; HUMAN; VIRUS REPLICATION;

ANTI-HCV ACTIVITY; BIOISOSTERES; DIKETO TETRAZOLES; DIKETO TRIAZOLES;

ANTIVIRAL AGENTS; CARBOXYLIC ACIDS; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG DISCOVERY; HEPACIVIRUS; HUMANS; INHIBITORY CONCENTRATION 50; MOLECULAR STRUCTURE; TETRAZOLES; TRIAZOLES;

HEPATITIS C VIRUS;

EID: 84880605376     PISSN: 0960894X     EISSN: 14643405     Source Type: Journal    
DOI: 10.1016/j.bmcl.2013.06.045     Document Type: Article

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