Epigenetic regulation of serotonin transporter in psychiatric disorders

Journal of Genetics and Genomics

Volumn 40, Issue 7, 2013, Pages 325-329

  Sugawara, Hiroko ^a,b   Bundo, Miki ^c   Ishigooka, Jun ^b   Iwamoto, Kazuya ^c   Kato, Tadafumi ^a  

^a RIKEN BRAIN SCIENCE INSTITUTE   (Japan)

^b TOKYO WOMEN'S MEDICAL UNIVERSITY   (Japan)

^c UNIVERSITY OF TOKYO   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

SEROTONIN TRANSPORTER;

ALCOHOLISM; ANXIETY DISORDER; ARTICLE; CPG ISLAND; DNA METHYLATION; ENVIRONMENTAL FACTOR; EPIGENETICS; GENE EXPRESSION; GENOTYPE; HUMAN; MAJOR DEPRESSION; MENTAL DISEASE; MOOD DISORDER; NONHUMAN;

ANIMALS; DNA METHYLATION; EPIGENESIS, GENETIC; GENOTYPE; HUMANS; MENTAL DISORDERS; SEROTONIN PLASMA MEMBRANE TRANSPORT PROTEINS;

EID: 84880586468     PISSN: 16738527     EISSN: 18735533     Source Type: Journal    
DOI: 10.1016/j.jgg.2012.10.002     Document Type: Article

References (31)

1. Antequera F., Boyes J., Bird A. High levels of de novo methylation and altered chromatin structure at CpG islands in cell lines. Cell 1990, 62:503-514.
2. Beach S.R., Brody G.H., Todorov A.A., Gunter T.D., Philibert R.A. Methylation at SLC6A4 is linked to family history of child abuse: an examination of the iowa adoptee sample. Am. J. Med. Genet. B Neuropsychiatr. Genet. 2010, 153B:710-713.
3. Beach S.R., Brody G.H., Todorov A.A., Gunter T.D., Philibert R.A. Methylation at 5HTT mediates the impact of child sex abuse on women's antisocial behavior: an examination of the iowa adoptee sample. Psychosom. Med. 2011, 73:83-87.
4. Bird A. DNA methylation patterns and epigenetic memory. Genes Dev. 2002, 16:6-21.
5. Bradley S.L., Dodelzon K., Sandhu H.K., Philibert R.A. Relationship of serotonin transporter gene polymorphisms and haplotypes to mRNA transcription. Am J. Med. Genet. B Neuropsychiatr. Genet. 2005, 136B:58-61.
6. Caspi A., Sugden K., Moffitt T.E., Taylor A., Craig I.W., Harrington H., McClay J., Mill J., Martin J., Braithwaite A., Poulton R. Influence of life stress on depression: moderation by a polymorphism in the 5-HTT gene. Science 2003, 301:386-389.
7. Devlin A.M., Brain U., Austin J., Oberlander T.F. Prenatal exposure to maternal depressed mood and the MTHFR C677T variant affect SLC6A4 methylation in infants at birth. PLoS ONE 2010, 5:e12201.
8. Feinberg A.P. Phenotypic plasticity and the epigenetics of human disease. Nature 2007, 447:433-440.
9. Feinn R., Nellissery M., Kranzler H.R. Meta-analysis of the association of a functional serotonin transporter promoter polymorphism with alcohol dependence. Am J. Med. Genet. B Neuropsychiatr. Genet. 2005, 133B:79-84.
10. Fraga M.F., Ballestar E., Paz M.F., Ropero S., Setien F., Ballestar M.L., Heine-Suner D., Cigudosa J.C., Urioste M., Benitez J., Boix-Chornet M., Sanchez-Aguilera A., Ling C., Carlsson E., Poulsen P., Vaag A., Stephan Z., Spector T.D., Wu Y.Z., Plass C., Esteller M. Epigenetic differences arise during the lifetime of monozygotic twins. Proc. Natl. Acad. Sci. USA 2005, 102:10604-10609.
11. Heils A., Teufel A., Petri S., Stober G., Riederer P., Bengel D., Lesch K.P. Allelic variation of human serotonin transporter gene expression. J. Neurochem. 1996, 66:2621-2624.
12. Irizarry R.A., Ladd-Acosta C., Wen B., Wu Z., Montano C., Onyango P., Cui H., Gabo K., Rongione M., Webster M., Ji H., Potash J.B., Sabunciyan S., Feinberg A.P. The human colon cancer methylome shows similar hypo- and hypermethylation at conserved tissue-specific CpG island shores. Nat. Genet. 2009, 41:178-186.
13. Kendler K.S., Kuhn J.W., Vittum J., Prescott C.A., Riley B. The interaction of stressful life events and a serotonin transporter polymorphism in the prediction of episodes of major depression: a replication. Arch. Gen. Psychiatry 2005, 62:529-535.
14. Kinnally E.L., Capitanio J.P., Leibel R., Deng L., LeDuc C., Haghighi F., Mann J.J. Epigenetic regulation of serotonin transporter expression and behavior in infant rhesus macaques. Genes Brain Behav. 2010, 9:575-582.
15. Kinnally E.L., Feinberg C., Kim D., Ferguson K., Leibel R., Coplan J.D., John Mann J. DNA methylation as a risk factor in the effects of early life stress. Brain Behav. Immun. 2011, 25:1548-1553.
16. Koenen K.C., Uddin M., Chang S.C., Aiello A.E., Wildman D.E., Goldmann E., Galea S. SLC6A4 methylation modifies the effect of the number of traumatic events on risk for posttraumatic stress disorder. Depress Anxiety 2011, 28:639-647.
17. Lesch K.P., Bengel D., Heils A., Sabol S.Z., Greenberg B.D., Petri S., Benjamin J., Muller C.R., Hamer D.H., Murphy D.L. Association of anxiety-related traits with a polymorphism in the serotonin transporter gene regulatory region. Science 1996, 274:1527-1531.
18. Nakamura M., Ueno S., Sano A., Tanabe H. The human serotonin transporter gene linked polymorphism (5-HTTLPR) shows ten novel allelic variants. Mol. Psychiatry 2000, 5:32-38.
19. Olsson C.A., Foley D.L., Parkinson-Bates M., Byrnes G., McKenzie M., Patton G.C., Morley R., Anney R.J., Craig J.M., Saffery R. Prospects for epigenetic research within cohort studies of psychological disorder: a pilot investigation of a peripheral cell marker of epigenetic risk for depression. Biol. Psychol. 2010, 83:159-165.
20. Park B.Y., Lee B.C., Jung K.H., Jung M.H., Park B.L., Chai Y.G., Choi I.G. Epigenetic changes of serotonin transporter in the patients with alcohol dependence: methylation of an serotonin transporter promoter CpG island. Psychiatry Investig. 2011, 8:130-133.
21. Petronis A. Epigenetics as a unifying principle in the aetiology of complex traits and diseases. Nature 2010, 465:721-727.
22. Philibert R., Madan A., Andersen A., Cadoret R., Packer H., Sandhu H. Serotonin transporter mRNA levels are associated with the methylation of an upstream CpG island. Am. J. Med. Genet. B Neuropsychiatr. Genet. 2007, 144B:101-105.
23. Philibert R.A., Sandhu H., Hollenbeck N., Gunter T., Adams W., Madan A. The relationship of 5HTT (SLC6A4) methylation and genotype on mRNA expression and liability to major depression and alcohol dependence in subjects from the iowa adoption studies. Am. J. Med. Genet. B Neuropsychiatr. Genet. 2008, 147B:543-549.
24. Sugawara H., Iwamoto K., Bundo M., Ueda J., Miyauchi T., Komori A., Kazuno A., Adati N., Kusumi I., Okazaki Y., Ishigooka J., Kojima T., Kato T. Hypermethylation of serotonin transporter gene in bipolar disorder detected by epigenome analysis of discordant monozygotic twins. Transl. Psychiatry 2011, 1:e24.
25. Sugawara H., Iwamoto K., Bundo M., Ueda J., Ishigooka J., Kato T. Comprehensive DNA methylation analysis of human peripheral blood leukocytes and lymphoblastoid cell lines. Epigenetics 2011, 6:508-515.
26. van Ijzendoorn M.H., Caspers K., Bakermans-Kranenburg M.J., Beach S.R., Philibert R. Methylation matters: interaction between methylation density and serotonin transporter genotype predicts unresolved loss or trauma. Biol. Psychiatry 2010, 68:405-407.
27. Vasiliou S.A., Ali F.R., Haddley K., Cardoso M.C., Bubb V.J., Quinn J.P. The SLC6A4 VNTR genotype determines transcription factor binding and epigenetic variation of this gene in response to cocaine invitro. Addict. Biol. 2012, 17:156-170.
28. Vijayendran M., Beach S.R., Plume J.M., Brody G.H., Philibert R.A. Effects of genotype and child abuse on DNA methylation and gene expression at the serotonin transporter. Front. Psychiatry 2012, 3:55.
29. Wang D., Szyf M., Benkelfat C., Provençal N., Turecki G., Caramaschi D., Côté S.M., Vitaro F., Tremblay R.E., Booij L. Peripheral SLC6A4 DNA methylation is associated with invivo measures of human brain serotonin synthesis and childhood physical aggression. PLoS ONE 2012, 7:e39501.
30. Weaver I.C., Cervoni N., Champagne F.A., D'Alessio A.C., Sharma S., Seckl J.R., Dymov S., Szyf M., Meaney M.J. Epigenetic programming by maternal behavior. Nat. Neurosci. 2004, 7:847-854.
31. Wong C.C., Caspi A., Williams B., Craig I.W., Houts R., Ambler A., Moffitt T.E., Mill J. A longitudinal study of epigenetic variation in twins. Epigenetics 2010, 5:516-526.