Overexpression of Bmi-1 contributes to the invasion and metastasis of hepatocellular carcinoma by increasing the expression of matrix metalloproteinase (MMP)-2, MMP-9 and vascular endothelial growth factor via the PTEN/PI3K/Akt pathway

International Journal of Oncology

Volumn 43, Issue 3, 2013, Pages 793-802

  Li, Xiaolei ^a   Yang, Zhaoxu ^a   Song, Wenjie ^a   Zhou, Liang ^a   Li, Qingjun ^a   Tao, Kaishan ^a   Zhou, Jingshi ^a   Wang, Xing ^a   Zheng, Zhigang ^a   You, Nan ^b   Dou, Kefeng ^a   Li, Haimin ^a  

^a FOURTH MILITARY MEDICAL UNIVERSITY   (China)

^b THIRD MILITARY MEDICAL UNIVERSITY   (China)

Author keywords

Bmi 1; Hepatocellular carcinoma; Invasion; Metastasis; Prognosis

Indexed keywords

BMI1 PROTEIN; GELATINASE A; GELATINASE B; PHOSPHATIDYLINOSITOL 3 KINASE; PHOSPHATIDYLINOSITOL 3,4,5 TRISPHOSPHATE 3 PHOSPHATASE; PROTEIN KINASE B; SHORT HAIRPIN RNA; VASCULOTROPIN;

ADULT; ARTICLE; CANCER PROGNOSIS; CANCER STAGING; CANCER SURVIVAL; CANCER TISSUE; CELL LINE; CLINICAL FEATURE; CONTROLLED STUDY; DISEASE ASSOCIATION; DOWN REGULATION; ENZYME ACTIVITY; ENZYME INDUCTION; ENZYME REGULATION; FEMALE; HUMAN; HUMAN CELL; HUMAN TISSUE; IN VITRO STUDY; LIVER; LIVER CELL CARCINOMA; MAJOR CLINICAL STUDY; MALE; METASTASIS; NUCLEOTIDE SEQUENCE; OVERALL SURVIVAL; PRIORITY JOURNAL; PROTEIN EXPRESSION; TUMOR INVASION; TUMOR VOLUME; UPREGULATION;

ADULT; AGED; CARCINOMA, HEPATOCELLULAR; ELAFIN; FEMALE; GENE EXPRESSION REGULATION, NEOPLASTIC; HEP G2 CELLS; HUMANS; LIVER NEOPLASMS; MALE; MATRIX METALLOPROTEINASE 2; MATRIX METALLOPROTEINASE 9; MIDDLE AGED; MITOGEN-ACTIVATED PROTEIN KINASE 7; NEOPLASM INVASIVENESS; NEOPLASM METASTASIS; NEOPLASM STAGING; PROGNOSIS; PROTO-ONCOGENE PROTEINS C-AKT; PTEN PHOSPHOHYDROLASE; SIGNAL TRANSDUCTION; VASCULAR ENDOTHELIAL GROWTH FACTOR A;

EID: 84880577197     PISSN: 10196439     EISSN: 17912423     Source Type: Journal    
DOI: 10.3892/ijo.2013.1992     Document Type: Article

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