Inhibition of ERK1/2 pathway suppresses adiponectin secretion via accelerating protein degradation by Ubiquitin-proteasome system: Relevance to obesity-related adiponectin decline

Metabolism: Clinical and Experimental

Volumn 62, Issue 8, 2013, Pages 1137-1148

  Gu, Dongfang ^a,b   Wang, Zhigang ^a   Dou, Xiaobing ^a,c   Zhang, Ximei ^a   Li, Songtao ^a   Vu, Lyndsey ^a   Yao, Tong ^a   Song, Zhenyuan ^a  

^a UNIVERSITY OF ILLINOIS AT CHICAGO   (United States)

^b HARBIN MEDICAL UNIVERSITY   (China)

^c ZHEJIANG CHINESE MEDICAL UNIVERSITY   (China)

Author keywords

Adiponectin; ERK1 2; Obesity; PPAR ; Ubiquitin

Indexed keywords

ADIPONECTIN; CYCLOHEXIMIDE; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; PROTEASOME; PROTEIN KINASE B; UBIQUITIN;

ADIPOCYTE; ANIMAL CELL CULTURE; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; ASSAY; CELL DIFFERENTIATION; CONTROLLED STUDY; CYTOKINE RELEASE; ENVIRONMENTAL EXPOSURE; ENZYME ACTIVITY; ENZYME LINKED IMMUNOSORBENT ASSAY; EPIDIDYMIS FAT; GENE EXPRESSION; IMMUNOPRECIPITATION; IN VITRO STUDY; INHIBITION KINETICS; LIPID DIET; MALE; MOLECULAR MECHANICS; MOUSE; NONHUMAN; OBESITY; PRIORITY JOURNAL; PROTEIN DEGRADATION; QUANTITATIVE ANALYSIS; REAL TIME POLYMERASE CHAIN REACTION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION; TRANSIENT TRANSFECTION; UBIQUITINATION; WESTERN BLOTTING;

ADIPONECTIN; ERK1/2; EXTRACELLULAR SIGNAL-REGULATED KINASES 1 AND 2; HFD; HIGH-FAT DIET; I PPAR-Γ; OBESITY; PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR GAMMA; PPAR-Γ; TNF-Α; TUMOR NECROSIS FACTOR-ALPHA; UBIQUITIN; UBIQUITIN-PROTEASOME SYSTEM; UPS;

3T3 CELLS; ADIPONECTIN; ADIPOSE TISSUE; AMINO ACID SEQUENCE; ANIMALS; BLOTTING, WESTERN; CELLS, CULTURED; DIET, HIGH-FAT; ENZYME-LINKED IMMUNOSORBENT ASSAY; EPIDIDYMIS; IMMUNOPRECIPITATION; MALE; MAP KINASE SIGNALING SYSTEM; MICE; MICE, INBRED C57BL; MOLECULAR SEQUENCE DATA; OBESITY; ONCOGENE PROTEIN V-AKT; PHOSPHORYLATION; PPAR GAMMA; PROTEASOME ENDOPEPTIDASE COMPLEX; REAL-TIME POLYMERASE CHAIN REACTION; TRANSFECTION; UBIQUITIN;

EID: 84880571783     PISSN: 00260495     EISSN: 15328600     Source Type: Journal    
DOI: 10.1016/j.metabol.2013.01.025     Document Type: Article

References (36)

1. P.E. Scherer, S. Williams, M. Fogliano, G. Baldini, and H.F. Lodish A novel serum protein similar to C1q, produced exclusively in adipocytes J Biol Chem 270 1995 26746 26749
2. F. Ziemke, and C.S. Mantzoros Adiponectin in insulin resistance: lessons from translational research Am J Clin Nutr 91 2010 258S 261S
3. J.K. Nien, R. Romero, O. Erez, J.P. Kusanovic, F. Gotsch, and B.L. Pineles Adiponectin in severe preeclampsia J Perinat Med 35 2007 503 512
4. Y.H. Lee, F. Magkos, C.S. Mantzoros, and E.S. Kang Effects of leptin and adiponectin on pancreatic β-cell function Metabolism 12 2011 1664 1672
5. L.E. Johansson, L.M. Johansson, P. Danielsson, S. Norgren, S. Johansson, and C. Marcus Genetic variance in the adiponutrin gene family and childhood obesity PLoS One 4 2009 e5327
6. M. Ryo, T. Nakamura, S. Kihara, M. Kumada, S. Shibazaki, and M. Takahashi Adiponectin as a biomarker of the metabolic syndrome Circ J 68 2004 975 981
7. K.M. Ajuwon, and M.E. Spurlock Adiponectin inhibits LPS-induced NF-kappaB activation and IL-6 production and increases PPARgamma2 expression in adipocytes Am J Physiolol-Regulat Integr Comp Physiol 288 2005 R1220 R1225
8. A.H. Berg, T.P. Combs, and P.E. Scherer ACRP30/adiponectin: an adipokine regulating glucose and lipid metabolism Trends Endocrinol Metab 13 2002 84 89
9. M. Fasshauer, S. Kralisch, M. Klier, U. Lossner, M. Bluher, and J. Klein Adiponectin gene expression and secretion is inhibited by interleukin-6 in 3T3-L1 adipocytes Biochem Biophys Res Commun 301 2003 1045 1050
10. A.S. Lihn, B. Richelsen, S.B. Pedersen, S.B. Haugaard, G.S. Rathje, and S. Madsbad Increased expression of TNF-alpha, IL-6, and IL-8 in HALS: implications for reduced adiponectin expression and plasma levels Am J Physiol Endocrinol Metab 285 2003 E1072 E1080
11. M.I. Lefterova, Y. Zhang, D.J. Steger, M. Schupp, J. Schug, and A. Cristancho PPARgamma and C/EBP factors orchestrate adipocyte biology via adjacent binding on a genome-wide scale Genes Dev 22 2008 2941 2952
12. B.T. Porse, T.A. Pedersen, X. Xu, B. Lindberg, U.M. Wewer, and H.L. Friis E2F repression by C/EBPalpha is required for adipogenesis and granulopoiesis in vivo Cell 107 2001 247 258
13. A.A. Richards, M.L. Colgrave, J. Zhang, J. Webster, F. Simpson, and E. Preston Sialic acid modification of adiponectin is not required for multimerization or secretion but determines half-life in circulation Mol Endocrinol 24 2010 229 239
14. T.P. Combs, U.B. Pajvani, A.H. Berg, Y. Lin, L.A. Jelicks, and M. Laplante A transgenic mouse with a deletion in the collagenous domain of adiponectin displays elevated circulating adiponectin and improved insulin sensitivity Endocrinology 45 2004 367 383
15. N. Ouchi, S. Kihara, Y. Arita, Y. Okamoto, K. Maeda, and H. Kuriyama Adiponectin, an adipocyte-derived plasma protein, inhibits endothelial NF-kappaB signaling through a cAMP-dependent pathway Circulation 102 2000 1296 1301
16. R. Clasen, M. Schupp, A. Foryst-Ludwig, C. Sprang, M. Clemenz, and M. Krikov PPARgamma-activating angiotensin type-1 receptor blockers induce adiponectin Hypertension 46 2005 137 143
17. U.B. Pajvani, X. Du, T.P. Combs, A.H. Berg, M.W. Rajala, and T. Schulthess Structure-function studies of the adipocyte-secreted hormone Acrp30/adiponectin. Implications for metabolic regulation and bioactivity J Biol Chem 278 2003 9073 9085
18. Z. Wang, X. Dou, D. Gu, C. Shen, T. Yao, and V. Nguyen 4-Hydroxynonenal differentially regulates adiponectin gene expression and secretion via activating PPARγ and accelerating ubiquitin-proteasome degradation Mol Cell Endocrinol 349 2012 222 231
19. Z. Song, Z. Zhou, I. Deaciuc, T. Chen, and C.J. McClain Inhibition of adiponectin production by homocysteine: a potential mechanism for alcoholic liver disease Hepatology 47 2008 867 879
20. S.A. Richards, V.C. Dreisbach, L.O. Murphy, and J. Blenis Characterization of regulatory events associated with membrane targeting of p90 ribosomal S6 kinase 1 Molec Cell Biol 21 2001 7470 7480
21. S.H. Yang, A.D. Sharrocks, and A.J. Whitmarsh Transcriptional regulation by the MAP kinase signaling cascades Gene 27 320 2003 3 21
22. M. Liu, and F. Liu Transcriptional and post-translational regulation of adiponectin Biochem J 425 2009 41 52
23. R.I. Pereira, J.W. Leitner, C. Erickson, and B. Draznin Pioglitazone acutely stimulates adiponectin secretion from mouse and human adipocytes via activation of the phosphatidylinositol 3′-kinase Life Sci 83 2008 638 643
24. M.M. Smith, and C.T. Minson Obesity and adipokines: effects on sympathetic over-activity J Physiol 590 2012 1787 1801
25. U. Ozcan, Q. Cao, E. Yilmaz, A.H. Lee, N.N. Iwakoshi, and E. Ozdelen Endoplasmic reticulum stress links obesity, insulin action, and type 2 diabetes Science 306 2004 457 461
26. H. Tilg, and A.R. Moschen Adipocytokines: mediators linking adipose tissue, inflammation and immunity Nat Rev Immunol 6 2006 772 783
27. F. Simpson, and J.P. Whitehead Adiponectin - it's all about the modifications Int J Biochem-Cell Biol 42 2010 785 788
28. E.N. Wardle Introduction to signaling cascades Guide Signal Pathw Immune Cells 2009 37 75
29. S.K. Park, S.Y. Oh, M.Y. Lee, S. Yoon, K.S. Kim, and J.W. Kim CCAAT/enhancer binding protein and nuclear factor-Y regulate adiponectin gene expression in adipose tissue Diabetes 53 2004 2757 2766
30. H.B. Kim, M. Kong, T.M. Kim, Y.H. Suh, W.H. Kim, and J.H. Lim NFATc4 and ATF3 negatively regulate adiponectin gene expression in 3T3-L1 adipocytes Diabetes 55 2006 1342 1352
31. N. Hosogai, A. Fukuhara, K. Oshima, Y. Miyata, S. Tanaka, and K. Segawa Adipose tissue hypoxia in obesity and its impact on adipocytokine dysregulation Diabetes 56 2007 901 911
32. E. Chevillotte, M. Giralt, B. Miroux, D. Ricquier, and F. Villarroya Uncoupling protein-2 controls adiponectin gene expression in adipose tissue through the modulation of reactive oxygen species production Diabetes 56 2007 1042 1050
33. Y.M. Park, Y.H. Lee, S.H. Kim, E.Y. Lee, K.S. Kim, and D.R. Williams Snail, a transcriptional regulator, represses adiponectin expression by directly binding to an E-box motif in the promoter Metabolism 61 2012 1622 1632
34. E.D. Rosen, and O.A. MacDougald Adipocyte differentiation from the inside out Nat Rev- Molec Cell Biol 7 2006 885 896
35. F. Bost, M. Aouadi, L. Caron, and B. Binétruy The role of MAPKs in adipocyte differentiation and obesity Biochimie 87 2005 51 56
36. S.E. Kahn, R.L. Hull, and K.M. Utzschneider Mechanisms linking obesity to insulin resistance and type 2 diabetes Nature 444 2006 840 846