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Volumn 68, Issue 8, 2013, Pages 892-902

Many faces of mitochondrial uncoupling during age: Damage or defense?

Author keywords

Mitochondrial biogenesis; Mitochondrial proton leak; Oxidative stress; Uncoupling proteins

Indexed keywords

ADENINE NUCLEOTIDE TRANSLOCASE; ADENOSINE TRIPHOSPHATE; FATTY ACID; FREE RADICAL; ION CHANNEL; MESSENGER RNA; MITOCHONDRIAL PROTEIN; MITOCHONDRIAL UNCOUPLING PROTEIN 2; MITOCHONDRIAL UNCOUPLING PROTEIN 3; PROTON;

EID: 84880530760     PISSN: 10795006     EISSN: 1758535X     Source Type: Journal    
DOI: 10.1093/gerona/gls332     Document Type: Article
Times cited : (27)

References (56)
  • 1
    • 0031854324 scopus 로고    scopus 로고
    • Theories of aging: An overview
    • Austad SN. Theories of aging: an overview. Aging (Milano). 1998;10:146-147.
    • (1998) Aging (Milano) , vol.10 , pp. 146-147
    • Austad, S.N.1
  • 2
    • 0030723518 scopus 로고    scopus 로고
    • The non-ohmic proton leak-25 years on
    • nicholls DG. The non-Ohmic proton leak-25 years on. Biosci Rep. 1997;17:251-257.
    • (1997) Biosci Rep. , vol.17 , pp. 251-257
    • Nicholls, D.G.1
  • 3
    • 33645888693 scopus 로고    scopus 로고
    • Nutrition and aging: Changes in the regulation of energy metabolism with aging
    • Roberts SB, Rosenberg I. nutrition and aging: changes in the regulation of energy metabolism with aging. Physiol Rev. 2006;86:651-667.
    • (2006) Physiol Rev. , vol.86 , pp. 651-667
    • Roberts, S.B.1    Rosenberg, I.2
  • 4
    • 33847059997 scopus 로고    scopus 로고
    • The mitochondrial energy transduction system and the aging process
    • navarro A, Boveris A. The mitochondrial energy transduction system and the aging process. Am J Physiol, cell Physiol. 2007;292:C670-C686.
    • (2007) Am J Physiol, Cell Physiol. , vol.292
    • Navarro, A.1    Boveris, A.2
  • 5
    • 33746829781 scopus 로고    scopus 로고
    • Aging in mitotic and post-mitotic cells
    • PII S156631240104024X, The Role of DNA Damage and Repair in Cell Aging
    • Campisi J, Warner HR. Aging in mitotic and post-mitotic cells. Adv Cells Aging Gerontol. 2001;4:1-16. (Pubitemid 33805586)
    • (2001) Advances in Cell Aging and Gerontology , vol.4 , pp. 1-16
    • Campisi, J.1    Warner, H.R.2
  • 6
    • 33645704767 scopus 로고    scopus 로고
    • Quantitative proteomic comparison of rat mitochondria from muscle, heart, and liver
    • Forner F, Foster LJ, Campanaro S, Valle G, Mann M. Quantitative proteomic comparison of rat mitochondria from muscle, heart, and liver. Mol cell Proteomics. 2006;5:608-619.
    • (2006) Mol Cell Proteomics , vol.5 , pp. 608-619
    • Forner, F.1    Foster, L.J.2    Campanaro, S.3    Valle, G.4    Mann, M.5
  • 8
  • 10
    • 0025046339 scopus 로고
    • Uncouplers of oxidative phosphorylation
    • Terada H. Uncouplers of oxidative phosphorylation. Environ Health Perspect. 1990;87:213-218. (Pubitemid 20316919)
    • (1990) Environmental Health Perspectives , vol.87 , pp. 213-218
    • Terada, H.1
  • 11
    • 0029765443 scopus 로고    scopus 로고
    • Role of uncoupled and non-coupled oxidations in maintenance of safely low levels of oxygen and its one-electron reductants
    • Skulachev VP. Role of uncoupled and non-coupled oxidations in maintenance of safely low levels of oxygen and its one-electron reductants. Q Rev Biophys. 1996;29:169-202. (Pubitemid 26280789)
    • (1996) Quarterly Reviews of Biophysics , vol.29 , Issue.2 , pp. 169-202
    • Skulachev, V.P.1
  • 12
    • 0033785071 scopus 로고    scopus 로고
    • Uncoupling to survive? The role of mitochondrial inefficiency in ageing
    • Brand MD. Uncoupling to survive? The role of mitochondrial inefficiency in ageing. Exp Gerontol. 2000;35:811-820.
    • (2000) Exp Gerontol. , vol.35 , pp. 811-820
    • Brand, M.D.1
  • 13
    • 77955553628 scopus 로고    scopus 로고
    • GDP and carboxyatractylate inhibit 4-hydroxynonenal-activated proton conductance to differing degrees in mitochondria from skeletal muscle and heart
    • Aguirre E, Cadenas S. GDP and carboxyatractylate inhibit 4-hydroxynonenal-activated proton conductance to differing degrees in mitochondria from skeletal muscle and heart. Biochim Biophys acta. 2010;1797:1716-1726.
    • (2010) Biochim Biophys Acta , vol.1797 , pp. 1716-1726
    • Aguirre, E.1    Cadenas, S.2
  • 17
    • 77950353810 scopus 로고    scopus 로고
    • Measurement of mitochondrial membrane potential and proton leak
    • Serviddio G, Sastre J. Measurement of mitochondrial membrane potential and proton leak. Methods Mol Biol. 2010;594:107-121.
    • (2010) Methods Mol Biol. , vol.594 , pp. 107-121
    • Serviddio, G.1    Sastre, J.2
  • 18
    • 0027480085 scopus 로고
    • + leak in mitochondria and its relevance to metabolic rate
    • DOI 10.1038/362628a0
    • Porter RK, Brand MD. Body mass dependence of H+ leak in mitochondria and its relevance to metabolic rate. Nature. 1993;362: 628-630. (Pubitemid 23109269)
    • (1993) Nature , vol.362 , Issue.6421 , pp. 628-630
    • Porter, R.K.1    Brand, M.D.2
  • 19
    • 0022554087 scopus 로고
    • Cooperative proton-transfer reactions in the respiratory chain: Redox bohr effects
    • Papa S, Guerrieri F, Izzo G. Cooperative proton-transfer reactions in the respiratory chain: redox bohr effects. Meth enzymol. 1986;126:331-343. (Pubitemid 16076403)
    • (1986) Methods in Enzymology , vol.VOL. 126 , pp. 331-343
    • Papa, S.1    Guerrieri, F.2    Izzo, G.3
  • 20
    • 0037098941 scopus 로고    scopus 로고
    • A convenient one-step extraction of cellular ATP using boiling water for the luciferin-luciferase assay of ATP
    • Yang nC, Ho WM, Chen YH, Hu ML. A convenient one-step extraction of cellular ATP using boiling water for the luciferin-luciferase assay of ATP. Anal Biochem. 2002;306:323-327.
    • (2002) Anal Biochem. , vol.306 , pp. 323-327
    • Yang, N.C.1    Ho, W.M.2    Chen, Y.H.3    Hu, M.L.4
  • 21
    • 33745970444 scopus 로고    scopus 로고
    • Methionine restriction decreases mitochondrial oxygen radical generation and leak as well as oxidative damage to mitochondrial DNA and proteins
    • DOI 10.1096/fj.05-5568com
    • Sanz A, Caro P, Ayala V, Portero-Otin M, Pamplona R, Barja G. Methionine restriction decreases mitochondrial oxygen radical generation and leak as well as oxidative damage to mitochondrial DnA and proteins. FaSeB J. 2006;20:1064-1073. (Pubitemid 44943902)
    • (2006) FASEB Journal , vol.20 , Issue.8 , pp. 1064-1073
    • Sanz, A.1    Caro, P.2    Ayala, V.3    Portero-Otin, M.4    Pamplona, R.5    Barja, G.6
  • 24
    • 33845261493 scopus 로고
    • A rapid method of total lipid extraction and purification
    • Bligh EG, Dyer WJ. A rapid method of total lipid extraction and purification. Can J Biochem Physiol. 1959;37:911-917.
    • (1959) Can J Biochem Physiol. , vol.37 , pp. 911-917
    • Bligh, E.G.1    Dyer, W.J.2
  • 29
    • 0035000177 scopus 로고    scopus 로고
    • Changes in uncoupling protein-2 and -3 expression in aging rat skeletal muscle, liver, and heart
    • Barazzoni R, nair KS. Changes in uncoupling protein-2 and -3 expression in aging rat skeletal muscle, liver, and heart. Am J Physiol endocrinol Metab. 2001;280:E413-E419.
    • (2001) Am J Physiol Endocrinol Metab. , vol.280
    • Barazzoni, R.1    Nair, K.S.2
  • 31
    • 0025814980 scopus 로고
    • Chemistry and biochemistry of 4-hydroxynonenal, malonaldehyde and related aldehydes
    • Esterbauer H, Schaur RJ, Zollner H. Chemistry and biochemistry of 4-hydroxynonenal, malonaldehyde and related aldehydes. Free Radic Biol Med. 1991;11:81-128. (Pubitemid 121003917)
    • (1991) Free Radical Biology and Medicine , vol.11 , Issue.1 , pp. 81-128
    • Esterbauer, H.1    Schaur, R.J.2    Zollner, H.3
  • 32
    • 1542373685 scopus 로고    scopus 로고
    • Transcriptional regulatory circuits controlling mitochondrial biogenesis and function
    • DOI 10.1101/gad.1177604
    • Kelly D P, Scarpulla RC. Transcriptional regulatory circuits controlling mitochondrial biogenesis and function. Genes Dev. 2004;18:357-368. (Pubitemid 38316342)
    • (2004) Genes and Development , vol.18 , Issue.4 , pp. 357-368
    • Kelly, D.P.1    Scarpulla, R.C.2
  • 33
    • 33745297834 scopus 로고    scopus 로고
    • Glucose-dependent transcriptional regulation by an evolutionarily conserved glucose-sensing module
    • DOI 10.2337/db05-0822
    • Li MV, Chang B, Imamura M, Poungvarin n, Chan L. Glucose-dependent transcriptional regulation by an evolutionarily conserved glucose-sensing module. Diabetes. 2006;55:1179-1189. (Pubitemid 44195353)
    • (2006) Diabetes , vol.55 , Issue.5 , pp. 1179-1189
    • Li, M.V.1    Chang, B.2    Imamura, M.3    Poungvarin, N.4    Chan, L.5
  • 36
    • 80052190938 scopus 로고    scopus 로고
    • Principles and therapeutic relevance for targeting mitochondria in aging and neurodegenerative diseases
    • Serviddio G, Romano AD, Cassano T, Bellanti F, Altomare E, Vendemiale G. Principles and therapeutic relevance for targeting mitochondria in aging and neurodegenerative diseases. Curr Pharm Des. 2011;17:2036-2055.
    • (2011) Curr Pharm Des. , vol.17 , pp. 2036-2055
    • Serviddio, G.1    Romano, A.D.2    Cassano, T.3    Bellanti, F.4    Altomare, E.5    Vendemiale, G.6
  • 39
    • 0034650763 scopus 로고    scopus 로고
    • The uncoupling protein homologues: UCP1, UCP2, UCP3, StUCP and AtUCP
    • DOI 10.1042/0264-6021:3450161
    • Ricquier D, Bouillaud F. The uncoupling protein homologues: UCP1, UCP2, UCP3, StUCP and AtUCP. Biochem J. 2000;345 Pt 2:161-179. (Pubitemid 30077154)
    • (2000) Biochemical Journal , vol.345 , Issue.2 , pp. 161-179
    • Ricquier, D.1    Bouillaud, F.2
  • 41
    • 0345355149 scopus 로고    scopus 로고
    • Transcription of the adenine nucleotide translocase isoforms in various types of tissues in the rat
    • DOI 10.1016/S0005-2736(98)00245-4, PII S0005273698002454
    • Dörner A, Olesch M, Giessen S, Pauschinger M, Schultheiss H P. Transcription of the adenine nucleotide translocase isoforms in various types of tissues in the rat. Biochim Biophys acta. 1999;1417:16-24. (Pubitemid 29078582)
    • (1999) Biochimica et Biophysica Acta - Biomembranes , vol.1417 , Issue.1 , pp. 16-24
    • Dorner, A.1    Olesch, M.2    Giessen, S.3    Pauschinger, M.4    Schultheiss, H.-P.5
  • 42
    • 0031898524 scopus 로고    scopus 로고
    • The proton permeability of the inner membrane of liver mitochondria from ectothermic and endothermic vertebrates and from obese rats: Correlations with standard metabolic rate and phospholipid fatty acid composition
    • DOI 10.1016/S0305-0491(97)00357-X, PII S030504919700357X
    • Brookes PS, Buckingham JA, Tenreiro AM, Hulbert AJ, Brand MD. The proton permeability of the inner membrane of liver mitochondria from ectothermic and endothermic vertebrates and from obese rats: correlations with standard metabolic rate and phospholipid fatty acid composition. Comp Biochem Physiol B, Biochem Mol Biol. 1998;119:325-334. (Pubitemid 28212042)
    • (1998) Comparative Biochemistry and Physiology - B Biochemistry and Molecular Biology , vol.119 , Issue.2 , pp. 325-334
    • Brookes, P.S.1    Buckingham, J.A.2    Tenreiro, A.M.3    Hulbert, A.J.4    Brand, M.D.5
  • 43
    • 0030444861 scopus 로고    scopus 로고
    • Allometry of mitochondrial proton leak: Influence of membrane surface area and fatty acid composition
    • Porter RK, Hulbert AJ, Brand MD. Allometry of mitochondrial proton leak: influence of membrane surface area and fatty acid composition. Am J Physiol. 1996;271(6 Pt 2):R1550-R1560.
    • (1996) Am J Physiol. , vol.271 , Issue.6 PART 2
    • Porter, R.K.1    Hulbert, A.J.2    Brand, M.D.3
  • 44
    • 46349087273 scopus 로고    scopus 로고
    • Uncoupling protein-2 (UCP2) induces mitochondrial proton leak and increases susceptibility of non-alcoholic steatohepatitis (NASH) liver to ischaemia-reperfusion injury
    • DOI 10.1136/gut.2007.147496
    • Serviddio G, Bellanti F, Tamborra R, et al. Uncoupling protein-2 (UCP2) induces mitochondrial proton leak and increases susceptibility of non-alcoholic steatohepatitis (nASH) liver to ischaemia-reper-fusion injury. Gut. 2008;57:957-965. (Pubitemid 351919530)
    • (2008) Gut , vol.57 , Issue.7 , pp. 957-965
    • Serviddio, G.1    Bellanti, F.2    Tamborra, R.3    Rollo, T.4    Capitanio, N.5    Romano, A.D.6    Sastre, J.7    Vendemiale, G.8    Altomare, E.9
  • 46
    • 0142063539 scopus 로고    scopus 로고
    • Method for measuring ATP production in isolated mitochondria: ATP production in brain and liver mitochondria of Fischer-344 rats with age and caloric restriction
    • Drew B, Leeuwenburgh C. Method for measuring ATP production in isolated mitochondria: ATP production in brain and liver mitochondria of Fischer-344 rats with age and caloric restriction. Am J Physiol Regul integr comp Physiol. 2003;285:R1259-R1267. (Pubitemid 37296381)
    • (2003) American Journal of Physiology - Regulatory Integrative and Comparative Physiology , vol.285 , Issue.5
    • Drew, B.1    Leeuwenburgh, C.2
  • 48
    • 70349449239 scopus 로고    scopus 로고
    • Visualization of ATP levels inside single living cells with fluorescence resonance energy transfer-based genetically encoded indicators
    • Imamura H, nhat KP, Togawa H, et al. Visualization of ATP levels inside single living cells with fluorescence resonance energy transfer-based genetically encoded indicators. Proc natl acad Sci USa. 2009;106:15651-15656.
    • (2009) Proc Natl Acad Sci USa. , vol.106 , pp. 15651-15656
    • Imamura, H.1    Nhat, K.P.2    Togawa, H.3
  • 50
    • 12244302878 scopus 로고    scopus 로고
    • Influence of age and caloric restriction on liver glycolytic enzyme activities and metabolite concentrations in mice
    • DOI 10.1016/S0531-5565(02)00203-6, PII S0531556502002036
    • Hagopian K, Ramsey JJ, Weindruch R. Influence of age and caloric restriction on liver glycolytic enzyme activities and metabolite concentrations in mice. Exp Gerontol. 2003;38:253-266. (Pubitemid 36170320)
    • (2003) Experimental Gerontology , vol.38 , Issue.3 , pp. 253-266
    • Hagopian, K.1    Ramsey, J.J.2    Weindruch, R.3
  • 52
    • 57649148823 scopus 로고    scopus 로고
    • Nuclear control of respiratory chain expression by nuclear respiratory factors and PGC-1-related coactivator
    • Scarpulla RC. nuclear control of respiratory chain expression by nuclear respiratory factors and PGC-1-related coactivator. Ann N Y acad Sci. 2008;1147:321-334.
    • (2008) Ann N y Acad Sci. , vol.1147 , pp. 321-334
    • Scarpulla, R.C.1
  • 53
    • 58149326913 scopus 로고    scopus 로고
    • Activation of mitochondrial biogenesis by hormesis
    • Sano M, Fukuda K. Activation of mitochondrial biogenesis by hormesis. Circ Res. 2008;103:1191-1193.
    • (2008) Circ Res. , vol.103 , pp. 1191-1193
    • Sano, M.1    Fukuda, K.2
  • 54
    • 67649402187 scopus 로고    scopus 로고
    • The nrf2-antioxidant response element signaling pathway and its activation by oxidative stress
    • nguyen T, nioi P, Pickett CB. The nrf2-antioxidant response element signaling pathway and its activation by oxidative stress. J Biol chem. 2009;284:13291-13295.
    • (2009) J Biol Chem. , vol.284 , pp. 13291-13295
    • Nguyen, T.1    Nioi, P.2    Pickett, C.B.3
  • 55
    • 0042526012 scopus 로고    scopus 로고
    • Uncoupling protein-2 overexpression inhibits mitochondrial death pathway in cardiomyocytes
    • DOI 10.1161/01.RES.0000085581.60197.4D
    • Teshima Y, Akao M, Jones SP, Marbán E. Uncoupling protein-2 over-expression inhibits mitochondrial death pathway in cardiomyocytes. Circ Res. 2003;93:192-200. (Pubitemid 36993229)
    • (2003) Circulation Research , vol.93 , Issue.3 , pp. 192-200
    • Teshima, Y.1    Akao, M.2    Jones, S.P.3    Marban, E.4


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