Toward single-walled carbon nanotube-gadolinium complex as advanced MRI contrast agents: Pharmacodynamics and global genomic response in small animals

Journal of Biomedical Materials Research - Part B Applied Biomaterials

Volumn 101 B, Issue 6, 2013, Pages 1039-1049

  Avti, Pramod K ^a   Talukdar, Yahfi ^a   Sirotkin, Matvey V ^b   Shroyer, Kenneth R ^c   Sitharaman, Balaji ^a  

^a St Francis Hospital The Heart Center   (United States)

^b Stony Brook University   (United States)

^c STONY BROOK UNIVERSITY   (United States)

Author keywords

animal model; biomaterials availability; histology; molecular imaging; nanomedicine

Indexed keywords

AMPHIPHILIC POLYMERS; ANIMAL MODEL; BIOMATERIALS AVAILABILITY; GENE EXPRESSION PROFILES; MAGNETIC RESONANCE IMAGING CONTRAST AGENTS; PRECLINICAL DEVELOPMENT; PROINFLAMMATORY CYTOKINES; TUMOR NECROSIS FACTORS;

ASSAYS; CATALYSIS; GADOLINIUM; GENE EXPRESSION; HISTOLOGY; LIPIDS; MAGNETIC RESONANCE IMAGING; MEDICAL NANOTECHNOLOGY; MOLECULAR IMAGING; PHARMACODYNAMICS; SINGLE-WALLED CARBON NANOTUBES (SWCN); TISSUE; TISSUE ENGINEERING; TRANSMISSION ELECTRON MICROSCOPY;

IRON COMPOUNDS;

AMPHOPHILE; GADOLINIUM; IRON; POLYMER; SINGLE WALLED NANOTUBE; TUMOR NECROSIS FACTOR ALPHA;

ANIMAL EXPERIMENT; ARTICLE; BRIGHT FIELD MICROSCOPY; CATALYSIS; CONTROLLED STUDY; DRUG DISTRIBUTION; DRUG SYNTHESIS; GENE CONTROL; GENE EXPRESSION; GENOMICS; HISTOLOGY; HOMEOSTASIS; LIPID PEROXIDATION; LIVER CELL; MALE; NANOANALYSIS; NONHUMAN; NUCLEAR MAGNETIC RESONANCE IMAGING; RAMAN SPECTROMETRY; RAT; TRANSMISSION ELECTRON MICROSCOPY;

ANIMAL MODEL; BIOMATERIALS AVAILABILITY; HISTOLOGY; MOLECULAR IMAGING; NANOMEDICINE;

ANIMALS; BIOCOMPATIBLE MATERIALS; CONTRAST MEDIA; GADOLINIUM; GENE EXPRESSION; LIPID PEROXIDATION; LIVER; MAGNETIC RESONANCE IMAGING; MALE; MATERIALS TESTING; NANOTUBES, CARBON; RATS; RATS, WISTAR; TISSUE DISTRIBUTION;

EID: 84880510283     PISSN: 15524973     EISSN: 15524981     Source Type: Journal    
DOI: 10.1002/jbm.b.32914     Document Type: Article

References (43)

1. Mansfield P,. Snapshot magnetic resonance imaging (Nobel lecture). Angew Chem Int Ed Engl 2004; 4 3: 5456-5464.
2. Merbach AE, Toth E,. The Chemistry of Contrast Agents in Medical Magnetic Resonance Imaging. Chichester, New York: Wiley; 2001.
3. Aime S, Botta M, Terreno E,. Gd(III)-based contrast agents for MRI. Adv Inorg Chem 2005; 5 7: 173-237.
4. Caravan P, Ellison JJ, McMurry TJ, Lauffer RB,. Gadolinium(III) chelates as MRI contrast agents: Structure, dynamics, and applications. Chem Rev 1999; 9 9: 2293-2352.
5. Na HB, Hyeon T,. Nanostructured T1 MRI contrast agents. J Mater Chem 2009; 19: 6267-6273.
6. Nunn AD, Linder KE, Tweedle MF,. Can receptors be imaged with MRI agents?. Q J Nucl Med 1997; 4 1: 155-162.
7. Sitharaman B, Wilson LJ,. Gadonanotubes as new high-performance MRI contrast agents. Int J Nanomedicine 2006; 1: 291-295.
8. Sitharaman B, Tran LA, Pham QP, Bolskar RD, Muthupillai R, Flamm SD, Mikos AG, Wilson LJ,. Gadofullerenes as nanoscale magnetic labels for cellular MRI. Contrast Media Mol Imaging 2007; 2: 139-146.
9. Richard C, Doan BT, Beloeil JC, Bessodes M, Tõth & Eacute;, Scherman D,. Noncovalent functionalization of carbon nanotubes with amphiphilic Gd3+ chelates: Toward powerful T1 and T2 MRI contrast agents. Nano Lett 2008; 8: 232-236.
10. Tran LA, Krishnamurthy R, Muthupillai R, Cabreira-Hansen MD, Willerson JT, Perin EC, Wilson LJ,. Gadonanotubes as magnetic nanolabels for stem cell detection. Biomaterials 2010; 3 1: 9482-9491.
11. Hassan AA, Chan BTY, Tran LA, Hartman KB, Ananta JS, Mackeyev Y, Hu LY, Pautler RG, Wilson LJ, Lee AV,. Serine-derivatized gadonanotubes as magnetic nanoprobes for intracellular labeling. Contrast Media Mol Imaging 2010; 5: 34-38.
12. Sitharaman B, Zande MVD, Ananta JS, Shi X, Veltien A, Walboomers XF, Wilson LJ, Mikos AG, Heerschap A, Jansen JA,. Magnetic resonance imaging studies on gadonanotube-reinforced biodegradable polymer nanocomposites. J Biomed Mater Res Part A 2010; 9 3A: 1454-1462.
13. Zande MVD, Sitharaman B, Walboomers XF, Tran L, Ananta JS, Veltien A, Wilson LJ, Álava JI, Heerschap A, Mikos AG, Jansen JA,. In vivo magnetic resonance imaging of the distribution pattern of gadonanotubes released from a degrading poly(lactic-co-glycolic acid) scaffold. Tissue Eng Part C: Methods 2011; 17: 19-26.
14. Idee JM, Port M, Medina C, Lancelot E, Fayoux E, Ballet S, Corot C,. Possible involvement of gadolinium chelates in the pathophysiology of nephrogenic systemic fibrosis: A critical review. Toxicology 2008; 24 8: 77-88.
15. FDA Drug Safety Communication: New warnings for using gadolinium-based contrast agents in patients with kidney dysfunction. Drug Safety and Availability: FDA U.S. Food and Drug Administration; 2010.
16. Liu Z, Tabakman S, Welsher K, Dai H,. Carbon nanotubes in biology and medicine: In vitro and in vivo detection, imaging and drug delivery. Nano Res 2009; 2: 85-120.
17. Swierczewska M, Rusakova I, Sitharaman B,. Gadolinium and europium catalyzed growth of single-walled carbon nanotubes. Carbon 2009; 4 7: 3139-3142.
18. Sitharaman B, Rajamani S, Avti PK,. Time-resolved red luminescence from europium-catalyzed single walled carbon nanotubes. Chem Commun 2011; 4 7: 1607-1609.
19. Sitharaman B, Jacobson B, Wadghiri YZ, Bryant H, Frank J,. The magnetic, relaxometric and optical properties of gadolinium-catalyzed single walled carbon nanotubes. J Appl Phys; Forthcoming.
20. Avti PK, Caparelli DE, Sitharaman B,. Cytotoxicity, cytocompatibility, cell-labeling efficiencies, and in vitro cellular magnetic resonance imaging of gadolinium-catalyzed single-walled carbon nanotubes. J Biomed Mater Res Part A; Forthcoming.
21. Liu Z, Davis C, Cai W, He L, Chen X, Dai H,. Circulation and long-term fate of functionalized, biocompatible single-walled carbon nanotubes in mice probed by Raman spectroscopy. Proc Natl Acad Sci USA 2008; 10 5: 1410-1415.
22. Hendriks T, Assmann RF,. On the fluorometric assay of circulating lipoperoxides. Clin Chim Acta 1988; 17 4: 263-269.
23. Liu Z, Cai W, He L, Nakayama N, Chen K, Sun X, Dai H,. In vivo biodistribution and highly efficient tumour targeting of carbon nanotubes in mice. Nat Nanotechnol 2007; 2: 47-52.
24. Malle E, Furtmuller PG, Sattler W, Obinger C,. Myeloperoxidase: A target for new drug development? Br J Pharmacol 2007; 15 2: 838-854.
25. Gupta RB, Harpaz N, Itzkowitz S, Hossain S, Matula S, Kornbluth A, Bodian C, Ullman T,. Histologic inflammation is a risk factor for progression to colorectal neoplasia in ulcerative colitis: A cohort study. Gastroenterology 2007; 13 3: 1099-1105.
26. Kagan VE, Konduru NV, Feng W, Allen BL, Conroy J, Volkov Y, Vlasova II, Belikova NA, Yanamala N, Kapralov A, and others. Carbon nanotubes degraded by neutrophil myeloperoxidase induce less pulmonary inflammation. Nat Nanotechnol 2010; 5: 354-359.
27. Shvedova AA, Kapralov AA, Feng WH, Kisin ER, Murray AR, Mercer RR, St Croix CM, Lang MA, Watkins SC, Konduru NV, and others. Impaired clearance and enhanced pulmonary inflammatory/fibrotic response to carbon nanotubes in myeloperoxidase-deficient mice. PLoS One 2012; 7: e30923.
28. Kapralov AA, Feng WH, Amoscato AA, Yanamala N, Balasubramanian K, Winnica DE, Kisin ER, Kotchey GP, Gou PP, Sparvero LJ, and others. Adsorption of surfactant lipids by single-walled carbon nanotubes in mouse lung upon pharyngeal aspiration. ACS Nano 2012; 6: 4147-4156.
29. Lam CW, James JT, McCluskey R, Hunter RL,. Pulmonary toxicity of single-wall carbon nanotubes in mice 7 and 90 days after intratracheal instillation. Toxicol Sci 2004; 77: 126-134.
30. Warheit DB, Laurence BR, Reed KL, Roach DH, Reynolds GA, Webb TR,. Comparative pulmonary toxicity assessment of single-wall carbon nanotubes in rats. Toxicol Sci 2004; 7 7: 117-125.
31. Patlolla A, McGinnis B, Tchounwou P,. Biochemical and histopathological evaluation of functionalized single-walled carbon nanotubes in Swiss-Webster mice. J Appl Toxicol 2011; 3 1: 75-83.
32. Lee HJ, Park J, Yoon OJ, Kim HW, Lee do Y, Kim do H, Lee WB, Lee NE, Bonventre JV, Kim SS,. Amine-modified single-walled carbon nanotubes protect neurons from injury in a rat stroke model. Nat Nanotechnol 2011; 6: 121-125.
33. McDevitt MR, Chattopadhyay D, Kappel BJ, Jaggi JS, Schiffman SR, Antczak C, Njardarson JT, Brentjens R, Scheinberg DA,. Tumor targeting with antibody-functionalized, radiolabeled carbon nanotubes. J Nucl Med 2007; 4 8: 1180-1189.
34. Singh R, Pantarotto D, Lacerda L, Pastorin G, Klumpp C, Prato M, Bianco A, Kostarelos K,. Tissue biodistribution and blood clearance rates of intravenously administered carbon nanotube radiotracers. Proc Natl Acad Sci USA 2006; 10 3: 3357-3362.
35. Cherukuri P, Gannon CJ, Leeuw TK, Schmidt HK, Smalley RE, Curley SA, Weisman RB,. Mammalian pharmacokinetics of carbon nanotubes using intrinsic near-infrared fluorescence. Proc Natl Acad Sci USA 2006; 10 3: 18882-18886.
36. Yang ST, Wang X, Jia G, Gu Y, Wang T, Nie H, Ge C, Wang H, Liu Y,. Long-term accumulation and low toxicity of single-walled carbon nanotubes in intravenously exposed mice. Toxicol Lett 2008; 18 1: 182-189.
37. Yang S-T, Guo W, Lin Y, Deng X-Y, Wang H-F, Sun H-F, Liu Y-F, Wang X, Wang W, Chen M, and others. Biodistribution of pristine single-walled carbon nanotubes in vivo. J Phys Chem C 2007; 111: 17761-17764.
38. Laskin DL, Pendino KJ,. Macrophages and inflammatory mediators in tissue injury. Annu Rev Pharmacol Toxicol 1995; 3 5: 655-677.
39. Alvarez-Gonzalez R,. Free radicals, oxidative stress, and DNA metabolism in human cancer. Cancer Invest 1999; 1 7: 376-377.
40. Deng X, Yang S, Nie H, Wang H, Liu Y,. A generally adoptable radiotracing method for tracking carbon nanotubes in animals. Nanotechnology 2008; 1 9: 75-101.
41. Alazzam A, Mfoumou E, Stiharu I, Kassab A, Darnel A, Yasmeen A, Sivakumar N, Bhat R, Al Moustafa AE,. Identification of deregulated genes by single wall carbon-nanotubes in human normal bronchial epithelial cells. Nanomedicine 2010; 6: 563-569.
42. Rivers RJ, Beckman JB, Frame MD,. Technique for using video-microscopy and indicator dilution for repeated measurements of cardiac output in small animals. Anesthesiology 2001; 9 4: 489-495.
43. Choi JH, Nguyen FT, Barone PW, Heller DA, Moll AE, Patel D, Boppart SA, Strano MS,. Multimodal biomedical imaging with asymmetric single-walled carbon nanotube/iron oxide nanoparticle complexes. Nano Lett 2007; 7: 861-867.