Scale-up of adventitious root cultures of Echinacea angustifolia in a pilot-scale bioreactor for the production of biomass and caffeic acid derivatives

Plant Biotechnology Reports

Volumn 7, Issue 3, 2013, Pages 297-308

  Cui, Hai Yan ^a   Abdullahil Baque, Md ^a,b   Lee, Eun Jung ^a   Paek, Kee Yoeup ^a  

^a Chungbuk National University   (South Korea)

^b SHER E BANGLA AGRICULTURAL UNIVERSITY   (Bangladesh)

Author keywords

Adventitious root; Bioreactor culture; Caffeic acid derivatives; Echinacoside; Growth kinetics; Methyl jasmonate; Scale up; Secondary metabolites

Indexed keywords

ECHINACEA ANGUSTIFOLIA;

EID: 84880510220     PISSN: 18635466     EISSN: 18635474     Source Type: Journal    
DOI: 10.1007/s11816-012-0263-y     Document Type: Article

References (35)

1. Akalezi CO, Liu S, Li QS, Yu JT, Zhong JJ (1999) Combined effects of initial sucrose concentration and inoculums size on cell growth and ginseng saponin production by suspension cultures of Panax ginseng. Process Biochem 34: 639-642.
2. Baque MA, Lee EJ, Paek KY (2010) Medium salt strength induced changes in growth, physiology and secondary metabolite content in adventitious roots of Morinda citrifolia: the role of antioxidant enzymes and phenylalanine ammonia lyase. Plant Cell Rep 29: 685-694.
3. Baque MA, Elgirban A, Lee EJ, Paek KY (2011) Sucrose regulated enhanced induction of anthraquinone, phenolics, flavonoids biosynthesis and activities of antioxidant enzymes in adventitious root suspension cultures of Morinda citrifolia. Acta Physiol Plant 34: 405-415.
4. Barrett B (2003) Medicinal properties of Echinacea: a critical review. Phytomedicine 10: 66-86.
5. Berti M, Wilckens R, Fischer S, Hevia F (2002) Effect of harvest season, nitrogen, phosphorus and potassium on root yield, echinacoside and alkylamides in Echinacea angustifolia L. in Chile. Acta Hortic 576: 303-310.
6. Cervellati R, Renzulli C, Guerra MC, Speroni E (2002) Evaluation of anti-oxidant activity of some natural polyphenolic compounds using the Birggs-Rauscher reaction method. J Agric Food Chem 50: 7506-7509.
7. Cui HY (2009) Adventitious root cultures of Echinacea angustifolia in bioreactors for the production of root biomass and secondary metabolites. MS thesis, Chungbuk National University, Cheong-ju, Republic of Korea.
8. Cui XH, Chakrabarty D, Lee EJ, Paek KY (2010a) Production of adventitious roots and secondary metabolites by Hypericum perforatum L. in a bioreactor. Bioresour Technol 101: 4708-4716.
9. Cui XH, Murthy HN, Wu CH, Paek KY (2010b) Sucrose-induced osmotic stress affects biomass, metabolite, and anti-oxidant levels in root suspension cultures of Hypericum perforatum L. Plant Cell Tissue Organ Cult 103: 7-14.
10. Cui XH, Murthy HN, Jin YX, Yim YH, Kim JY, Paek KY (2011) Production of adventitious root biomass and secondary metabolites of Hypericum perforatum L. in a balloon type airlift reactor. Bioresour Technol 102: 10072-10079.
11. Dal Toso R, Melandri F (2011a) Echinacea angustifolia cell culture extract: added value for sport and fitness. Nutra foods 10: 19-25.
12. Dal Toso R, Melandri F (2011b) Sustainable sourcing of natural food ingredients by plant cell cultures. Agro Food Ind Hi Tech 22: 26-28.
13. Hahn EJ, Kim YS, Yu KW, Jeong CS, Paek KY (2003) Adventitious root cultures of Panax ginseng C. V. Meyer and ginsenoside production through large-scale bioreactor system. J Plant Biotechnol 5: 1-6.
14. Jeong CS, Chakrabarty D, Hahn EJ, Lee HL, Paek KY (2006) Effect of oxygen, carbon dioxide and ethylene on growth and bioactive compound production in bioreactor culture of ginseng adventitious roots. Biochem Eng J 27: 252-263.
15. Jeong JA, Wu CH, Murthy HN, Hahn EJ, Paek KY (2009) Application of an airlift bioreactor system for the production of adventitious root biomass and caffeic acid derivatives of Echinacea purpurea. Biotechnol Bioprocess Eng 14: 91-98.
16. Kilayri JM, Bahrany AM (2002) Callus growth and proline accumulation in response to sorbitol and sucrose induced osmotic stress in rice. Biol Plant 45: 609-611.
17. Kim SI, Choi HK, Kim JH (2001) Effect of osmotic pressure on paclitaxel production in suspension cell cultures of Taxus chinensis. Enzyme Microb Technol 28: 202-209.
18. Lee EJ, Mobin M, Hahn EJ, Paek KY (2006) Effects of sucrose, inoculums density, auxins, and aeration volume on cell growth of Gymnema sylvestre. J Plant Biol 49: 427-431.
19. Lin Z, Neamati N, Zhao H, Kiryu Y, Turpin JA, Aberham C, Strebel K, Kohn K, Witvrouw M, Pannecouque C, Debyser Z, Clercq ED, Rice WG, Pommier Y, Burke TR (1999) Cichoric acid analogues as HIV-1 integrase inhibitors. J Med Chem 42: 1401-1414.
20. Liu CZ, Cheng XY (2008) Enhancement of phenylethanoid glycosides biosynthesis in cell cultures of Cistanche deserticola by osmotic stress. Plant Cell Rep 27: 357-362.
21. Murashige T, Skoog F (1962) A revised medium for rapid growth and bioassay with tobacco tissue cultures. Physiol Plant 15: 473-497.
22. Nandwal AS, Godara M, Sheokand A, Kamboj DV, Kundu BS, Kuhad MS, Kumar B, Sharma SK (2000) Salinity induced changes in plant water status, nodule functioning, and ionic distribution in phenotypically differing genotypes of Vigna raline L. J Plant Physiol 156: 350-359.
23. Pellati F, Benvenuti S, Magro L, Melegari M, Soragni F (2004) Analysis of phenolic compounds and radical scavenging activity of Echinacea spp. J Pharm Biomed Anal 35: 289-301.
24. Silveira JAG, Melo ARB, Viegas RA, Oliveira JTA (2001) Salinity induced effects on nitrogen assimilation related to growth in cowpea plants. Environ Exp Bot 46: 171-179.
25. Sivakumar G (2006) Bioreactor technology: a novel industrial tool for high-tech production of bioactive molecules and biopharmaceuticals from plant roots. J Biotechnol 1: 1419-1427.
26. Sivakumar G, Yu KW, Paek KY (2005) Production of biomass and ginsenoside from adventitious roots of Panax ginseng in bioreactor cultures. Eng Life Sci 5: 333-342.
27. Speroni E, Govoni P, Guizzardi S, Renzulli C, Guerra MC (2002) Anti-inflammatory and cicatrizing activity of Echinacea Pallida Nutt root extract. J Ethanopharmacol 79: 265-272.
28. Wang HQ, Wu JT, Zhong JJ (1999) Significant improvement of taxane production in suspension cultures of Taxus chinensis by sucrose feeding strategy. Process Biochem 35: 479-483.
29. Wu JY, Wong K, Ho KP, Zhou LG (2005) Enhancement of saponin production in Panax ginseng cell cultures by osmotic stress and nutrient feeding. Enzyme Microb Technol 36: 133-138.
30. Wu CH, Dewir YH, Hahn EJ, Paek KY (2006) Optimization of culturing conditions for the production of biomass and phenolics from adventitious roots of Echinacea angustifolia. J Plant Biol 49: 193-199.
31. Wu CH, Murthy HN, Hahn EJ, Paek KY (2007a) Improved production of caffeic acid derivatives in suspension cultures of Echinacea purpuria by medium replenishment strategy. Arch Pharm Res 30: 945-949.
32. Wu CH, Murthy HN, Hahn EJ, Paek KY (2007b) Large-scale cultivation of adventitious roots of Echinacea purpuria in airlift bioreactors for the production of cichoric acid, chlorogenic acid and cafteric acid. Biotechnol Lett 29: 1179-1182.
33. Zhang YH, Zhong JJ, Yu JT (1996) Enhancement of ginseng saponin production in suspension cultures of Panax notoginseng: manipulation of medium sucrose. J Biotechnol 51: 49-56.
34. Zhong JJ (2002) Plant cell culture for production of paclitaxel and other taxanes. J Biosci Bioeng 94: 591-599.
35. Zhong JJ, Xu GR, Yoshida T (1995) Effect of initial sucrose concentration on excretion of anthocyanin pigments in suspension cultures of Perilla frutescens cells. World J Microbiol Biotechnol 10: 590-592.