Application of an airlift bioreactor system for the production of adventitious root biomass and caffeic acid derivatives of Echinacea purpurea

Biotechnology and Bioprocess Engineering

Volumn 14, Issue 1, 2009, Pages 91-98

  Jeong, Jin A ^a   Wu, Chun Hua ^a   Murthy, Hosakatte Niranjana ^a,b   Hahn, Eun Joo ^a   Paek, Kee Yoeup ^a  

^a Chungbuk National University   (South Korea)

^b KARNATAK UNIVERSITY   (India)

Author keywords

Adventitious roots; Balloon type bubble bioreactor; Caffeic acid; Cichoric acid; Echinacea

Indexed keywords

BALLOONS; BIOCONVERSION; BIOMASS; BIOREACTORS; INDUSTRIAL CHEMICALS; METABOLITES; SANDWICH STRUCTURES; SUGAR (SUCROSE);

ADVENTITIOUS ROOTS; BALLOON TYPE BUBBLE BIOREACTOR; CAFFEIC ACID; CICHORIC ACID; ECHINACEA;

ACIDS;

CAFFEIC ACID DERIVATIVE; CAFTARIC ACID; CHLOROGENIC ACID; CICHORIC ACID; FLAVANOID; PHENOL DERIVATIVE; UNCLASSIFIED DRUG;

AIRLIFT REACTOR; ARTICLE; BIOMASS PRODUCTION; CONDUCTANCE; CONTROLLED STUDY; CULTURE MEDIUM; CULTURE OPTIMIZATION; DRUG DETERMINATION; ECHINACEA PURPUREA; GROWTH INHIBITION; INCUBATION TEMPERATURE; INOCULATION; NONHUMAN; PH; PLANT ROOT; SPECIES CULTIVATION;

ECHINACEA PURPUREA;

EID: 62649118259     PISSN: 12268372     EISSN: None     Source Type: Journal    
DOI: 10.1007/s12257-007-0142-5     Document Type: Article

References (37)

1. Barrett, B. (1989) Medicinal properties of Echinacea: A critical review. Phytomedicine 10: 66-86.
2. Baurer, R. and H. Wagner (1991) Echinacea species as potential immunostimulatory drugs. Econ Medic Plant Res. 5: 253-321.
3. Hobbs, C. (1989) The Echinacea Handbook. pp. 1-118. Elcectic Medical Publications. Portland, OR, USA.
4. Lin, Z., N. Neamati, H. Zhao, Y. Kiryu, J. A. Turpin, C. Aberham, K. Strebel, K. Kohn, M. Witvrouw, C. Pannecouque, Z. Debyser, E. D. Clercq, W. G. Rice, Y. Pommier, and T. R. Burke (1999) Cichoric acid analogues as HIV-1 integrase inhibitors. J. Med. Chem. 42: 1301-1414.
5. Kim, Y. S., E. J. Hahn, H. N. Murthy, and K. Y. Paek (2004) Adventitious root growth and ginsenoside accumulation in Panax ginseng cultures as affected by methyl jasmonate. Biotech. Lett. 26:1619-1622.
6. Thanh, N. T., H. N. Murthy, E. J. Hahn, and K. Y. Paek (2005) Methyl jasomonate elicitation enhanced synthesis of ginsenoside by cell suspension cultures of Panax ginseng in 5-l balloon type bubble reactors. Appl. Microbiol. Biotechnol. 67: 197-201.
7. Yu, K.W., E. J. Hahn, and K. Y. Paek (2000) Production of ginseng adventitious roots using bioreactors. Korean J. Plant Tissue Cult. 27: 309-315.
8. Park, S. Y., J. K. Ahn, W. Y. Lee, H. N. Murthy, and K. Y. Paek (2005) Mass production of Eleutherococcus koreanum plantlets via somatic embryogenesis from root cultures and accumulation of eleutherosides in regenerants. Plant Sci. 168: 1221-1225.
9. Shohael, A. M., D. Chakrabarty, K. W. Yu, E. J. Hahn, and K. Y. Paek (2005) Application of bioreactor system for large-scale production of Eleutherococcus sessiliflorus somatic embryos in an air-lift bioreactor and production of eleutheorsides. J. Biotehnol. 120: 228-236.
10. Min, J. Y., H. Y. Jung, S. M. Kang, Y. D. Kim, Y. M. Kang, D. J. Park, D. T. Prasad, and M. S. Choi (2007) Production of tropane alkaloids by small-scale bubble column bioreactors of Scopolia parviflora adventitious roots. Bioresource Technol. 98: 1748-1753.
11. Jeon, B. Y., S. J. Kim, D. H. Kim, B. K. Na, D. H. Park, H. T., Tran, R. Zhang, and D. H. Ahn (2007) Development of a serial bioreactor system for direct ethanol production from starch using Aspergillus niger and Saccharomyces cerevisiae. Biotechnol. Bioprocess Eng. 12: 566-573.
12. Humphery, A. (1998) Shake flask to fermentor: What have we learned? Biotechnol. Prog. 14: 3-7.
13. Kim, Y., B. Wyslouzil, and P. Weathers (2002) Secondary metabolism of hairy root cultures in bioreactors. In Vitro Cell. Dev. Biol. Plant 38: 1-10.
14. Wu, C. H., H. N. Murthy, E. J. Hahn, and K. Y. Paek (2007) Large-scale cultivation of adventitious roots of Echinacea purpurea in airlift bioreactors for the production of chichoric acid, chlorogenic acid and caftaric acid. Biotechnol Lett. 29: 1179-1182.
15. Wu, C. H., Y. H. Dewir, E. J. Hahn, and K. Y. Paek (2006) Optimization of culturing conditions for the production of biomass and phenolics from adventitious roots of Echinacea anguistifolia. J. Plant Biol. 49: 193-199.
16. Murashige, T. and F. Skoog (1962) A revised medium for rapid growth and bioassays with tobacco tissue cultures. Physiol. Plant. 15: 473-497.
17. Shin, K. S., D. Charkrabarty, J. Y. Ko, S. S. Hahn, and K. Y. Paek (2003) Sucrose utilization and mineral nutrient uptake during hairy root growth of red beet (Beta vulgaris L.) in liquid cultures. Plant Growth Regl. 39: 187-193.
18. Jeong, C. S., D. Chakrabarty, E. J. Hahn, H. L. Lee, and K. Y. Paek (2006) Effect of oxygen, carbon dioxide and ethylene on growth and bioactive compound production in bioreactor culture of ginseng adventitious roots. Biochem. Eng. J. 27: 252-263.
19. Zhishen, J., T. Mengcheng, and W. Jianming (1999) The determination of flavonoid contents in mulberry and their scavenging effects on superoxide radicals. Food Chem. 64: 555-559.
20. Pellati, F., S. Benvenuti, L. Magro, M. Melegari, and F. Soragni (2004) Analysis of phenolic compounds and radical scavenging activity of Echinacea spp. J. Pharm. Biomed. Anal. 35: 289-301.
21. Ryu, D. D. Y., S. O. Lee, and R. J. Romani (1990) Determination of specific growth rate for plant cell cultures: Comparative studies. Biotechnol. Bioeng 35: 305-311.
22. Taya, M., M. Hegglin, J. E. Prenosil, and J. R. Bourne (1989) Online monitoring of cell growth in plant tissue cultures by conductivity. Enzyme Microb. Technol. 20:469-474.
23. Hahn, J. J., A. C. Eschenlauer, M. H. Narrol, D. A. Somers, and F. Srienc (1997) Growth kinetics, nutrient uptake, and expression of the Alocaligenes europhus poly (beta-hydroxybutyrate) synthesis pathway in transgenic maize cell suspension cultures. Biotechnol. Prog. 13: 347-354.
24. Lee, C. W. T. and M. L. Shuler (2000) The effect of inoculum density and conditioned medium on the production of ajmalicine and catharanthine from immobilized Cataranthus roseus cell. Biotechnol. Bioeng. 67: 61-71.
25. McDonald, K. A. and A. P. Jackman (1989) Bioreactor studies of growth and nutrient utilization in alfalfa suspension cultures. Plant Cell Rep. 8: 455-458
26. Tautorus, T. E., M. M. Lulsdorf, S. I. Kikcio, and D. I. Dunstan (1992) Bioreactor culture of Picea mariana Mill (black spruce) and the species complex Picea glauca Engelmannii (interior spruce) somatic embryo - growth parameters. Appl. Microb. Biotechnol. 38: 46-51.
27. Amino, S. I. and M. Tazawa (1988) Uptake and utilization of sugars in cultured rice cells. Plant Physiol. 29: 483-487.
28. Shin, K. S., H. N. Murthy, J. Y. Ko, and K. Y. Paek (2002) Growth and betacyanin production by hairy root cultures of Beta vulgaris L. in air lift bioreactors. Biotechnol. Lett. 24: 2067-2069.
29. Morad, P., C. Fulcheri, and M. Henry (1998) Kinetics of mineral nutrient uptake by Saponaria officinalis L. suspension cell cultures in different media. Plant Cell Rep. 18: 260-265.
30. Kintzios, S., E. Stavropoulou, and S. Skamneli (2004) Accumulation of selected macronutrients and carbohydrates in melon tissue cultures: association with pathways of in vitro dedifferentiation and differentiation (organogenesis, somatic embryogenesis). Plant Sci. 167: 655-664.
31. Liu, C. Z., B. H. Abbasi, M. Gao, S. J. Murch, and P. K. Saxena (2006) Caffeic acid derivatives production by hairy root cultures of Echinacea purpurea. J. Agric. Food Chem. 54: 8456-8460.
32. Huang, S. Y., C. H. Hung, and S. N. Chou (2004) Innovative strategies for operation of mist trickling reactors for enhanced hairy root proliferation and secondary metabolite productivity. Enzyme Microb. Technol. 35: 22-32.
33. Chattopadhyay, S., S. Farkya, A. K. Srivatava, and V. S. Bisaria (2002) Bioprocess considerations for production of secondary metabolites by plant cell suspension cultures. Biotechnol. Bioprocess Eng. 7: 138-149.
34. Gao, J. and J. M. Lee (1992) Effect of oxygen supply on the suspension cultures of genetically modified tobacco cells. Biotechnol. Prog. 8: 285-290.
35. Schlatmann, J. E., E. Fonck, H. J. G. ten Hoopen, and J. J. Heijnen (1994) The negligible role of carbon dioxide and ethylene in ajmalicine production by Catharanthus roseus cell suspensions. Plant Cell Rep. 14: 157-160.
36. Wang, B., G. Zhang, L. Zhu, L. Chen, and Y. Zhang (2006) Genetic transformation of Echinacea purpurea with Agrobacterium rhizogenes and bioactive ingredient analysis in transformed cultures. Colloids Surf B. 53: 101-104.
37. Wills, R., B. H. and D. L. Stuart (1999) Alkylaminde and cichoric acid levels in Echinacea purpurea grown in Australia. Food Chem. 67: 385-388.