Mitochondrial calcium uniporter silencing potentiates caspase-independent cell death in MDA-MB-231 breast cancer cells

Biochemical and Biophysical Research Communications

Volumn 434, Issue 3, 2013, Pages 695-700

  Curry, Merril C ^a   Peters, Amelia A ^a   Kenny, Paraic A ^b   Roberts Thomson, Sarah J ^a   Monteith, Gregory R ^a  

^a UNIVERSITY OF QUEENSLAND   (Australia)

^b ALBERT EINSTEIN COLLEGE OF MEDICINE   (United States)

Author keywords

ABT 263; Breast cancer; Calcium; Cell death; Ionomycin; Mitochondrial calcium uniporter

Indexed keywords

CALCIUM; CASPASE; ESTROGEN RECEPTOR; IONOMYCIN; MITOCHONDRIAL CALCIUM UNIPORTER; MITOCHONDRIAL PROTEIN; NAVITOCLAX; UNCLASSIFIED DRUG; ANILINE DERIVATIVE; ANTINEOPLASTIC AGENT; CALCIUM CHANNEL; MESSENGER RNA; SULFONAMIDE;

ARTICLE; BASAL LIKE BREAST CANCER; BREAST CANCER; BREAST CANCER CELL LINE; CALCIUM CELL LEVEL; CANCER CELL; CELL DEATH; CELL PROLIFERATION; CELL SURVIVAL; CELL VIABILITY; CONTROLLED STUDY; CYTOSOL; ENZYME INHIBITION; GENE SILENCING; HUMAN; HUMAN CELL; MICROARRAY ANALYSIS; PRIORITY JOURNAL; BREAST TUMOR; ENZYMOLOGY; FEMALE; GENETICS; METABOLISM; MITOCHONDRION; PATHOLOGY; REAL TIME POLYMERASE CHAIN REACTION; TUMOR CELL LINE;

ANILINE COMPOUNDS; ANTINEOPLASTIC AGENTS; BREAST NEOPLASMS; CALCIUM CHANNELS; CASPASES; CELL LINE, TUMOR; CELL PROLIFERATION; FEMALE; GENE SILENCING; HUMANS; IONOMYCIN; MITOCHONDRIA; REAL-TIME POLYMERASE CHAIN REACTION; RNA, MESSENGER; SULFONAMIDES;

MLCS; MLOWN;

EID: 84880471564     PISSN: 0006291X     EISSN: 10902104     Source Type: Journal    
DOI: 10.1016/j.bbrc.2013.04.015     Document Type: Article

References (30)

1. R. Rizzuto, D. De Stefani, A. Raffaello, C. Mammucari, Mitochondria as sensors and regulators of calcium signalling, Nature Rev. Mol. cell Biol. 13 (2012) 566-578.
2. M.J. Berridge, M.D. Bootman, P. Lipp, Calcium-a life and death signal, Nature 395 (1998) 645-648.
3. 2+ transfer in the control of apoptosis, Oncogene 27 (2008) 6407-6418.
4. 2+ concentration of the endoplasmic reticulum is a key determinant of ceramide-induced apoptosis: significance for the molecular mechanism of Bcl-2 action, EMBO J. 20 (2001) 2690-2701.
5. G.R. Monteith, D. McAndrew, H.M. Faddy, S.J. Roberts-Thomson, Calcium and cancer: targeting Ca2+ transport, Nature Rev. Cancer 7 (2007) 519-530.
6. D.C. Wallace, Mitochondria and cancer, Nature Rev. Cancer 12 (2012) 685-698.
7. V. Shoshan-Barmatz, V. De Pinto, M. Zweckstetter, Z. Raviv, N. Keinan, N. Arbel, VDAC, a multi-functional mitochondrial protein regulating cell life and death, Mol. Aspects Med. 31 (2010) 227-285.
8. M. Patron, A. Raffaello, V. Granatiero, A. Tosatto, G. Merli, D. De Stefani, L. Wright, G. Pallafacchina, A. Terrin, C. Mammucari, R. Rizzuto, The Mitochondrial Calcium Uniporter (MCU) molecular identity and physiological roles, J. Biol. chem. (2013).
9. J.M. Baughman, F. Perocchi, H.S. Girgis, M. Plovanich, C.A. Belcher-Timme, Y. Sancak, X.R. Bao, L. Strittmatter, O. Goldberger, R.L. Bogorad, V. Koteliansky, V.K. Mootha, Integrative genomics identifies MCU as an essential component of the mitochondrial calcium uniporter, Nature 476 (2011) 341-345.
10. D. De Stefani, A. Raffaello, E. Teardo, I. Szabo, R. Rizzuto, A forty-kilodalton protein of the inner membrane is the mitochondrial calcium uniporter, Nature 476 (2011) 336-340.
11. 2+ peaks in cardiomyocytes, Proc. Nat. Acad. Sci. USA 109 (2012) 12986-12991.
12. M.C. Curry, N.A. Luk, P.A. Kenny, S.J. Roberts-Thomson, G.R. Monteith, Distinct regulation of cytoplasmic calcium signals and cell death pathways by different plasma membrane calcium ATPase isoforms in MDA-MB-231 breast cancer cells, J. Biol. Chem. 287 (2012) 28598-28608.
13. S. Marchi, L. Lupini, S. Patergnani, A. Rimessi, S. Missiroli, M. Bonora, A. Bononi, F. Corra, C. Giorgi, E. De Marchi, F. Poletti, R. Gafa, G. Lanza, M. Negrini, R. Rizzuto, P. Pinton, Downregulation of the mitochondrial calcium uniporter by cancer-related miR-25, Curr. Biol.: CB 23 (2013) 58-63.
14. J.I. Herschkowitz, K. Simin, V.J. Weigman, I. Mikaelian, J. Usary, Z. Hu, K.E. Rasmussen, L.P. Jones, S. Assefnia, S. Chandrasekharan, M.G. Backlund, Y. Yin, A.I. Khramtsov, R. Bastein, J. Quackenbush, R.I. Glazer, P.H. Brown, J.E. Green, L. Kopelovich, P.A. Furth, J.P. Palazzo, O.I. Olopade, P.S. Bernard, G.A. Churchill, T. Van Dyke, C.M. Perou, Identification of conserved gene expression features between murine mammary carcinoma models and human breast tumors, Genome Biol. 8 (2007) R76.
15. J.S. Parker, M. Mullins, M.C. Cheang, S. Leung, D. Voduc, T. Vickery, S. Davies, C. Fauron, X. He, Z. Hu, J.F. Quackenbush, I.J. Stijleman, J. Palazzo, J.S. Marron, A.B. Nobel, E. Mardis, T.O. Nielsen, M.J. Ellis, C.M. Perou, P.S. Bernard, Supervised risk predictor of breast cancer based on intrinsic subtypes, J. Clin. Oncol. 27 (2009) 1160-1167.
16. A.L. Jackson, J. Burchard, D. Leake, A. Reynolds, J. Schelter, J. Guo, J.M. Johnson, L. Lim, J. Karpilow, K. Nichols, W. Marshall, A. Khvorova, P.S. Linsley, Position-specific chemical modification of siRNAs reduces "off-target" transcript silencing, RNA 12 (2006) 1197-1205.
17. A. Birmingham, E.M. Anderson, A. Reynolds, D. Ilsley-Tyree, D. Leake, Y. Fedorov, S. Baskerville, E. Maksimova, K. Robinson, J. Karpilow, W.S. Marshall, A. Khvorova, 3′ UTR seed matches, but not overall identity, are associated with RNAi off-targets, Nat. Meth. 3 (2006) 199-204.
18. K.M. Suchanek, F.J. May, J.A. Robinson, W.J. Lee, N.A. Holman, G.R. Monteith, S.J. Roberts-Thomson, Peroxisome proliferator-activated receptor alpha in the human breast cancer cell lines MCF-7 and MDA-MB-231, Mol. Carcinogenesis 34 (2002) 165-171.
19. A.A. Peters, P.T. Simpson, J.J. Bassett, J.M. Lee, L. Da Silva, L.E. Reid, S. Song, M.O. Parat, S.R. Lakhani, P.A. Kenny, S.J. Roberts-Thomson, G.R. Monteith, Calcium channel TRPV6 as a potential therapeutic target in estrogen receptor-negative breast cancer, Mol. Cancer Therapeutics 11 (2012) 2158-2168.
20. 2+ signaling as a consequence of EGF-induced epithelial-mesenchymal transition in breast cancer cells, PloS One 6 (2011) e23464.
21. G.R. Monteith, G.S. Bird, Techniques: high-throughput measurement of intracellular Ca(2+) - back to basics, Trends Pharmacol. Sci. 26 (2005) 218-223.
22. T. Sorlie, C.M. Perou, R. Tibshirani, T. Aas, S. Geisler, H. Johnsen, T. Hastie, M.B. Eisen, M. van de Rijn, S.S. Jeffrey, T. Thorsen, H. Quist, J.C. Matese, P.O. Brown, D. Botstein, P.E. Lonning, A.L. Borresen-Dale, Gene expression patterns of breast carcinomas distinguish tumor subclasses with clinical implications, Proc. Nat. Acad. Sci. USA 98 (2001) 10869-10874.
23. T. Sorlie, Y. Wang, C. Xiao, H. Johnsen, B. Naume, R.R. Samaha, A.L. Borresen-Dale, Distinct molecular mechanisms underlying clinically relevant subtypes of breast cancer: gene expression analyses across three different platforms, BMC Genomics 7 (2006) 127.
24. R.M. Neve, K. Chin, J. Fridlyand, J. Yeh, F.L. Baehner, T. Fevr, L. Clark, N. Bayani, J.P. Coppe, F. Tong, T. Speed, P.T. Spellman, S. DeVries, A. Lapuk, N.J. Wang, W.L. Kuo, J.L. Stilwell, D. Pinkel, D.G. Albertson, F.M. Waldman, F. McCormick, R.B. Dickson, M.D. Johnson, M. Lippman, S. Ethier, A. Gazdar, J.W. Gray, A collection of breast cancer cell lines for the study of functionally distinct cancer subtypes, Cancer Cell 10 (2006) 515-527.
25. Kruman II, M.P. Mattson, Pivotal role of mitochondrial calcium uptake in neural cell apoptosis and necrosis, J. Neurochem. 72 (1999) 529-540.
26. H.I. Hung, J.M. Schwartz, E.N. Maldonado, J.J. Lemasters, A.L. Nieminen, Mitoferrin-2-dependent mitochondrial iron uptake sensitizes human head and neck squamous carcinoma cells to photodynamic therapy, J. Biol. Chem. 288 (2013) 677-686.
27. H. Zaid, S. Abu-Hamad, A. Israelson, I. Nathan, V. Shoshan-Barmatz, The voltage-dependent anion channel-1 modulates apoptotic cell death, Cell Death Differentiation 12 (2005) 751-760.
28. 2+ transfer to mitochondria, Cell 142 (2010) 270-283.
29. S. Patergnani, J.M. Suski, C. Agnoletto, A. Bononi, M. Bonora, E. De Marchi, C. Giorgi, S. Marchi, S. Missiroli, F. Poletti, A. Rimessi, J. Duszynski, M.R. Wieckowski, P. Pinton, Calcium signaling around Mitochondria Associated Membranes (MAMs), Cell Commun. Signal.: CCS 9 (2011) 19.
30. 2+ signals to mitochondria, Cell Death Differentiation 19 (2012) 267-273.