Hepatocellular Carcinomas in B6C3F1 Mice Treated with Ginkgo biloba Extract for Two Years Differ from Spontaneous Liver Tumors in Cancer Gene Mutations and Genomic Pathways

Toxicologic Pathology

Volumn 41, Issue 6, 2013, Pages 826-841

  Hoenerhoff, Mark J ^a   Pandiri, Arun R ^b   Snyder, Stephanie A ^a   Hong, Hue Hua L ^a   Ton, Thai vu ^a   Peddada, Shyamal ^a   Shockley, Keith ^a   Witt, Kristine ^a   Chan, po ^a   Rider, Cynthia ^a   Kooistra, Linda ^c   Nyska, Abraham ^d   Sills, Robert C ^a  

^a NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES   (United States)

^b EXPERIMENTAL PATHOLOGY LABORATORIES INC   (United States)

^c CHARLES RIVER LABORATORIES   (United States)

^d INTEGRATED LABORATORY SYSTEMS   (United States)

Author keywords

carcinogenesis; liver; microarray; molecular pathology; toxicogenomics

Indexed keywords

BETA CATENIN; GINKGO BILOBA EXTRACT; MESSENGER RNA; PROTEIN P53; XENOBIOTIC AGENT;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BIOASSAY; CANCER GROWTH; CANCER INCIDENCE; CARCINOGENESIS; CONTROLLED STUDY; DOSE RESPONSE; DRUG MEGADOSE; FEMALE; GENE EXPRESSION; GENE EXPRESSION PROFILING; GENE MUTATION; GENOTOXICITY; HISTOPATHOLOGY; HUMAN; HUMAN CELL; HYPEREOSINOPHILIA; IMMUNOHISTOCHEMISTRY; IMMUNOPRECIPITATION; IN VITRO STUDY; LIVER ADENOMA; LIVER CARCINOGENESIS; LIVER CELL CARCINOMA; LIVER HYPERTROPHY; LIVER NECROSIS; MALE; MOUSE; NONHUMAN; ONCOGENE H RAS; OXIDATIVE STRESS; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; RNA SEQUENCE; TREATMENT DURATION; TUMOR GENE; TUMOR SUPPRESSOR GENE; WESTERN BLOTTING; WNT SIGNALING PATHWAY;

CARCINOGENESIS; LIVER; MICROARRAY; MOLECULAR PATHOLOGY; TOXICOGENOMICS;

ADMINISTRATION, ORAL; ANIMALS; BETA CATENIN; CARCINOGENICITY TESTS; CLUSTER ANALYSIS; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUGS, CHINESE HERBAL; FEMALE; GENE EXPRESSION REGULATION, NEOPLASTIC; GINKGO BILOBA; IMMUNOHISTOCHEMISTRY; LIVER; LIVER NEOPLASMS, EXPERIMENTAL; MALE; MICE; MUTAGENICITY TESTS; OXIDATIVE STRESS; REPRODUCIBILITY OF RESULTS; SIGNAL TRANSDUCTION;

EID: 84880443612     PISSN: 01926233     EISSN: 15331601     Source Type: Journal    
DOI: 10.1177/0192623312467520     Document Type: Article

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