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Volumn 346, Issue 2, 2013, Pages 318-327

Selective and potent agonists and antagonists for investigating the role of mouse oxytocin receptors

Author keywords

[No Author keywords available]

Indexed keywords

OXYTOCIN RECEPTOR; VASOPRESSIN V1A RECEPTOR; VASOPRESSIN V1B RECEPTOR;

EID: 84880417117     PISSN: 00223565     EISSN: 15210103     Source Type: Journal    
DOI: 10.1124/jpet.113.202994     Document Type: Article
Times cited : (76)

References (47)
  • 3
    • 84856759440 scopus 로고    scopus 로고
    • Functional selective oxytocin-derived agonists discriminate between individual G protein family subtypes
    • Busnelli M, Saulière A, Manning M, Bouvier M, Galés C, and Chini B (2012) Functional selective oxytocin-derived agonists discriminate between individual G protein family subtypes. J Biol Chem 287:3617-3629.
    • (2012) J Biol Chem , vol.287 , pp. 3617-3629
    • Busnelli, M.1    Saulière, A.2    Manning, M.3    Bouvier, M.4    Galés, C.5    Chini, B.6
  • 4
    • 34548149533 scopus 로고    scopus 로고
    • Agonist selectivity in the oxytocin/vasopressin receptor family: New insights and challenges
    • Chini B and Manning M (2007) Agonist selectivity in the oxytocin/vasopressin receptor family: new insights and challenges. Biochem Soc Trans 35:737-741.
    • (2007) Biochem Soc Trans , vol.35 , pp. 737-741
    • Chini, B.1    Manning, M.2
  • 5
    • 47749138850 scopus 로고    scopus 로고
    • Affinity and efficacy of selective agonists and antagonists for vasopressin and oxytocin receptors: An "easy guide" to receptor pharmacology
    • Chini B, Manning M, and Guillon G (2008) Affinity and efficacy of selective agonists and antagonists for vasopressin and oxytocin receptors: an "easy guide" to receptor pharmacology. Prog Brain Res 170:513-517.
    • (2008) Prog Brain Res , vol.170 , pp. 513-517
    • Chini, B.1    Manning, M.2    Guillon, G.3
  • 7
    • 84858110277 scopus 로고    scopus 로고
    • Homology modeling of class A G protein-coupled receptors
    • Costanzi S (2012) Homology modeling of class A G protein-coupled receptors. Methods Mol Biol 857:259-279.
    • (2012) Methods Mol Biol , vol.857 , pp. 259-279
    • Costanzi, S.1
  • 8
    • 80052082999 scopus 로고    scopus 로고
    • Structural insights into agonist-induced activation of G-protein-coupled receptors
    • Deupi X and Standfuss J (2011) Structural insights into agonist-induced activation of G-protein-coupled receptors. Curr Opin Struct Biol 21:541-551.
    • (2011) Curr Opin Struct Biol , vol.21 , pp. 541-551
    • Deupi, X.1    Standfuss, J.2
  • 9
    • 0023838087 scopus 로고
    • [3H]-[Thr4,Gly7] OT: A highly selective ligand for central and peripheral OT receptors
    • Elands J, Barberis C, and Jard S (1988) [3H]-[Thr4,Gly7]OT: a highly selective ligand for central and peripheral OT receptors. Am J Physiol 254:E31-E38.
    • (1988) Am J Physiol , vol.254
    • Elands, J.1    Barberis, C.2    Jard, S.3
  • 10
    • 0029787642 scopus 로고    scopus 로고
    • Behavioral consequences of intracerebral vasopressin and oxytocin: Focus on learning and memory
    • Engelmann M, Wotjak CT, Neumann I, Ludwig M, and Landgraf R (1996) Behavioral consequences of intracerebral vasopressin and oxytocin: focus on learning and memory. Neurosci Biobehav Rev 20:341-358.
    • (1996) Neurosci Biobehav Rev , vol.20 , pp. 341-358
    • Engelmann, M.1    Wotjak, C.T.2    Neumann, I.3    Ludwig, M.4    Landgraf, R.5
  • 11
    • 0035887604 scopus 로고    scopus 로고
    • Oxytocin in the medial amygdala is essential for social recognition in the mouse
    • Ferguson JN, Aldag JM, Insel TR, and Young LJ (2001) Oxytocin in the medial amygdala is essential for social recognition in the mouse. J Neurosci 21:8278-8285.
    • (2001) J Neurosci , vol.21 , pp. 8278-8285
    • Ferguson, J.N.1    Aldag, J.M.2    Insel, T.R.3    Young, L.J.4
  • 13
    • 19944397128 scopus 로고    scopus 로고
    • Distribution and cellular localization of insulin-regulated aminopeptidase in the rat central nervous system
    • Fernando RN, Larm J, Albiston AL, and Chai SY (2005) Distribution and cellular localization of insulin-regulated aminopeptidase in the rat central nervous system. J Comp Neurol 487:372-390.
    • (2005) J Comp Neurol , vol.487 , pp. 372-390
    • Fernando, R.N.1    Larm, J.2    Albiston, A.L.3    Chai, S.Y.4
  • 16
    • 77955130851 scopus 로고    scopus 로고
    • Dual modulation of inward rectifier potassium currents in olfactory neuronal cells by promiscuous G protein coupling of the oxytocin receptor
    • Gravati M, Busnelli M, Bulgheroni E, Reversi A, Spaiardi P, Parenti M, Toselli M, and Chini B (2010) Dual modulation of inward rectifier potassium currents in olfactory neuronal cells by promiscuous G protein coupling of the oxytocin receptor. J Neurochem 114:1424-1435.
    • (2010) J Neurochem , vol.114 , pp. 1424-1435
    • Gravati, M.1    Busnelli, M.2    Bulgheroni, E.3    Reversi, A.4    Spaiardi, P.5    Parenti, M.6    Toselli, M.7    Chini, B.8
  • 17
    • 58149203324 scopus 로고    scopus 로고
    • Discovery of new GPCR biology: One receptor structure at a time
    • Hanson MA and Stevens RC (2009) Discovery of new GPCR biology: one receptor structure at a time. Structure 17:8-14.
    • (2009) Structure , vol.17 , pp. 8-14
    • Hanson, M.A.1    Stevens, R.C.2
  • 19
    • 16444367602 scopus 로고    scopus 로고
    • Vasopressin and oxytocin excite distinct neuronal populations in the central amygdala
    • Huber D, Veinante P, and Stoop R (2005) Vasopressin and oxytocin excite distinct neuronal populations in the central amygdala. Science 308:245-248.
    • (2005) Science , vol.308 , pp. 245-248
    • Huber, D.1    Veinante, P.2    Stoop, R.3
  • 20
    • 84865228105 scopus 로고    scopus 로고
    • New insights for drug design from the X-ray crystallographic structures of G-protein-coupled receptors
    • Jacobson KA and Costanzi S (2012) New insights for drug design from the X-ray crystallographic structures of G-protein-coupled receptors. Mol Pharmacol 82: 361-371.
    • (2012) Mol Pharmacol , vol.82 , pp. 361-371
    • Jacobson, K.A.1    Costanzi, S.2
  • 23
    • 78751498756 scopus 로고    scopus 로고
    • Functional selectivity and biased receptor signaling
    • Kenakin T (2011) Functional selectivity and biased receptor signaling. J Pharmacol Exp Ther 336:296-302.
    • (2011) J Pharmacol Exp Ther , vol.336 , pp. 296-302
    • Kenakin, T.1
  • 24
    • 38749131545 scopus 로고    scopus 로고
    • New G-protein-coupled receptor crystal structures: Insights and limitations
    • Kobilka B and Schertler GF (2008) New G-protein-coupled receptor crystal structures: insights and limitations. Trends Pharmacol Sci 29:79-83.
    • (2008) Trends Pharmacol Sci , vol.29 , pp. 79-83
    • Kobilka, B.1    Schertler, G.F.2
  • 26
    • 0017351262 scopus 로고
    • Synthesis and some pharmacological properties of [4-threonine, 7-glycine]oxytocin, [1-(L-2-hydroxy-3- mercaptopropanoic acid), 4-threonine, 7-glycine]oxytocin (hydroxyl[Thr4, Gly7] oxytocin), and [7-glycine]oxytocin: Peptides with high oxytocic-antidiuretic selectivity
    • Lowbridge J, Manning M, Haldar J, and Sawyer WH (1977) Synthesis and some pharmacological properties of [4-threonine, 7-glycine]oxytocin, [1-(L-2-hydroxy-3- mercaptopropanoic acid), 4-threonine, 7-glycine]oxytocin (hydroxyl[Thr4, Gly7] oxytocin), and [7-glycine]oxytocin: peptides with high oxytocic-antidiuretic selectivity. J Med Chem 20:120-123.
    • (1977) J Med Chem , vol.20 , pp. 120-123
    • Lowbridge, J.1    Manning, M.2    Haldar, J.3    Sawyer, W.H.4
  • 27
    • 65549098719 scopus 로고    scopus 로고
    • Targeting V1A-vasopressin receptors with [Arg6, D-Trp7,9, NmePhe8]-substance P (6-11) identifies a strategy to develop novel anti-cancer therapies
    • MacKinnon AC, Tufail-Hanif U, Wheatley M, Rossi AG, Haslett C, Seckl M, and Sethi T (2009) Targeting V1A-vasopressin receptors with [Arg6, D-Trp7,9, NmePhe8]-substance P (6-11) identifies a strategy to develop novel anti-cancer therapies. Br J Pharmacol 156:36-47.
    • (2009) Br J Pharmacol , vol.156 , pp. 36-47
    • Mackinnon, A.C.1    Tufail-Hanif, U.2    Wheatley, M.3    Rossi, A.G.4    Haslett, C.5    Seckl, M.6    Sethi, T.7
  • 29
    • 47649122194 scopus 로고    scopus 로고
    • Peptide and non-peptide agonists and antagonists for the vasopressin and oxytocin V1a, V1b, V2 and OT receptors: Research tools and potential therapeutic agents
    • Manning M, Stoev S, Chini B, Durroux T, Mouillac B, and Guillon G (2008) Peptide and non-peptide agonists and antagonists for the vasopressin and oxytocin V1a, V1b, V2 and OT receptors: research tools and potential therapeutic agents. Prog Brain Res 170:473-512.
    • (2008) Prog Brain Res , vol.170 , pp. 473-512
    • Manning, M.1    Stoev, S.2    Chini, B.3    Durroux, T.4    Mouillac, B.5    Guillon, G.6
  • 30
    • 67349088738 scopus 로고    scopus 로고
    • Community-wide assessment of GPCR structure modelling and ligand docking: GPCR Dock 2008
    • GPCR Dock 2008 participants
    • Michino M, Abola E, Brooks CL, 3rd, Dixon JS, Moult J, and Stevens RC; GPCR Dock 2008 participants (2009) Community-wide assessment of GPCR structure modelling and ligand docking: GPCR Dock 2008. Nat Rev Drug Discov 8:455-463.
    • (2009) Nat Rev Drug Discov , vol.8 , pp. 455-463
    • Michino, M.1    Abola, E.2    Brooks, C.L.3    Dixon, J.S.4    Moult, J.5    Stevens, R.C.6
  • 31
    • 84872477580 scopus 로고    scopus 로고
    • Neuroscience. The promise and perils of oxytocin
    • Miller G (2013) Neuroscience. The promise and perils of oxytocin. Science 339: 267-269.
    • (2013) Science , vol.339 , pp. 267-269
    • Miller, G.1
  • 32
    • 84858674139 scopus 로고    scopus 로고
    • The oxytocin system in drug discovery for autism: Animal models and novel therapeutic strategies
    • Modi ME and Young LJ (2012) The oxytocin system in drug discovery for autism: animal models and novel therapeutic strategies. Horm Behav 61:340-350.
    • (2012) Horm Behav , vol.61 , pp. 340-350
    • Modi, M.E.1    Young, L.J.2
  • 33
    • 1342265782 scopus 로고    scopus 로고
    • Vasopressin stimulates insulin release from islet cells through V1b receptors: A combined pharmacological/knockout approach
    • Oshikawa S, Tanoue A, Koshimizu TA, Kitagawa Y, and Tsujimoto G (2004) Vasopressin stimulates insulin release from islet cells through V1b receptors: a combined pharmacological/knockout approach. Mol Pharmacol 65:623-629.
    • (2004) Mol Pharmacol , vol.65 , pp. 623-629
    • Oshikawa, S.1    Tanoue, A.2    Koshimizu, T.A.3    Kitagawa, Y.4    Tsujimoto, G.5
  • 34
    • 25144439996 scopus 로고    scopus 로고
    • Neurohypophysial peptides: Gatekeepers in the amygdala
    • Pittman QJ and Spencer SJ (2005) Neurohypophysial peptides: gatekeepers in the amygdala. Trends Endocrinol Metab 16:343-344.
    • (2005) Trends Endocrinol Metab , vol.16 , pp. 343-344
    • Pittman, Q.J.1    Spencer, S.J.2
  • 36
    • 18144422077 scopus 로고    scopus 로고
    • The oxytocin receptor antagonist atosiban inhibits cell growth via a "biased agonist" mechanism
    • Reversi A, Rimoldi V, Marrocco T, Cassoni P, Bussolati G, Parenti M, and Chini B (2005) The oxytocin receptor antagonist atosiban inhibits cell growth via a "biased agonist" mechanism. J Biol Chem 280:16311-16318.
    • (2005) J Biol Chem , vol.280 , pp. 16311-16318
    • Reversi, A.1    Rimoldi, V.2    Marrocco, T.3    Cassoni, P.4    Bussolati, G.5    Parenti, M.6    Chini, B.7
  • 38
    • 84873042521 scopus 로고    scopus 로고
    • Mice heterozygous for the oxytocin receptor gene (Oxtr(1/-)) show impaired social behaviour but not increased aggression or cognitive inflexibility: Evidence of a selective haploinsufficiency gene effect
    • Sala M, Braida D, Donzelli A, Martucci R, Busnelli M, Bulgheroni E, Rubino T, Parolaro D, Nishimori K, and Chini B (2013) Mice heterozygous for the oxytocin receptor gene (Oxtr(1/-)) show impaired social behaviour but not increased aggression or cognitive inflexibility: evidence of a selective haploinsufficiency gene effect. J Neuroendocrinol 25:107-118.
    • (2013) J Neuroendocrinol , vol.25 , pp. 107-118
    • Sala, M.1    Braida, D.2    Donzelli, A.3    Martucci, R.4    Busnelli, M.5    Bulgheroni, E.6    Rubino, T.7    Parolaro, D.8    Nishimori, K.9    Chini, B.10
  • 39
    • 79954594363 scopus 로고    scopus 로고
    • Pharmacologic rescue of impaired cognitive flexibility, social deficits, increased aggression, and seizure susceptibility in oxytocin receptor null mice: A neurobehavioral model of autism
    • Sala M, Braida D, Lentini D, Busnelli M, Bulgheroni E, Capurro V, Finardi A, Donzelli A, Pattini L, and Rubino T, et al. (2011) Pharmacologic rescue of impaired cognitive flexibility, social deficits, increased aggression, and seizure susceptibility in oxytocin receptor null mice: a neurobehavioral model of autism. Biol Psychiatry 69:875-882.
    • (2011) Biol Psychiatry , vol.69 , pp. 875-882
    • Sala, M.1    Braida, D.2    Lentini, D.3    Busnelli, M.4    Bulgheroni, E.5    Capurro, V.6    Finardi, A.7    Donzelli, A.8    Pattini, L.9    Rubino, T.10
  • 43
    • 84867029981 scopus 로고    scopus 로고
    • Molecular evolution of the neurohypophysial hormone precursors in mammals: Comparative genomics reveals novel mammalian oxytocin and vasopressin analogues
    • Wallis M (2012) Molecular evolution of the neurohypophysial hormone precursors in mammals: comparative genomics reveals novel mammalian oxytocin and vasopressin analogues. Gen Comp Endocrinol 179:313-318.
    • (2012) Gen Comp Endocrinol , vol.179 , pp. 313-318
    • Wallis, M.1
  • 44
    • 0037161230 scopus 로고    scopus 로고
    • Agonist-specific, highaffinity binding epitopes are contributed by an arginine in the N-terminus of the human oxytocin receptor
    • Wesley VJ, Hawtin SR, Howard HC, and Wheatley M (2002) Agonist-specific, highaffinity binding epitopes are contributed by an arginine in the N-terminus of the human oxytocin receptor. Biochemistry 41:5086-5092.
    • (2002) Biochemistry , vol.41 , pp. 5086-5092
    • Wesley, V.J.1    Hawtin, S.R.2    Howard, H.C.3    Wheatley, M.4
  • 45
    • 79951521238 scopus 로고    scopus 로고
    • Chemogenomic analysis of G-protein coupled receptors and their ligands deciphers locks and keys governing diverse aspects of signalling
    • Wichard JD, Ter Laak A, Krause G, Heinrich N, Kühne R, and Kleinau G (2011) Chemogenomic analysis of G-protein coupled receptors and their ligands deciphers locks and keys governing diverse aspects of signalling. PLoS ONE 6:e16811.
    • (2011) PLoS ONE , vol.6
    • Wichard, J.D.1    Ter Laak, A.2    Krause, G.3    Heinrich, N.4    Kühne, R.5    Kleinau, G.6
  • 46
    • 84858120018 scopus 로고    scopus 로고
    • Ice breaking in GPCR structural biology
    • Zhao Q and Wu BL (2012) Ice breaking in GPCR structural biology. Acta Pharmacol Sin 33:324-334.
    • (2012) Acta Pharmacol Sin , vol.33 , pp. 324-334
    • Zhao, Q.1    Wu, B.L.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.