The oxytocin receptor antagonist atosiban inhibits cell growth via a "biased agonist" mechanism

Journal of Biological Chemistry

Volumn 280, Issue 16, 2005, Pages 16311-16318

  Reversi, Alessandra ^a   Rimoldi, Valeria ^a   Marrocco, Tiziana ^b   Cassoni, Paola ^b   Bussolati, Giovanni ^b   Parenti, Marco ^c   Chini, Bice ^a  

^a CNR   (Italy)

^b UNIVERSITY OF TURIN   (Italy)

^c UNIVERSITY OF MILANO BICOCCA   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

BIOCHEMISTRY; CONFORMATIONS; GROWTH KINETICS; HUMAN ENGINEERING; PHARMACODYNAMICS; PROTEINS; SIGNALING;

CELL GROWTH; GROWTH INHIBITION; HUMAN CELLS; PROTEIN PATHWAYS;

CELLS;

ATOSIBAN; GUANINE NUCLEOTIDE BINDING PROTEIN; GUANINE NUCLEOTIDE BINDING PROTEIN I SUBUNIT; GUANINE NUCLEOTIDE BINDING PROTEIN Q SUBUNIT; GUANOSINE 5' O (3 THIOTRIPHOSPHATE); MEMBRANE PROTEIN; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; OXYTOCIN; OXYTOCIN DERIVATIVE; OXYTOCIN RECEPTOR; PHOSPHOLIPASE C; PROTEIN P21; RECEPTOR BLOCKING AGENT; SULFUR 35; UNCLASSIFIED DRUG;

AGONIST; ANIMAL CELL; ARTICLE; BINDING AFFINITY; CANCER CELL; CELL GROWTH; CELL MEMBRANE; CELL STRAIN HEK293; COMPETITIVE INHIBITION; CONTROLLED STUDY; DESENSITIZATION; DRUG ACTIVITY; DRUG EXPOSURE; DRUG MECHANISM; ENZYME ACTIVATION; GENETIC TRANSFECTION; GROWTH INHIBITION; HUMAN; HUMAN CELL; INHIBITION KINETICS; INTERNALIZATION; ISOTOPE LABELING; KIDNEY CELL; NONHUMAN; PRIORITY JOURNAL; PROSTATE CANCER; PROTEIN EXPRESSION; PROTEIN INDUCTION; SIGNAL TRANSDUCTION;

CELL PROLIFERATION; GENE TRANSFER TECHNIQUES; HUMANS; RECEPTORS, OXYTOCIN; TIME FACTORS; TRITIUM; VASOTOCIN;

EID: 18144422077     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M409945200     Document Type: Article

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