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Volumn 28, Issue 8, 2013, Pages 999-1006

Melatonin prevents dopaminergic cell loss induced by lentiviral vectors expressing A30P mutant alpha-synuclein

Author keywords

Alpha synuclein (A30P); Lentiviral vectors; Melatonin; Neuroprotection; Parkinson's disease

Indexed keywords

ALPHA SYNUCLEIN; ANTIOXIDANT; COMPLEMENTARY DNA; DOPAMINE; DOPAMINE RECEPTOR; GREEN FLUORESCENT PROTEIN; MELATONIN; NEUROPROTECTIVE AGENT;

EID: 84880405488     PISSN: 02133911     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article
Times cited : (22)

References (75)
  • 1
    • 0033948968 scopus 로고    scopus 로고
    • Protective effect of melatonin against the 1-methyl-4-phenylpyridinium-induced inhibition of complex I of the mitochondrial respiratory chain
    • Absi E., Ayala A., Machado A. and Parrado J. (2000). Protective effect of melatonin against the 1-methyl-4-phenylpyridinium-induced inhibition of complex I of the mitochondrial respiratory chain. J. Pineal Res. 29, 40-47.
    • (2000) J. Pineal Res. , vol.29 , pp. 40-47
    • Absi, E.1    Ayala, A.2    McHado, A.3    Parrado, J.4
  • 2
    • 34247502759 scopus 로고    scopus 로고
    • Melatonin: Effects on dopaminergic and serotonergic neurons of the caudate nucleus of the striatum of male Syrian hamsters
    • Alexiuk N.A. and Vriend J. (2007). Melatonin: effects on dopaminergic and serotonergic neurons of the caudate nucleus of the striatum of male Syrian hamsters. J. Neural Transm. 114, 549-554.
    • (2007) J. Neural Transm. , vol.114 , pp. 549-554
    • Alexiuk, N.A.1    Vriend, J.2
  • 7
    • 0343517507 scopus 로고    scopus 로고
    • Lentiviral vectors as a gene delivery system in the mouse midbrain: Cellular and behavioral improvements in a 6-OHDA model of Parkinson's disease using GDNF
    • Bensadoun J.C., Déglon N., Tseng J.L., Ridet J.L., Zurn A.D. and Aebischer P. (2000). Lentiviral vectors as a gene delivery system in the mouse midbrain: cellular and behavioral improvements in a 6-OHDA model of Parkinson's disease using GDNF. Exp. Neurol. 164, 15-24.
    • (2000) Exp. Neurol. , vol.164 , pp. 15-24
    • Bensadoun, J.C.1    Déglon, N.2    Tseng, J.L.3    Ridet, J.L.4    Zurn, A.D.5    Aebischer, P.6
  • 10
    • 1842411367 scopus 로고    scopus 로고
    • Highly efficient and sustained gene transfer in adult neurons with a lentivirus vector
    • Blömer U., Naldini L., Kafri T., Trono D., Verma I.M. and Gage F.H. (1997). Highly efficient and sustained gene transfer in adult neurons with a lentivirus vector. J. Virol. 71, 6641-6649.
    • (1997) J. Virol. , vol.71 , pp. 6641-6649
    • Blömer, U.1    Naldini, L.2    Kafri, T.3    Trono, D.4    Verma, I.M.5    Gage, F.H.6
  • 11
    • 79952573098 scopus 로고    scopus 로고
    • Reaction mechanism of melatonin oxidation by reactive oxygen species in vitro
    • Bonnefont-Rousselot D., Collin F., Jore D. and Gardès-Albert M. (2011). Reaction mechanism of melatonin oxidation by reactive oxygen species in vitro. J. Pineal Res. 50, 328-335.
    • (2011) J. Pineal Res. , vol.50 , pp. 328-335
    • Bonnefont-Rousselot, D.1    Collin, F.2    Jore, D.3    Gardès-Albert, M.4
  • 12
    • 26844505808 scopus 로고    scopus 로고
    • Toxin-induced models of Parkinson's disease
    • Bové J., Prou D., Perier C. and Przedborski S. (2005). Toxin-induced models of Parkinson's disease. NeuroRx. 2, 484-494.
    • (2005) NeuroRx. , vol.2 , pp. 484-494
    • Bové, J.1    Prou, D.2    Perier, C.3    Przedborski, S.4
  • 15
    • 77956232379 scopus 로고    scopus 로고
    • Rasagiline protects against alpha-synuclein induced sensitivity to oxidative stress in dopaminergic cells
    • Chau K.Y., Cooper J.M. and Schapira A.H. (2010). Rasagiline protects against alpha-synuclein induced sensitivity to oxidative stress in dopaminergic cells. Neurochem. Int. 57, 525-529.
    • (2010) Neurochem. Int. , vol.57 , pp. 525-529
    • Chau, K.Y.1    Cooper, J.M.2    Schapira, A.H.3
  • 16
    • 0027686249 scopus 로고
    • Oxidative stress, glutamate, and neurodegenerative disorders
    • Coyle J.T. and Puttfarcken P. (1993). Oxidative stress, glutamate, and neurodegenerative disorders. Science 262, 689-695.
    • (1993) Science , vol.262 , pp. 689-695
    • Coyle, J.T.1    Puttfarcken, P.2
  • 17
    • 0032816549 scopus 로고    scopus 로고
    • The substantia nigra of the human brain. II. Patterns of loss of dopaminecontaining neurons in Parkinson's disease
    • Damier P., Hirsch E.C., Agid Y. and Graybiel A.M. (1999). The substantia nigra of the human brain. II. Patterns of loss of dopaminecontaining neurons in Parkinson's disease. Brain 122, 1437-1448.
    • (1999) Brain , vol.122 , pp. 1437-1448
    • Damier, P.1    Hirsch, E.C.2    Agid, Y.3    Graybiel, A.M.4
  • 20
    • 15744391811 scopus 로고    scopus 로고
    • Peroxynitrite in the pathogenesis of Parkinson's disease and the neuroprotective role of metallothioneins
    • Ebadi M., Sharma S.K., Ghafourifar P., Brown-Borg H. and El Refaey H. (2005). Peroxynitrite in the pathogenesis of Parkinson's disease and the neuroprotective role of metallothioneins. Methods Enzymol. 396, 276-298.
    • (2005) Methods Enzymol. , vol.396 , pp. 276-298
    • Ebadi, M.1    Sharma, S.K.2    Ghafourifar, P.3    Brown-Borg, H.4    El Refaey, H.5
  • 21
    • 78549282095 scopus 로고    scopus 로고
    • Antiinflammatory activity of melatonin in central nervous system
    • Esposito E. and Cuzzocrea S. (2010). Antiinflammatory activity of melatonin in central nervous system. Curr. Neuropharmacol. 8, 228-242.
    • (2010) Curr. Neuropharmacol. , vol.8 , pp. 228-242
    • Esposito, E.1    Cuzzocrea, S.2
  • 22
    • 0034040751 scopus 로고    scopus 로고
    • Gene transfer by lentiviral vectors is limited by nuclear translocation and rescued by HIV-1 pol sequences
    • Follenzi A., Ailles L.E., Bakovic S., Geuna M. and Naldini L. (2000). Gene transfer by lentiviral vectors is limited by nuclear translocation and rescued by HIV-1 pol sequences. Nat. Genet. 25, 217-222.
    • (2000) Nat. Genet. , vol.25 , pp. 217-222
    • Follenzi, A.1    Ailles, L.E.2    Bakovic, S.3    Geuna, M.4    Naldini, L.5
  • 23
    • 0030877835 scopus 로고    scopus 로고
    • Dopamine transporter is required for in vivo MPTP neurotoxicity: Evidence from mice lacking the transporter
    • Gainetdinov R.R., Fumagalli F., Jones S.R. and Caron M.G. (1997). Dopamine transporter is required for in vivo MPTP neurotoxicity: evidence from mice lacking the transporter. J. Neurochem. 69, 1322-1325.
    • (1997) J. Neurochem. , vol.69 , pp. 1322-1325
    • Gainetdinov, R.R.1    Fumagalli, F.2    Jones, S.R.3    Caron, M.G.4
  • 24
    • 79960380554 scopus 로고    scopus 로고
    • Melatonin as a natural ally against oxidative stress: A physicochemical examination
    • Galano A., Tan D.X. and Reiter R.J. (2011). Melatonin as a natural ally against oxidative stress: a physicochemical examination. J. Pineal Res. 51, 1-16.
    • (2011) J. Pineal Res. , vol.51 , pp. 1-16
    • Galano, A.1    Tan, D.X.2    Reiter, R.J.3
  • 25
    • 0024434128 scopus 로고
    • Midbrain dopaminergic cell loss in Parkinson's disease: Computer visualization
    • German D.C., Manaye K., Smith W.K., Woodward D.J. and Saper C.B. (1989). Midbrain dopaminergic cell loss in Parkinson's disease: computer visualization. Ann. Neurol. 26, 507-514.
    • (1989) Ann. Neurol. , vol.26 , pp. 507-514
    • German, D.C.1    Manaye, K.2    Smith, W.K.3    Woodward, D.J.4    Saper, C.B.5
  • 27
    • 77952303591 scopus 로고    scopus 로고
    • Phenotype, compartmental organization and differential vulnerability of nigral dopaminergic neurons
    • González-Hernández T., Afonso-Oramas D. and Cruz-Muros I. (2009). Phenotype, compartmental organization and differential vulnerability of nigral dopaminergic neurons. J. Neural Transm. Suppl. 73: 21-37.
    • (2009) J. Neural Transm. Suppl. , vol.73 , pp. 21-37
    • González-Hernández, T.1    Afonso-Oramas, D.2    Cruz-Muros, I.3
  • 28
    • 0141702110 scopus 로고    scopus 로고
    • Neuroprotective role of melatonin in oxidative stress vulnerable brain
    • Gupta Y.K., Gupta M. and Kohli K. (2003). Neuroprotective role of melatonin in oxidative stress vulnerable brain. Indian J. Physiol. Pharmacol. 47, 373-386.
    • (2003) Indian J. Physiol. Pharmacol. , vol.47 , pp. 373-386
    • Gupta, Y.K.1    Gupta, M.2    Kohli, K.3
  • 29
    • 33846921608 scopus 로고    scopus 로고
    • Melatonin inhibits maneb-induced aggregation of asynuclein in rat pheochromocytoma cells
    • Ishido M. (2007). Melatonin inhibits maneb-induced aggregation of asynuclein in rat pheochromocytoma cells. J. Pineal Res. 42, 125-130.
    • (2007) J. Pineal Res. , vol.42 , pp. 125-130
    • Ishido, M.1
  • 30
    • 0031839674 scopus 로고    scopus 로고
    • Effect of melatonin on methamphetamine-and 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced dopaminergic neurotoxicity and methamphetamine-induced behavioral sensitization
    • Itzhak Y., Martin J.L., Black M.D. and Ali S.F. (1998). Effect of melatonin on methamphetamine-and 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced dopaminergic neurotoxicity and methamphetamine-induced behavioral sensitization. Neuropharmacology 37, 781-791.
    • (1998) Neuropharmacology , vol.37 , pp. 781-791
    • Itzhak, Y.1    Martin, J.L.2    Black, M.D.3    Ali, S.F.4
  • 31
    • 0026514643 scopus 로고
    • What process causes nigral cell death in Parkinson's disease
    • Jenner P. (1992). What process causes nigral cell death in Parkinson's disease? Neurol. Clin. 10, 387-403.
    • (1992) Neurol. Clin. , vol.10 , pp. 387-403
    • Jenner, P.1
  • 33
    • 0037040491 scopus 로고    scopus 로고
    • Human alpha-synuclein overexpression increases intracellular reactive oxygen species levels and susceptibility to dopamine
    • Junn E. and Mouradian M.M. (2002). Human alpha-synuclein overexpression increases intracellular reactive oxygen species levels and susceptibility to dopamine. Neurosci. Lett. 320, 146-150.
    • (2002) Neurosci. Lett. , vol.320 , pp. 146-150
    • Junn, E.1    Mouradian, M.M.2
  • 35
    • 0345269757 scopus 로고    scopus 로고
    • Nigrostriatal alpha-synucleinopathy induced by viral vector-mediated overexpression of human alpha-synuclein: A new primate model of Parkinson's disease
    • Kirik D., Annett L.E., Burger C., Muzyczka N., Mandel R.J. and Björklund A. (2003). Nigrostriatal alpha-synucleinopathy induced by viral vector-mediated overexpression of human alpha-synuclein: a new primate model of Parkinson's disease. Proc. Natl. Acad. Sci. USA 100, 2884-2889.
    • (2003) Proc. Natl. Acad. Sci. USA , vol.100 , pp. 2884-2889
    • Kirik, D.1    Annett, L.E.2    Burger, C.3    Muzyczka, N.4    Mandel, R.J.5    Björklund, A.6
  • 36
    • 0036202813 scopus 로고    scopus 로고
    • Dopaminergic cell loss induced by human A30P alpha-synuclein gene transfer to the rat substantia nigra
    • Klein R.L., King M.A., Hamby M.E. and Meyer E.M. (2002). Dopaminergic cell loss induced by human A30P alpha-synuclein gene transfer to the rat substantia nigra. Hum. Gene Ther. 13, 605-612.
    • (2002) Hum. Gene Ther. , vol.13 , pp. 605-612
    • Klein, R.L.1    King, M.A.2    Hamby, M.E.3    Meyer, E.M.4
  • 37
    • 34447118322 scopus 로고    scopus 로고
    • Melatonin protects SK-N-SH neuroblastoma cells from amphetamine-induced neurotoxicity
    • Klongpanichapak S., Phansuwan-Pujito P., Ebadi M. and Govitrapong P. (2007). Melatonin protects SK-N-SH neuroblastoma cells from amphetamine-induced neurotoxicity. J. Pineal Res. 43, 65-73.
    • (2007) J. Pineal Res. , vol.43 , pp. 65-73
    • Klongpanichapak, S.1    Phansuwan-Pujito, P.2    Ebadi, M.3    Govitrapong, P.4
  • 38
    • 43049165779 scopus 로고    scopus 로고
    • Melatonin inhibits amphetamine-induced increase in alpha-synuclein and decrease in phosphorylated tyrosine hydroxylase in SK-N-SH cells
    • Klongpanichapak S., Phansuwan-Pujito P., Ebadi M. and Govitrapong P. (2008). Melatonin inhibits amphetamine-induced increase in alpha-synuclein and decrease in phosphorylated tyrosine hydroxylase in SK-N-SH cells. Neurosci. Lett. 436, 309-313.
    • (2008) Neurosci. Lett. , vol.436 , pp. 309-313
    • Klongpanichapak, S.1    Phansuwan-Pujito, P.2    Ebadi, M.3    Govitrapong, P.4
  • 40
    • 0032497504 scopus 로고    scopus 로고
    • Parkinson's disease. First of two parts
    • Lang A.E. and Lozano A.M. (1998). Parkinson's disease. First of two parts. N. Engl. J. Med. 339, 1044-1053.
    • (1998) N. Engl. J. Med. , vol.339 , pp. 1044-1053
    • Lang, A.E.1    Lozano, A.M.2
  • 41
    • 0041625923 scopus 로고    scopus 로고
    • Neuropathology and neurodegeneration in rodent brain induced by lentiviral vector-mediated overexpression of alpha-synuclein
    • Lauwers E., Debyser Z., Van Dorpe J., De Strooper B., Nuttin B. and Baekelandt V. (2003). Neuropathology and neurodegeneration in rodent brain induced by lentiviral vector-mediated overexpression of alpha-synuclein. Brain. Pathol. 13, 364-372.
    • (2003) Brain. Pathol. , vol.13 , pp. 364-372
    • Lauwers, E.1    Debyser, Z.2    van Dorpe, J.3    de Strooper, B.4    Nuttin, B.5    Baekelandt, V.6
  • 43
    • 34447558382 scopus 로고    scopus 로고
    • Melatonin attenuates arsenite-induced apoptosis in rat brain: Involvement of mitochondrial and endoplasmic reticulum pathways and aggregation of alpha-synuclein
    • Lin A.M., Fang S.F., Chao P.L. and Yang C.H. (2007). Melatonin attenuates arsenite-induced apoptosis in rat brain: involvement of mitochondrial and endoplasmic reticulum pathways and aggregation of alpha-synuclein. J. Pineal Res. 43, 163-171.
    • (2007) J. Pineal Res. , vol.43 , pp. 163-171
    • Lin, A.M.1    Fang, S.F.2    Chao, P.L.3    Yang, C.H.4
  • 44
    • 39149122800 scopus 로고    scopus 로고
    • Melatonin reduces the neuronal loss, downregulation of dopamine transporter, and upregulation of D2 receptor in rotenone-induced parkinsonian rats
    • Lin C.H., Huang J.Y., Ching C.H. and Chuang J.I. (2008). Melatonin reduces the neuronal loss, downregulation of dopamine transporter, and upregulation of D2 receptor in rotenone-induced parkinsonian rats. J. Pineal Res. 44, 205-213.
    • (2008) J. Pineal Res. , vol.44 , pp. 205-213
    • Lin, C.H.1    Huang, J.Y.2    Ching, C.H.3    Chuang, J.I.4
  • 45
    • 0036679197 scopus 로고    scopus 로고
    • (alpha)-synucleinopathy and selective dopaminergic neuron loss in a rat lentiviral-based model of Parkinson's disease
    • Lo Bianco C., Ridet J.L., Schneider B.L., Deglon N. and Aebischer P. (2002). (alpha)-synucleinopathy and selective dopaminergic neuron loss in a rat lentiviral-based model of Parkinson's disease. Proc. Natl. Acad. Sci. USA 99, 10813-10818.
    • (2002) Proc. Natl. Acad. Sci. USA , vol.99 , pp. 10813-10818
    • Lo Bianco, C.1    Ridet, J.L.2    Schneider, B.L.3    Deglon, N.4    Aebischer, P.5
  • 46
    • 10644281090 scopus 로고    scopus 로고
    • Lentiviral vector delivery of parkin prevents dopaminergic degeneration in an alpha-synuclein rat model of Parkinson's disease
    • Lo Bianco C., Schneider B.L., Bauer M., Sajadi A., Brice A., Iwatsubo T. and Aebischer P. (2004). Lentiviral vector delivery of parkin prevents dopaminergic degeneration in an alpha-synuclein rat model of Parkinson's disease. Proc. Natl. Acad. Sci. USA 101, 17510-17515.
    • (2004) Proc. Natl. Acad. Sci. USA , vol.101 , pp. 17510-17515
    • Lo Bianco, C.1    Schneider, B.L.2    Bauer, M.3    Sajadi, A.4    Brice, A.5    Iwatsubo, T.6    Aebischer, P.7
  • 47
    • 0022447043 scopus 로고
    • Prevention of the nigrostriatal toxicity of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine by inhibitors of 3,4-dihydroxyphenylethylamine transport
    • Mayer R.A., Kindt M.V. and Heikkila R.E. (1986). Prevention of the nigrostriatal toxicity of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine by inhibitors of 3,4-dihydroxyphenylethylamine transport. J. Neurochem. 47, 1073-1079.
    • (1986) J. Neurochem. , vol.47 , pp. 1073-1079
    • Mayer, R.A.1    Kindt, M.V.2    Heikkila, R.E.3
  • 48
    • 20744435383 scopus 로고    scopus 로고
    • Molecular pathophysiology of Parkinson's disease
    • Moore J.D., West A.B. and Dawson V.L. (2005). Molecular pathophysiology of Parkinson's disease. Annu. Rev. Neurosci. 28, 57-87.
    • (2005) Annu. Rev. Neurosci. , vol.28 , pp. 57-87
    • Moore, J.D.1    West, A.B.2    Dawson, V.L.3
  • 49
    • 0035824271 scopus 로고    scopus 로고
    • Chronic administration of pharmacological levels of melatonin does not ameliorate the MPTPinduced degeneration of the nigrostriatal pathway
    • Morgan W.W. and Nelson J.F. (2001). Chronic administration of pharmacological levels of melatonin does not ameliorate the MPTPinduced degeneration of the nigrostriatal pathway. Brain. Res. 921, 115-121.
    • (2001) Brain. Res. , vol.921 , pp. 115-121
    • Morgan, W.W.1    Nelson, J.F.2
  • 50
    • 38949146348 scopus 로고    scopus 로고
    • Mitochondrial dysfunction and oxidative stress in Parkinson's disease
    • Onyango I.G. (2008). Mitochondrial dysfunction and oxidative stress in Parkinson's disease. Neurochem. Res. 33, 589-597.
    • (2008) Neurochem. Res. , vol.33 , pp. 589-597
    • Onyango, I.G.1
  • 52
    • 68949151944 scopus 로고    scopus 로고
    • Alpha-synuclein overexpression and aggregation exacerbates impairment of mitochondrial functions by augmenting oxidative stress in human neuroblastoma cells
    • Parihar M.S., Parihar A., Fujita M., Hashimoto M. and Ghafourifar P. (2009). Alpha-synuclein overexpression and aggregation exacerbates impairment of mitochondrial functions by augmenting oxidative stress in human neuroblastoma cells. Int. J. Biochem. Cell. Biol. 41, 2015-2024.
    • (2009) Int. J. Biochem. Cell. Biol. , vol.41 , pp. 2015-2024
    • Parihar, M.S.1    Parihar, A.2    Fujita, M.3    Hashimoto, M.4    Ghafourifar, P.5
  • 53
  • 55
    • 41149131090 scopus 로고    scopus 로고
    • Differential effects of overexpression of wild-type and mutant human alpha-synuclein on MPP+-induced neurotoxicity in PC12 cells
    • Qian J.J., Cheng Y.B., Yang Y.P., Mao C.J., Qin Z.H., Li K. and Liu C.F. (2008). Differential effects of overexpression of wild-type and mutant human alpha-synuclein on MPP+-induced neurotoxicity in PC12 cells. Neurosci. Lett. 435, 142-146.
    • (2008) Neurosci. Lett. , vol.435 , pp. 142-146
    • Qian, J.J.1    Cheng, Y.B.2    Yang, Y.P.3    Mao, C.J.4    Qin, Z.H.5    Li, K.6    Liu, C.F.7
  • 57
    • 83555174870 scopus 로고    scopus 로고
    • Melatonin reduces the expression of alpha-synuclein in the dopamine containing neuronal regions of amphetamine-treated postnatal rats
    • Sae-Ung K., Uéda K., Govitrapong P. and Phansuwan-Pujito P. (2012). Melatonin reduces the expression of alpha-synuclein in the dopamine containing neuronal regions of amphetamine-treated postnatal rats. J. Pineal Res. 52, 128-137.
    • (2012) J. Pineal Res. , vol.52 , pp. 128-137
    • Sae-Ung, K.1    Uéda, K.2    Govitrapong, P.3    Phansuwan-Pujito, P.4
  • 58
    • 33744982893 scopus 로고    scopus 로고
    • Etiology of Parkinson's disease
    • Schapira A.H. (2006). Etiology of Parkinson's disease. Neurology 66, S10-S23.
    • (2006) Neurology , vol.66
    • Schapira, A.H.1
  • 59
    • 0030175258 scopus 로고    scopus 로고
    • Unilateral 6-hydroxydopamine lesions of meso-striatal dopamine neurons and their physiological sequelae
    • Schwarting R.K. and Huston J.P. (1996). Unilateral 6-hydroxydopamine lesions of meso-striatal dopamine neurons and their physiological sequelae. Prog. Neurobiol. 49, 215-266.
    • (1996) Prog. Neurobiol. , vol.49 , pp. 215-266
    • Schwarting, R.K.1    Huston, J.P.2
  • 60
    • 31344477300 scopus 로고    scopus 로고
    • Physiological neuroprotection by melatonin in a 6-hydroxydopamine model of Parkinson's disease
    • Sharma R., McMillan C.R., Tenn C.C. and Niles L.P. (2006). Physiological neuroprotection by melatonin in a 6-hydroxydopamine model of Parkinson's disease. Brain Res. 1068, 230-236.
    • (2006) Brain Res. , vol.1068 , pp. 230-236
    • Sharma, R.1    McMillan, C.R.2    Tenn, C.C.3    Niles, L.P.4
  • 61
    • 0037104723 scopus 로고    scopus 로고
    • An in vitro model of Parkinson's disease: Linking mitochondrial impairment to altered alpha-synuclein metabolism and oxidative damage
    • Sherer T.B., Betarbet R., Stout A.K., Lund S., Baptista M., Panov A.V., Cookson M.R. and Greenamyre J.T. (2002). An in vitro model of Parkinson's disease: linking mitochondrial impairment to altered alpha-synuclein metabolism and oxidative damage. J. Neurosci. 22, 7006-7015.
    • (2002) J. Neurosci. , vol.22 , pp. 7006-7015
    • Sherer, T.B.1    Betarbet, R.2    Stout, A.K.3    Lund, S.4    Baptista, M.5    Panov, A.V.6    Cookson, M.R.7    Greenamyre, J.T.8
  • 62
    • 79951634450 scopus 로고    scopus 로고
    • Melatonin or silymarin reduces maneb-and paraquatinduced Parkinson's disease phenotype in the mouse
    • Singhal N.K., Srivastava G., Patel D.K., Jain S.K. and Singh M.P. (2011). Melatonin or silymarin reduces maneb-and paraquatinduced Parkinson's disease phenotype in the mouse. J. Pineal Res. 50, 97-109.
    • (2011) J. Pineal Res. , vol.50 , pp. 97-109
    • Singhal, N.K.1    Srivastava, G.2    Patel, D.K.3    Jain, S.K.4    Singh, M.P.5
  • 63
    • 84856721686 scopus 로고    scopus 로고
    • Melatonin as a neuroprotective agent in the rodent models of Parkinson's disease: Is it all set to irrefutable clinical translation? Mol
    • Singhal N.K., Srivastava G., Agrawal S., Jain S.K., Singh M.P. (2012). Melatonin as a neuroprotective agent in the rodent models of Parkinson's disease: is it all set to irrefutable clinical translation? Mol. Neurobiol. 45, 186-199.
    • (2012) Neurobiol. , vol.45 , pp. 186-199
    • Singhal, N.K.1    Srivastava, G.2    Agrawal, S.3    Jain, S.K.4    Singh, M.P.5
  • 66
    • 74049134972 scopus 로고    scopus 로고
    • Melatonin treatment potentiates neurodegeneration in a rat rotenone Parkinson's disease model
    • Tapias V., Cannon J.R. and Greenamyre J.T. (2010). Melatonin treatment potentiates neurodegeneration in a rat rotenone Parkinson's disease model. J. Neurosci. Res. 88, 420-427.
    • (2010) J. Neurosci. Res. , vol.88 , pp. 420-427
    • Tapias, V.1    Cannon, J.R.2    Greenamyre, J.T.3
  • 67
    • 5444255433 scopus 로고    scopus 로고
    • Neurotoxicant-induced animal models of Parkinson's disease: Understanding the role of rotenone, maneb and paraquat in neurodegeneration
    • Uversky V.N. (2004). Neurotoxicant-induced animal models of Parkinson's disease: understanding the role of rotenone, maneb and paraquat in neurodegeneration. Cell. Tissue Res. 318, 225-241.
    • (2004) Cell. Tissue Res. , vol.318 , pp. 225-241
    • Uversky, V.N.1
  • 68
  • 69
    • 0037448010 scopus 로고    scopus 로고
    • 2in a human neuroblastoma divided cell line transfected with alpha-synuclein and its familial Parkinson's disease-linked mutants
    • 2in a human neuroblastoma divided cell line transfected with alpha-synuclein and its familial Parkinson's disease-linked mutants. Neurosci. Lett. 342, 124-128.
    • (2003) Neurosci. Lett. , vol.342 , pp. 124-128
    • Wersinger, C.1    Sidhu, A.2
  • 72
    • 0035562519 scopus 로고    scopus 로고
    • Melatonin-dopamine interactions: From basic neurochemistry to a clinical setting
    • Zisapel N. (2001). Melatonin-dopamine interactions: from basic neurochemistry to a clinical setting. Cell. Mol. Neurobiol. 21, 605-616.
    • (2001) Cell. Mol. Neurobiol. , vol.21 , pp. 605-616
    • Zisapel, N.1
  • 73
  • 74
    • 0030819379 scopus 로고    scopus 로고
    • Multiply attenuated lentiviral vector achieves efficient gene delivery in vivo
    • Zufferey R., Nagy D., Mandel R.J., Naldini L. and Trono D. (1997). Multiply attenuated lentiviral vector achieves efficient gene delivery in vivo. Nat. Biotech. 15, 871-875.
    • (1997) Nat. Biotech. , vol.15 , pp. 871-875
    • Zufferey, R.1    Nagy, D.2    Mandel, R.J.3    Naldini, L.4    Trono, D.5
  • 75
    • 0032978712 scopus 로고    scopus 로고
    • Woodchuck hepatitis virus posttranscriptional regulatory element enhances expression of transgenes delivered by retroviral vectors
    • Zufferey R., Donello J.E., Trono D. and Hope T.J. (1999). Woodchuck hepatitis virus posttranscriptional regulatory element enhances expression of transgenes delivered by retroviral vectors. J. Virol. 73, 2886-2892.
    • (1999) J. Virol. , vol.73 , pp. 2886-2892
    • Zufferey, R.1    Donello, J.E.2    Trono, D.3    Hope, T.J.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.