Cardamonin is a bifunctional vasodilator that inhibits Cav1.2 current and stimulates KCa1.1 current in rat tail artery myocytes

Journal of Pharmacology and Experimental Therapeutics

Volumn 332, Issue 2, 2010, Pages 531-540

  Fusi, Fabio ^a   Cavalli, Maurizio ^b   Mulholland, Dulcie ^c,d   Crouch, Neil ^d,e   Coombes, Phil ^d   Dawson, Gill ^d   Bova, Sergio ^b   Sgaragli, Giampietro ^a   Saponara, Simona ^a  

^a UNIVERSITY OF SIENA   (Italy)

^b UNIVERSITY OF PADOVA   (Italy)

^c UNIVERSITY OF SURREY   (United Kingdom)

^d UNIVERSITY OF KWAZULU NATAL   (South Africa)

^e SOUTH AFRICAN NATIONAL BIODIVERSITY INSTITUTE   (South Africa)

Author keywords

[No Author keywords available]

Indexed keywords

2',4' DIHYDROXY 6 METHOXYCHALCONE; CARDAMONIN; CHALCONE DERIVATIVE; IBERIOTOXIN; UNCLASSIFIED DRUG; VASODILATOR AGENT; VOLTAGE GATED CALCIUM CHANNEL; VOLTAGE GATED POTASSIUM CHANNEL;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; CELL ISOLATION; CONCENTRATION RESPONSE; DRUG STRUCTURE; ELECTRIC POTENTIAL; HYPERTENSION; KINETICS; MALE; MUSCLE CELL; NONHUMAN; PATCH CLAMP; PRIORITY JOURNAL; RAT; SMOOTH MUSCLE FIBER; SPRAGUE DAWLEY RAT; STIMULATION; TAIL ARTERY; WHOLE CELL;

ANIMALS; ARTERIES; CALCIUM; CALCIUM CHANNELS, L-TYPE; CHALCONES; LARGE-CONDUCTANCE CALCIUM-ACTIVATED POTASSIUM CHANNEL ALPHA SUBUNITS; MALE; MEMBRANE POTENTIALS; MUSCLE CONTRACTION; MUSCLE RELAXATION; MYOCYTES, SMOOTH MUSCLE; RATS; RATS, SPRAGUE-DAWLEY; TAIL; VASODILATOR AGENTS;

EID: 76749118898     PISSN: 00223565     EISSN: 15210103     Source Type: Journal    
DOI: 10.1124/jpet.109.161265     Document Type: Article

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