Merkel cell polyomavirus-positive merkel cell carcinoma cells do not require expression of the viral small T antigen

Journal of Investigative Dermatology

Volumn 133, Issue 8, 2013, Pages 2059-2064

  Angermeyer, Sabrina ^a   Hesbacher, Sonja ^a   Becker, Jürgen C ^b   Schrama, David ^b   Houben, Roland ^a  

^a UNIVERSITY HOSPITAL WÜRZBURG   (Germany)

^b MEDICAL UNIVERSITY OF GRAZ   (Austria)

Author keywords

[No Author keywords available]

Indexed keywords

SHORT HAIRPIN RNA; VIRUS SMALL T ANTIGEN;

ANTIGEN EXPRESSION; ARTICLE; CANCER CELL CULTURE; CARCINOMA CELL; CELL GROWTH; CELL PROLIFERATION; CELL SURVIVAL; CONTROLLED STUDY; FIBROBLAST; GROWTH INHIBITION; GROWTH RETARDATION; MERKEL CELL; MERKEL CELL POLYOMAVIRUS; MERKEL CELL TUMOR; NONHUMAN; OBSERVATIONAL STUDY; PRIORITY JOURNAL; PROTEIN EXPRESSION; VIRUS EXPRESSION;

EID: 84880331638     PISSN: 0022202X     EISSN: 15231747     Source Type: Journal    
DOI: 10.1038/jid.2013.82     Document Type: Article

References (30)

1. Ali SH, DeCaprio JA (2001) Cellular transformation by SV40 large T antigen: interaction with host proteins. Semin Cancer Biol 11:15-23
2. Becker JC (2010) Merkel cell carcinoma. Ann Oncol 21:vii81-5
3. Becker JC, Houben R, Ugurel S et al. (2009a) MC polyomavirus is frequently present in Merkel cell carcinoma of European patients. J Invest Dermatol 129:248-50
4. Becker JC, Schrama D, Houben R (2009b) Merkel cell carcinoma. Cell Mol Life Sci 66:1-8
5. Boccardo E, Lepique AP, Villa LL (2010) The role of inflammation in HPV carcinogenesis. Carcinogenesis 31:1905-12
6. Feng H, Shuda M, Chang Y et al. (2008) Clonal integration of a polyomavirus in human Merkel cell carcinoma. Science 319:1096-100 (Pubitemid 351300792)
7. Garneski KM, Warcola AH, Feng Q et al. (2009) Merkel cell polyomavirus is more frequently present in North American than Australian Merkel cell carcinoma tumors. J Invest Dermatol 129:246-8
8. Gillis S, Watson J (1980) Biochemical and biological characterization of lymphocyte regulatory molecules. V. Identification of an interleukin 2-producing human leukemia T cell line. J Exp Med 152:1709-19 (Pubitemid 11210348)
9. Hahn WC, Dessain SK, Brooks MW et al. (2002) Enumeration of the simian virus 40 early region elements necessary for human cell transformation. Mol Cell Biol 22:2111-23 (Pubitemid 34224619)
10. Hodgson NC (2005) Merkel cell carcinoma: changing incidence trends. J Surg Oncol 89:1-4 (Pubitemid 40075960)
11. Houben R, Adam C, Baeurle A et al. (2012) An intact retinoblastoma proteinbinding site in Merkel cell polyomavirus large T antigen is required for promoting growth of Merkel cell carcinoma cells. Int J Cancer 130: 847-56
12. Houben R, Becker JC, Kappel A et al. (2004) Constitutive activation of the Ras-Raf signaling pathway in metastatic melanoma is associated with poor prognosis. J Carcinog 3:6
13. Houben R, Shuda M, Weinkam R et al. (2010) Merkel cell polyomavirusinfected Merkel cell carcinoma cells require expression of viral T antigens. J Virol 84:7064-72
14. Jackson AL, Burchard J, Schelter J et al. (2006) Widespread siRNA "off-target" transcript silencing mediated by seed region sequence complementarity. RNA 12:1179-87 (Pubitemid 43990543)
15. Kassem A, Schopflin A, Diaz C et al. (2008) Frequent detection of Merkel cell polyomavirus in human Merkel cell carcinomas and identification of a unique deletion in the VP1 gene. Cancer Res 68:5009-13
16. Leonard JH, Dash P, Holland P et al. (1995) Characterisation of four Merkel cell carcinoma adherent cell lines. Int J Cancer 60:100-7
17. Madkan VK, Cook-Norris RH, Steadman MC et al. (2007) The oncogenic potential of human papillomaviruses: a review on the role of host genetics and environmental cofactors. Br J Dermatol 157:228-41 (Pubitemid 47083833)
18. Martel-Jantin C, Filippone C, Cassar O et al. (2012) Genetic variability and integration of Merkel cell polyomavirus in Merkel cell carcinoma. Virology 426:134-42
19. Matsushita M, Kuwamoto S, Iwasaki T et al. (2012) Detection of Merkel Cell Polyomavirus in the human tissues from 41 Japanese autopsy cases using polymerase chain reaction. Intervirology 56:1-5
20. Mesri EA, Cesarman E, Boshoff C (2010) Kaposi's sarcoma and its associated herpesvirus. Nat Rev Cancer 10:707-19
21. Pastrana DV, Tolstov YL, Becker JC et al. (2009) Quantitation of human seroresponsiveness to merkel cell polyomavirus. PLoS Pathog 5: e1000578
22. Rodig SJ, Cheng J, Wardzala J et al. (2012) Improved detection suggests all Merkel cell carcinomas harbor Merkel polyomavirus. J Clin Invest 122:4645-53
23. Rosen ST, Gould VE, Salwen HR et al. (1987) Establishment and characterization of a neuroendocrine skin carcinoma cell line. Lab Invest 56: 302-12 (Pubitemid 17065350)
24. Schmitt M, Wieland U, Kreuter A et al. (2012) C-terminal deletions of Merkel cell polyomavirus large T-antigen, a highly specific surrogate marker for virally induced malignancy. Int J Cancer 131:2863-8
25. Schowalter RM, Reinhold WC, Buck CB (2012) Entry tropism of BK and Merkel Cell Polyomaviruses in cell culture. PLoS One 7:e42181
26. Shuda M, Arora R, Kwun HJ et al. (2009) Human Merkel cell polyomavirus infection I. MCV T antigen expression in Merkel cell carcinoma, lymphoid tissues and lymphoid tumors. Int J Cancer 125:1243-9
27. Shuda M, Feng H, Kwun HJ et al. (2008) T antigen mutations are a human tumor-specific signature for Merkel cell polyomavirus. Proc Natl Acad Sci USA 105:16272-7
28. Shuda M, Kwun HJ, Feng H et al. (2011) Human Merkel cell polyomavirus small T antigen is an oncoprotein targeting the 4E-BP1 translation regulator. J Clin Invest 121:3623-34
29. Van Gele M, Leonard JH, Van RN et al. (2002) Combined karyotyping, CGH and M-FISH analysis allows detailed characterization of unidentified chromosomal rearrangements in Merkel cell carcinoma. Int J Cancer 101:137-45 (Pubitemid 34970905)
30. Verhaegen M, Bauer JA, Martin de la Vega C et al. (2006) A novel BH3 mimetic reveals a mitogen-activated protein kinase-dependent mechanism of melanoma cell death controlled by p53 and reactive oxygen species. Cancer Res 66:11348-59 (Pubitemid 46009966)