Comparative impacts of knockouts of two antioxidant enzymes on acetaminophen-induced hepatotoxicity in mice

Experimental Biology and Medicine

Volumn 234, Issue 12, 2009, Pages 1477-1483

  Zhu, Jian Hong ^a   McClung, James P ^a   Zhang, Xiaomei ^a   Aregullin, Manuel ^a   Chen, Chi ^b   Gonzalez, Frank J ^b   Kim, Tae Wan ^a   Lei, Xin Gen ^a  

^a 252 Morrison Hall ^*  (United States)

^b NATIONAL CANCER INSTITUTE   (United States)

Author keywords

Acetaminophen; Cu,Zn superoxide dismutase; Glutathione peroxidase; Oxidative stress; Protein nitration; Toxicity

Indexed keywords

ALANINE AMINOTRANSFERASE; COPPER ZINC SUPEROXIDE DISMUTASE; GLUTATHIONE; GLUTATHIONE PEROXIDASE 1; NITRATE; NITRITE; PARACETAMOL; PARACETAMOL CYSTEINE; PARACETAMOL DERIVATIVE; PARACETAMOL GLUCURONIDE; PARACETAMOL N ACETYLCYSTEINE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ARTICLE; COMPARATIVE STUDY; CONTROLLED STUDY; DISEASE PREDISPOSITION; DRUG URINE LEVEL; ENZYME ACTIVITY; ENZYME INACTIVATION; KNOCKOUT MOUSE; LIVER TOXICITY; MALE; MOUSE; NONHUMAN;

ACETAMINOPHEN; ANALGESICS, NON-NARCOTIC; ANIMALS; ANTIOXIDANTS; DRUG-INDUCED LIVER INJURY; GLUTATHIONE PEROXIDASE; MICE; MICE, KNOCKOUT; NITRATES; NITRITES; SUPEROXIDE DISMUTASE; TRANSAMINASES;

MURINAE; MUS;

EID: 72449207657     PISSN: 15353702     EISSN: 15353699     Source Type: Journal    
DOI: 10.3181/0904-RM-142     Document Type: Article

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