-
1
-
-
24944460598
-
Shelterin: The protein complex that shapes and safeguards human telomeres
-
de Lange, T. Shelterin: the protein complex that shapes and safeguards human telomeres. Genes Dev. 19, 2100-2110 (2005).
-
(2005)
Genes Dev.
, vol.19
, pp. 2100-2110
-
-
De Lange, T.1
-
2
-
-
10944240539
-
Telosome, a mammalian telomere-associated complex formed by multiple telomeric proteins
-
Liu, D., O'Connor, M. S., Qin, J. & Songyang, Z. Telosome, a mammalian telomere-associated complex formed by multiple telomeric proteins. J. Biol. Chem. 279, 51338-51342 (2004).
-
(2004)
J. Biol. Chem.
, vol.279
, pp. 51338-51342
-
-
Liu, D.1
O'Connor, M.S.2
Qin, J.3
Songyang, Z.4
-
3
-
-
46249125488
-
How shelterin protects Mammalian telomeres
-
Palm, W. & de Lange, T. How shelterin protects Mammalian telomeres. Annu. Rev. Genet. 42, 301-334 (2008).
-
(2008)
Annu. Rev. Genet.
, vol.42
, pp. 301-334
-
-
Palm, W.1
De Lange, T.2
-
4
-
-
0347723876
-
Importance of TRF1 for functional telomere structure
-
Iwano, T., Tachibana, M., Reth, M. & Shinkai, Y. Importance of TRF1 for functional telomere structure. J. Biol. Chem. 279, 1442-1448 (2004).
-
(2004)
J. Biol. Chem.
, vol.279
, pp. 1442-1448
-
-
Iwano, T.1
Tachibana, M.2
Reth, M.3
Shinkai, Y.4
-
5
-
-
69749092744
-
Increased telomere fragility and fusions resulting from TRF1 deficiency lead to degenerative pathologies and increased cancer in mice
-
Martinez, P. et al. Increased telomere fragility and fusions resulting from TRF1 deficiency lead to degenerative pathologies and increased cancer in mice. Genes Dev. 23, 2060-2075 (2009).
-
(2009)
Genes Dev.
, vol.23
, pp. 2060-2075
-
-
Martinez, P.1
-
6
-
-
68949198783
-
TERRA RNA binding to TRF2 facilitates heterochromatin formation and ORC recruitment at telomeres
-
Deng, Z., Norseen, J., Wiedmer, A., Riethman, H. & Lieberman, P. M. TERRA RNA binding to TRF2 facilitates heterochromatin formation and ORC recruitment at telomeres. Mol. Cell 35, 403-413 (2009).
-
(2009)
Mol. Cell
, vol.35
, pp. 403-413
-
-
Deng, Z.1
Norseen, J.2
Wiedmer, A.3
Riethman, H.4
Lieberman, P.M.5
-
7
-
-
7044232011
-
Homologous recombination generates T-loop-sized deletions at human telomeres
-
Wang, R. C., Smogorzewska, A. & de Lange, T. Homologous recombination generates T-loop-sized deletions at human telomeres. Cell 119, 355-368 (2004).
-
(2004)
Cell
, vol.119
, pp. 355-368
-
-
Wang, R.C.1
Smogorzewska, A.2
De Lange, T.3
-
8
-
-
67649635974
-
Mammalian telomeres resemble fragile sites and require TRF1 for efficient replication
-
Sfeir, A. et al. Mammalian telomeres resemble fragile sites and require TRF1 for efficient replication. Cell 138, 90-103 (2009).
-
(2009)
Cell
, vol.138
, pp. 90-103
-
-
Sfeir, A.1
-
9
-
-
70249132548
-
Arginine methylation regulates telomere length and stability
-
Mitchell, T. R., Glenfield, K., Jeyanthan, K. & Zhu, X. D. Arginine methylation regulates telomere length and stability. Mol. Cell. Biol. 29, 4918-4934 (2009).
-
(2009)
Mol. Cell. Biol.
, vol.29
, pp. 4918-4934
-
-
Mitchell, T.R.1
Glenfield, K.2
Jeyanthan, K.3
Zhu, X.D.4
-
10
-
-
0032489012
-
TRF2 protects human telomeres from end-to-end fusions
-
van Steensel, B., Smogorzewska, A. & de Lange, T. TRF2 protects human telomeres from end-to-end fusions. Cell 92, 401-413 (1998).
-
(1998)
Cell
, vol.92
, pp. 401-413
-
-
Van Steensel, B.1
Smogorzewska, A.2
De Lange, T.3
-
11
-
-
22144490491
-
DNA processing is not required for ATM-mediated telomere damage response after TRF2 deletion
-
Celli, G. B. & de Lange, T. DNA processing is not required for ATM-mediated telomere damage response after TRF2 deletion. Nat. Cell. Biol. 7, 712-718 (2005).
-
(2005)
Nat. Cell. Biol.
, vol.7
, pp. 712-718
-
-
Celli, G.B.1
De Lange, T.2
-
12
-
-
0042420304
-
DNA damage foci at dysfunctional telomeres
-
Takai, H., Smogorzewska, A. & de Lange, T. DNA damage foci at dysfunctional telomeres. Curr. Biol. 13, 1549-1556 (2003).
-
(2003)
Curr. Biol.
, vol.13
, pp. 1549-1556
-
-
Takai, H.1
Smogorzewska, A.2
De Lange, T.3
-
13
-
-
0029586089
-
A human telomeric protein
-
Chong, L. et al. A human telomeric protein. Science 270, 1663-1667 (1995).
-
(1995)
Science
, vol.270
, pp. 1663-1667
-
-
Chong, L.1
-
14
-
-
0041689966
-
Targeted deletion reveals an essential function for the telomere length regulator Trf1
-
Karlseder, J. et al. Targeted deletion reveals an essential function for the telomere length regulator Trf1. Mol. Cell. Biol. 23, 6533-6541 (2003).
-
(2003)
Mol. Cell. Biol.
, vol.23
, pp. 6533-6541
-
-
Karlseder, J.1
-
15
-
-
0031027618
-
Control of telomere length by the human telomeric protein TRF1 [see comments]
-
van Steensel, B. & de Lange, T. Control of telomere length by the human telomeric protein TRF1 [see comments]. Nature 385, 740-743 (1997).
-
(1997)
Nature
, vol.385
, pp. 740-743
-
-
Van Steensel, B.1
De Lange, T.2
-
16
-
-
0033961281
-
Control of human telomere length by TRF1 and TRF2
-
Smogorzewska, A. et al. Control of human telomere length by TRF1 and TRF2. Mol. Cell Biol. 20, 1659-1668 (2000).
-
(2000)
Mol. Cell Biol.
, vol.20
, pp. 1659-1668
-
-
Smogorzewska, A.1
-
17
-
-
0036241994
-
Targeting assay to study the cis functions of human telomeric proteins: Evidence for inhibition of telomerase by TRF1 and for activation of telomere degradation by TRF2
-
Ancelin, K. et al. Targeting assay to study the cis functions of human telomeric proteins: evidence for inhibition of telomerase by TRF1 and for activation of telomere degradation by TRF2. Mol. Cell Biol. 22, 3474-3487 (2002).
-
(2002)
Mol. Cell Biol.
, vol.22
, pp. 3474-3487
-
-
Ancelin, K.1
-
18
-
-
36549030804
-
Protein requirements for sister telomere association in human cells
-
Canudas, S. et al. Protein requirements for sister telomere association in human cells. EMBO J. 26, 4867-4878 (2007).
-
(2007)
EMBO J.
, vol.26
, pp. 4867-4878
-
-
Canudas, S.1
-
19
-
-
0036766023
-
Replication and/or separation of some human telomeres is delayed beyond S-phase in pre-senescent cells
-
Ofir, R. et al. Replication and/or separation of some human telomeres is delayed beyond S-phase in pre-senescent cells. Chromosoma 111, 147-155 (2002).
-
(2002)
Chromosoma
, vol.111
, pp. 147-155
-
-
Ofir, R.1
-
20
-
-
2942580948
-
Sister chromatid separation at human telomeric regions
-
Yalon, M., Gal, S., Segev, Y., Selig, S. & Skorecki, K. L. Sister chromatid separation at human telomeric regions. J. Cell Sci. 117, 1961-1970 (2004).
-
(2004)
J. Cell Sci.
, vol.117
, pp. 1961-1970
-
-
Yalon, M.1
Gal, S.2
Segev, Y.3
Selig, S.4
Skorecki, K.L.5
-
21
-
-
1842424729
-
Resolution of sister telomere association is required for progression through mitosis
-
Dynek, J. N. & Smith, S. Resolution of sister telomere association is required for progression through mitosis. Science 304, 97-100 (2004).
-
(2004)
Science
, vol.304
, pp. 97-100
-
-
Dynek, J.N.1
Smith, S.2
-
22
-
-
0032553473
-
Tankyrase, a poly(ADP-ribose) polymerase at human telomeres
-
see comments
-
Smith, S., Giriat, I., Schmitt, A. & de Lange, T. Tankyrase, a poly(ADP-ribose) polymerase at human telomeres (see comments). Science 282, 1484-1487 (1998).
-
(1998)
Science
, vol.282
, pp. 1484-1487
-
-
Smith, S.1
Giriat, I.2
Schmitt, A.3
De Lange, T.4
-
23
-
-
0037610123
-
TRF1 is degraded by ubiquitin-mediated proteolysis after release from telomeres
-
Chang, W., Dynek, J. N. & Smith, S. TRF1 is degraded by ubiquitin-mediated proteolysis after release from telomeres. Genes Dev. 17, 1328-1333 (2003).
-
(2003)
Genes Dev.
, vol.17
, pp. 1328-1333
-
-
Chang, W.1
Dynek, J.N.2
Smith, S.3
-
24
-
-
33644855565
-
The F-box protein FBX4 targets PIN2/TRF1 for ubiquitin-mediated degradation and regulates telomere maintenance
-
Lee, T. H., Perrem, K., Harper, J. W., Lu, K. P. & Zhou, X. Z. The F-box protein FBX4 targets PIN2/TRF1 for ubiquitin-mediated degradation and regulates telomere maintenance. J. Biol. Chem. 281, 759-768 (2006).
-
(2006)
J. Biol. Chem.
, vol.281
, pp. 759-768
-
-
Lee, T.H.1
Perrem, K.2
Harper, J.W.3
Lu, K.P.4
Zhou, X.Z.5
-
25
-
-
70449731229
-
Differential regulation of telomere and centromere cohesion by the Scc3 homologues SA1 and SA2, respectively, in human cells
-
Canudas, S. & Smith, S. Differential regulation of telomere and centromere cohesion by the Scc3 homologues SA1 and SA2, respectively, in human cells. J. Cell Biol. 187, 165-173 (2009).
-
(2009)
J. Cell Biol.
, vol.187
, pp. 165-173
-
-
Canudas, S.1
Smith, S.2
-
26
-
-
0033695002
-
Control of mitosis by changes in the subcellular location of cyclin-B1-Cdk1 and Cdc25C
-
Takizawa, C. G. & Morgan, D. O. Control of mitosis by changes in the subcellular location of cyclin-B1-Cdk1 and Cdc25C. Curr. Opin. Cell Biol. 12, 658-665 (2000).
-
(2000)
Curr. Opin. Cell Biol.
, vol.12
, pp. 658-665
-
-
Takizawa, C.G.1
Morgan, D.O.2
-
27
-
-
65349102972
-
The decision to enter mitosis: Feedback and redundancy in the mitotic entry network
-
Lindqvist, A., Rodriguez-Bravo, V. & Medema, R. H. The decision to enter mitosis: feedback and redundancy in the mitotic entry network. J. Cell Biol. 185, 193-202 (2009).
-
(2009)
J. Cell Biol.
, vol.185
, pp. 193-202
-
-
Lindqvist, A.1
Rodriguez-Bravo, V.2
Medema, R.H.3
-
28
-
-
0342561644
-
Cell-cycle-regulated association of RAD50/MRE11/NBS1 with TRF2 and human telomeres
-
Zhu, X. D., Kuster, B., Mann, M., Petrini, J. H. & Lange, T. Cell-cycle-regulated association of RAD50/MRE11/NBS1 with TRF2 and human telomeres. Nat. Genet. 25, 347-352 (2000).
-
(2000)
Nat. Genet.
, vol.25
, pp. 347-352
-
-
Zhu, X.D.1
Kuster, B.2
Mann, M.3
Petrini, J.H.4
Lange, T.5
-
29
-
-
54449087207
-
Plk1 phosphorylation of TRF1 is essential for its binding to telomeres
-
Wu, Z. Q., Yang, X., Weber, G. & Liu, X. Plk1 phosphorylation of TRF1 is essential for its binding to telomeres. J. Biol. Chem. 283, 25503-25513 (2008).
-
(2008)
J. Biol. Chem.
, vol.283
, pp. 25503-25513
-
-
Wu, Z.Q.1
Yang, X.2
Weber, G.3
Liu, X.4
-
30
-
-
0034847376
-
Structure of the TRFH dimerization domain of the human telomeric proteins TRF1 and TRF2
-
Fairall, L., Chapman, L., Moss, H., de Lange, T. & Rhodes, D. Structure of the TRFH dimerization domain of the human telomeric proteins TRF1 and TRF2. Mol. Cell 8, 351-361 (2001).
-
(2001)
Mol. Cell
, vol.8
, pp. 351-361
-
-
Fairall, L.1
Chapman, L.2
Moss, H.3
De Lange, T.4
Rhodes, D.5
-
31
-
-
2642535870
-
TIN2 is a tankyrase 1 PARP modulator in the TRF1 telomere length control complex
-
Ye, J. Z. & de Lange, T. TIN2 is a tankyrase 1 PARP modulator in the TRF1 telomere length control complex. Nat. Genet. 36, 618-623 (2004).
-
(2004)
Nat. Genet.
, vol.36
, pp. 618-623
-
-
Ye, J.Z.1
De Lange, T.2
-
32
-
-
0036032778
-
Regulators of serine/threonine protein phosphatases at the dawn of a clinical era?
-
Honkanen, R. E. & Golden, T. Regulators of serine/threonine protein phosphatases at the dawn of a clinical era? Curr. Med. Chem. 9, 2055-2075 (2002).
-
(2002)
Curr. Med. Chem.
, vol.9
, pp. 2055-2075
-
-
Honkanen, R.E.1
Golden, T.2
-
33
-
-
77949486429
-
p53 Prevents entry into mitosis with uncapped telomeres
-
Thanasoula, M. et al. p53 Prevents entry into mitosis with uncapped telomeres. Curr. Biol. 20, 521-526 (2010).
-
(2010)
Curr. Biol.
, vol.20
, pp. 521-526
-
-
Thanasoula, M.1
-
34
-
-
2942587456
-
Dynamics of protein binding to telomeres in living cells: Implications for telomere structure and function
-
Mattern, K. A. et al. Dynamics of protein binding to telomeres in living cells: implications for telomere structure and function. Mol. Cell. Biol. 24, 5587-5594 (2004).
-
(2004)
Mol. Cell. Biol.
, vol.24
, pp. 5587-5594
-
-
Mattern, K.A.1
-
35
-
-
33846210498
-
XPF with mutations in its conserved nuclease domain is defective in DNA repair but functions in TRF2-mediated telomere shortening
-
Wu, Y., Zacal, N. J., Rainbow, A. J. & Zhu, X. D. XPF with mutations in its conserved nuclease domain is defective in DNA repair but functions in TRF2-mediated telomere shortening. DNA. Repair. (Amst) 6, 157-166 (2007).
-
(2007)
DNA. Repair. (Amst)
, vol.6
, pp. 157-166
-
-
Wu, Y.1
Zacal, N.J.2
Rainbow, A.J.3
Zhu, X.D.4
-
36
-
-
0033082686
-
Overcoming expression and purification problems of RhoGDI using a family of 'parallel' expression vectors
-
Sheffield, P., Garrard, S. & Derewenda, Z. Overcoming expression and purification problems of RhoGDI using a family of 'parallel' expression vectors. Protein Expr. Purif. 15, 34-39 (1999).
-
(1999)
Protein Expr. Purif.
, vol.15
, pp. 34-39
-
-
Sheffield, P.1
Garrard, S.2
Derewenda, Z.3
-
37
-
-
0037192462
-
Senescence induced by altered telomere state, not telomere loss
-
Karlseder, J., Smogorzewska, A. & de Lange, T. Senescence induced by altered telomere state, not telomere loss. Science 295, 2446-2449 (2002).
-
(2002)
Science
, vol.295
, pp. 2446-2449
-
-
Karlseder, J.1
Smogorzewska, A.2
De Lange, T.3
-
38
-
-
0347416975
-
ERCC1/XPF removes the 3′ overhang from uncapped telomeres and represses formation of telomeric DNA-containing double minute chromosomes
-
Zhu, X. D. et al. ERCC1/XPF removes the 3′ overhang from uncapped telomeres and represses formation of telomeric DNA-containing double minute chromosomes. Mol. Cell 12, 1489-1498 (2003).
-
(2003)
Mol. Cell
, vol.12
, pp. 1489-1498
-
-
Zhu, X.D.1
-
39
-
-
0038451396
-
POT1 as a terminal transducer of TRF1 telomere length control
-
Loayza, D. & De Lange, T. POT1 as a terminal transducer of TRF1 telomere length control. Nature 424, 1013-1018 (2003).
-
(2003)
Nature
, vol.424
, pp. 1013-1018
-
-
Loayza, D.1
De Lange, T.2
-
40
-
-
34548492016
-
MRE11-RAD50-NBS1 and ATM function as co-mediators of TRF1 in telomere length control
-
Wu, Y., Xiao, S. & Zhu, X. D. MRE11-RAD50-NBS1 and ATM function as co-mediators of TRF1 in telomere length control. Nat. Struct. Mol. Biol. 14, 832-840 (2007).
-
(2007)
Nat. Struct. Mol. Biol.
, vol.14
, pp. 832-840
-
-
Wu, Y.1
Xiao, S.2
Zhu, X.D.3
-
41
-
-
0029939848
-
Heterogeneity in telomere length of human chromosomes
-
Lansdorp, P. M. et al. Heterogeneity in telomere length of human chromosomes. Hum. Mol. Genet. 5, 685-691 (1996).
-
(1996)
Hum. Mol. Genet.
, vol.5
, pp. 685-691
-
-
Lansdorp, P.M.1
-
42
-
-
0030970087
-
TRF1 is a dimer and bends telomeric DNA
-
Bianchi, A., Smith, S., Chong, L., Elias, P. & de Lange, T. TRF1 is a dimer and bends telomeric DNA. EMBO J 16, 1785-1794 (1997).
-
(1997)
EMBO J
, vol.16
, pp. 1785-1794
-
-
Bianchi, A.1
Smith, S.2
Chong, L.3
Elias, P.4
De Lange, T.5
-
43
-
-
54249112218
-
Human XPF controls TRF2 and telomere length maintenance through distinctive mechanisms
-
Wu, Y., Mitchell, T. R. & Zhu, X. D. Human XPF controls TRF2 and telomere length maintenance through distinctive mechanisms. Mech. Ageing Dev. 129, 602-610 (2008).
-
(2008)
Mech. Ageing Dev.
, vol.129
, pp. 602-610
-
-
Wu, Y.1
Mitchell, T.R.2
Zhu, X.D.3
|