메뉴 건너뛰기




Volumn 8, Issue 7, 2013, Pages

Rupatadine Protects against Pulmonary Fibrosis by Attenuating PAF-Mediated Senescence in Rodents

Author keywords

[No Author keywords available]

Indexed keywords

[2 METHOXY 3 (N OCTADECYLCARBAMOYLOXY)PROPYL] (2 THIAZOLIOETHYL) PHOSPHATE; BLEOMYCIN; COLLAGEN; CYTOKINE; LORATADINE; PIRFENIDONE; PROTEIN P21; PROTEIN P53; RUPATADINE;

EID: 84880300767     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0068631     Document Type: Article
Times cited : (48)

References (51)
  • 1
    • 79960381007 scopus 로고    scopus 로고
    • Integrating mechanisms of pulmonary fibrosis
    • doi:10.1084/jem.20110551. PubMed: 21727191
    • Wynn TA, (2011) Integrating mechanisms of pulmonary fibrosis. J Exp Med 208: 1339-1350. doi:10.1084/jem.20110551. PubMed: 21727191.
    • (2011) J Exp Med , vol.208 , pp. 1339-1350
    • Wynn, T.A.1
  • 2
    • 84864740280 scopus 로고    scopus 로고
    • Pulmonary fibrosis: Patterns and perpetrators
    • doi:10.1172/JCI60323. PubMed: 22850886
    • Noble PW, Barkauskas CE, Jiang D, (2012) Pulmonary fibrosis: Patterns and perpetrators. J Clin Invest 122: 2756-2762. doi:10.1172/JCI60323. PubMed: 22850886.
    • (2012) J Clin Invest , vol.122 , pp. 2756-2762
    • Noble, P.W.1    Barkauskas, C.E.2    Jiang, D.3
  • 3
    • 75949130829 scopus 로고    scopus 로고
    • Strategies for treating idiopathic pulmonary fibrosis
    • doi:10.1038/nrd2958. PubMed: 20094055
    • du Bois RM, (2010) Strategies for treating idiopathic pulmonary fibrosis. Nat Rev Drug Discov 9: 129-140. doi:10.1038/nrd2958. PubMed: 20094055.
    • (2010) Nat Rev Drug Discov , vol.9 , pp. 129-140
    • du Bois, R.M.1
  • 4
    • 84865113809 scopus 로고    scopus 로고
    • New cellular and molecular mechanisms of lung injury and fibrosis in idiopathic pulmonary fibrosis
    • doi:10.1016/S0140-6736(12)61144-1. PubMed: 22901889
    • Fernandez IE, Eickelberg O, (2012) New cellular and molecular mechanisms of lung injury and fibrosis in idiopathic pulmonary fibrosis. Lancet 380: 680-688. doi:10.1016/S0140-6736(12)61144-1. PubMed: 22901889.
    • (2012) Lancet , vol.380 , pp. 680-688
    • Fernandez, I.E.1    Eickelberg, O.2
  • 5
    • 59849084848 scopus 로고    scopus 로고
    • Targeting TLR2 attenuates pulmonary inflammation and fibrosis by reversion of suppressive immune microenvironment
    • PubMed: 19109203
    • Yang HZ, Cui B, Liu HZ, Chen ZR, Yan HM, et al. (2009) Targeting TLR2 attenuates pulmonary inflammation and fibrosis by reversion of suppressive immune microenvironment. J Immunol 182: 692-702. PubMed: 19109203.
    • (2009) J Immunol , vol.182 , pp. 692-702
    • Yang, H.Z.1    Cui, B.2    Liu, H.Z.3    Chen, Z.R.4    Yan, H.M.5
  • 6
    • 77952525647 scopus 로고    scopus 로고
    • Nrf2 protects against pulmonary fibrosis by regulating the lung oxidant level and th1/th2 balance
    • doi:10.1186/1465-9921-11-31. PubMed: 20298567
    • Kikuchi N, Ishii Y, Morishima Y, Yageta Y, Haraguchi N, et al. (2010) Nrf2 protects against pulmonary fibrosis by regulating the lung oxidant level and th1/th2 balance. Respir Res 11: 31. doi:10.1186/1465-9921-11-31. PubMed: 20298567.
    • (2010) Respir Res , vol.11 , pp. 31
    • Kikuchi, N.1    Ishii, Y.2    Morishima, Y.3    Yageta, Y.4    Haraguchi, N.5
  • 7
    • 80053070208 scopus 로고    scopus 로고
    • Blocking IL-17A promotes the resolution of pulmonary inflammation and fibrosis via TGF-beta1-dependent and -independent mechanisms
    • doi:10.4049/jimmunol.1004081. PubMed: 21841134
    • Mi S, Li Z, Yang HZ, Liu H, Wang JP, et al. (2011) Blocking IL-17A promotes the resolution of pulmonary inflammation and fibrosis via TGF-beta1-dependent and-independent mechanisms. J Immunol 187: 3003-3014. doi:10.4049/jimmunol.1004081. PubMed: 21841134.
    • (2011) J Immunol , vol.187 , pp. 3003-3014
    • Mi, S.1    Li, Z.2    Yang, H.Z.3    Liu, H.4    Wang, J.P.5
  • 8
    • 67449083692 scopus 로고    scopus 로고
    • Global impairment of CD4+ CD25+FOXP3+ regulatory T cells in idiopathic pulmonary fibrosis
    • doi:10.1164/rccm.200812-1936OC. PubMed: 19342412
    • Kotsianidis I, Nakou E, Bouchliou I, Tzouvelekis A, Spanoudakis E, et al. (2009) Global impairment of CD4+ CD25+FOXP3+ regulatory T cells in idiopathic pulmonary fibrosis. Am J Respir Crit Care Med 179: 1121-1130. doi:10.1164/rccm.200812-1936OC. PubMed: 19342412.
    • (2009) Am J Respir Crit Care Med , vol.179 , pp. 1121-1130
    • Kotsianidis, I.1    Nakou, E.2    Bouchliou, I.3    Tzouvelekis, A.4    Spanoudakis, E.5
  • 9
    • 67349086910 scopus 로고    scopus 로고
    • Th1/Th2 balance in concomitant immediate and delayed-type hypersensitivity diseases
    • doi:10.1016/j.imlet.2009.04.011. PubMed: 19433108
    • de Mello LM, Bechara MI, Solé D, Rodrigues V, (2009) Th1/Th2 balance in concomitant immediate and delayed-type hypersensitivity diseases. Immunol Lett 124: 88-94. doi:10.1016/j.imlet.2009.04.011. PubMed: 19433108.
    • (2009) Immunol Lett , vol.124 , pp. 88-94
    • de Mello, L.M.1    Bechara, M.I.2    Solé, D.3    Rodrigues, V.4
  • 10
    • 39449133957 scopus 로고    scopus 로고
    • A mechanism for the initiation of allergen-induced T helper type 2 responses
    • doi:10.1038/ni1558. PubMed: 18300366
    • Sokol CL, Barton GM, Farr AG, Medzhitov R, (2008) A mechanism for the initiation of allergen-induced T helper type 2 responses. Nat Immunol 9: 310-318. doi:10.1038/ni1558. PubMed: 18300366.
    • (2008) Nat Immunol , vol.9 , pp. 310-318
    • Sokol, C.L.1    Barton, G.M.2    Farr, A.G.3    Medzhitov, R.4
  • 11
    • 56349118794 scopus 로고    scopus 로고
    • The IL-17 cytokine family and their role in allergic inflammation
    • doi:10.1016/j.coi.2008.09.004. PubMed: 18832032
    • Wang YH, Liu YJ, (2008) The IL-17 cytokine family and their role in allergic inflammation. Curr Opin Immunol 20: 697-702. doi:10.1016/j.coi.2008.09.004. PubMed: 18832032.
    • (2008) Curr Opin Immunol , vol.20 , pp. 697-702
    • Wang, Y.H.1    Liu, Y.J.2
  • 12
    • 84865774852 scopus 로고    scopus 로고
    • Mast cell activation and degranulation promotes renal fibrosis in experimental unilateral ureteric obstruction
    • doi:10.1038/ki.2012.211. PubMed: 22673890
    • Summers SA, Gan PY, Dewage L, Ma FT, Ooi JD, et al. (2012) Mast cell activation and degranulation promotes renal fibrosis in experimental unilateral ureteric obstruction. Kidney Int 82: 676-685. doi:10.1038/ki.2012.211. PubMed: 22673890.
    • (2012) Kidney Int , vol.82 , pp. 676-685
    • Summers, S.A.1    Gan, P.Y.2    Dewage, L.3    Ma, F.T.4    Ooi, J.D.5
  • 13
    • 77949659552 scopus 로고    scopus 로고
    • Histamine stimulates human lung fibroblast migration
    • doi:10.1007/s11010-009-0287-y. PubMed: 19851834
    • Kohyama T, Yamauchi Y, Takizawa H, Kamitani S, Kawasaki S, et al. (2010) Histamine stimulates human lung fibroblast migration. Mol Cell Biochem 337: 77-81. doi:10.1007/s11010-009-0287-y. PubMed: 19851834.
    • (2010) Mol Cell Biochem , vol.337 , pp. 77-81
    • Kohyama, T.1    Yamauchi, Y.2    Takizawa, H.3    Kamitani, S.4    Kawasaki, S.5
  • 14
    • 0037246364 scopus 로고    scopus 로고
    • Roles of cysteinyl leukotrienes in airway inflammation, smooth muscle function, and remodeling
    • doi:10.1067/mai.2003.25. PubMed: 12532084
    • Holgate ST, Peters-Golden M, Panettieri RA, Henderson WR Jr, (2003) Roles of cysteinyl leukotrienes in airway inflammation, smooth muscle function, and remodeling. J Allergy Clin Immunol 111: S18-S36. doi:10.1067/mai.2003.25. PubMed: 12532084.
    • (2003) J Allergy Clin Immunol , vol.111
    • Holgate, S.T.1    Peters-Golden, M.2    Panettieri, R.A.3    Henderson Jr., W.R.4
  • 15
    • 75749141625 scopus 로고    scopus 로고
    • Chymase mediates paraquat-induced collagen production in human lung fibroblasts
    • doi:10.1016/j.toxlet.2009.12.001. PubMed: 19969051
    • Lang YD, Chang SF, Wang LF, Chen CM, (2010) Chymase mediates paraquat-induced collagen production in human lung fibroblasts. Toxicol Lett 193: 19-25. doi:10.1016/j.toxlet.2009.12.001. PubMed: 19969051.
    • (2010) Toxicol Lett , vol.193 , pp. 19-25
    • Lang, Y.D.1    Chang, S.F.2    Wang, L.F.3    Chen, C.M.4
  • 16
    • 78650524720 scopus 로고    scopus 로고
    • Rupatadine for the treatment of allergic rhinitis and urticaria
    • doi:10.1586/eci.10.85. PubMed: 21162645
    • Metz M, Maurer M, (2011) Rupatadine for the treatment of allergic rhinitis and urticaria. Expert Rev Clin Immunol 7: 15-20. doi:10.1586/eci.10.85. PubMed: 21162645.
    • (2011) Expert Rev Clin Immunol , vol.7 , pp. 15-20
    • Metz, M.1    Maurer, M.2
  • 17
    • 33749353525 scopus 로고    scopus 로고
    • Rupatadine: Pharmacological profile and its use in the treatment of allergic disorders
    • doi:10.1517/14656566.7.14.1989. PubMed: 17020424
    • Picado C, (2006) Rupatadine: Pharmacological profile and its use in the treatment of allergic disorders. Expert Opin Pharmacother 7: 1989-2001. doi:10.1517/14656566.7.14.1989. PubMed: 17020424.
    • (2006) Expert Opin Pharmacother , vol.7 , pp. 1989-2001
    • Picado, C.1
  • 18
    • 59349099345 scopus 로고    scopus 로고
    • Mast cells and gastrointestinal dysmotility in the cystic fibrosis mouse
    • doi:10.1371/journal.pone.0004283. PubMed: 19172182
    • De Lisle RC, Meldi L, Roach E, Flynn M, Sewell R, (2009) Mast cells and gastrointestinal dysmotility in the cystic fibrosis mouse. PLOS ONE 4: e4283. doi:10.1371/journal.pone.0004283. PubMed: 19172182.
    • (2009) PLOS ONE , vol.4
    • De Lisle, R.C.1    Meldi, L.2    Roach, E.3    Flynn, M.4    Sewell, R.5
  • 19
    • 0029881336 scopus 로고    scopus 로고
    • A simplified method for the analysis of hydroxyproline in biological tissues
    • doi:10.1016/0009-9120(96)00003-6. PubMed: 8740508
    • Reddy GK, Enwemeka CS, (1996) A simplified method for the analysis of hydroxyproline in biological tissues. Clin Biochem 29: 225-229. doi:10.1016/0009-9120(96)00003-6. PubMed: 8740508.
    • (1996) Clin Biochem , vol.29 , pp. 225-229
    • Reddy, G.K.1    Enwemeka, C.S.2
  • 20
    • 77954682669 scopus 로고    scopus 로고
    • Differential polarization of alveolar macrophages and bone marrow-derived monocytes following chemically and pathogen-induced chronic lung inflammation
    • doi:10.1189/jlb.0609378. PubMed: 20360403
    • Redente EF, Higgins DM, Dwyer-Nield LD, Orme IM, Gonzalez-Juarrero M, et al. (2010) Differential polarization of alveolar macrophages and bone marrow-derived monocytes following chemically and pathogen-induced chronic lung inflammation. J Leukoc Biol 88: 159-168. doi:10.1189/jlb.0609378. PubMed: 20360403.
    • (2010) J Leukoc Biol , vol.88 , pp. 159-168
    • Redente, E.F.1    Higgins, D.M.2    Dwyer-Nield, L.D.3    Orme, I.M.4    Gonzalez-Juarrero, M.5
  • 21
    • 84864057839 scopus 로고    scopus 로고
    • Bleomycin induced lung fibrosis increases work of breathing in the mouse
    • doi:10.1016/j.pupt.2011.10.001. PubMed: 22024054
    • Phillips JE, Peng R, Burns L, Harris P, Garrido R, et al. (2012) Bleomycin induced lung fibrosis increases work of breathing in the mouse. Pulm Pharmacol Ther 25: 281-285. doi:10.1016/j.pupt.2011.10.001. PubMed: 22024054.
    • (2012) Pulm Pharmacol Ther , vol.25 , pp. 281-285
    • Phillips, J.E.1    Peng, R.2    Burns, L.3    Harris, P.4    Garrido, R.5
  • 22
    • 80355149079 scopus 로고    scopus 로고
    • Monitoring tumor metastases and osteolytic lesions with bioluminescence and micro CT imaging
    • PubMed: 21525842
    • Lim E, Modi K, Christensen A, Meganck J, Oldfield S, et al. (2011) Monitoring tumor metastases and osteolytic lesions with bioluminescence and micro CT imaging. J Vis Exp: pp. e2775. PubMed: 21525842.
    • (2011) J Vis Exp
    • Lim, E.1    Modi, K.2    Christensen, A.3    Meganck, J.4    Oldfield, S.5
  • 23
    • 34447309766 scopus 로고    scopus 로고
    • The myofibroblast: One function, multiple origins
    • doi:10.2353/ajpath.2007.070112. PubMed: 17525249
    • Hinz B, Phan SH, Thannickal VJ, Galli A, Bochaton-Piallat ML, et al. (2007) The myofibroblast: One function, multiple origins. Am J Pathol 170: 1807-1816. doi:10.2353/ajpath.2007.070112. PubMed: 17525249.
    • (2007) Am J Pathol , vol.170 , pp. 1807-1816
    • Hinz, B.1    Phan, S.H.2    Thannickal, V.J.3    Galli, A.4    Bochaton-Piallat, M.L.5
  • 24
    • 33244463813 scopus 로고    scopus 로고
    • Complex networks orchestrate epithelial-mesenchymal transitions
    • doi:10.1038/nrm1835. PubMed: 16493418
    • Thiery JP, Sleeman JP, (2006) Complex networks orchestrate epithelial-mesenchymal transitions. Nat Rev Mol Cell Biol 7: 131-142. doi:10.1038/nrm1835. PubMed: 16493418.
    • (2006) Nat Rev Mol Cell Biol , vol.7 , pp. 131-142
    • Thiery, J.P.1    Sleeman, J.P.2
  • 25
    • 80052613002 scopus 로고    scopus 로고
    • Pirfenidone: In idiopathic pulmonary fibrosis
    • doi:10.2165/11207710-000000000-00000. PubMed: 21902295
    • Carter NJ, (2011) Pirfenidone: In idiopathic pulmonary fibrosis. Drugs 71: 1721-1732. doi:10.2165/11207710-000000000-00000. PubMed: 21902295.
    • (2011) Drugs , vol.71 , pp. 1721-1732
    • Carter, N.J.1
  • 26
    • 68349097382 scopus 로고    scopus 로고
    • Rupatadine inhibits proinflammatory mediator secretion from human mast cells triggered by different stimuli
    • doi:10.1159/000232569. PubMed: 19672095
    • Vasiadi M, Kalogeromitros D, Kempuraj D, Clemons A, Zhang B, et al. (2010) Rupatadine inhibits proinflammatory mediator secretion from human mast cells triggered by different stimuli. Int Arc Allergy Immunol 151: 38-45. doi:10.1159/000232569. PubMed: 19672095.
    • (2010) Int Arc Allergy Immunol , vol.151 , pp. 38-45
    • Vasiadi, M.1    Kalogeromitros, D.2    Kempuraj, D.3    Clemons, A.4    Zhang, B.5
  • 27
    • 49449109723 scopus 로고    scopus 로고
    • The mouse mast cell-restricted tetramer-forming tryptases mouse mast cell protease 6 and mouse mast cell protease 7 are critical mediators in inflammatory arthritis
    • doi:10.1002/art.23639. PubMed: 18668540
    • McNeil HP, Shin K, Campbell IK, Wicks IP, Adachi R, et al. (2008) The mouse mast cell-restricted tetramer-forming tryptases mouse mast cell protease 6 and mouse mast cell protease 7 are critical mediators in inflammatory arthritis. Arthritis Rheum 58: 2338-2346. doi:10.1002/art.23639. PubMed: 18668540.
    • (2008) Arthritis Rheum , vol.58 , pp. 2338-2346
    • McNeil, H.P.1    Shin, K.2    Campbell, I.K.3    Wicks, I.P.4    Adachi, R.5
  • 28
    • 79952754822 scopus 로고    scopus 로고
    • M2 polarized macrophages and giant cells contribute to myofibrosis in neuromuscular sarcoidosis
    • doi:10.1016/j.ajpath.2010.11.065. PubMed: 21356378
    • Prokop S, Heppner FL, Goebel HH, Stenzel W, (2011) M2 polarized macrophages and giant cells contribute to myofibrosis in neuromuscular sarcoidosis. Am J Pathol 178: 1279-1286. doi:10.1016/j.ajpath.2010.11.065. PubMed: 21356378.
    • (2011) Am J Pathol , vol.178 , pp. 1279-1286
    • Prokop, S.1    Heppner, F.L.2    Goebel, H.H.3    Stenzel, W.4
  • 29
    • 84864507857 scopus 로고    scopus 로고
    • Pathogenic mycobacterium bovis strains differ in their ability to modulate the proinflammatory activation phenotype of macrophages
    • doi:10.1186/1471-2180-12-166. PubMed: 22863292
    • Andrade MR, Amaral EP, Ribeiro SC, Almeida FM, Peres TV, et al. (2012) Pathogenic mycobacterium bovis strains differ in their ability to modulate the proinflammatory activation phenotype of macrophages. BMC Microbiol 12: 166. doi:10.1186/1471-2180-12-166. PubMed: 22863292.
    • (2012) BMC Microbiol , vol.12 , pp. 166
    • Andrade, M.R.1    Amaral, E.P.2    Ribeiro, S.C.3    Almeida, F.M.4    Peres, T.V.5
  • 30
    • 34548173504 scopus 로고    scopus 로고
    • TGF-beta, Smad3 and the process of progressive fibrosis
    • doi:10.1042/BST0350661. PubMed: 17635115
    • Gauldie J, Bonniaud P, Sime P, Ask K, Kolb M, (2007) TGF-beta, Smad3 and the process of progressive fibrosis. Biochem Soc Trans 035: 661-664. doi:10.1042/BST0350661. PubMed: 17635115.
    • (2007) Biochem Soc Trans , vol.35 , pp. 661-664
    • Gauldie, J.1    Bonniaud, P.2    Sime, P.3    Ask, K.4    Kolb, M.5
  • 31
    • 84863799096 scopus 로고    scopus 로고
    • Caveolin-1 deficiency protects from pulmonary fibrosis by modulating epithelial cell senescence in mice
    • doi:10.1165/rcmb.2011-0349OC. PubMed: 22362388
    • Shivshankar P, Brampton C, Miyasato S, Kasper M, Thannickal VJ, et al. (2012) Caveolin-1 deficiency protects from pulmonary fibrosis by modulating epithelial cell senescence in mice. Am J Respir Cell Mol Biol 47: 28-36. doi:10.1165/rcmb.2011-0349OC. PubMed: 22362388.
    • (2012) Am J Respir Cell Mol Biol , vol.47 , pp. 28-36
    • Shivshankar, P.1    Brampton, C.2    Miyasato, S.3    Kasper, M.4    Thannickal, V.J.5
  • 32
    • 44649120132 scopus 로고    scopus 로고
    • Chemokine signaling via the CXCR2 receptor reinforces senescence
    • doi:10.1016/j.cell.2008.03.038. PubMed: 18555777
    • Acosta JC, O'Loghlen A, Banito A, Guijarro MV, Augert A, et al. (2008) Chemokine signaling via the CXCR2 receptor reinforces senescence. Cell 133: 1006-1018. doi:10.1016/j.cell.2008.03.038. PubMed: 18555777.
    • (2008) Cell , vol.133 , pp. 1006-1018
    • Acosta, J.C.1    O'Loghlen, A.2    Banito, A.3    Guijarro, M.V.4    Augert, A.5
  • 33
    • 80052303130 scopus 로고    scopus 로고
    • Autophagy and aging
    • doi:10.1016/j.cell.2011.07.030. PubMed: 21884931
    • Rubinsztein DC, Mariño G, Kroemer G, (2011) Autophagy and aging. Cell 146: 682-695. doi:10.1016/j.cell.2011.07.030. PubMed: 21884931.
    • (2011) Cell , vol.146 , pp. 682-695
    • Rubinsztein, D.C.1    Mariño, G.2    Kroemer, G.3
  • 35
    • 77949881221 scopus 로고    scopus 로고
    • The senescence-associated secretory phenotype: The dark side of tumor suppression
    • doi:10.1146/annurev-pathol-121808-102144. PubMed: 20078217
    • Coppé JP, Desprez PY, Krtolica A, Campisi J, (2010) The senescence-associated secretory phenotype: The dark side of tumor suppression. Annu Rev Pathol 5: 99-118. doi:10.1146/annurev-pathol-121808-102144. PubMed: 20078217.
    • (2010) Annu Rev Pathol , vol.5 , pp. 99-118
    • Coppé, J.P.1    Desprez, P.Y.2    Krtolica, A.3    Campisi, J.4
  • 36
    • 67650502393 scopus 로고    scopus 로고
    • Th9 and allergic disease
    • doi:10.1111/j.1365-2567.2009.03114.x. PubMed: 19604299
    • Soroosh P, Doherty TA, (2009) Th9 and allergic disease. Immunology 127: 450-458. doi:10.1111/j.1365-2567.2009.03114.x. PubMed: 19604299.
    • (2009) Immunology , vol.127 , pp. 450-458
    • Soroosh, P.1    Doherty, T.A.2
  • 37
    • 84863094021 scopus 로고    scopus 로고
    • Immunophenotyping of circulating T helper cells argues for multiple functions and plasticity of T cells in vivo in humans--possible role in asthma
    • doi:10.1371/journal.pone.0040012. PubMed: 22768198
    • Malmhäll C, Bossios A, Rådinger M, Sjöstrand M, Lu Y, Lundbäck B, et al. (2012) Immunophenotyping of circulating T helper cells argues for multiple functions and plasticity of T cells in vivo in humans--possible role in asthma. PLOS ONE 7: e40012. doi:10.1371/journal.pone.0040012. PubMed: 22768198.
    • (2012) PLOS ONE , vol.7
    • Malmhäll, C.1    Bossios, A.2    Rådinger, M.3    Sjöstrand, M.4    Lu, Y.5    Lundbäck, B.6
  • 38
    • 0022503826 scopus 로고
    • Analysis of bronchoalveolar lavage fluid from bleomycin-induced pulmonary fibrosis in hamsters
    • doi:10.1177/019262338601400202. PubMed: 2429361
    • Giri SN, Hyde DM, Nakashima JM, (1986) Analysis of bronchoalveolar lavage fluid from bleomycin-induced pulmonary fibrosis in hamsters. Toxicol Pathol 14: 149-157. doi:10.1177/019262338601400202. PubMed: 2429361.
    • (1986) Toxicol Pathol , vol.14 , pp. 149-157
    • Giri, S.N.1    Hyde, D.M.2    Nakashima, J.M.3
  • 39
    • 66849093867 scopus 로고    scopus 로고
    • Histamine H1-receptor antagonists with immunomodulating activities: Potential use for modulating T helper type1 (Th1)/Th2 cytokine imbalance and inflammatory responses in allergic diseases
    • doi:10.1111/j.1365-2249.2009.03958.x. PubMed: 19659767
    • Okamoto T, Iwata S, Ohnuma K, Dang NH, Morimoto C, (2009) Histamine H1-receptor antagonists with immunomodulating activities: Potential use for modulating T helper type1 (Th1)/Th2 cytokine imbalance and inflammatory responses in allergic diseases. Clin Exp Immunol 157: 27-34. doi:10.1111/j.1365-2249.2009.03958.x. PubMed: 19659767.
    • (2009) Clin Exp Immunol , vol.157 , pp. 27-34
    • Okamoto, T.1    Iwata, S.2    Ohnuma, K.3    Dang, N.H.4    Morimoto, C.5
  • 40
    • 0028939649 scopus 로고
    • Amelioration of bleomycin-induced lung fibrosis by treatment with the platelet activating factor receptor antagonist WEB 2086 in hamsters
    • doi:10.3109/01902149509068833. PubMed: 7539741
    • Giri SN, Sharma AK, Hyde DM, Wild JS, (1995) Amelioration of bleomycin-induced lung fibrosis by treatment with the platelet activating factor receptor antagonist WEB 2086 in hamsters. Exp Lung Res 21: 287-307. doi:10.3109/01902149509068833. PubMed: 7539741.
    • (1995) Exp Lung Res , vol.21 , pp. 287-307
    • Giri, S.N.1    Sharma, A.K.2    Hyde, D.M.3    Wild, J.S.4
  • 41
    • 79951912532 scopus 로고    scopus 로고
    • Four faces of cellular senescence
    • doi:10.1083/jcb.201009094. PubMed: 21321098
    • Rodier F, Campisi J, (2011) Four faces of cellular senescence. J Cell Biol 192: 547-556. doi:10.1083/jcb.201009094. PubMed: 21321098.
    • (2011) J Cell Biol , vol.192 , pp. 547-556
    • Rodier, F.1    Campisi, J.2
  • 42
    • 49749145668 scopus 로고    scopus 로고
    • Senescence of activated stellate cells limits liver fibrosis
    • doi:10.1016/j.cell.2008.06.049. PubMed: 18724938
    • Krizhanovsky V, Yon M, Dickins RA, Hearn S, Simon J, et al. (2008) Senescence of activated stellate cells limits liver fibrosis. Cell 134: 657-667. doi:10.1016/j.cell.2008.06.049. PubMed: 18724938.
    • (2008) Cell , vol.134 , pp. 657-667
    • Krizhanovsky, V.1    Yon, M.2    Dickins, R.A.3    Hearn, S.4    Simon, J.5
  • 43
    • 77953812712 scopus 로고    scopus 로고
    • Alveolar cell senescence exacerbates pulmonary inflammation in patients with chronic obstructive pulmonary disease
    • doi:10.1159/000268287. PubMed: 20016134
    • Tsuji T, Aoshiba K, Nagai A, (2010) Alveolar cell senescence exacerbates pulmonary inflammation in patients with chronic obstructive pulmonary disease. Respiration 80: 59-70. doi:10.1159/000268287. PubMed: 20016134.
    • (2010) Respiration , vol.80 , pp. 59-70
    • Tsuji, T.1    Aoshiba, K.2    Nagai, A.3
  • 44
    • 34548238224 scopus 로고    scopus 로고
    • Downregulation of caveolin-1 affects bleomycin-induced growth arrest and cellular senescence in A549 cells
    • doi:10.1016/j.biocel.2007.05.018. PubMed: 17662641
    • Linge A, Weinhold K, Bläsche R, Kasper M, Barth K, (2007) Downregulation of caveolin-1 affects bleomycin-induced growth arrest and cellular senescence in A549 cells. Int J Biochem Cell Biol 39: 1964-1974. doi:10.1016/j.biocel.2007.05.018. PubMed: 17662641.
    • (2007) Int J Biochem Cell Biol , vol.39 , pp. 1964-1974
    • Linge, A.1    Weinhold, K.2    Bläsche, R.3    Kasper, M.4    Barth, K.5
  • 45
    • 70350125106 scopus 로고    scopus 로고
    • Cell surface-bound IL-1alpha is an upstream regulator of the senescence-associated IL-6/IL-8 cytokine network
    • doi:10.1073/pnas.0905299106. PubMed: 19805069
    • Orjalo AV, Bhaumik D, Gengler BK, Scott GK, Campisi J, (2009) Cell surface-bound IL-1alpha is an upstream regulator of the senescence-associated IL-6/IL-8 cytokine network. Proc Natl Acad Sci U S A 106: 17031-17036. doi:10.1073/pnas.0905299106. PubMed: 19805069.
    • (2009) Proc Natl Acad Sci U S A , vol.106 , pp. 17031-17036
    • Orjalo, A.V.1    Bhaumik, D.2    Gengler, B.K.3    Scott, G.K.4    Campisi, J.5
  • 46
    • 78751672975 scopus 로고    scopus 로고
    • Autophagy in immunity and inflammation
    • doi:10.1038/nature09782. PubMed: 21248839
    • Levine B, Mizushima N, Virgin HW, (2011) Autophagy in immunity and inflammation. Nature 469: 323-335. doi:10.1038/nature09782. PubMed: 21248839.
    • (2011) Nature , vol.469 , pp. 323-335
    • Levine, B.1    Mizushima, N.2    Virgin, H.W.3
  • 47
    • 84871916713 scopus 로고    scopus 로고
    • Insufficient autophagy promotes bronchial epithelial cell senescence in chronic obstructive pulmonary disease
    • doi:10.4161/onci.20297. PubMed: 22934255
    • Fujii S, Hara H, Araya J, Takasaka N, Kojima J, et al. (2012) Insufficient autophagy promotes bronchial epithelial cell senescence in chronic obstructive pulmonary disease. OncoImmunology 1: 630-641. doi:10.4161/onci.20297. PubMed: 22934255.
    • (2012) OncoImmunology , vol.1 , pp. 630-641
    • Fujii, S.1    Hara, H.2    Araya, J.3    Takasaka, N.4    Kojima, J.5
  • 48
    • 83455230751 scopus 로고    scopus 로고
    • Tlr4 activity is required in the resolution of pulmonary inflammation and fibrosis after acute and chronic lung injury
    • doi:10.1016/j.ajpath.2011.09.019. PubMed: 22062220
    • Yang HZ, Wang JP, Mi S, Liu HZ, Cui B, et al. (2012) Tlr4 activity is required in the resolution of pulmonary inflammation and fibrosis after acute and chronic lung injury. Am J Pathol 180: 275-292. doi:10.1016/j.ajpath.2011.09.019. PubMed: 22062220.
    • (2012) Am J Pathol , vol.180 , pp. 275-292
    • Yang, H.Z.1    Wang, J.P.2    Mi, S.3    Liu, H.Z.4    Cui, B.5
  • 49
    • 84877336464 scopus 로고    scopus 로고
    • Interleukin 17A inhibits autophagy through activation of PIK3CA to interrupt the GSK3B-mediated degradation of BCL2 in lung epithelial cells
    • PubMed: 23514933
    • Liu H, Mi S, Li Z, Hua F, Hu ZW, (2013) Interleukin 17A inhibits autophagy through activation of PIK3CA to interrupt the GSK3B-mediated degradation of BCL2 in lung epithelial cells. Autophagy 5: 730-742. PubMed: 23514933.
    • (2013) Autophagy , vol.5 , pp. 730-742
    • Liu, H.1    Mi, S.2    Li, Z.3    Hua, F.4    Hu, Z.W.5
  • 50
    • 66549109929 scopus 로고    scopus 로고
    • Pharmacological profile, efficacy and safety of rupatadine in allergic rhinitis
    • PubMed: 18695846
    • Katiyar S, Prakash S, (2009) Pharmacological profile, efficacy and safety of rupatadine in allergic rhinitis. Prim Care Respir J 18: 57-68. PubMed: 18695846.
    • (2009) Prim Care Respir J , vol.18 , pp. 57-68
    • Katiyar, S.1    Prakash, S.2
  • 51
    • 77949388473 scopus 로고    scopus 로고
    • No cardiac effects of therapeutic and supratherapeutic doses of rupatadine: Results from a 'thorough QT/QTc study' performed according to ICH guidelines
    • 10.1111/j.1365-2125.2009.03599.x
    • Donado E, Izquierdo I, Pérez I, García O, Antonijoan RM, et al. (2010) No cardiac effects of therapeutic and supratherapeutic doses of rupatadine: Results from a 'thorough QT/QTc study' performed according to ICH guidelines. Br J Clin Pharmacol 69: 401-410. doi:10.1111/j.1365-2125.2009.03599.x. PubMed: 20406224.
    • (2010) Br J Clin Pharmacol , vol.69 , pp. 401-410
    • Donado, E.1    Izquierdo, I.2    Pérez, I.3    García, O.4    Antonijoan, R.M.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.