Osteoblast extracellular Ca2+-sensing receptor regulates bone development, mineralization, and turnover

Journal of Bone and Mineral Research

Volumn 26, Issue 12, 2011, Pages 2935-2947

  Dvorak Ewell, Melita M ^a,b   Chen, Tsui Hua ^a   Liang, Nathan ^a   Garvey, Caitlin ^a   Liu, Betty ^a   Tu, Chialing ^a   Chang, Wenhan ^a   Bikle, Daniel D ^a   Shoback, Dolores M ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b BIOMARIN PHARMACEUTICAL INC   (United States)

Author keywords

BONE DEVELOPMENT; EXTRACELLULAR Ca2+ SENSING RECEPTOR; OSTEOBLAST DIFFERENTIATION; OSTEOBLASTS

Indexed keywords

ALANINE AMINOTRANSFERASE; ALBUMIN; ALKALINE PHOSPHATASE; ASPARTATE AMINOTRANSFERASE; CALCIUM; CALCIUM SENSING RECEPTOR; CHLORIDE; COLLAGEN TYPE 1; CREATININE; MAGNESIUM; MESSENGER RNA; OSTEOCALCIN; OSTEOCLAST DIFFERENTIATION FACTOR; PARATHYROID HORMONE; PHOSPHORUS; PROTEIN; SCLEROSTIN; SODIUM;

ALANINE AMINOTRANSFERASE BLOOD LEVEL; ALBUMIN BLOOD LEVEL; ALKALINE PHOSPHATASE BLOOD LEVEL; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; ASPARTATE AMINOTRANSFERASE BLOOD LEVEL; BONE DEVELOPMENT; BONE MINERALIZATION; BONE STRUCTURE; BONE TURNOVER; CALCIUM BLOOD LEVEL; CELL COUNT; CELL DIFFERENTIATION; CELLULAR DISTRIBUTION; CHLORIDE BLOOD LEVEL; COCULTURE; CONTROLLED STUDY; CREATININE BLOOD LEVEL; FEMALE; GENE EXPRESSION REGULATION; GENE INACTIVATION; GENE INDUCTION; GROWTH INHIBITION; HISTOPATHOLOGY; MAGNESIUM BLOOD LEVEL; MALE; MOUSE; NONHUMAN; OSTEOBLAST; OSTEOCLAST; OSTEOCLASTOGENESIS; PARATHYROID HORMONE BLOOD LEVEL; PHOSPHATE BLOOD LEVEL; PROTEIN BLOOD LEVEL; PROTEIN FUNCTION; SODIUM BLOOD LEVEL; ANIMAL; BONE REMODELING; CELL CULTURE; CELL SEPARATION; EXTRACELLULAR SPACE; FEMUR; GENE DELETION; GENETICS; GROWTH, DEVELOPMENT AND AGING; HUMERUS; METABOLISM; MICRO-COMPUTED TOMOGRAPHY; MOUSE MUTANT; ORGAN SIZE; PATHOLOGY; PHENOTYPE; PHYSIOLOGY; RADIOGRAPHY;

ANIMALS; BONE DEVELOPMENT; BONE REMODELING; CALCIFICATION, PHYSIOLOGIC; CELL COUNT; CELL DIFFERENTIATION; CELL SEPARATION; CELLS, CULTURED; EXTRACELLULAR SPACE; FEMUR; GENE DELETION; GENE EXPRESSION REGULATION, DEVELOPMENTAL; HUMERUS; MICE; MICE, KNOCKOUT; ORGAN SIZE; OSTEOBLASTS; OSTEOCLASTS; PHENOTYPE; RECEPTORS, CALCIUM-SENSING; X-RAY MICROTOMOGRAPHY;

EID: 81855196096     PISSN: 08840431     EISSN: 15234681     Source Type: Journal    
DOI: 10.1002/jbmr.520     Document Type: Article

References (39)

1. Dvorak MM, Riccardi D,. Ca2+ as an extracellular signal in bone. Cell Calcium. 2004; 35: 249-55.
2. Brown EM, MacLeod RJ,. Extracellular calcium sensing and extracellular calcium signaling. Physiol Rev. 2001; 81: 239-97. (Pubitemid 32096177)
3. Dvorak MM, Siddiqua A, Ward DT, Carter DH, Dallas SL, Nemeth EF, Riccardi D,. Physiological changes in extracellular calcium concentration directly control osteoblast function in the absence of calciotropic hormones. Proc Natl Acad Sci USA. 2004; 101: 5140-5. (Pubitemid 38469215)
4. Chang W, Tu C, Chen TH, Komuves L, Oda Y, Pratt SA, Miller S, Shoback D,. Expression and signal transduction of calcium-sensing receptors in cartilage and bone. Endocrinology. 1999; 140: 5883-93. (Pubitemid 30645377)
5. Yamaguchi T, Chattopadhyay N, Kifor O, Brown EM,. Extracellular calcium (Ca2+(o))-sensing receptor in a murine bone marrow-derived stromal cell line (ST2): potential mediator of the actions of Ca2+(o) on the function of ST2cells. Endocrinology. 1998; 139: 3561-8. (Pubitemid 28512314)
6. Yamaguchi T, Chattopadhyay N, Kifor O, Butters RR Jr, Sugimoto T, Brown EM,. Mouse osteoblastic cell line (MC3T3-E1) expresses extracellular calcium (Ca2+o)-sensing receptor and its agonists stimulate chemotaxis and proliferation of MC3T3-E1cells. J Bone Miner Res. 1998; 13: 1530-8. (Pubitemid 28465293)
7. Chattopadhyay N, Yano S, Tfelt-Hansen J, Rooney P, Kanuparthi D, Bandyopadhyay S, Ren X, Terwilliger E, Brown EM,. Mitogenic action of calcium-sensing receptor on rat calvarial osteoblasts. Endocrinology. 2004; 145: 3451-62. (Pubitemid 38830018)
8. Yamauchi M, Yamaguchi T, Kaji H, Sugimoto T, Chihara K,. Involvement of calcium-sensing receptor in osteoblastic differentiation of mouse MC3T3-E1cells. Am J Physiol Endocrinol Metab. 2005; 288: E608-16. (Pubitemid 40250557)
9. Tu Q, Pi M, Karsenty G, Simpson L, Liu S, Quarles LD,. Rescue of the skeletal phenotype in CasR-deficient mice by transfer onto the Gcm2 null background. J Clin Invest. 2003; 111: 1029-37. (Pubitemid 36397479)
10. Pi M, Hinson TK, Quarles L,. Failure to detect the extracellular calcium-sensing receptor (CasR) in human osteoblast cell lines. J Bone Miner Res. 1999; 14: 1310-9. (Pubitemid 29368293)
11. Pi M, Garner SC, Flannery P, Spurney RF, Quarles LD,. Sensing of extracellular cations in CasR-deficient osteoblasts. Evidence for a novel cation-sensing mechanism. J Biol Chem. 2000; 275: 3256-63. (Pubitemid 30083026)
12. Ho C, Conner DA, Pollak MR, Ladd DJ, Kifor O, Warren HB, Brown EM, Seidman JG, Seidman CE,. A mouse model of human familial hypocalciuric hypercalcemia and neonatal severe hyperparathyroidism. Nat Genet. 1995; 11: 389-94.
13. Garner SC, Pi M, Tu Q, Quarles LD,. Rickets in cation-sensing receptor-deficient mice: an unexpected skeletal phenotype. Endocrinology. 2001; 142: 3996-4005. (Pubitemid 32802673)
14. Oda Y, Tu CL, Pillai S, Bikle DD,. The calcium sensing receptor and its alternatively spliced form in keratinocyte differentiation. J Biol Chem. 1998; 273: 23344-52. (Pubitemid 28417522)
15. Rodriguez L, Tu C, Cheng Z, Chen TH, Bikle D, Shoback D, Chang W,. Expression and functional assessment of an alternatively spliced extracellular Ca2+-sensing receptor in growth plate chondrocytes. Endocrinology. 2005; 146: 5294-303. (Pubitemid 41653042)
16. Chang W, Tu C, Chen TH, Bikle D, Shoback D,. The extracellular calcium-sensing receptor (CaSR) is a critical modulator of skeletal development. Science Signal. 2008; 1: ra1.
17. Liu F, Woitge HW, Braut A, Kronenberg MS, Lichtler AC, Mina M, Kream BE,. Expression and activity of osteoblast-targeted Cre recombinase transgenes in murine skeletal tissues. Int J Dev Biol. 2004; 48: 645-53. (Pubitemid 39506707)
18. Jiang X, Kalajzic Z, Maye P, Braut A, Bellizzi J, Mina M, Rowe DW,. Histological analysis of GFP expression in murine bone. J Histochem Cytochem. 2005; 53: 593-602. (Pubitemid 40593972)
19. Chang W, Pratt S, Chen TH, Nemeth E, Huang Z, Shoback D,. Coupling of calcium receptors to inositol phosphate and cyclic AMP generation in mammalian cells and Xenopus laevis oocytes and immunodetection of receptor protein by region-specific antipeptide antisera. J Bone Miner Res. 1998; 13: 570-80. (Pubitemid 28163008)
20. Iwaniec UT, Yuan D, Power RA, Wronski TJ,. Strain-dependent variations in the response of cancellous bone to ovariectomy in mice. J Bone Miner Res. 2006; 21: 1068-74. (Pubitemid 43962835)
21. Kalajzic I, Kalajzic Z, Kaliterna M, Gronowicz G, Clark SH, Lichtler AC, Rowe D,. Use of type I collagen green fluorescent protein transgenes to identify subpopulations of cells at different stages of the osteoblast lineage. J Bone Miner Res. 2002; 17: 15-25. (Pubitemid 33150992)
22. Dvorak MM, De Joussineau C, Carter DH, Pisitkun T, Knepper MA, Gamba G, Kemp PJ, Riccardi D,. Thiazide diuretics directly induce osteoblast differentiation and mineralized nodule formation by interacting with a sodium chloride co-transporter in bone. J Am Soc Nephrol. 2007; 18: 2509-16. (Pubitemid 47378867)
23. Wang Y, Nishida S, Elalieh HZ, Long RK, Halloran BP, Bikle DD,. Role of IGF-I signaling in regulating osteoclastogenesis. J Bone Miner Res. 2006; 21: 1350-8. (Pubitemid 44300041)
24. Dvorak MM, Chen TH, Orwoll B, Garvey C, Chang W, Bikle DD, Shoback DM,. Constitutive activity of the osteoblast Ca2+-sensing receptor promotes loss of cancellous bone. Endocrinology. 2007; 148: 3156-63. (Pubitemid 46996999)
25. Fernandez NJ, Kidney BA,. Alkaline phosphatase: beyond the liver. Vet Clin Pathol. 2007; 36: 223-33. (Pubitemid 351761826)
26. Hessle L, Johnson KA, Anderson HC, Narisawa S, Sali A, Goding JW, Terkeltaub R, Millan JL,. Tissue-nonspecific alkaline phosphatase and plasma cell membrane glycoprotein-1 are central antagonistic regulators of bone mineralization. Proc Natl Acad Sci USA. 2002; 99: 9445-9. (Pubitemid 34764633)
27. Sakamoto M, Hosoda Y, Kojimahara K, Yamazaki T, Yoshimura Y,. Arthritis and ankylosis in twy mice with hereditary multiple osteochondral lesions: with special reference to calcium deposition. Pathol Int. 1994; 44: 420-7. (Pubitemid 24193675)
28. Ho AM, Johnson MD, Kingsley DM,. Role of the mouse ank gene in control of tissue calcification and arthritis. Science. 2000; 289: 265-70. (Pubitemid 30469899)
29. Harmey D, Hessle L, Narisawa S, Johnson KA, Terkeltaub R, Millan JL,. Concerted regulation of inorganic pyrophosphate and osteopontin by akp2, enpp1, and ank: an integrated model of the pathogenesis of mineralization disorders. Am J Pathol. 2004; 164: 1199-209. (Pubitemid 38387787)
30. Narisawa S, Frohlander N, Millan JL,. Inactivation of two mouse alkaline phosphatase genes and establishment of a model of infantile hypophosphatasia. Dev Dyn. 1997; 208: 432-46. (Pubitemid 27114295)
31. Kostenuik PJ,. Osteoprotegerin and RANKL regulate bone resorption, density, geometry and strength. Curr Opin Pharmacol. 2005; 5: 618-25. (Pubitemid 41614462)
32. Suda T, Nakamura I, Jimi E, Takahashi N,. Regulation of osteoclast function. J Bone Miner Res. 1997; 12: 869-79. (Pubitemid 27224995)
33. Kos CH, Karaplis AC, Peng JB, Hediger MA, Goltzman D, Mohammmad KS, Guise TA, Pollak MR,. The calcium-sensing receptor is required for normal calcium homeostasis independent of parathyroid hormone. J Clin Invest. 2003; 111: 1021-8. (Pubitemid 36397478)
34. Frisancho AR, Garn SM, Ascoli W,. Subperiosteal and endosteal bone apposition during adolescence. Hum Biol. 1970; 42: 639-64.
35. Giachelli CM, Steitz S,. Osteopontin: a versatile regulator of inflammation and biomineralization. Matrix Biol. 2000; 19: 615-22.
36. Boyce BF, Xing L,. Biology of RANK, RANKL, and osteoprotegerin. Arthritis Res Ther. 2007; 9 (Suppl 1): S1.
37. Fazzalari NL, Kuliwaba JS, Atkins GJ, Forwood MR, Findlay DM,. The ratio of messenger RNA levels of receptor activator of nuclear factor kappaB ligand to osteoprotegerin correlates with bone remodeling indices in normal human cancellous bone but not in osteoarthritis. J Bone Miner Res. 2001; 16: 1015-27. (Pubitemid 32467145)
38. Alford AI, Hankenson KD,. Matricellular proteins: extracellular modulators of bone development, remodeling, and regeneration. Bone. 2006; 38: 749-57. (Pubitemid 44498588)
39. Mentaverri R, Yano S, Chattopadhyay N, Petit L, Kifor O, Kamel S, Terwilliger EF, Brazier M, Brown EM,. The calcium sensing receptor is directly involved in both osteoclast differentiation and apoptosis. Faseb J. 2006; 20: 2562-4.