Calcium-sensing receptor and recovery from hypocalcaemia in thyroparathyroidectomized rats

European Journal of Clinical Investigation

Volumn 37, Issue 3, 2007, Pages 214-221

  Huan, J ^a   Martuseviciene, G ^a   Olgaard, K ^a   Lewin, E ^a,b  

^a UNIVERSITY OF COPENHAGEN   (Denmark)

^b University of Copenhagen   (Denmark)

Author keywords

Calcimimetics; CaR; EGTA; Gentamycin; Hypocalcaemia; R 568

Indexed keywords

CALCIUM DERIVATIVE; CALCIUM ION; CALCIUM SENSING RECEPTOR; EGTAZIC ACID; GENTAMICIN; R 568; UNCLASSIFIED DRUG;

ANALYTIC METHOD; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CALCIUM BLOOD LEVEL; CALCIUM CELL LEVEL; COMPARATIVE STUDY; CONTROLLED STUDY; HYPOCALCEMIA; INFUSION; MALE; NONHUMAN; PRIORITY JOURNAL; RAT; THYROPARATHYROIDECTOMY;

ANIMALS; ANTIDOTES; EGTAZIC ACID; GENTAMICINS; HYPOCALCEMIA; MALE; PARATHYROIDECTOMY; RATS; RATS, WISTAR; RECEPTORS, CALCIUM-SENSING; THYROIDECTOMY;

EID: 33847237325     PISSN: 00142972     EISSN: 13652362     Source Type: Journal    
DOI: 10.1111/j.1365-2362.2007.01770.x     Document Type: Article

References (51)

1. Bronner F, Stein WD. Modulation of bone calcium-binding sites regulates plasma calcium: a hypothesis. Calcif Tissue Int 1992;50:483-9.
2. Parfitt AM. Calcium Homeostasis. In: Born GVR, Cuatrecasas P, Herken H, Melmon K (eds). Handbook of Experimental Pharmacology. Berlin: Springer-Verlag;1993,pp. 1-65.
3. Parfitt AM. Misconceptions (3): calcium leaves bone only by resorption and enters only by formation. Bone 2003;33:259-63.
4. Lewin E, Wang W, Olgaard K. Rapid recovery of plasma ionized calcium after acute induction of hypocalcaemia in parathyroidectomized and nephrectomized rats. Nephrol Dial Transplant 1999;14:604-9.
5. 2+ homeostasis in the rat. Steroids 1999;64:726-34.
6. 2+ homeostasis in rats. Eur J Clin Invest 1999;29:309-20.
7. 2+ homeostasis in the rat. Eur J Clin Invest 2002;32:674-81.
8. 2+ and other ions as extracellular (first) messengers. Physiol Rev 1991;71:371-411.
9. 2+-sensing receptor from bovine parathyroid. Nature 1993;366:575-80.
10. 2+ on renal function? J Am Soc Nephrol 1995;6:1530-40.
11. Hebert SC, Brown EM. The extracellular calcium receptor. Curr Opin Cell Biol 1995;7:484-92.
12. Attie MF, Gill JR Jr, Stock JL, Spiegel AM, Downs RW Jr, Levine MA et al. Urinary calcium excretion in familial hypocalciuric hypercalcemia. Persistence of relative hypocalciuria after induction of hypoparathyroidism. J Clin Invest 1983;72:667-76.
13. Davies M, Adams PH, Lumb GA, Berry JL, Loveridge N. Familial hypocalciuric hypercalcaemia: evidence for continued enhanced renal tubular reabsorption of calcium following total parathyroidectomy. Acta Endocrinologica 1984;106:499-504.
14. 2+-sensing receptor mRNAs along the rat nephron. Am J Physiol 1997;272:F751-F758.
15. Parfitt A. Equilibrium and disequilibrium hypercalcemia. New lights on an old concept. Metab Bone Dis Relat Res 1979;1:279-93.
16. Fox J, Lowe SH, Petty BA, Nemeth EF. NPS R-568: a type II calcimimetic compound that acts on parathyroid cell calcium receptor of rats to reduce plasma levels of parathyroid hormone and calcium. J Pharmacol Exp Ther 1999;290:473-9.
17. McLarnon S, Holden D, Ward D, Jones M, Elliott A, Riccardi D. Aminoglycoside antibiotics induce pH-sensitive activation of the calcium-sensing receptor. Biochem Biophys Res Commun 2002;297:71-7.
18. Olgaard K, Lewin E. Prevention of uremic bone disease using calcimimetic compounds. Annu Rev Med 2001;52:203-20.
19. Nagano N. Pharmacological and clinical properties of calcimimetics: calcium receptor activators that afford an innovative approach to controlling hyperparathyroidism. Pharmacol Ther 2006;109:339-65.
20. Huan J, Olgaard K, Nielsen LB, Lewin E. Parathyroid hormone 7-84 induces hypocalcemia and inhibits the parathyroid hormone 1-84 secretory response to hypocalcemia in rats with intact parathyroid glands. J Am Soc Nephrol 2006;17:1923-30.
21. Bieglmayer C, Prager G, Niederle B. Kinetic analyses of parathyroid hormone clearance as measured by three rapid immunoassays during parathyroidectomy. Clin Chem 2002;48:1731-8.
22. Lewin E. Parathyroid hormone regulation in normal and uremic rats. Reversibility of secondary hyperparathyroidism after experimental kidney transplantation. Dan Med Bull 2004;51:184-206.
23. Quinn SJ, Bai M, Brown EM. pH Sensing by the calcium-sensing receptor. J Biol Chem 2004;279:37241-9.
24. Markowitz M, Rotkin L, Rosen JF. Circadian rhythms of blood minerals in humans. Science 1981;213:672-4.
25. Markowitz ME, Arnaud S, Rosen JF, Thorpy M, Laximinarayan S. Temporal interrelationships between the circadian rhythms of serum parathyroid hormone and calcium concentrations. J Clin Endocrinol Metab 1988;67:1068- 73.
26. Kurokawa K. The kidney and calcium homeostasis. Kidney Int, Suppl 1994;44:S97-S105.
27. Kurokawa K. How is plasma calcium held constant? Milieu interieur of calcium. Kidney Int 1996;49:1760-4.
28. Copp DH. Endocrine regulation of calcium metabolism. Annu Rev Physiol 1970;32:61-86.
29. Copp DH. The discovery of calcitonin. Bone Miner 1992;16:157-9.
30. Nordin BE, Peacock M. Role of kidney in regulation of plasma-calcium. Lancet 1969;2:1280-3.
31. Peacock M, Robertson WG, Nordin BE. Relation between serum and urinary calcium with particular reference to parathyroid activity. Lancet 1969;1:384-6.
32. Iida K, Taniguchi S, Kurokawa K. Distribution of 1,25-dihydroxyvitamin D3 receptor and 25-hydroxyvitamin D3-24-hydroxylase mRNA expression along rat nephron segments. Biochem Biophys Res Commun 1993;194:659-64.
33. Kumar R, Schaefer J, Grande JP, Roche PC. Immunolocalization of calcitriol receptor, 24-hydroxylase cytochrome P-450, and calbindin D28k in human kidney. Am J Physiol 1994;266:F477-F485.
34. Riccardi D, Lee WS, Lee K, Segre GV, Brown EM, Hebert SC. Localization of the extracellular Ca(2+)-sensing receptor and PTH/PTHrP receptor in rat kidney. Am J Physiol 1996;271:F951-F956.
35. Hemmingsen C, Staun M, Lewin E, Nielsen PK, Olgaard K. Effect of parathyroid hormone on renal calbindin-D28k. J Bone Miner Res 1996;11:1086-93.
36. 2+ as an extracellular signal in bone. Cell Calcium 2004;35:249-55.
37. Kanatani M, Sugimoto T, Fukase M, Fujita T. Effect of elevated extracellular calcium on the proliferation of osteoblastic MC3T3-E1 cells: its direct and indirect effects via monocytes. Biochem Biophys Res Commun 1991;181:1425-30.
38. Sugimoto T, Kanatani M, Kano J, Kaji H, Tsukamoto T, Yamaguchi T et al. Effects of high calcium concentration on the functions and interactions of osteoblastic cells and monocytes and on the formation of osteoclast-like cells. J Bone Miner Res 1993;8:1445-52.
39. Kanatani M, Sugimoto T, Kanzawa M, Yano S, Chihara K. High extracellular calcium inhibits osteoclast-like cell formation by directly acting on the calcium-sensing receptor existing in osteoclast precursor cells. Biochem Biophys Res Commun 1999;261:144-8.
40. Pi M, Garner SC, Flannery P, Spurney RF, Quarles LD. Sensing of extracellular cations in CasR-deficient osteoblasts. Evidence for a novel cation-sensing mechanism. J Biol Chem 2000;275:3256-63.
41. Dvorak MM, Siddiqua A, Ward DT, Carter DH, Dallas SL, Nemeth EF et al. Physiological changes in extracellular calcium concentration directly control osteoblast function in the absence of calciotropic hormones. Proc Natl Acad Sci U S A 2004;101:5140-5.
42. Shalhoub V, Grisanti M, Padagas J, Scully S, Rattan A, Qi M et al. In vitro studies with the calcimimetic, cinacalcet HCl, on normal human adult osteoblastic and osteoclastic cells. Crit Rev Eukaryot Gene Expr 2003;13:89-106.
43. Yamauchi M, Yamaguchi T, Kaji H, Sugimoto T, Chihara K. Involvement of calcium-sensing receptor in osteoblastic differentiation of mouse MC3T3-E1 cells. Am J Physiol Endocrinol Metab 2005;288:E608-E616.
44. 2+ on the function of ST2 cells. Endocrinology 1998;139:3561-8.
45. Zaidi M, Moonga BS, Huang CL. Calcium sensing and cell signalling processes in the local regulation of osteoclastic bone resorption. Biol Rev Camb Philos Soc 2004;79:79-100.
46. Chattopadhyay N, Yano S, Tfelt-Hansen J, Rooney P, Kanuparthi D, Bandyopadhyay S et al. Mitogenic action of calcium-sensing receptor on rat calvarial osteoblasts. Endocrinology 2004;145:3451-62.
47. Garner SC, Pi M, Tu Q, Quarles LD. Rickets in cation-sensing receptor-deficient mice: an unexpected skeletal phenotype. Endocrinology 2001;142:3996-4005.
48. Pi M, Quarles LD. Osteoblast calcium-sensing receptor has characteristics of ANF/7TM receptors. J Cell Biochem 2005;95:1081-92.
49. Pi M, Faber P, Ekema G, Jackson PD, Ting A, Wang N et al. Identification of a novel extracellular cation-sensing G-protein-coupled receptor. J Biol Chem 2005;280:40201-9.
50. Quarles LD. Cation sensing receptors in bone: a novel paradigm for regulating bone remodeling? J Bone Miner Res 1997;12:1971-4.
51. Rodan GA, Liberman UA, Paran M, Anbar M. Lack of physicochemical equilibrium between blood and bone calcium in isolated perfused dog limb. Isr J Med Sci 1967;3:702-13.