메뉴 건너뛰기




Volumn 63, Issue 3, 2013, Pages 263-271

Comprehensive assessment of HIV target cells in the distal human gut suggests increasing HIV susceptibility toward the anus

Author keywords

CCR5; Colon; Gut; HIV; Immunohistochemistry; Macrophages; Mucosa; Rectum; T cells

Indexed keywords

CD209 ANTIGEN; CD68 ANTIGEN; CHEMOKINE RECEPTOR CCR5;

EID: 84880249764     PISSN: 15254135     EISSN: 10779450     Source Type: Journal    
DOI: 10.1097/QAI.0b013e3182898392     Document Type: Article
Times cited : (56)

References (56)
  • 1
    • 44349159423 scopus 로고    scopus 로고
    • Setting the stage: Host invasion by HIV
    • Hladik F, McElrath MJ. Setting the stage: host invasion by HIV. Nat Rev Immunol. 2008;8:447-457.
    • (2008) Nat Rev Immunol. , vol.8 , pp. 447-457
    • Hladik, F.1    McElrath, M.J.2
  • 2
    • 0034253086 scopus 로고    scopus 로고
    • Anal sex among HIV-seronegative women at high risk of HIV exposure. The HIVNET Vaccine Preparedness Study 2 Protocol Team
    • Gross M, Holte SE, Marmor M, et al. Anal sex among HIV-seronegative women at high risk of HIV exposure. The HIVNET Vaccine Preparedness Study 2 Protocol Team. J Acquir Immune Defic Syndr. 2000;24: 393-398.
    • (2000) J Acquir Immune Defic Syndr. , vol.24 , pp. 393-398
    • Gross, M.1    Holte, S.E.2    Marmor, M.3
  • 3
    • 43549084574 scopus 로고    scopus 로고
    • Women's anal sex practices: Implications for formulation and promotion of a rectal micro-bicide
    • Exner TM, Correale J, Carballo-Dieguez A, et al. Women's anal sex practices: implications for formulation and promotion of a rectal micro-bicide, AIDS Educ Prev. 2008;20:148-159.
    • (2008) AIDS Educ Prev. , vol.20 , pp. 148-159
    • Exner, T.M.1    Correale, J.2    Carballo-Dieguez, A.3
  • 4
    • 33750087895 scopus 로고    scopus 로고
    • Anal and dry sex in commercial sex work, and relation to risk for sexually transmitted infections and HIV in Meru, Kenya
    • Schwandt M, Morris C, Ferguson A, et al. Anal and dry sex in commercial sex work, and relation to risk for sexually transmitted infections and HIV in Meru, Kenya. Sex Transm Infect. 2006;82:392-396.
    • (2006) Sex Transm Infect. , vol.82 , pp. 392-396
    • Schwandt, M.1    Morris, C.2    Ferguson, A.3
  • 5
    • 77953119008 scopus 로고    scopus 로고
    • Heterosexual anal intercourse has the potential to cause a significant loss of power in vaginal microbicide effectiveness studies
    • McGowan I, Taylor DJ. Heterosexual anal intercourse has the potential to cause a significant loss of power in vaginal microbicide effectiveness studies. Sex Transm Dis. 2010;37:361-364.
    • (2010) Sex Transm Dis. , vol.37 , pp. 361-364
    • McGowan, I.1    Taylor, D.J.2
  • 6
    • 77953942340 scopus 로고    scopus 로고
    • HIV transmission risk through anal intercourse: Systematic review, meta-analysis and implications for HIV prevention
    • Baggaley RF, White RG, Boily MC. HIV transmission risk through anal intercourse: systematic review, meta-analysis and implications for HIV prevention. Int J Epidemiol. 2010;39:1048-1063.
    • (2010) Int J Epidemiol. , vol.39 , pp. 1048-1063
    • Baggaley, R.F.1    White, R.G.2    Boily, M.C.3
  • 7
    • 70350348699 scopus 로고    scopus 로고
    • The role of heterosexual anal intercourse for HIV transmission in developing countries: Are we ready to draw conclusions?
    • Boily MC, Baggaley RF, Masse B. The role of heterosexual anal intercourse for HIV transmission in developing countries: are we ready to draw conclusions? Sex Transm Infect. 2009;85:408-410.
    • (2009) Sex Transm Infect. , vol.85 , pp. 408-410
    • Boily, M.C.1    Baggaley, R.F.2    Masse, B.3
  • 8
    • 79955831984 scopus 로고    scopus 로고
    • Rapid dissemination of SIV follows multisite entry after rectal inoculation
    • Ribeiro Dos Santos P, Rancez M, Pretet JL, et al. Rapid dissemination of SIV follows multisite entry after rectal inoculation. PLoS One. 2011;6:e19493.
    • (2011) PLoS One. , vol.6
    • Ribeiro Dos Santos, P.1    Rancez, M.2    Pretet, J.L.3
  • 9
    • 83655191970 scopus 로고    scopus 로고
    • Distribution of cell-free and cell-associated HIV surrogates in the colon after simulated receptive anal intercourse in men who have sex with men
    • Louissaint NA, Nimmagadda S, Fuchs EJ, et al. Distribution of cell-free and cell-associated HIV surrogates in the colon after simulated receptive anal intercourse in men who have sex with men. J Acquir Immune Defic Syndr. 2012;59:10-17.
    • (2012) J Acquir Immune Defic Syndr. , vol.59 , pp. 10-17
    • Louissaint, N.A.1    Nimmagadda, S.2    Fuchs, E.J.3
  • 10
    • 84857362834 scopus 로고    scopus 로고
    • Quality and quantity: Mucosal CD4+ T cells and HIV susceptibility
    • McKinnon LR, Kaul R. Quality and quantity: mucosal CD4+ T cells and HIV susceptibility. Curr Opin HIV AIDS. 2012;7:195-202.
    • (2012) Curr Opin HIV AIDS , vol.7 , pp. 195-202
    • McKinnon, L.R.1    Kaul, R.2
  • 11
    • 0032540418 scopus 로고    scopus 로고
    • Gastrointestinal tract as a major site of CD4+ T cell depletion and viral replication in SIV infection
    • Veazey RS, DeMaria M, Chalifoux LV, et al. Gastrointestinal tract as a major site of CD4+ T cell depletion and viral replication in SIV infection. Science. 1998;280:427-431.
    • (1998) Science. , vol.280 , pp. 427-431
    • Veazey, R.S.1    Demaria, M.2    Chalifoux, L.V.3
  • 12
    • 0031925896 scopus 로고    scopus 로고
    • Gastrointestinal T lymphocytes retain high potential for cytokine responses but have severe CD4(+) T-cell depletion at all stages of simian immunodeficiency virus infection compared to peripheral lymphocytes
    • Smit-McBride Z, Mattapallil JJ, McChesney M, et al. Gastrointestinal T lymphocytes retain high potential for cytokine responses but have severe CD4(+) T-cell depletion at all stages of simian immunodeficiency virus infection compared to peripheral lymphocytes. J Virol. 1998;72:6646-6656.
    • (1998) J Virol. , vol.72 , pp. 6646-6656
    • Smit-Mcbride, Z.1    Mattapallil, J.J.2    McChesney, M.3
  • 13
    • 4644289983 scopus 로고    scopus 로고
    • Primary HIV-1 infection is associated with preferential depletion of CD4+ T lymphocytes from effector sites in the gastrointestinal tract
    • Mehandru S, Poles MA, Tenner-Racz K, et al. Primary HIV-1 infection is associated with preferential depletion of CD4+ T lymphocytes from effector sites in the gastrointestinal tract. J Exp Med. 2004;200:761-770.
    • (2004) J Exp Med. , vol.200 , pp. 761-770
    • Mehandru, S.1    Poles, M.A.2    Tenner-Racz, K.3
  • 14
    • 17844374605 scopus 로고    scopus 로고
    • Massive infection and loss of memory CD4+ T cells in multiple tissues during acute SIV infection
    • Mattapallil JJ, Douek DC, Hill B, et al. Massive infection and loss of memory CD4+ T cells in multiple tissues during acute SIV infection, Nature. 2005;434:1093-1097.
    • (2005) Nature. , vol.434 , pp. 1093-1097
    • Mattapallil, J.J.1    Douek, D.C.2    Hill, B.3
  • 15
    • 0142092389 scopus 로고    scopus 로고
    • Severe CD4+ T-cell depletion in gut lymphoid tissue during primary human immunodeficiency virus type 1 infection and substantial delay in restoration following highly active antiretroviral therapy
    • Guadalupe M, Reay E, Sankaran S, et al. Severe CD4+ T-cell depletion in gut lymphoid tissue during primary human immunodeficiency virus type 1 infection and substantial delay in restoration following highly active antiretroviral therapy. J Virol. 2003;77:11708-11717.
    • (2003) J Virol. , vol.77 , pp. 11708-11717
    • Guadalupe, M.1    Reay, E.2    Sankaran, S.3
  • 16
    • 4644342929 scopus 로고    scopus 로고
    • CD4+ T cell depletion during all stages of HIV disease occurs predominantly in the gastrointestinal tract
    • Brenchley JM, Schacker TW, Ruff LE, et al. CD4+ T cell depletion during all stages of HIV disease occurs predominantly in the gastrointestinal tract. J Exp Med. 2004;200:749-759.
    • (2004) J Exp Med. , vol.200 , pp. 749-759
    • Brenchley, J.M.1    Schacker, T.W.2    Ruff, L.E.3
  • 17
    • 17844376742 scopus 로고    scopus 로고
    • Peak SIV replication in resting memory CD4+ T cells depletes gut lamina propria CD4+ T cells
    • Li Q, Duan L, Estes JD, et al. Peak SIV replication in resting memory CD4+ T cells depletes gut lamina propria CD4+ T cells. Nature. 2005; 434:1148-1152.
    • (2005) Nature. , vol.434 , pp. 1148-1152
    • Li, Q.1    Duan, L.2    Estes, J.D.3
  • 18
    • 33846034454 scopus 로고    scopus 로고
    • Mechanisms of gastrointestinal CD4+ T-cell depletion during acute and early human immunodeficiency virus type 1 infection
    • Mehandru S, Poles MA, Tenner-Racz K, et al. Mechanisms of gastrointestinal CD4+ T-cell depletion during acute and early human immunodeficiency virus type 1 infection. J Virol. 2007;81:599-612.
    • (2007) J Virol. , vol.81 , pp. 599-612
    • Mehandru, S.1    Poles, M.A.2    Tenner-Racz, K.3
  • 19
    • 0034888099 scopus 로고    scopus 로고
    • A preponderance of CCR5(+) CXCR4 (+) mononuclear cells enhances gastrointestinal mucosal susceptibility to human immunodeficiency virus type 1 infection
    • Poles MA, Elliott J, Taing P, et al. A preponderance of CCR5(+) CXCR4 (+) mononuclear cells enhances gastrointestinal mucosal susceptibility to human immunodeficiency virus type 1 infection. J Virol. 2001;75: 8390-8399.
    • (2001) J Virol. , vol.75 , pp. 8390-8399
    • Poles, M.A.1    Elliott, J.2    Taing, P.3
  • 20
    • 0033827042 scopus 로고    scopus 로고
    • Enhanced levels of functional HIV-1 co-receptors on human mucosal T cells demonstrated using intestinal biopsy tissue
    • Anton PA, Elliott J, Poles MA, et al. Enhanced levels of functional HIV-1 co-receptors on human mucosal T cells demonstrated using intestinal biopsy tissue. AIDS. 2000;14:1761-1765.
    • (2000) AIDS , vol.14 , pp. 1761-1765
    • Anton, P.A.1    Elliott, J.2    Poles, M.A.3
  • 21
    • 0033639229 scopus 로고    scopus 로고
    • Biological parameters of HIV-1 infection in primary intestinal lymphocytes and macrophages
    • Smith PD, Meng G, Sellers MT, et al. Biological parameters of HIV-1 infection in primary intestinal lymphocytes and macrophages. J Leukoc Biol. 2000;68:360-365.
    • (2000) J Leukoc Biol. , vol.68 , pp. 360-365
    • Smith, P.D.1    Meng, G.2    Sellers, M.T.3
  • 22
    • 63149107945 scopus 로고    scopus 로고
    • Macrophages in vaginal but not intestinal mucosa are monocyte-like and permissive to human immunodeficiency virus type 1 infection
    • Shen R, Richter HE, Clements RH, et al. Macrophages in vaginal but not intestinal mucosa are monocyte-like and permissive to human immunodeficiency virus type 1 infection. J Virol. 2009;83:3258-3267.
    • (2009) J Virol. , vol.83 , pp. 3258-3267
    • Shen, R.1    Richter, H.E.2    Clements, R.H.3
  • 23
    • 79958184404 scopus 로고    scopus 로고
    • Stromal down-regulation of macrophage CD4/CCR5 expression and NF-kappaB activation mediates HIV-1 non-permissiveness in intestinal macrophages
    • Shen R, Meng G, Ochsenbauer C, et al. Stromal down-regulation of macrophage CD4/CCR5 expression and NF-kappaB activation mediates HIV-1 non-permissiveness in intestinal macrophages. PLoS Pathog. 2011;7:e1002060.
    • (2011) PLoS Pathog. , vol.7
    • Shen, R.1    Meng, G.2    Ochsenbauer, C.3
  • 24
    • 0033831646 scopus 로고    scopus 로고
    • Lamina propria lymphocytes, not macrophages, express CCR5 and CXCR4 and are the likely target cell for human immunodeficiency virus type 1 in the intestinal mucosa
    • Meng G, Sellers MT, Mosteller-Barnum M, et al. Lamina propria lymphocytes, not macrophages, express CCR5 and CXCR4 and are the likely target cell for human immunodeficiency virus type 1 in the intestinal mucosa. J Infect Dis. 2000;182:785-791.
    • (2000) J Infect Dis. , vol.182 , pp. 785-791
    • Meng, G.1    Sellers, M.T.2    Mosteller-Barnum, M.3
  • 25
    • 0032907999 scopus 로고    scopus 로고
    • Intestinal macrophages display reduced permissiveness to human immunodeficiency virus 1 and decreased surface CCR5
    • Li L, Meng G, Graham MF, et al. Intestinal macrophages display reduced permissiveness to human immunodeficiency virus 1 and decreased surface CCR5. Gastroenterology. 1999;116:1043-1053.
    • (1999) Gastroenterology. , vol.116 , pp. 1043-1053
    • Li, L.1    Meng, G.2    Graham, M.F.3
  • 26
    • 0036172706 scopus 로고    scopus 로고
    • Primary intestinal epithelial cells selectively transfer R5 HIV-1 to CCR5+ cells
    • Meng G, Wei X, Wu X, et al. Primary intestinal epithelial cells selectively transfer R5 HIV-1 to CCR5+ cells. Nat Med. 2002;8: 150-156.
    • (2002) Nat Med. , vol.8 , pp. 150-156
    • Meng, G.1    Wei, X.2    Wu, X.3
  • 27
    • 77950555894 scopus 로고    scopus 로고
    • Dendritic cells transmit HIV-1 through human small intestinal mucosa
    • Shen R, Smythies LE, Clements RH, et al. Dendritic cells transmit HIV-1 through human small intestinal mucosa. J Leukoc Biol. 2009;87: 663-670.
    • (2009) J Leukoc Biol. , vol.87 , pp. 663-670
    • Shen, R.1    Smythies, L.E.2    Clements, R.H.3
  • 28
    • 17444400465 scopus 로고    scopus 로고
    • Binding and transfer of human immunodeficiency virus by DC-SIGN+ cells in human rectal mucosa
    • Gurney KB, Elliott J, Nassanian H, et al. Binding and transfer of human immunodeficiency virus by DC-SIGN+ cells in human rectal mucosa. J Virol. 2005;79:5762-5773.
    • (2005) J Virol. , vol.79 , pp. 5762-5773
    • Gurney, K.B.1    Elliott, J.2    Nassanian, H.3
  • 29
    • 36049009354 scopus 로고    scopus 로고
    • Characterization of baseline intestinal mucosal indices of injury and inflammation in men for use in rectal microbicide trials (HIV Prevention Trials Network-056)
    • McGowan I, Elliott J, Cortina G, et al. Characterization of baseline intestinal mucosal indices of injury and inflammation in men for use in rectal microbicide trials (HIV Prevention Trials Network-056). J Acquir Immune Defic Syndr. 2007;46:417-425.
    • (2007) J Acquir Immune Defic Syndr. , vol.46 , pp. 417-425
    • McGowan, I.1    Elliott, J.2    Cortina, G.3
  • 30
    • 56649105122 scopus 로고    scopus 로고
    • Efficacy assessment of a cell-mediated immunity HIV-1 vaccine (the Step Study): A double-blind, randomised, placebo-controlled, test-of-concept trial
    • Buchbinder SP, Mehrotra DV, Duerr A, et al. Efficacy assessment of a cell-mediated immunity HIV-1 vaccine (the Step Study): a double-blind, randomised, placebo-controlled, test-of-concept trial. Lancet. 2008;372:1881-1893.
    • (2008) Lancet. , vol.372 , pp. 1881-1893
    • Buchbinder, S.P.1    Mehrotra, D.V.2    Duerr, A.3
  • 31
    • 56649114351 scopus 로고    scopus 로고
    • HIV-1 vaccine-induced immunity in the test-of-concept Step Study: A case-cohort analysis
    • McElrath MJ, De Rosa SC, Moodie Z, et al. HIV-1 vaccine-induced immunity in the test-of-concept Step Study: a case-cohort analysis. Lancet. 2008;372:1894-1905.
    • (2008) Lancet. , vol.372 , pp. 1894-1905
    • McElrath, M.J.1    De Rosa, S.C.2    Moodie, Z.3
  • 32
    • 0347320927 scopus 로고    scopus 로고
    • Macrophage HIV-1 infection and the gastrointestinal tract reservoir
    • Smith PD, Meng G, Salazar-Gonzalez JF, et al. Macrophage HIV-1 infection and the gastrointestinal tract reservoir. J Leukoc Biol. 2003; 74:642-649.
    • (2003) J Leukoc Biol. , vol.74 , pp. 642-649
    • Smith, P.D.1    Meng, G.2    Salazar-Gonzalez, J.F.3
  • 33
    • 80555148949 scopus 로고    scopus 로고
    • A high-throughput single-cell analysis of human CD8+ T cell functions reveals discordance for cytokine secretion and cytolysis
    • Varadarajan N, Julg B, Yamanaka YJ, et al. A high-throughput single-cell analysis of human CD8+ T cell functions reveals discordance for cytokine secretion and cytolysis. J Clin Invest. 2011;121: 4322-4331.
    • (2011) J Clin Invest. , vol.121 , pp. 4322-4331
    • Varadarajan, N.1    Julg, B.2    Yamanaka, Y.J.3
  • 34
    • 79955750055 scopus 로고    scopus 로고
    • Single-cell mass cytometry of differential immune and drug responses across a human hematopoietic continuum
    • Bendall SC, Simonds EF, Qiu P, et al. Single-cell mass cytometry of differential immune and drug responses across a human hematopoietic continuum. Science. 2011;332:687-696.
    • (2011) Science. , vol.332 , pp. 687-696
    • Bendall, S.C.1    Simonds, E.F.2    Qiu, P.3
  • 35
    • 78650807608 scopus 로고    scopus 로고
    • Intestinal macrophages and response to microbial encroachment
    • Smith PD, Smythies LE, Shen R, et al. Intestinal macrophages and response to microbial encroachment. Mucosal Immunol. 2011;4:31-42.
    • (2011) Mucosal Immunol. , vol.4 , pp. 31-42
    • Smith, P.D.1    Smythies, L.E.2    Shen, R.3
  • 36
    • 80054882496 scopus 로고    scopus 로고
    • Mucosal macrophages in intestinal homeostasis and inflammation
    • Mowat AM, Bain CC. Mucosal macrophages in intestinal homeostasis and inflammation. J Innate Immun. 2011;3:550-564.
    • (2011) J Innate Immun. , vol.3 , pp. 550-564
    • Mowat, A.M.1    Bain, C.C.2
  • 37
    • 33745842280 scopus 로고    scopus 로고
    • Ex vivo culture of human colo-rectal tissue for the evaluation of candidate microbicides
    • Fletcher PS, Elliott J, Grivel JC, et al. Ex vivo culture of human colo-rectal tissue for the evaluation of candidate microbicides. AIDS. 2006;20: 1237-1245.
    • (2006) AIDS , vol.20 , pp. 1237-1245
    • Fletcher, P.S.1    Elliott, J.2    Grivel, J.C.3
  • 38
    • 0032733508 scopus 로고    scopus 로고
    • Expression of lymphocyte-endothe-lial receptor-ligand pairs, alpha4beta7/MAdCAM-1 and OX40/OX40 ligand in the colon and jejunum of patients with inflammatory bowel disease
    • Souza HS, Elia CC, Spencer J, et al. Expression of lymphocyte-endothe- lial receptor-ligand pairs, alpha4beta7/MAdCAM-1 and OX40/OX40 ligand in the colon and jejunum of patients with inflammatory bowel disease. Gut. 1999;45:856-863.
    • (1999) Gut. , vol.45 , pp. 856-863
    • Souza, H.S.1    Elia, C.C.2    Spencer, J.3
  • 39
    • 67849135873 scopus 로고    scopus 로고
    • Up-regulation of alpha4beta7 integrin on peripheral T cell subsets correlates with the development of acute intestinal graft-versus-host disease following allogeneic stem cell transplantation
    • Chen YB, Kim HT, McDonough S, et al. Up-regulation of alpha4beta7 integrin on peripheral T cell subsets correlates with the development of acute intestinal graft-versus-host disease following allogeneic stem cell transplantation. Biol Blood Marrow Transplant. 2009;15: 1066-1076.
    • (2009) Biol Blood Marrow Transplant. , vol.15 , pp. 1066-1076
    • Chen, Y.B.1    Kim, H.T.2    McDonough, S.3
  • 40
    • 39449098115 scopus 로고    scopus 로고
    • HIV-1 envelope protein binds to and signals through integrin alpha4beta7, the gut mucosal homing receptor for peripheral T cells
    • Arthos J, Cicala C, Martinelli E, et al. HIV-1 envelope protein binds to and signals through integrin alpha4beta7, the gut mucosal homing receptor for peripheral T cells. Nat Immunol. 2008;9:301-309.
    • (2008) Nat Immunol. , vol.9 , pp. 301-309
    • Arthos, J.1    Cicala, C.2    Martinelli, E.3
  • 41
    • 73949112038 scopus 로고    scopus 로고
    • The integrin alpha4beta7 forms a complex with cell-surface CD4 and defines a T-cell subset that is highly susceptible to infection by HIV-1
    • Cicala C, Martinelli E, McNally JP, et al. The integrin alpha4beta7 forms a complex with cell-surface CD4 and defines a T-cell subset that is highly susceptible to infection by HIV-1. Proc Natl Acad Sci U S A. 2009;106: 20877-20882.
    • (2009) Proc Natl Acad Sci U S A. , vol.106 , pp. 20877-20882
    • Cicala, C.1    Martinelli, E.2    McNally, J.P.3
  • 42
    • 34250009590 scopus 로고    scopus 로고
    • HIV-1 pathogenesis differs in recto-sigmoid and tonsillar tissues infected ex vivo with CCR5-and CXCR4-tropic HIV-1
    • Grivel JC, Elliott J, Lisco A, et al. HIV-1 pathogenesis differs in recto-sigmoid and tonsillar tissues infected ex vivo with CCR5-and CXCR4-tropic HIV-1. AIDS. 2007;21:1263-1272.
    • (2007) AIDS , vol.21 , pp. 1263-1272
    • Grivel, J.C.1    Elliott, J.2    Lisco, A.3
  • 43
    • 50949097030 scopus 로고    scopus 로고
    • Prevention of SIV rectal transmission and priming of T cell responses in macaques after local pre-exposure application of tenofovir gel
    • discussion e157
    • Cranage M, Sharpe S, Herrera C, et al. Prevention of SIV rectal transmission and priming of T cell responses in macaques after local pre-exposure application of tenofovir gel. PLoS Med. 2008;5:e157; discussion e157.
    • (2008) PLoS Med. , vol.5
    • Cranage, M.1    Sharpe, S.2    Herrera, C.3
  • 44
    • 77949532283 scopus 로고    scopus 로고
    • In vitro and ex vivo testing of tenofovir shows it is effective as an HIV-1 microbicide
    • Rohan LC, Moncla BJ, Kunjara Na Ayudhya RP, et al. In vitro and ex vivo testing of tenofovir shows it is effective as an HIV-1 microbicide. PLoS One. 2010;5:e9310.
    • (2010) PLoS One. , vol.5
    • Rohan, L.C.1    Moncla, B.J.2    Kunjara Na Ayudhya, R.P.3
  • 45
    • 27144527077 scopus 로고    scopus 로고
    • A human colorectal explant culture to evaluate topical microbicides for the prevention of HIV infection
    • Abner SR, Guenthner PC, Guarner J, et al. A human colorectal explant culture to evaluate topical microbicides for the prevention of HIV infection. J Infect Dis. 2005;192:1545-1556.
    • (2005) J Infect Dis. , vol.192 , pp. 1545-1556
    • Abner, S.R.1    Guenthner, P.C.2    Guarner, J.3
  • 46
    • 80055005719 scopus 로고    scopus 로고
    • Colorectal microbicide design: Triple combinations of reverse transcriptase inhibitors are optimal against HIV-1 in tissue explants
    • Herrera C, Cranage M, McGowan I, et al. Colorectal microbicide design: triple combinations of reverse transcriptase inhibitors are optimal against HIV-1 in tissue explants. AIDS. 2011;25:1971-1979.
    • (2011) AIDS , vol.25 , pp. 1971-1979
    • Herrera, C.1    Cranage, M.2    McGowan, I.3
  • 47
    • 80053248640 scopus 로고    scopus 로고
    • First phase 1 double-blind, placebo-controlled, randomized rectal microbicide trial using UC781 gel with a novel index of ex vivo efficacy
    • Anton PA, Saunders T, Elliott J, et al. First phase 1 double-blind, placebo-controlled, randomized rectal microbicide trial using UC781 gel with a novel index of ex vivo efficacy. PLoS One. 2011;6:e23243.
    • (2011) PLoS One. , vol.6
    • Anton, P.A.1    Saunders, T.2    Elliott, J.3
  • 48
    • 0031925974 scopus 로고    scopus 로고
    • In vivo distribution of the human immunodeficiency virus/simian immunodeficiency virus coreceptors: CXCR4, CCR3, and CCR5
    • Zhang L, He T, Talal A, et al. In vivo distribution of the human immunodeficiency virus/simian immunodeficiency virus coreceptors: CXCR4, CCR3, and CCR5. J Virol. 1998;72:5035-5045.
    • (1998) J Virol. , vol.72 , pp. 5035-5045
    • Zhang, L.1    He, T.2    Talal, A.3
  • 49
    • 78751706261 scopus 로고    scopus 로고
    • CD4(+) lymphoid tissue-inducer cells promote innate immunity in the gut
    • Sonnenberg GF, Monticelli LA, Elloso MM, et al. CD4(+) lymphoid tissue-inducer cells promote innate immunity in the gut. Immunity. 2011;34:122-134.
    • (2011) Immunity. , vol.34 , pp. 122-134
    • Sonnenberg, G.F.1    Monticelli, L.A.2    Elloso, M.M.3
  • 50
    • 44549085037 scopus 로고    scopus 로고
    • Expression of chemokine receptors on natural killer cells in HIV-infected individuals
    • Jiang Y, Zhang Z, Diao Y, et al. Expression of chemokine receptors on natural killer cells in HIV-infected individuals. Cell Immunol. 2008;251: 19-24.
    • (2008) Cell Immunol. , vol.251 , pp. 19-24
    • Jiang, Y.1    Zhang, Z.2    Diao, Y.3
  • 51
    • 63549124487 scopus 로고    scopus 로고
    • CD4+ NK cells can be productively infected with HIV, leading to downregulation of CD4 expression and changes in function
    • Bernstein HB, Wang G, Plasterer MC, et al. CD4+ NK cells can be productively infected with HIV, leading to downregulation of CD4 expression and changes in function. Virology. 2009;387:59-66.
    • (2009) Virology. , vol.387 , pp. 59-66
    • Bernstein, H.B.1    Wang, G.2    Plasterer, M.C.3
  • 52
    • 33750112087 scopus 로고    scopus 로고
    • Apoptotic neutrophils and T cells sequester chemokines during immune response resolution through modulation of CCR5 expression
    • Ariel A, Fredman G, Sun YP, et al. Apoptotic neutrophils and T cells sequester chemokines during immune response resolution through modulation of CCR5 expression. Nat Immunol. 2006;7:1209-1216.
    • (2006) Nat Immunol. , vol.7 , pp. 1209-1216
    • Ariel, A.1    Fredman, G.2    Sun, Y.P.3
  • 53
    • 0033929004 scopus 로고    scopus 로고
    • Transfer of the chemokine receptor CCR5 between cells by membrane-derived microparticles: A mechanism for cellular human immunodeficiency virus 1 infection
    • Mack M, Kleinschmidt A, Bruhl H, et al. Transfer of the chemokine receptor CCR5 between cells by membrane-derived microparticles: a mechanism for cellular human immunodeficiency virus 1 infection. Nat Med. 2000;6:769-775.
    • (2000) Nat Med. , vol.6 , pp. 769-775
    • MacK, M.1    Kleinschmidt, A.2    Bruhl, H.3
  • 54
    • 65249168098 scopus 로고    scopus 로고
    • Topical microbicides to prevent HIV: Clinical drug development challenges
    • Hendrix CW, Cao YJ, Fuchs EJ. Topical microbicides to prevent HIV: clinical drug development challenges. Annu Rev Pharmacol Toxicol. 2009;49:349-375.
    • (2009) Annu Rev Pharmacol Toxicol. , vol.49 , pp. 349-375
    • Hendrix, C.W.1    Cao, Y.J.2    Fuchs, E.J.3
  • 55
    • 83155177076 scopus 로고    scopus 로고
    • Penetration of tenofovir and emtricitabine in mucosal tissues: Implications for prevention of HIV-1 transmission
    • Patterson KB, Prince HA, Kraft E, et al. Penetration of tenofovir and emtricitabine in mucosal tissues: implications for prevention of HIV-1 transmission. Sci Transl Med. 2011;3:112-114.
    • (2011) Sci Transl Med. , vol.3 , pp. 112-114
    • Patterson, K.B.1    Prince, H.A.2    Kraft, E.3
  • 56
    • 24644446235 scopus 로고    scopus 로고
    • Toward a live microbial microbicide for HIV: Commensal bacteria secreting an HIV fusion inhibitor peptide
    • Rao S, Hu S, McHugh L, et al. Toward a live microbial microbicide for HIV: commensal bacteria secreting an HIV fusion inhibitor peptide. Proc Natl Acad Sci U S A. 2005;102:11993-11998.
    • (2005) Proc Natl Acad Sci U S A. , vol.102 , pp. 11993-11998
    • Rao, S.1    Hu, S.2    McHugh, L.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.