CD4+ NK cells can be productively infected with HIV, leading to downregulation of CD4 expression and changes in function

Virology

Volumn 387, Issue 1, 2009, Pages 59-66

  Bernstein, Helene B ^a   Wang, Guangwu ^b   Plasterer, Mary C ^b   Zack, Jerome A ^b   Ramasastry, Parthasarathy ^b   Mumenthaler, Shannon M ^b   Kitchen, Christina M R ^c  

^a CASE WESTERN RESERVE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

CD4 downregulation; CD4 expression; Chemotaxis; HIV; NK cells

Indexed keywords

CD4 ANTIGEN; CHEMOKINE RECEPTOR CCR5; CHEMOKINE RECEPTOR CXCR4; IMMUNOGLOBULIN ANTIBODY; INTERLEUKIN 16; PLERIXAFOR; STROMAL CELL DERIVED FACTOR 1ALPHA;

ANTIGEN EXPRESSION; ARTICLE; CD4+ T LYMPHOCYTE; CELL FUNCTION; CHEMOTAXIS; CONTROLLED STUDY; DISEASE PREDISPOSITION; HUMAN; HUMAN CELL; HUMAN IMMUNODEFICIENCY VIRUS; HUMAN IMMUNODEFICIENCY VIRUS INFECTED PATIENT; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; NATURAL KILLER T CELL; PRIORITY JOURNAL; PROTEIN EXPRESSION; RECEPTOR DOWN REGULATION; RECEPTOR UPREGULATION; TARGET CELL; TROPICS; VIRUS ISOLATION;

ANTIGENS, CD4; CELLS, CULTURED; DOWN-REGULATION; HIV INFECTIONS; HIV-1; HUMANS; KILLER CELLS, NATURAL; RECEPTORS, CCR5;

EID: 63549124487     PISSN: 00426822     EISSN: 10960341     Source Type: Journal    
DOI: 10.1016/j.virol.2009.01.044     Document Type: Article

References (29)

1. Ahmad A., and Menezes J. Positive correlation between the natural killer and gp 120/41-specific antibody-dependent cellular cytotoxic effector functions in HIV-infected individuals. J. Acquir. Immune. Defic. Syndr. Hum. Retrovirol. 10 2 (1995) 115-119
2. Ahmad R., Sindhu S.T., Tran P., Toma E., Morisset R., Menezes J., and Ahmad A. Modulation of expression of the MHC class I-binding natural killer cell receptors, and NK activity in relation to viral load in HIV-infected/AIDS patients. J. Med. Virol. 65 3 (2001) 431-440
3. Bernstein H.B., Jackson R.W., Anderson J., and Kinter A.L. The effect of elective cesarean delivery and intrapartum infection on fetal lymphocyte activation and susceptibility to HIV infection. Am. J. Obstet. Gynecol. 187 5 (2002) 1283-1289
4. Bernstein H.B., Plasterer M.C., Schiff S.E., Kitchen C.M., Kitchen S., and Zack J.A. CD4 expression on activated NK cells: ligation of CD4 induces cytokine expression and cell migration. J. Immunol. 177 6 (2006) 3669-3676
5. Biswas P., Mantelli B., Sica A., Malnati M., Panzeri C., Saccani A., Hasson H., Vecchi A., Saniabadi A., Lusso P., Lazzarin A., and Beretta A. Expression of CD4 on human peripheral blood neutrophils. Blood 101 11 (2003) 4452-4456
6. Brenner B.G., Gornitsky M., and Wainberg M.A. Interleukin-2-inducible natural immune (lymphokine-activated killer cell) responses as a functional correlate of progression to AIDS. Clin. Diagn. Lab. Immunol. 1 5 (1994) 538-544
7. Brooks D.G., and Zack J.A. Effect of latent human immunodeficiency virus infection on cell surface phenotype. J. Virol. 76 4 (2002) 1673-1681
8. Cecilia D., KewalRamani V.N., O'Leary J., Volsky B., Nyambi P., Burda S., Xu S., Littman D.R., and Zolla-Pazner S. Neutralization profiles of primary human immunodeficiency virus type 1 isolates in the context of coreceptor usage. J. Virol. 72 9 (1998) 6988-6996
9. Chaitidis P., and Kuhn H. Induction of 15-lipoxygenase-1 impairs expression of HIV-1 receptors CD4 and CXCR4 in monocytic cells. FEBS Lett. 579 17 (2005) 3691-3694
10. Chen B.K., Gandhi R.T., and Baltimore D. CD4 down-modulation during infection of human T cells with human immunodeficiency virus type 1 involves independent activities of vpu, env, and nef. J. Virol. 70 9 (1996) 6044-6053
11. Chun T.W., Carruth L., Finzi D., Shen X., DiGiuseppe J.A., Taylor H., Hermankova M., Chadwick K., Margolick J., Quinn T.C., Kuo Y.H., Brookmeyer R., Zeiger M.A., Barditch-Crovo P., and Siliciano R.F. Quantification of latent tissue reservoirs and total body viral load in HIV-1 infection. Nature 387 6629 (1997) 183-188
12. Ellenberger D.L., Sullivan P.S., Dorn J., Schable C., Spira T.J., Folks T.M., and Lal R.B. Viral and immunologic examination of human immunodeficiency virus type 1-infected, persistently seronegative persons. J. Infect. Dis. 180 4 (1999) 1033-1042
13. Fleuridor R., Wilson B., Hou R., Landay A., Kessler H., and Al-Harthi L. CD1d-restricted natural killer T cells are potent targets for human immunodeficiency virus infection. Immunology 108 1 (2003) 3-9
14. Harada H., Goto Y., Ohno T., Suzu S., and Okada S. Proliferative activation up-regulates expression of CD4 and HIV-1 co-receptors on NK cells and induces their infection with HIV-1. Eur. J. Immunol. 37 8 (2007) 2148-2155
15. Inngjerdingen M., Damaj B., and Maghazachi A.A. Expression and regulation of chemokine receptors in human natural killer cells. Blood 97 2 (2001) 367-375
16. Kitchen S.G., Korin Y.D., Roth M.D., Landay A., and Zack J.A. Costimulation of naive CD8(+) lymphocytes induces CD4 expression and allows human immunodeficiency virus type 1 infection. J. Virol. 72 11 (1998) 9054-9060
17. Kitchen S.G., Jones N.R., LaForge S., Whitmire J.K., Vu B.A., Galic Z., Brooks D.G., Brown S.J., Kitchen C.M., and Zack J.A. CD4 on CD8(+) T cells directly enhances effector function and is a target for HIV infection. Proc. Natl. Acad. Sci. U.S.A. 101 23 (2004) 8727-8732
18. Kottilil S., Chun T.W., Moir S., Liu S., McLaughlin M., Hallahan C.W., Maldarelli F., Corey L., and Fauci A.S. Innate immunity in human immunodeficiency virus infection: effect of viremia on natural killer cell function. J. Infect. Dis. 187 7 (2003) 1038-1045
19. Louwagie J., Delwart E.L., Mullins J.I., McCutchan F.E., Eddy G., and Burke D.S. Genetic analysis of HIV-1 isolates from Brazil reveals presence of two distinct genetic subtypes. AIDS Res. Hum. Retroviruses 10 5 (1994) 561-567
20. Lusso P., De Maria A., Malnati M., Lori F., DeRocco S.E., Baseler M., and Gallo R.C. Induction of CD4 and susceptibility to HIV-1 infection in human CD8+ T lymphocytes by human herpesvirus 6. Nature 349 6309 (1991) 533-535
21. Mavilio D., Lombardo G., Kinter A., Fogli M., La Sala A., Ortolano S., Farschi A., Follmann D., Gregg R., Kovacs C., Marcenaro E., Pende D., Moretta A., and Fauci A.S. Characterization of the defective interaction between a subset of natural killer cells and dendritic cells in HIV-1 infection. J. Exp. Med. 203 10 (2006) 2339-2350
22. Motsinger A., Haas D.W., Stanic A.K., Van Kaer L., Joyce S., and Unutmaz D. CD1d-restricted human natural killer T cells are highly susceptible to human immunodeficiency virus 1 infection. J. Exp. Med. 195 7 (2002) 869-879
23. Nieto M., Navarro F., Perez-Villar J.J., del Pozo M.A., Gonzalez-Amaro R., Mellado M., Frade J.M., Martinez A.C., Lopez-Botet M., and Sanchez-Madrid F. Roles of chemokines and receptor polarization in NK-target cell interactions. J. Immunol. 161 7 (1998) 3330-3339
24. Ratcliffe L.T., Lukey P.T., MacKenzie C.R., and Ress S.R. Reduced NK activity correlates with active disease in HIV-patients with multidrug-resistant pulmonary tuberculosis. Clin. Exp. Immunol. 97 3 (1994) 373-379
25. Robinson Jr. W.E., Mitchell W.M., Chambers W.H., Schuffman S.S., Montefiori D.C., and Oeltmann T.N. Natural killer cell infection and inactivation in vitro by the human immunodeficiency virus. Hum. Pathol. 19 5 (1988) 535-540
26. Sullivan P.S., Schable C., Koch W., Do A.N., Spira T., Lansky A., Ellenberger D., Lal R.B., Hyer C., Davis R., Marx M., Paul S., Kent J., Armor R., McFarland J., Lafontaine J., Mottice S., Cassol S.A., and Michael N. Persistently negative HIV-1 antibody enzyme immunoassay screening results for patients with HIV-1 infection and AIDS: serologic, clinical, and virologic results. Seronegative AIDS Clinical Study Group. Aids 13 1 (1999) 89-96
27. Valentin A., Rosati M., Patenaude D.J., Hatzakis A., Kostrikis L.G., Lazanas M., Wyvill K.M., Yarchoan R., and Pavlakis G.N. Persistent HIV-1 infection of natural killer cells in patients receiving highly active antiretroviral therapy. Proc. Natl. Acad. Sci. U.S.A. 99 10 (2002) 7015-7020
28. Wang G., Izadpanah N., Kitchen C.M., and Bernstein H.B. Fetal allostimulation of maternal cells: a potential mechanism for perinatal HIV transmission following obstetrical hemorrhage. AIDS Res. Hum. Retroviruses 24 12 (2008) 1545-1554
29. Zolla-Pazner S., and Sharpe S. A resting cell assay for improved detection of antibody-mediated neutralization of HIV type 1 primary isolates. AIDS Res. Hum. Retroviruses 11 12 (1995) 1449-1458