Lamina propria lymphocytes, not macrophages, express CCR5 and CXCR4 and are the likely target cell for human immunodeficiency virus type 1 in the intestinal mucosa

Journal of Infectious Diseases

Volumn 182, Issue 3, 2000, Pages 785-791

  Meng, Gang ^a   Sellers, Marty T ^c   Mosteller Barnum, Meg ^a,d   Rogers, Tina S ^b   Shaw, George M ^e   Smith, Phillip D ^a,d  

^a University of Alabama at Birmingham   (United States)

^b UNIVERSITY OF ALABAMA AT BIRMINGHAM   (United States)

^c Kentucky   (United States)

^d BIRMINGHAM VA MEDICAL CENTER   (United States)

^e HOWARD HUGHES MEDICAL INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CD4 ANTIGEN; CHEMOKINE RECEPTOR CCR5; CHEMOKINE RECEPTOR CXCR4;

ANTIGEN EXPRESSION; ARTICLE; BINDING SITE; CYTOKINE RELEASE; HUMAN; HUMAN CELL; HUMAN IMMUNODEFICIENCY VIRUS 1; INTESTINE MUCOSA; LAMINA PROPRIA; LYMPHOCYTE FUNCTION; PRIORITY JOURNAL; VIRUS TRANSMISSION;

ANTIGENS, CD4; CELLS, CULTURED; HIV INFECTIONS; HIV-1; HUMANS; INTESTINAL MUCOSA; LYMPHOCYTES; MACROPHAGES; RECEPTORS, CCR5; RECEPTORS, CXCR4; VIRUS REPLICATION;

EID: 0033831646     PISSN: 00221899     EISSN: None     Source Type: Journal    
DOI: 10.1086/315790     Document Type: Article

References (34)

1. Transcytosis of infectious human immunodeficiency virus across a tight human epithelial cell line barrier
2. Genotypic and phenotypic characterization of HIV-1 in patients with primary infection
3. Overview of the mucosal immune system
4. Cytomegalovirus induces expression of tumor necrosis factor by human monocytes and mucosal macrophages
5. Immunology of mucosal HIV-1 infection
6. Gastrointestinal complications of the acquired immunodeficiency syndrome
7. Human cytomegalovirus-stimulated peripheral blood mononuclear cells induce HIV-1 replication via a tumor necrosis factor-a-mediated mechanism
8. Macrophages as a source of HIV during opportunistic infections
9. Intestinal macrophages display reduced permissiveness to human immunodeficiency virus 1 and decreased surface CCR5
10. Quantitative analysis of mononuclear cells expressing human immunodeficiency virus type-1 RNA in esophageal mucosa
11. Relationship of human immunodeficiency virus type 1 sequence heterogenicity to stage of disease
12. Selective transmission of human immunodeficiency virus type-1 variants from mothers to infants
13. Macrophagetropic variants initiate human immunodeficiency virus type 1 infection after sexual, parenteral, and vertical transmission
14. Isolation and purification of CD14-negative mucosal macrophages from normal human small intestine
15. Isolation of macrophages/monocytes from human peripheral blood and tissues
16. Quantitative fluorescence flow cytometry: A comparison of the three techniques for direct and indirect immunofluorescence
17. Quantitation of CD38 expression using QuantiBRITE beads
18. Quantification of CD4, CCR5, and CXCR4 levels on lymphocyte subsets, dendritic cells, and differentially conditioned monocyte-derived macrophages
19. Isolation and generation of human dendritic cells
20. Mucosal immune responses. An overview
21. - T cells results in altered cytokine production, activation threshold, and costimulatory requirements
22. Fusion of monocytes and macrophages with HIV-1 correlates with biochemical properties of CXCR4 and CCR5
23. Expression and use of human immunodeficiency virus type 1 coreceptors by human alveolar macrophages
24. Infection and AIDS in adult macaques after nontraumatic oral exposure to cell-free SIV
25. Quantitative image analysis of HIV-1 infection in lymphoid tissue
26. Kinetics of response in lymphoid tissues to antiretroviral therapy of HIV-1 infection
27. + T cell demographics and dynamics in lymphatic tissues
28. Mycobacterium avium complex augments macrophage HIV-1 production and increases CCR5 expression
29. Dendritic cells, the major antigen-presenting cells of the human colonic lamina propria
30. Distinct populations of dendritic cells are present in the subepithelial dome and T cell regions of the murine Peyer's patch
31. - T cell depletion and viral replication in SIV infection
32. Rapid infection of oral mucosal-associated lymphoid tissue with simian immunodeficiency virus
33. + T cells
34. In vivo distribution of the human immunodeficiency virus/simian immunodeficiency virus coreceptors: CXCR4, CCR3, and CCR5