Brahma-related gene 1 bridges epigenetic regulation of proinflammatory cytokine production to steatohepatitis in mice

Hepatology

Volumn 58, Issue 2, 2013, Pages 576-588

  Tian, Wenfang ^a   Xu, Huihui ^a   Fang, Fei ^a   Chen, Qi ^a   Xu, Yong ^a   Shen, Aiguo ^b,c  

^a NANJING MEDICAL UNIVERSITY   (China)

^b NANTONG MEDICAL COLLEGE   (China)

^c NANTONG UNIVERSITY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

AUTACOID; BRG1 PROTEIN; BRM PROTEIN; CYTOKINE; ESTRADIOL; FATTY ACID; GLUCOSE; HISTONE H3; HISTONE H4; INTERLEUKIN 1; INTERLEUKIN 6; MONOCYTE CHEMOTACTIC PROTEIN 1; PALMITIC ACID; SHORT HAIRPIN RNA; TRANSCRIPTION FACTOR RELA; TUMOR NECROSIS FACTOR ALPHA;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CARBOHYDRATE DIET; CELL CULTURE; CHOLESTEROL DIET; CHROMATIN; CONTROLLED STUDY; CYTOKINE PRODUCTION; CYTOKINE RELEASE; EPIGENETICS; EX VIVO STUDY; GENE ACTIVATION; GENE AMPLIFICATION; GENE OVEREXPRESSION; GENE SILENCING; GENE TARGETING; GENETIC REGULATION; GENETIC TRANSCRIPTION; HISTONE MODIFICATION; HUMAN; HUMAN CELL; IN VITRO STUDY; IN VIVO STUDY; LIPID DIET; LIVER CELL; LIVER HOMOGENATE; MICROENVIRONMENT; MOUSE; NONALCOHOLIC FATTY LIVER; NONHUMAN; NUTRIENT SUPPLY; PATHOGENESIS; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN BINDING; PROTEIN DEPLETION; PROTEIN STABILITY; RNA INTERFERENCE; UPREGULATION;

ANIMALS; CELL LINE, TUMOR; CELLS, CULTURED; CYTOKINES; DISEASE MODELS, ANIMAL; DNA HELICASES; EPIGENESIS, GENETIC; FATTY LIVER; FOOD; HEP G2 CELLS; HEPATOCYTES; HUMANS; LIVER; MALE; MICE; MICE, KNOCKOUT; MICE, MUTANT STRAINS; NUCLEAR PROTEINS; SIGNAL TRANSDUCTION; TRANSCRIPTION FACTORS; UP-REGULATION;

EID: 84880206988     PISSN: 02709139     EISSN: 15273350     Source Type: Journal    
DOI: 10.1002/hep.26207     Document Type: Article

References (43)

1. Hossain P, Kawar B, El Nahas M.Obesity and diabetes in the developing world-a growing challenge.N Engl J Med 2007;356:213-215.
2. Fan JG, Farrell GC.Epidemiology of non-alcoholic fatty liver disease in China.J Hepatol 2009;50:204-210.
3. Duseja A, Sharma B, Kumar A, Kapil S, Das A, Dhiman RK, et al.Nonalcoholic fatty liver in a developing country is responsible for significant liver disease.Hepatology 2010;52:2248-2249.
4. Kotronen A, Yki-Jarvinen H.Fatty liver: a novel component of the metabolic syndrome.Arterioscler Thromb Vasc Biol 2008;28:27-38.
5. Gines P, Cardenas A, Arroyo V, Rodes J.Management of cirrhosis and ascites.N Engl J Med 2004;350:1646-1654.
6. Negro F.Abnormalities of lipid metabolism in hepatitis C virus infection.Gut 2010;59:1279-1287.
7. Fabbrini E, Sullivan S, Klein S.Obesity and nonalcoholic fatty liver disease: biochemical, metabolic, and clinical implications.Hepatology 2010;51:679-689.
8. Hotamisligil GS.Inflammation and metabolic disorders.Nature 2006;444:860-867.
9. Kamari Y, Shaish A, Vax E, Shemesh S, Kandel-Kfir M, Arbel Y, et al.Lack of interleukin-1alpha or interleukin-1beta inhibits transformation of steatosis to steatohepatitis and liver fibrosis in hypercholesterolemic mice.J Hepatol 2011;55:1086-1094.
10. Mas E, Danjoux M, Garcia V, Carpentier S, Segui B, Levade T.IL-6 deficiency attenuates murine diet-induced non-alcoholic steatohepatitis.PLoS One 2009;4:e7929.
11. Haukeland JW, Damas JK, Konopski Z, Loberg EM, Haaland T, Goverud I, et al.Systemic inflammation in nonalcoholic fatty liver disease is characterized by elevated levels of CCL2.J Hepatol 2006;44:1167-1174.
12. Crespo J, Cayon A, Fernandez-Gil P, Hernandez-Guerra M, Mayorga M, Dominguez-Diez A, et al.Gene expression of tumor necrosis factor alpha and TNF-receptors, p55 and p75, in nonalcoholic steatohepatitis patients.Hepatology 2001;34:1158-1163.
13. Joshi-Barve S, Barve SS, Amancherla K, Gobejishvili L, Hill D, Cave M, et al.Palmitic acid induces production of proinflammatory cytokine interleukin-8 from hepatocytes.Hepatology 2007;46:823-830.
14. Donath MY, Shoelson SE.Type 2 diabetes as an inflammatory disease.Nat Rev Immunol 2011;11:98-107.
15. Baker RG, Hayden MS, Ghosh S.NF-kappaB, inflammation, and metabolic disease.Cell Metab 2011;13:11-22.
16. Natoli G.Control of NF-kappaB-dependent transcriptional responses by chromatin organization.Cold Spring Harb Perspect Biol 2009;1:a000224.
17. Saha A, Wittmeyer J, Cairns BR.Chromatin remodelling: the industrial revolution of DNA around histones.Nat Rev Mol Cell Biol 2006;7:437-447.
18. Ramirez-Carrozzi VR, Nazarian AA, Li CC, Gore SL, Sridharan R, Imbalzano AN, et al.Selective and antagonistic functions of SWI/SNF and Mi-2beta nucleosome remodeling complexes during an inflammatory response.Genes Dev 2006;20:282-296.
19. Bissell DM, Guzelian PS.Degradation of endogenous hepatic heme by pathways not yielding carbon monoxide. Studies in normal rat liver and in primary hepatocyte culture.J Clin Invest 1980;65:1135-1140.
20. Fang F, Yang Y, Yuan Z, Gao Y, Zhou J, Chen Q, et al.Myocardin-related transcription factor A mediates OxLDL-induced endothelial injury.Circ Res 2011;108:797-807.
21. Fang M, Kong X, Li P, Fang F, Wu X, Bai H, et al.RFXB and its splice variant RFXBSV mediate the antagonism between IFNgamma and TGFbeta on COL1A2 transcription in vascular smooth muscle cells.Nucleic Acids Res 2009;37:4393-4406.
22. Xu Y, Luchsinger L, Lucey EC, Smith BD.The effect of class II transactivator mutations on bleomycin-induced lung inflammation and fibrosis.Am J Respir Cell Mol Biol 2011;44:898-890.
23. Tilg H, Moschen AR.Evolution of inflammation in nonalcoholic fatty liver disease: the multiple parallel hits hypothesis.Hepatology 2010;52:1836-1846.
24. McGill MR, Yan HM, Ramachandran A, Murray GJ, Rollins DE, Jaeschke H.HepaRG cells: a human model to study mechanisms of acetaminophen hepatotoxicity.Hepatology 2011;53:974-982.
25. Kamada Y, Kiso S, Yoshida Y, Chatani N, Kizu T, Hamano M, et al.Estrogen deficiency worsens steatohepatitis in mice fed high-fat and high-cholesterol diet.Am J Physiol Gastrointest Liver Physiol 2011;301:G1031-G1043.
26. Shimizu I, Ito S.Protection of estrogens against the progression of chronic liver disease.Hepatol Res 2007;37:239-247.
27. Te Sligte K, Bourass I, Sels JP, Driessen A, Stockbrugger RW, Koek GH.Non-alcoholic steatohepatitis: review of a growing medical problem.Eur J Intern Med 2004;15:10-21.
28. Dela Pena A, Leclercq I, Field J, George J, Jones B, Farrell G.NF-kappaB activation, rather than TNF, mediates hepatic inflammation in a murine dietary model of steatohepatitis.Gastroenterology 2005;129:1663-1674.
29. Li T, Chanda D, Zhang Y, Choi HS, Chiang JY.Glucose stimulates cholesterol 7alpha-hydroxylase gene transcription in human hepatocytes.J Lipid Res 2010;51:832-842.
30. Lemke U, Krones-Herzig A, Berriel Diaz M, Narvekar P, Ziegler A, Vegiopoulos A, et al.The glucocorticoid receptor controls hepatic dyslipidemia through Hes1.Cell Metab 2008;8:212-223.
31. Zhang X, Zhou D, Strakovsky R, Zhang Y, Pan YX.Hepatic cellular senescence pathway genes are induced through histone modifications in a diet-induced obese rat model.Am J Physiol Gastrointest Liver Physiol 2012;302:G558-G564.
32. Chang X, Yan H, Fei J, Jiang M, Zhu H, Lu D, et al.Berberine reduces methylation of the MTTP promoter and alleviates fatty liver induced by a high-fat diet in rats.J Lipid Res 2010;51:2504-2515.
33. Jeong KW, Kim K, Situ AJ, Ulmer TS, An W, Stallcup MR.Recognition of enhancer element-specific histone methylation by TIP60 in transcriptional activation.Nat Struct Mol Biol 2011;18:1358-1365.
34. Lee S, Lee JW, Lee SK.UTX, a histone H3-lysine 27 demethylase, acts as a critical switch to activate the cardiac developmental program.Dev Cell 2012;22:25-37.
35. Rada-Iglesias A, Bajpai R, Swigut T, Brugmann SA, Flynn RA, Wysocka J.A unique chromatin signature uncovers early developmental enhancers in humans.Nature 2011;470:279-283.
36. Nieto N.Ethanol and fish oil induce NFkappaB transactivation of the collagen alpha2(I) promoter through lipid peroxidation-driven activation of the PKC-PI3K-Akt pathway.Hepatology 2007;45:1433-1445.
37. Ferreira AM, Takagawa S, Fresco R, Zhu X, Varga J, DiPietro LA.Diminished induction of skin fibrosis in mice with MCP-1 deficiency.J Invest Dermatol 2006;126:1900-1908.
38. Gieling RG, Wallace K, Han YP.Interleukin-1 participates in the progression from liver injury to fibrosis.Am J Physiol Gastrointest Liver Physiol 2009;296:G1324-G1331.
39. Xi Q, He W, Zhang XH, Le HV, Massague J.Genome-wide impact of the BRG1 SWI/SNF chromatin remodeler on the transforming growth factor beta transcriptional program.J Biol Chem 2008;283:1146-1155.
40. Ross S, Cheung E, Petrakis TG, Howell M, Kraus WL, Hill CS.Smads orchestrate specific histone modifications and chromatin remodeling to activate transcription.EMBO J 2006;25:4490-4502.
41. Bultman S, Gebuhr T, Yee D, La Mantia C, Nicholson J, Gilliam A, et al.A Brg1 null mutation in the mouse reveals functional differences among mammalian SWI/SNF complexes.Mol Cell 2000;6:1287-1295.
42. Hang CT, Yang J, Han P, Cheng HL, Shang C, Ashley E, et al.Chromatin regulation by Brg1 underlies heart muscle development and disease.Nature 2010;466:62-67.
43. Naito M, Zager RA, Bomsztyk K.BRG1 increases transcription of proinflammatory genes in renal ischemia.J Am Soc Nephrol 2009;20:1787-1796.