The cancer tumor: A metabolic parasite?;La tumeur cancéreuse: Un parasite métabolique ?

Bulletin du Cancer

Volumn 100, Issue 5, 2013, Pages 427-433

  Icard, Philippe ^a,b,d   Lincet, Hubert ^a,b,c,d  

^a NORMANDIE UNIVERSITÉ   (France)

^b EA 4656   (France)

^c CLCC Centre de Lutte Contre le Cancer François Baclesse   (France)

^d CAEN UNIVERSITY HOSPITAL   (France)

Author keywords

Biochemical pathways; Cancer; Energetic metabolism; Glutaminolysis; Glycolysis

Indexed keywords

LACTATE DEHYDROGENASE; PYRUVATE DEHYDROGENASE; PYRUVIC ACID;

BIOSYNTHESIS; CANCER CELL; CATABOLISM; CELL GROWTH; DNA SYNTHESIS; GLYCOLYSIS; LIPOGENESIS; NEOPLASM; OXYGEN CONCENTRATION; REVIEW; TUMOR MICROENVIRONMENT;

EID: 84880198853     PISSN: 00074551     EISSN: 17696917     Source Type: Journal    
DOI: 10.1684/bdc.2013.1742     Document Type: Article

References (31)

1. Israël M. Four hidden metamorphoses: a remark on blood, muscle, mental diseases and cancer. Montrouge: John Libbey Eurotext, 2004.
2. Vander Heiden MG, Cantley LC, Thompson CB. Understanding the Warburg effect: the metabolic requirements of cell proliferation. Science 2009 ; 324: 1029-33.
3. Warburg O. On the origin of cancer cells. Science 1956 ; 123: 309-14.
4. Icard P, Lincet H. A global view of the biochemical pathways involved in the regulation of the metabolism of cancer cells. Biochim Biophys Acta 2012 ; 1826: 423-33.
5. Cairns RA, Harris IS, Mak TW. Regulation of cancer cell metabolism. Nat Rev Cancer 2011 ; 11: 85-95.
6. Mazurek S. Pyruvate kinase M2: a key enzyme of the tumor metabolome and its medical relevance. Biomed Res 2012 ; 23: 133-41.
7. Icard P, Poulain L, Lincet H. Understanding the central role of citrate in the metabolism of cancer cells. Biochim Biophys Acta 2012 ; 1825: 111-6.
8. Keith B, Johnson RS, Simon MC. HIF1alpha and HIF2alpha: sibling rivalry in hypoxic tumour growth and progression. Nat Rev Cancer 2012 ; 12: 9-22.
9. Deberardinis RJ, Cheng T. Q's next: the diverse functions of glutamine in metabolism, cell biology and cancer. Oncogene 2010 ; 29: 313-24.
10. Israël M. Cancer: a dysmethylation syndrome. Montrouge: John Libbey Eurotext, 2005.
11. Nieman KM, Kenny HA, Penicka CV, et al. Adipocytes promote ovarian cancer metastasis and provide energy for rapid tumor growth. Nat Med 2011 ; 17: 1498-503.
12. Israël M, Schwartz L. On the metabolic origin of cancer: substances that target tumor. Biomed Res 2011 ; 22: 130-64.
13. Mullen AR, Wheaton WW, Jin ES, et al. Reductive carboxylation supports growth in tumour cells with defective mitochondria. Nature 2012 ; 481: 385-8.
14. Lepleux C, Abeilard-Lemoisson E, Duval M, Icard P, Lincet H. siPGK1 sensitizes chemoresistant human ovarian cancer cell lines to cisplatin. Anticancer Res 2012 ; 32: 4277-86.
15. Lu Y, Zhang XD, Lan J, et al. Citrate induces apoptotic cell death: a promising way for treating gastric carcinoma? Anticancer Res 2011 ; 31: 797-805.
16. Zhang X, Varin E, Allouche S, Lu Y, Poulain L, Icard P. Effect of citrate on malignant pleural mesothelioma cells: a synergistic effect with cisplatin. Anticancer Res 2009 ; 29: 1249-54.
17. Varin E, Denoyelle C, Brotin E, et al. Downregulation of BclxL and Mcl-1 is sufficient to induce cell death in mesothelioma cells highly refractory to conventional chemotherapy. Carcinogenesis 2010 ; 31: 984-93.
18. Li J, Li G, Xu W. Histone deacetylase inhibitors: an attractive strategy for cancer therapy. Curr Med Chem 2012. [Epub ahead of print].
19. Lehninger. Biochemistry: the molecular basis of cell structure and function. Book ; 1975.
20. Feron O. Pyruvate into lactate and back: from theWarburg effect to symbiotic energy fuel exchange in cancer cells. Radiother Oncol 2009 ; 92: 329-33.
21. Witkiewicz AK, Whitaker-Menezes D, Dasgupta A, et al. Using the "reverse Warburg effect" to identify high-risk breast cancer patients: stromal MCT4 predicts poor clinical outcome in triplenegative breast cancers. Cell Cycle 2012 ; 11: 1108-17.
22. Delage B, Fennell DA, Nicholson L, et al. Arginine deprivation and argininosuccinate synthetase expression in the treatment of cancer. Int J Cancer 2010 ; 126: 2762-72.
23. Soda K. The mechanisms by which polyamines accelerate tumor spread. J Exp Clin Cancer Res 2011 ; 30: 95.
24. Moellering RE, Black KC, Krishnamurty C, et al. Acid treatment of melanoma cells selects for invasive phenotypes. Clin Exp Metastasis 2008 ; 25: 411-25.
25. Chiche J, Ilc K, Laferriere J, et al. Hypoxia-inducible carbonic anhydrase IX and XII promote tumor cell growth by counteracting acidosis through the regulation of the intracellular pH. Cancer Res 2009 ; 69: 358-68.
26. Porporato PE, Dhup S, Dadhich RK, Copetti T, Sonveaux P. Anticancer targets in the glycolytic metabolism of tumors: a comprehensive review. Front Pharmacol 2011 ; 2: 49 (doi: 10.3389/fphar.2011.00049.).
27. Eng CH, Yu K, Lucas J, White E, Abraham RT. Ammonia derived from glutaminolysis is a diffusible regulator of autophagy. Sci Signal 2010 ; 3: ra31.
28. Mujoo K, Sharin VG, Martin E, et al. Role of soluble guanylyl cyclase-cyclic GMP signaling in tumor cell proliferation. Nitric Oxide 2010 ; 22: 43-50.
29. Zhang X, Deslandes E, Villedieu M, et al. Effect of 2-deoxy-D-glucose on various malignant cell lines in vitro. Anticancer Res 2006 ; 26: 3561-6.
30. Schwartz L, Guais A, Israel M, et al. Tumor regression with a combination of drugs interfering with the tumor metabolism: efficacy of hydroxycitrate, lipoic acid and capsaicin. Invest New Drugs 2012 ; 31: 256-64.
31. Icard P, Zhang XD, Lemoisson E, et al. Experimental results using 3-bromopyruvate in mesothelioma: in vitro and in vivo studies. J Bioenerg Biomembr 2012 ; 44: 673.