Semisynthesis, cytotoxic activity, and oral availability of new lipophilic 9-substituted camptothecin derivatives

ACS Medicinal Chemistry Letters

Volumn 4, Issue 7, 2013, Pages 651-655

  Rodriguez Berna, Guillermo ^a   Cabañas, Maria Jose Díaz ^a   Mangas Sanjuán, Victor ^b   Gonzalez Alvarez, Marta ^b   Gonzalez Alvarez, Isabel ^b   Abasolo, Ibane ^c   Schwartz, Simó ^c   Bermejo, Marival ^b   Corma, Avelino ^a  

^a CSIC   (Spain)

^b MIGUEL HERNÁNDEZ UNIVERSITY   (Spain)

^c HOSPITAL UNIVERSITARI VALL D HEBRON   (Spain)

Author keywords

9 substituted camptothecins; Lipophilic camptothecin; oral administration; Tscherniac Einhorn derivatives

Indexed keywords

ANTINEOPLASTIC AGENT; CAMPTOTHECIN DERIVATIVE; DNA TOPOISOMERASE; TOPOTECAN;

ANIMAL EXPERIMENT; ANTINEOPLASTIC ACTIVITY; ANTIPROLIFERATIVE ACTIVITY; ARTICLE; CONTROLLED STUDY; DRUG ABSORPTION; DRUG BIOAVAILABILITY; DRUG CYTOTOXICITY; DRUG EFFICACY; DRUG POTENCY; DRUG SCREENING; DRUG SYNTHESIS; ENZYME INHIBITION; HUMAN; HUMAN CELL; IC 50; LIPOPHILICITY; NONHUMAN; PRIORITY JOURNAL; RAT;

EID: 84880164399     PISSN: None     EISSN: 19485875     Source Type: Journal    
DOI: 10.1021/ml400125z     Document Type: Article

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