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84880140625
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This strategy is similar to that of the total synthesis of STX by Looper (ref. 17). They synthesized the STX skeleton by a silver and iodine -mediated one-pot cascade cyclization from a bis-guanidino-acetylene
-
This strategy is similar to that of the total synthesis of STX by Looper (ref. 17). They synthesized the STX skeleton by a silver and iodine -mediated one-pot cascade cyclization from a bis-guanidino-acetylene.
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38
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78651401680
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Hydroaminations of guanidino-acetylenes have recently been reported
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43
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84880166361
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Recently, Looper reported an iodocyclization between guanidine and olen (see ref. 17)
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Recently, Looper reported an iodocyclization between guanidine and olen (see ref. 17).
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47
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48
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33747427301
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Similar structures have been reported
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84957144948
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51
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84880140825
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When the corresponding salt with TFA was employed for this cyclization, the yield of 30 decreased
-
When the corresponding salt with TFA was employed for this cyclization, the yield of 30 decreased.
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52
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0033582523
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84880180167
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Du Bois reported the synthesis of a similar compound to 57 (see ref. 15b)
-
Du Bois reported the synthesis of a similar compound to 57 (see ref. 15b).
-
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60
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84880167609
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The conditions were identical to those employed in the total synthesis of saxitoxin by Du Bois and Nagasawa (see Ref. 15 and 16)
-
The conditions were identical to those employed in the total synthesis of saxitoxin by Du Bois and Nagasawa (see Ref. 15 and 16).
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