Pharmacology of tetrodotoxin

Journal of Toxicology - Toxin Reviews

Volumn 20, Issue 1, 2001, Pages 67-84

  Narahashi, T ^a  

^a NORTHWESTERN UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ION CHANNEL; NEUROTOXIN; SAXITOXIN; SODIUM CHANNEL; TETRODOTOXIN;

BACTERIUM; BINDING SITE; FISH; MEMBRANE DEPOLARIZATION; REVIEW; SYNAPTIC TRANSMISSION; TISSUE DISTRIBUTION; TOXICOKINETICS; TOXIN STRUCTURE;

BACTERIA (MICROORGANISMS); TETRAODONTIDAE;

EID: 0035069576     PISSN: 07313837     EISSN: None     Source Type: Journal    
DOI: 10.1081/TXR-100102537     Document Type: Review

References (87)

1. Microflora and tetrodotoxin-producing bacteria in a gastropod, Niotha clathrata
2. A tetrodotoxin-producing Vibrio strain, LM-1, from the puffer fish Fugu vermicularis radiatus
3. Environmental microbiology: A tetrodotoxin-producing marine pathogen
4. Taxonomy of four marine bacterial strains that produce tetrodotoxin
5. Interspecies distribution and possible origin of tetrodotoxin
6. Production of tetrodotoxin and its derivatives by Pseudomonas sp. isolated from the skin of a pufferfish
7. Reexamination of tetrodotoxin production by bacteria
8. Absence of tetro-dotoxins in a captive-raised riparian frog, Atelopus varius
9. Tetrodotoxin, saxitoxin and their significance in the study of excitation phenomena
10. The purification and characterization of the poison produced by Gonyaulax catenella in axenic culture
11. Occurrence of carbamoyl-N-hydroxy derivatives of xanitoxin and neosaxitoxin in a xanthid crab Zosimus aeneus
12. Isolation and some properties of neosaxitoxin from a xanthid crab Zosimus aeneus
13. Natural occurrence of decarbamoylsaxitoxin in tropical dinoflagellate and bivalves
14. Occurrence of neosaxitoxin and other paralytic shellfish poisons in toxic crabs belonging to the family Xanthidae
15. Identity of the crab toxin with saxitoxin
16. Occurrence of tetrodotoxin as the major toxin in a xanthid crab Atergatis floridus
17. Analysis of paralytic shellfish toxins of xanthid crabs in Okinawa
18. Tetrodotoxin and paralytic shellfish toxins in Philippine crabs
19. Chemicals as tools in the study of excitable membranes
20. Stabilization and rectification of muscle fiber membrane by tetrodotoxin
21. Tetrodotoxin blockage of sodium conductance increase in lobster giant axons
22. Voltage-regulated sodium channel molecules
23. Neurotoxins that act on voltage-sensitive sodium channels in excitable membranes
24. Cellular and molecular biology of voltage-gated sodium channels
25. From ionic currents to molecular mechanisms: The structure and function of voltage-gated sodium channels
26. Mechanism of tetrodotoxin and saxitoxin action
27. Chemical modulation of sodium channels
28. Recent advances in the study of mechanism of action of marine neurotoxins
29. Ion permeation in cell membranes
30. The binding of sanitoxin and tetrodotoxin to excitable tissue
31. Primary structure and functional expression of the β1 subunit of the rat brain sodium channel
32. Structure and function of the β2 subunit of brain sodium channels, a transmembrane glycoprotein with a CAM-motif
33. Mechanism of modulation of single sodium channels from skeletal muscle by the β1-subunit from rat brain
34. Molecular model of the action potential sodium channel
35. Tetrodotoxin block of sodium channels in rabbit Purkinje fibers
36. + channels in isolated single cultured rat myocardial cells
37. Voltage-dependent action of tetrodotoxin in mammalian cardiac muscle
38. Differential expression of Na channel subtypes in two populations of sensory neurons
39. Differential gating of TTX-sensitive and -resistant Na currents in bullfrog sensory neurons
40. Two sodium currents in dissociated bullfrog sympathetic neurons
41. Patch-clamp study of the tetrodotoxin-resistant sodium current in group C sensory neurones
42. Tetrodotoxin-resistant sodium current of rat nodose neurones: Monovalent cation selectivity and divalent cation block
43. 2+ currents of acutely isolated adult rat nodose ganglion cells
44. Ionic currents in the somatic membrane of rat dorsal root ganglion neurons-I. Sodium currents
45. Tetrodotoxin sensitivity and Ca component of action potentials of mouse dorsal root ganglion cells cultured in vitro
46. Subtypes of dorsal root ganglion neurons based on different inward currents as measured by wholecell voltage clamp
47. Structural and developmental differences between three types of Na channels in dorsal root ganglion cells of newborn rats
48. Tetrodotoxin-resistant sodium and calcium components of action potentials in dorsal root ganglion cells of the adult mouse
49. Capsaicin blocks tetrodotoxin-resistant sodium potentials and calcium potentials in unmyelinated C fibres of biopsied human sural nerve in vitro
50. + channels in neurons of rat dorsal root ganglia
51. Differential properties of tetrodotoxin-sensitive and tetrodotoxin-resistant sodium channels in rat dorsal root ganglion neurons
52. Differential sensitivity of tetrodotoxin-sensitive and tetrodotoxin-resistant sodium channels to the insecticide allethrin in rat dorsal root ganglion neurons
53. Differential mechanism of actin of the pyrethroid tetramethrin on tetrodotoxin-sensitive and tetrodotoxin-resistant sodium channels
54. Stabilization of sodium channel states by deltamethrin in mouse neuroblastoma cells
55. Modification of single sodium channels by the insecticide tetramethrin
56. Structure and function of voltage-gated ion channels
57. Diversity of mammalian voltage-gated sodium channels
58. Structure and function of voltage-activated sodium channels
59. Evolution and diversity of mammalian sodium channel genes
60. Occurrence of tetrodotoxin-binding high molecular weight substances in the body fluid of shore crab (Hemigrapsus sanguineus)
61. A tetrodotoxin neutralizing system in the haemolymph of the horseshoe crab, Carcinoscorpius rotundicauda
62. The receptor for tetrodotoxin and saxitoxin. A structural hypothesis
63. Molecular localization of an ion-binding site within the pore of mammalian sodium channels
64. Molecular basis for pharmacological differences between brain and cardiac sodium channels
65. + channel outer vestibule
66. A mutant of TTX-resistant cardiac sodium channels with TTX-sensitive properties
67. A critical residue for isoform difference in tetrodotoxin affinity is a molecular determinant of the external access path for local anesthetics in the cardiac sodium channel
68. A single serine residue confers tetrodotoxin insensitivity on the rat sensory-neuron-specific sodium channel SNS
69. Emerging treatments for stoke in humans
70. The possible involvement of tetrodotoxin-sensitive ion channels in ischemic neuronal damage in the rat hippocampus
71. + channel modulator and glutamate release inhibitor in cultured rat cerebellar neurons and in gerbil global brain ischemia
72. Effects of the sodium channel blocker tetrodotoxin on acute white matter pathology after experimental contusive spinal cord injury
73. Selective suppression of in vitro electrographic seizures by low-dose tetrodotoxin: A novel anticonvulsant effect
74. Tetrodotoxin prevents posttraumatic epileptogenesis in rats
75. 4-Aminopyridine antagonizes saxitoxin-and tetrodotoxin-induced cardiorespiratory depression
76. 4-Aminopyridine reverses saxitoxin (STX)- and tetrodotoxin (TTX)-induced cardiorespiratory depression in chronically instrumented guinea pigs
77. Experimental use of tetrodotoxin for corneal pain after excimer laser keratectomy
78. Experimental study of tetrodotoxin, a long-acting topical anesthetic
79. A reexamination of tetrodotoxin for prolonged duration local anesthesia
80. Effects of tetrodotoxin and OKY-046 in renal ischemia reperfusion
81. Tetrodotoxin protects against acute ischemic renal failure in the rat
82. In vivo neutralization of tetrodotoxin by a monoclonal antibody
83. A monoclonal antibody against tetrodotoxin that reacts to the active group for the toxicity
84. Prophylaxis and treatment with a monoclonal antibody of tetrodotoxin poisoning in mice
85. Dependence of tetrodotoxin blockage of nerve membrane conductance on external pH
86. Mode of action of dinoflagellate toxins on nerve membranes
87. Local anesthetics