Synaptic transmission and the susceptibility of HIV infection to anti-viral drugs

Scientific Reports

Volumn 3, Issue , 2013, Pages

  Komarova, Natalia L ^a   Levy, David N ^b   Wodarz, Dominik ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b NEW YORK UNIVERSITY COLLEGE OF DENTISTRY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTI HUMAN IMMUNODEFICIENCY VIRUS AGENT;

HIV INFECTIONS; HUMAN; SYNAPTIC TRANSMISSION; THEORETICAL MODEL; ARTICLE; HUMAN IMMUNODEFICIENCY VIRUS INFECTION;

ANTI-HIV AGENTS; HIV INFECTIONS; HUMANS; MODELS, THEORETICAL; SYNAPTIC TRANSMISSION;

EID: 84880121275     PISSN: None     EISSN: 20452322     Source Type: Journal    
DOI: 10.1038/srep02103     Document Type: Article

References (36)

1. Nowak, M. A. & May, R. M. Virus dynamics. Mathematical principles of immunology and virology. (Oxford University Press, 2000).
2. Perelson, A. S. Modelling viral and immune system dynamics. Nature Rev Immunol 2, 28-36 (2002). (Pubitemid 37328773)
3. Douek, D. C., Picker, L. J. & Koup, R. A. T cell dynamics in HIV-1 infection. Annu Rev Immunol 21, 265-304 (2003). (Pubitemid 37174533)
4. Simon, V. & Ho, D. D. HIV-1 dynamics in vivo: implications for therapy. Nat Rev Microbiol 1, 181-190 (2003).
5. Chen, P., Hubner, W., Spinelli, M. A. & Chen, B. K. Predominant mode of human immunodeficiency virus transfer between T cells is mediated by sustained Env-dependent neutralization-resistant virological synapses. J Virol 81, 12582-12595 (2007). (Pubitemid 350085872)
6. Feldmann, J. & Schwartz, O. HIV-1 Virological Synapse: Live Imaging of Transmission. 2, 1666-1680 (2010).
7. Hubner, W. et al. Quantitative 3D video microscopy of HIV transfer across T cell virological synapses. Science 323, 1743-1747 (2009).
8. Martin, N. & Sattentau, Q. Cell-to-cell HIV-1 spread and its implications for immune evasion. Curr Opin HIV AIDS 4, 143-149 (2009).
9. Sattentau, Q. Avoiding the void: cell-to-cell spread of human viruses. Nat Rev Microbiol 6, 815-826 (2008).
10. Sattentau, Q. J. Cell-to-Cell Spread of Retroviruses. 2, 1306-1321 (2010).
11. Sourisseau, M., Sol-Foulon, N., Porrot, F., Blanchet, F. & Schwartz, O. Inefficient human immunodeficiency virus replication in mobile lymphocytes. J Virol 81, 1000-1012 (2007). (Pubitemid 46067924)
12. Jung, A. et al. Multiply infected spleen cells in HIV patients. Nature 418, 144 (2002). (Pubitemid 34773761)
13. Josefsson, L. et al. Majority of CD41 T cells from peripheral blood of HIV-1-infected individuals contain only one HIV DNA molecule. Proc Natl Acad Sci U S A 108, 11199-11204 (2011).
14. Bonhoeffer, S., Chappey, C., Parkin, N. T., Whitcomb, J. M. & Petropoulos, C. J. Evidence for positive epistasis in HIV-1. Science 306, 1547-1550 (2004). (Pubitemid 39564948)
15. Fraser, C. HIV recombination: what is the impact on antiretroviral therapy? J R Soc Interface 2, 489-503 (2005).
16. Vijay, N. N., Vasantika, Ajmani, R., Perelson, A. S. & Dixit, N. M. Recombination increases human immunodeficiency virus fitness, but not necessarily diversity. The Journal of general virology 89, 1467-1477 (2008).
17. Althaus, C. L. & Bonhoeffer, S. Stochastic interplay between mutation and recombination during the acquisition of drug resistance mutations in human immunodeficiency virus type 1. J Virol 79, 13572-13578 (2005). (Pubitemid 41508169)
18. Kouyos, R. D., Althaus, C. L. & Bonhoeffer, S. Stochastic or deterministic: what is the effective population size of HIV-1? Trends Microbiol 14, 507-511 (2006). (Pubitemid 44751456)
19. Kouyos, R. D., Silander, O. K. & Bonhoeffer, S. Epistasis between deleterious mutations and the evolution of recombination. Trends Ecol Evol 22, 308-315 (2007). (Pubitemid 46734517)
20. Gelderblom, H. C. et al. Viral complementation allows HIV-1 replication without integration. Retrovirology 5, 60 (2008).
21. Iwabu, Y. et al. Superinfection of defective human immunodeficiency virus type 1 with different subtypes of wild-type virus efficiently produces infectious variants with the initial viral phenotypes by complementation followed by recombination. Microbes Infect 10, 504-513 (2008).
22. Wodarz, D. & Levy, D. N. Human immunodeficiency virus evolution towards reduced replicative fitness in vivo and the development of AIDS. Proc Biol Sci 274, 2481-2490 (2007). (Pubitemid 47436611)
23. Wodarz, D. & Levy, D. N. Multiple HIV-1 infection of cells and the evolutionary dynamics of cytotoxic T lymphocyte escape mutants. Evolution 63, 2326-2339 (2009).
24. Wodarz, D. &Levy, D. N. Effectofdifferent modesof viral spreadonthe dynamics of multiply infected cells in human immunodeficiency virus infection. J R Soc Interface 8, 289-300 (2011).
25. Wodarz, D. & Levy, D. N. Effect of multiple infection of cells on the evolutionary dynamics of HIV in vivo: implications for host adaptation mechanisms. Exp Biol Med (Maywood) 236, 926-937 (2011).
26. Sigal, A. et al. Cell-to-cell spread of HIV permits ongoing replication despite antiretroviral therapy. Nature 477, 95-98 (2011).
27. De Boer, R. J. & Perelson, A. S. Target cell limited and immune control models of HIV infection: a comparison. J Theor Biol 190, 201-214 (1998). (Pubitemid 28132653)
28. Bonhoeffer, S., May, R.M., Shaw, G. M. & Nowak, M. A. Virus dynamics and drug therapy. Proceedings of the National Academy of Sciences of the United States of America 94, 6971-6976 (1997). (Pubitemid 27281975)
29. Dixit, N. M. & Perelson, A. S. Multiplicity of human immunodeficiency virus infections in lymphoid tissue. J Virol 78, 8942-8945 (2004). (Pubitemid 39025162)
30. Dixit, N. M. & Perelson, A. S. HIV dynamics with multiple infections of target cells. Proc Natl Acad Sci U S A 102, 8198-8203 (2005). (Pubitemid 40800066)
31. Dimitrov, D. S. et al. Quantitation of human immunodeficiency virus type 1 infection kinetics. J Virol 67, 2182-2190 (1993). (Pubitemid 23088394)
32. Cummings, K. W., Levy, D. N. & Wodarz, D. Increased burst size in multiply infected cells can alter basic virus dynamics. Biol Direct 7, 16 (2012).
33. Gupta, P., Balachandran, R., Ho, M., Enrico, A. & Rinaldo, C. Cell-to-cell transmission of human immunodeficiency virus type 1 in the presence of azidothymidine and neutralizing antibody. J Virol 63, 2361-2365 (1989). (Pubitemid 19107837)
34. Martin, N. et al. Virological synapse-mediated spread of human immunodeficiency virus type 1 between T cells is sensitive to entry inhibition. J Virol 84, 3516-3527 (2010).
35. Massanella, M. et al. Antigp41 antibodies fail to block early events of virological synapses but inhibit HIV spread between T cells. AIDS 23, 183-188 (2009).
36. Permanyer, M. et al. Antiretroviral Agents Effectively Block HIV Replication after Cell-to-Cell Transfer. J Virol 86, 8773-8780 (2012).