How can nanotechnology help to repair the body? Advances in cardiac, skin, bone, cartilage and nerve tissue regeneration

Materials

Volumn 6, Issue 4, 2013, Pages 1333-1359

  Perán, Macarena ^a   García, María Angel ^b   Lopez Ruiz, Elena ^a   Jiménez, Gema ^c   Marchal, Juan Antonio ^c  

^a UNIVERSITY OF JAÉN   (Spain)

^b HOSPITAL UNIVERSITARIO VIRGEN DE LAS NIEVES   (Spain)

^c UNIVERSITY OF GRANADA   (Spain)

Author keywords

Bio scaffold; Nanostructures; Nanotechnology; Tissue engineering

Indexed keywords

BIO-SCAFFOLDS; CELL DELIVERY; CELL THERAPY; IN-VIVO; REGENERATIVE MEDICINE; RESEARCH ADVANCES; TISSUE REPAIR;

BONE; CARTILAGE; NANOSTRUCTURES; NANOTECHNOLOGY; REPAIR; TISSUE; TISSUE ENGINEERING;

SCAFFOLDS (BIOLOGY);

EID: 84880083521     PISSN: None     EISSN: 19961944     Source Type: Journal    
DOI: 10.3390/ma6041333     Document Type: Article

References (130)

1. de Mel, A.; Seifalian, A.M.; Birchall, M.A. Orchestrating cell/material interactions for tissue engineering of surgical implants. Macromol. Biosci. 2012, 12, 1010-1021.
2. Peran, M.; Garcia, M.A.; Lopez-Ruiz, E.; Bustamante, M.; Jimenez, G.; Madeddu, R.; Marchal, J.A. Functionalized nanostructures with application in regenerative medicine. Int. J. Mol. Sci. 2012, 13, 3847-3886.
3. Badylak, S.F.; Freytes, D.O.; Gilbert, T.W. Extracellular matrix as a biological scaffold material: Structure and function. Acta Biomater. 2009, 5, 1-13.
4. Kakisis, J.D.; Liapis, C.D.; Breuer, C.; Sumpio, B.E. Artificial blood vessel: the Holy Grail of peripheral vascular surgery. J. Vasc. Surg. 2005, 41, 349-354.
5. Li, W.J.; Laurencin, C.T.; Caterson, E.J.; Tuan, R.S.; Ko, F.K. Electrospun nanofibrous structure: A novel scaffold for tissue engineering. J. Biomed. Mater. Res. 2002, 60, 613-621.
6. Liang, D.; Hsiao, B.S.; Chu, B. Functional electrospun nanofibrous scaffolds for biomedical applications. Adv. Drug Deliv. Rev. 2007, 59, 1392-1412.
7. Sen, C.K.; Gordillo, G.M.; Roy, S.; Kirsner, R.; Lambert, L.; Hunt, T.K.; Gottrup, F.; Gurtner, G.C.; Longaker, M.T. Human skin wounds: a major and snowballing threat to public health and the economy. Wound Repair Regen. 2009, 17, 763-771.
8. Clark, K.L. Nutritional considerations in joint health. Clin. Sports Med. 2007, 26, 101-118.
9. Viswanathan, H.N.; Curtis, J.R.; Yu, J.; White, J.; Stolshek, B.S.; Merinar, C.; Balasubramanian, A.; Kallich, J.D.; Adams, J.L.; Wade, S.W. Direct healthcare costs of osteoporosis-related fractures in managed care patients receiving pharmacological osteoporosis therapy. Appl. Health Econ. Health Policy 2012, 10, 163-173.
10. Jamison, D.T.; Breman, J.G.; Measham, A.R.; Alleyne, G.; Claeson, M.; Evans, D.B.; Jha, P.; Mills, A.; Musgrove, P. Priorities in Health; World Bank: Washington, DC, USA, 2006.
11. Heidenreich, P.A.; Trogdon, J.G.; Khavjou, O.A.; Butler, J.; Dracup, K.; Ezekowitz, M.D.; Finkelstein, E.A.; Hong, Y.; Johnston, S.C.; Khera, A.; et al. Forecasting the future of cardiovascular disease in the United States: A policy statement from the American Heart Association. Circulation 2011, 123, 933-944.
12. Ramakrishna, S.; Fujihara, K.; Teo, W.E.; Lim,T.C.; Ma, Z. An Introduction to Electrospinning and Nanofibers; World Scientific Publishing Co.: Hackensack, NJ, USA, 2005.
13. Pham, Q.P.; Sharma, U.; Mikos, A.G. Electrospinning of polymeric nanofibers for tissue engineering applications: a review. Tissue Eng. 2006, 12, 1197-1211.
14. Venugopal, J.; Ramakrishna, S. Applications of polymer nanofibers in biomedicine and biotechnology. Appl. Biochem. Biotechnol. 2005, 125, 147-158.
15. La Francesca, S. Nanotechnology and stem cell therapy for cardiovascular diseases: Potential applications. Methodist Debakey Cardiovasc. J. 2012, 8, 28-35.
16. Mohamed, A.; Xing, M.M. Nanomaterials and nanotechnology for skin tissue engineering. Int. J. Burns Trauma 2012, 2, 29-41.
17. Huang, S.; Fu, X. Naturally derived materials-based cell and drug delivery systems in skin regeneration. J. Control. Release 2010, 142, 149-159.
18. Stynes, G.; Kiroff, G.K.; Morrison, W.A.; Kirkland, M.A. Tissue compatibility of biomaterials: Benefits and problems of skin biointegration. ANZ J. Surg. 2008, 78, 654-659.
19. Liu, W.; Cao, Y.L. Application of scaffold materials in tissue reconstruction in immunocompetent mammals: Our experience and future requirements. Biomaterials 2007, 28, 5078-5086.
20. Tran, P.A.; Zhang, L.; Webster, T.J. Carbon nanofibers and carbon nanotubes in regenerative medicine. Adv. Drug Deliv. Rev. 2009, 61, 1097-1114.
21. Khil, M.S.; Cha, D.I.; Kim, H.Y.; Kim, I.S.; Bhattarai, N. Electrospun nanofibrous polyurethane membrane as wound dressing. J. Biomed. Mater. Res. B Appl. Biomater. 2003, 67, 675-679.
22. Wang, C.C.; Su, C.H.; Chen, C.C. Water absorbing and antibacterial properties of N-isopropyl acrylamide grafted and collagen/chitosan immobilized polypropylene nonwoven fabric and its application on wound healing enhancement. J. Biomed. Mater. Res. A 2008, 84, 1006-1017.
23. van den Bogaerdt, A.J.; van Zuijlen, P.P.; van Galen, M.; Lamme, E.N.; Middelkoop, E. The suitability of cells from different tissues for use in tissue-engineered skin substitutes. Arch. Dermatol. Res. 2002, 294, 135-142.
24. Ojeh, N.O.; Frame, J.D.; Navsaria, H.A. In vitro characterization of an artificial dermal scaffold. Tissue Eng. 2001, 7, 457-472.
25. Chandrasekaran, A.R.; Venugopal, J.; Sundarrajan, S.; Ramakrishna, S. Fabrication of a nanofibrous scaffold with improved bioactivity for culture of human dermal fibroblasts for skin regeneration. Biomed. Mater. 2011, 6, 015001:1-015001:10.
26. Venugopal, J.R.; Zhang, Y.; Ramakrishna, S. In vitro culture of human dermal fibroblasts on electrospun polycaprolactone collagen nanofibrous membrane. Artif. Organs 2006, 30, 440-446.
27. Jin, G.; Prabhakaran, M.P.; Ramakrishna, S. Stem cell differentiation to epidermal lineages on electrospun nanofibrous substrates for skin tissue engineering. Acta Biomater. 2011, 7, 3113-3122.
28. Tchemtchoua, V.T.; Atanasova, G.; Aqil, A.; Filee, P.; Garbacki, N.; Vanhooteghem, O.; Deroanne, C.; Noel, A.; Jerome, C.; Nusgens, B.; et al. Development of a chitosan nanofibrillar scaffold for skin repair and regeneration. Biomacromolecules 2011, 12, 3194-3204.
29. Lenz, G.; Mansson, P. Growth factors as pharmaceuticals. Pharm. Technol. 1991, 15, 34-38.
30. Yang, Y.; Xia, T.; Chen, F.; Wei, W.; Liu, C.; He, S.; Li, X. Electrospun fibers with plasmid bFGF polyplex loadings promote skin wound healing in diabetic rats. Mol. Pharm. 2012, 9, 48-58.
31. Tocco, I.; Zavan, B.; Bassetto, F.; Vindigni, V. Nanotechnology-based therapies for skin wound regeneration. J. Nanomater. 2012, doi:10.1155/2012/714134.
32. Ziv-Polat, O.; Topaz, M.; Brosh, T.; Margel, S. Enhancement of incisional wound healing by thrombin conjugated iron oxide nanoparticles. Biomaterials 2010, 31, 741-747.
33. Lopez-Ruiz, E.; Peran, M.; Cobo-Molinos, J.; Jimenez, G.; Picon, M.; Bustamante, M.; Arrebola, F.; Hernandez-Lamas, M.C.; Delgado-Martinez, A.D.; Montanez, E.; Marchal, J.A. Chondrocytes extract from patients with osteoarthritis induces chondrogenesis in infrapatellar fat pad-derived stem cells. Osteoarthr. Cartil. 2013, 21, 246-258.
34. Vinatier, C.; Bouffi, C.; Merceron, C.; Gordeladze, J.; Brondello, J.M.; Jorgensen, C.; Weiss, P.; Guicheux, J.; Noel, D. Cartilage tissue engineering: Towards a biomaterial-assisted mesenchymal stem cell therapy. Curr. Stem Cell Res. Ther. 2009, 4, 318-329.
35. Lee, S.H.; Shin, H. Matrices and scaffolds for delivery of bioactive molecules in bone and cartilage tissue engineering. Adv. Drug Deliv. Rev. 2007, 59, 339-359.
36. Capito, R.M.; Spector, M. Scaffold-based articular cartilage repair. IEEE Eng. Med. Biol. Mag. 2003, 22, 42-50.
37. Alves da Silva, M.L.; Martins, A.; Costa-Pinto, A.R.; Costa, P.; Faria, S.; Gomes, M.; Reis, R.L.; Neves, N.M. Cartilage tissue engineering using electrospun PCL nanofiber meshes and MSCs. Biomacromolecules 2010, 11, 3228-3236.
38. Dahl, J.P.; Caballero, M.; Pappa, A.K.; Madan, G.; Shockley, W.W.; van Aalst, J.A. Analysis of human auricular cartilage to guide tissue-engineered nanofiber-based chondrogenesis: Implications for microtia reconstruction. Otolaryngol. Head Neck Surg. 2011, 145, 915-923.
39. Coburn, J.M.; Gibson, M.; Monagle, S.; Patterson, Z.; Elisseeff, J.H. Bioinspired nanofibers support chondrogenesis for articular cartilage repair. Proc. Natl. Acad. Sci. USA 2012, 109, 10012-10017.
40. Shafiee, A.; Soleimani, M.; Chamheidari, G.A.; Seyedjafari, E.; Dodel, M.; Atashi, A.; Gheisari, Y. Electrospun nanofiber-based regeneration of cartilage enhanced by mesenchymal stem cells. J. Biomed. Mater. Res. A 2011, 99, 467-478.
41. Jung, Y.; Chung, Y.I.; Kim, S.H.; Tae, G.; Kim, Y.H.; Rhie, J.W. In situ chondrogenic differentiation of human adipose tissue-derived stem cells in a TGF-beta1 loaded fibrin-poly(lactide-caprolactone) nanoparticulate complex. Biomaterials 2009, 30, 4657-4664.
42. Park, J.S.; Yang, H.N.; Woo, D.G.; Jeon, S.Y.; Do, H.J.; Lim, H.Y.; Kim, J.H.; Park, K.H. Chondrogenesis of human mesenchymal stem cells mediated by the combination of SOX trio SOX5, 6, and 9 genes complexed with PEI-modified PLGA nanoparticles. Biomaterials 2011, 32, 3679-3688.
43. Kim, J.H.; Park, J.S.; Yang, H.N.; Woo, D.G.; Jeon, S.Y.; Do, H.J.; Lim, H.Y.; Kim, J.M.; Park, K.H. The use of biodegradable PLGA nanoparticles to mediate SOX9 gene delivery in human mesenchymal stem cells (hMSCs) and induce chondrogenesis. Biomaterials 2011, 32, 268-278.
44. Jeon, S.Y.; Park, J.S.; Yang, H.N.; Woo, D.G.; Park, K.H. Co-delivery of SOX9 genes and anti-Cbfa-1 siRNA coated onto PLGA nanoparticles for chondrogenesis of human MSCs. Biomaterials 2012, 33, 4413-4423.
45. Park, J.S.; Yang, H.N.; Woo, D.G.; Chung, H.M.; Park, K.H. In vitro and in vivo chondrogenesis of rabbit bone marrow-derived stromal cells in fibrin matrix mixed with growth factor loaded in nanoparticles. Tissue Eng. A 2009, 15, 2163-2175.
46. Park, J.S.; Yang, H.N.; Woo, D.G.; Jeon, S.Y.; Park, K.H. Chondrogenesis of human mesenchymal stem cells in fibrin constructs evaluated in vitro and in nude mouse and rabbit defects models. Biomaterials 2011, 32, 1495-1507.
47. Na, K.; Kim, S.; Park, K.; Kim, K.; Woo, D.G.; Kwon, I.C.; Chung, H.M.; Park, K.H. Heparin/poly(L-lysine) nanoparticle-coated polymeric microspheres for stem-cell therapy. J. Am. Chem Soc. 2007, 129, 5788-5789.
48. Hsu, S.H.; Huang, T.B.; Cheng, S.J.; Weng, S.Y.; Tsai, C.L.; Tseng, C.S.; Chen, D.C.; Liu, T.Y.; Fu, K.Y.; Yen, B.L. Chondrogenesis from human placenta-derived mesenchymal stem cells in three-dimensional scaffolds for cartilage tissue engineering. Tissue Eng. A 2011, 17, 1549-1560.
49. Liu, L.; Wang, Y.; Guo, S.; Wang, Z.; Wang, W. Porous polycaprolactone/nanohydroxyapatite tissue engineering scaffolds fabricated by combining NaCl and PEG as co-porogens: structure, property, and chondrocyte-scaffold interaction in vitro. J. Biomed. Mater. Res. B Appl. Biomater. 2012, 100, 956-966.
50. Xue, D.; Zheng, Q.; Zong, C.; Li, Q.; Li, H.; Qian, S.; Zhang, B.; Yu, L.; Pan, Z. Osteochondral repair using porous poly(lactide-co-glycolide)/nano-hydroxyapatite hybrid scaffolds with undifferentiated mesenchymal stem cells in a rat model. J. Biomed. Mater. Res. A 2010, 94, 259-270.
51. Kon, E.; Delcogliano, M.; Filardo, G.; Busacca, M.; Di Martino, A.; Marcacci, M. Novel nano-composite multilayered biomaterial for osteochondral regeneration: A pilot clinical trial. Am. J. Sports Med. 2011, 39, 1180-1190.
52. Arrington, E.D.; Smith, W.J.; Chambers, H.G.; Bucknell, A.L.; Davino, N.A. Complications of iliac crest bone graft harvesting. Clin. Orthop. Relat. Res. 1996, 300-309.
53. Giannoudis, P.V.; Dinopoulos, H.; Tsiridis, E. Bone substitutes: An update. Injury 2005, 36, S20-S27.
54. Miyazaki, M.; Tsumura, H.; Wang, J.C.; Alanay, A. An update on bone substitutes for spinal fusion. Eur. Spine J. 2009, 18, 783-799.
55. Kneser, U.; Schaefer, D.J.; Polykandriotis, E.; Horch, R.E. Tissue engineering of bone: The reconstructive surgeon's point of view. J. Cell. Mol. Med. 2006, 10, 7-19.
56. Rho, J.Y.; Kuhn-Spearing, L.; Zioupos, P. Mechanical properties and the hierarchical structure of bone. Med. Eng. Phys. 1998, 20, 92-102.
57. Yoshimoto, H.; Shin, Y.M.; Terai, H.; Vacanti, J.P. A biodegradable nanofiber scaffold by electrospinning and its potential for bone tissue engineering. Biomaterials 2003, 24, 2077-2082.
58. Frohbergh, M.E.; Katsman, A.; Botta, G.P.; Lazarovici, P.; Schauer, C.L.; Wegst, U.G.; Lelkes, P.I. Electrospun hydroxyapatite-containing chitosan nanofibers crosslinked with genipin for bone tissue engineering. Biomaterials 2012, 33, 9167-9178.
59. Kim, K.H.; Jeong, L.; Park, H.N.; Shin, S.Y.; Park, W.H.; Lee, S.C.; Kim, T.I.; Park, Y.J.; Seol, Y.J.; Lee, Y.M.; et al. Biological efficacy of silk fibroin nanofiber membranes for guided bone regeneration. J. Biotechnol. 2005, 120, 327-339.
60. Nguyen, L.T.; Liao, S.; Chan, C.K.; Ramakrishna, S. Enhanced osteogenic differentiation with 3D electrospun nanofibrous scaffolds. Nanomedicine 2012, 7, 1561-1575.
61. Ravichandran, R.; Venugopal, J.R.; Sundarrajan, S.; Mukherjee, S.; Ramakrishna, S. Precipitation of nanohydroxyapatite on PLLA/PBLG/Collagen nanofibrous structures for the differentiation of adipose derived stem cells to osteogenic lineage. Biomaterials 2012, 33, 846-855.
62. Schofer, M.D.; Roessler, P.P.; Schaefer, J.; Theisen, C.; Schlimme, S.; Heverhagen, J.T.; Voelker, M.; Dersch, R.; Agarwal, S.; Fuchs-Winkelmann, S.; Paletta, J.R. Electrospun PLLA nanofiber scaffolds and their use in combination with BMP-2 for reconstruction of bone defects. PLoS One 2011, 6, e25462.
63. Schofer, M.D.; Tunnermann, L.; Kaiser, H.; Roessler, P.P.; Theisen, C.; Heverhagen, J.T.; Hering, J.; Voelker, M.; Agarwal, S.; Efe, T.; et al. Functionalisation of PLLA nanofiber scaffolds using a possible cooperative effect between collagen type I and BMP-2: Impact on colonization and bone formation in vivo. J. Mater. Sci. Mater. Med. 2012, 23, 2227-2233.
64. Dalby, M.J.; Gadegaard, N.; Curtis, A.S.; Oreffo, R.O. Nanotopographical control of human osteoprogenitor differentiation. Curr. Stem Cell Res. Ther. 2007, 2, 129-138.
65. Felice, P.; Pistilli, R.; Piattelli, M.; Soardi, E.; Corvino, V.; Esposito, M. Posterior atrophic jaws rehabilitated with prostheses supported by 5 × 5 mm implants with a novel nanostructured calcium-incorporated titanium surface or by longer implants in augmented bone. Preliminary results from a randomised controlled trial. Eur. J. Oral Implantol. 2012, 5, 149-161.
66. Peltola, T.; Jokinen, M.; Rahiala, H.; Patsi, M.; Heikkila, J.; Kangasniemi, I.; Yli-Urpo, A. Effect of aging time of sol on structure and in vitro calcium phosphate formation of sol-gel-derived titania films. J. Biomed. Mater. Res. 2000, 51, 200-208.
67. Wennerberg, A.; Frojd, V.; Olsson, M.; Nannmark, U.; Emanuelsson, L.; Johansson, P.; Josefsson, Y.; Kangasniemi, I.; Peltola, T.; Tirri, T.; et al. Nanoporous TiO(2) thin film on titanium oral implants for enhanced human soft tissue adhesion: a light and electron microscopy study. Clin. Implant. Dent. Relat. Res. 2011, 13, 184-196.
68. Rani, V.V.; Vinoth-Kumar, L.; Anitha, V.C.; Manzoor, K.; Deepthy, M.; Shantikumar, V.N. Osteointegration of titanium implant is sensitive to specific nanostructure morphology. Acta Biomater. 2012, 8, 1976-1989.
69. Wang, X.; Gittens, R.A.; Song, R.; Tannenbaum, R.; Olivares-Navarrete, R.; Schwartz, Z.; Chen, H.; Boyan, B.D. Effects of structural properties of electrospun TiO2 nanofiber meshes on their osteogenic potential. Acta Biomater. 2012, 8, 878-885.
70. Zhang, L.; Chen, Y.; Rodriguez, J.; Fenniri, H.; Webster, T.J. Biomimetic helical rosette nanotubes and nanocrystalline hydroxyapatite coatings on titanium for improving orthopedic implants. Int. J. Nanomed. 2008, 3, 323-333.
71. Sun, L.; Zhang, L.; Hemraz, U.D.; Fenniri, H.; Webster, T.J. Bioactive rosette nanotube-hydroxyapatite nanocomposites improve osteoblast functions. Tissue Eng. A 2012, 18, 1741-1750.
72. Sahithi, K.; Swetha, M.; Ramasamy, K.; Srinivasan, N.; Selvamurugan, N. Polymeric composites containing carbon nanotubes for bone tissue engineering. Int. J. Biol. Macromol. 2010, 46, 281-283.
73. Li, X.; Liu, H.; Niu, X.; Yu, B.; Fan, Y.; Feng, Q.; Cui, F.Z.; Watari, F. The use of carbon nanotubes to induce osteogenic differentiation of human adipose-derived MSCs in vitro and ectopic bone formation in vivo. Biomaterials 2012, 33, 4818-4827.
74. Dallari, D.; Savarino, L.; Albisinni, U.; Fornasari, P.; Ferruzzi, A.; Baldini, N.; Giannini, S. A prospective, randomised, controlled trial using a Mg-hydroxyapatite-demineralized bone matrix nanocomposite in tibial osteotomy. Biomaterials 2012, 33, 72-79.
75. Schwarz, F.; Sahm, N.; Bieling, K.; Becker, J. Surgical regenerative treatment of peri-implantitis lesions using a nanocrystalline hydroxyapatite or a natural bone mineral in combination with a collagen membrane: a four-year clinical follow-up report. J. Clin. Periodontol. 2009, 36, 807-814.
76. Tan, A.; Rajadas, J.; Seifalian, A.M. Biochemical engineering nerve conduits using peptide amphiphiles. J. Control. Release 2012, 163, 342-352.
77. Kehoe, S.; Zhang, X.F.; Boyd, D. Composition-property relationships for an experimental composite nerve guidance conduit: Evaluating cytotoxicity and initial tensile strength. J. Mater. Sci. Mater. Med. 2011, 22, 945-959.
78. Weber, R.A.; Breidenbach, W.C.; Brown, R.E.; Jabaley, M.E.; Mass, D.P. A randomized prospective study of polyglycolic acid conduits for digital nerve reconstruction in humans. Plast Reconstr. Surg. 2000, 106, 1036-1045; discussion 1046-1048.
79. Xiong, Y.; Zhu, J.X.; Fang, Z.Y.; Zeng, C.G.; Zhang, C.; Qi, G.L.; Li, M.H.; Zhang, W.; Quan, D.P.; Wan, J. Coseeded Schwann cells myelinate neurites from differentiated neural stem cells in neurotrophin-3-loaded PLGA carriers. Int. J. Nanomed. 2012, 7, 1977-1989.
80. de Boer, R.; Borntraeger, A.; Knight, A.M.; Hebert-Blouin, M.N.; Spinner, R.J.; Malessy, M.J.; Yaszemski, M.J.; Windebank, A.J. Short- and long-term peripheral nerve regeneration using a poly-lactic-co-glycolic-acid scaffold containing nerve growth factor and glial cell line-derived neurotrophic factor releasing microspheres. J. Biomed. Mater. Res. A 2012, 100, 2139-2146.
81. Sasaki, R.; Aoki, S.; Yamato, M.; Uchiyama, H.; Wada, K.; Ogiuchi, H.; Okano, T.; Ando, T. PLGA artificial nerve conduits with dental pulp cells promote facial nerve regeneration. J. Tissue Eng. Regen. Med. 2011, 5, 823-830.
82. Xue, C.; Hu, N.; Gu, Y.; Yang, Y.; Liu, Y.; Liu, J.; Ding, F.; Gu, X. Joint use of a chitosan/PLGA scaffold and MSCs to bridge an extra large gap in dog sciatic nerve. Neurorehabil. Neural Repair 2012, 26, 96-106.
83. Kang, K.N.; Kim da, Y.; Yoon, S.M.; Lee, J.Y.; Lee, B.N.; Kwon, J.S.; Seo, H.W.; Lee, I.W.; Shin, H.C.; Kim, Y.M.; et al. Tissue engineered regeneration of completely transected spinal cord using human mesenchymal stem cells. Biomaterials 2012, 33, 4828-4835.
84. Kehoe, S.; Zhang, X.F.; Boyd, D. FDA approved guidance conduits and wraps for peripheral nerve injury: A review of materials and efficacy. Injury 2012, 43, 553-572.
85. Meek, M.F.; Coert, J.H. Synthetic nerve guide implants in humans: A comprehensive survey. Neurosurgery 2007, 61, E1340; doi:10.1227/01.neu.0000306132.21108.25.
86. Frattini, F.; Lopes, F.R.; Almeida, F.M.; Rodrigues, R.F.; Boldrini, L.C.; Tomaz, M.A.; Baptista, A.F.; Melo, P.A.; Martinez, A.M. Mesenchymal stem cells in a polycaprolactone conduit promote sciatic nerve regeneration and sensory neuron survival after nerve injury. Tissue Eng. A 2012, 18, 2030-2039.
87. Yu, W.; Zhao, W.; Zhu, C.; Zhang, X.; Ye, D.; Zhang, W.; Zhou, Y.; Jiang, X.; Zhang, Z. Sciatic nerve regeneration in rats by a promising electrospun collagen/poly(epsilon-caprolactone) nerve conduit with tailored degradation rate. BMC Neurosci. 2011, doi:10.1186/1471-2202-12-68.
88. Beniash, E.; Hartgerink, J.D.; Storrie, H.; Stendahl, J.C.; Stupp, S.I. Self-assembling peptide amphiphile nanofiber matrices for cell entrapment. Acta Biomater. 2005, 1, 387-397.
89. Liu, W.Q.; Martinez, J.A.; Durand, J.; Wildering, W.; Zochodne, D.W. RGD-mediated adhesive interactions are important for peripheral axon outgrowth in vivo. Neurobiol. Dis. 2009, 34, 11-22.
90. Taras, J.S.; Nanavati, V.; Steelman, P. Nerve conduits. J. Hand Ther. 2005, 18, 191-197.
91. Antoniadou, E.V.; Ahmad, R.K.; Jackman, R.B.; Seifalian, A.M. Next generation brain implant coatings and nerve regeneration via novel conductive nanocomposite development. Conf. Proc. IEEE Eng. Med. Biol. Soc. 2011, doi:10.1109/IEMBS.2011.6090884.
92. Ibrahim, A.; Ohshima, H.; Allison, S.A.; Cottet, H. Determination of effective charge of small ions, polyelectrolytes and nanoparticles by capillary electrophoresis. J. Chromatogr. A 2012, 1247, 154-164.
93. Subramaniam, R.; Astot, C.; Juhlin, L.; Nilsson, C.; Ostin, A. Determination of S-2-(N,N-diisopropylaminoethyl)- and S-2-(N,N-diethylaminoethyl) methylphosphonothiolate, nerve agent markers, in water samples using strong anion-exchange disk extraction, in vial trimethylsilylation, and gas chromatography-mass spectrometry analysis. J. Chromatogr. A 2012, 1229, 86-94.
94. Kwon, O.S.; Park, S.J.; Lee, J.S.; Park, E.; Kim, T.; Park, H.W.; You, S.A.; Yoon, H.; Jang, J. Multidimensional conducting polymer nanotubes for ultrasensitive chemical nerve agent sensing. Nano Lett. 2012, 12, 2797-2802.
95. Tandon, V.; Zhang, B.; Radisic, M.; Murthy, S.K. Generation of tissue constructs for cardiovascular regenerative medicine: From cell procurement to scaffold design. Biotechnol. Adv. 2012, In Press.
96. Prabhakaran, M.P.; Kai, D.; Ghasemi-Mobarakeh, L.; Ramakrishna, S. Electrospun biocomposite nanofibrous patch for cardiac tissue engineering. Biomed. Mater. 2011, 6, 055001:1-055001:12.
97. Kocher, A.A.; Schuster, M.D.; Szabolcs, M.J.; Takuma, S.; Burkhoff, D.; Wang, J.; Homma, S.; Edwards, N.M.; Itescu, S. Neovascularization of ischemic myocardium by human bone-marrow-derived angioblasts prevents cardiomyocyte apoptosis, reduces remodeling and improves cardiac function. Nat. Med. 2001, 7, 430-436.
98. Penn, M.S.; Francis, G.S.; Ellis, S.G.; Young, J.B.; McCarthy, P.M.; Topol, E.J. Autologous cell transplantation for the treatment of damaged myocardium. Prog. Cardiovasc. Dis. 2002, 45, 21-32.
99. Fuchs, S.; Kornowski, R.; Weisz, G.; Satler, L.F.; Smits, P.C.; Okubagzi, P.; Baffour, R.; Aggarwal, A.; Weissman, N.J.; Cerqueira, M.; et al. Safety and feasibility of transendocardial autologous bone marrow cell transplantation in patients with advanced heart disease. Am. J. Cardiol. 2006, 97, 823-829.
100. van Ramshorst, J.; Bax, J.J.; Beeres, S.L.; Dibbets-Schneider, P.; Roes, S.D.; Stokkel, M.P.; de Roos, A.; Fibbe, W.E.; Zwaginga, J.J.; Boersma, E.; et al. Intramyocardial bone marrow cell injection for chronic myocardial ischemia: a randomized controlled trial. JAMA 2009, 301, 1997-2004.
101. Tse, H.F.; Thambar, S.; Kwong, Y.L.; Rowlings, P.; Bellamy, G.; McCrohon, J.; Thomas, P.; Bastian, B.; Chan, J.K.; Lo, G.; et al. Prospective randomized trial of direct endomyocardial implantation of bone marrow cells for treatment of severe coronary artery diseases (PROTECT-CAD trial). Eur. Heart J. 2007, 28, 2998-3005.
102. Perin, E.C.; Silva, G.V.; Henry, T.D.; Cabreira-Hansen, M.G.; Moore, W.H.; Coulter, S.A.; Herlihy, J.P.; Fernandes, M.R.; Cheong, B.Y.; Flamm, S.D.; et al. A randomized study of transendocardial injection of autologous bone marrow mononuclear cells and cell function analysis in ischemic heart failure (FOCUS-HF). Am. Heart J. 2011, 161, 1078-1087.
103. Williams, A.R.; Trachtenberg, B.; Velazquez, D.L.; McNiece, I.; Altman, P.; Rouy, D.; Mendizabal, A.M.; Pattany, P.M.; Lopera, G.A.; Fishman, J.; et al. Intramyocardial stem cell injection in patients with ischemic cardiomyopathy: Functional recovery and reverse remodeling. Circ. Res. 2011, 108, 792-796.
104. Clifford, D.M.; Fisher, S.A.; Brunskill, S.J.; Doree, C.; Mathur, A.; Watt, S.; Martin-Rendon, E. Stem cell treatment for acute myocardial infarction. Cochrane Database Syst. Rev. 2012, doi:10.1002/14651858.CD006536.pub3.
105. Shin, M.; Ishii, O.; Sueda, T.; Vacanti, J.P. Contractile cardiac grafts using a novel nanofibrous mesh. Biomaterials 2004, 25, 3717-3723.
106. Kai, D.; Prabhakaran, M.P.; Jin, G.; Ramakrishna, S. Guided orientation of cardiomyocytes on electrospun aligned nanofibers for cardiac tissue engineering. J. Biomed. Mater. Res. B Appl. Biomater. 2011, 98B, 379-386.
107. Mukherjee, S.; Gualandi, C.; Focarete, M.L.; Ravichandran, R.; Venugopal, J.R.; Raghunath, M.; Ramakrishna, S. Elastomeric electrospun scaffolds of poly(L-lactide-co-trimethylene carbonate) for myocardial tissue engineering. J. Mater. Sci. Mater. Med. 2011, 22, 1689-1699.
108. Prabhakaran, M.P.; Nair, A.S.; Kai, D.; Ramakrishna, S. Electrospun composite scaffolds containing poly(octanediol-co-citrate) for cardiac tissue engineering. Biopolymers 2012, 97, 529-538.
109. Gupta, M.K.; Walthall, J.M.; Venkataraman, R.; Crowder, S.W.; Jung, D.K.; Yu, S.S.; Feaster, T.K.; Wang, X.; Giorgio, T.D.; Hong, C.C.; Baudenbacher, F.J.; Hatzopoulos, A.K.; Sung, H.J. Combinatorial polymer electrospun matrices promote physiologically-relevant cardiomyogenic stem cell differentiation. PLoS One 2011, 6, e28935:1-e28935:12.
110. Sreerekha, P.R.; Menon, D.; Nair, S.V.; Chennazhi, K.P. Fabrication of Electrospun Poly (Lactide-co-Glycolide)-Fibrin Multiscale Scaffold for Myocardial Regeneration In Vitro. Tissue Eng. A 2013, 19, 849-859.
111. Hussain, A.; Collins, G.; Yip, D.; Cho, C.H. Functional 3-D cardiac co-culture model using bioactive chitosan nanofiber scaffolds. Biotechnol. Bioeng. 2013, 110, 637-647.
112. Kim, D.H.; Kshitiz; Smith, R.R.; Kim, P.; Ahn, E.H.; Kim, H.N.; Marban, E.; Suh, K.Y.; Levchenko, A. Nanopatterned cardiac cell patches promote stem cell niche formation and myocardial regeneration. Integr. Biol. 2012, 4, 1019-1033.
113. Dvir, T.; Bauer, M.; Schroeder, A.; Tsui, J.H.; Anderson, D.G.; Langer, R.; Liao, R.; Kohane, D.S. Nanoparticles targeting the infarcted heart. Nano Lett. 2011, 11, 4411-4414.
114. Yang, X. Nano- and microparticle-based imaging of cardiovascular interventions: Overview. Radiology 2007, 243, 340-347.
115. Harel-Adar, T.; Ben Mordechai, T.; Amsalem, Y.; Feinberg, M.S.; Leor, J.; Cohen, S. Modulation of cardiac macrophages by phosphatidylserine-presenting liposomes improves infarct repair. Proc. Natl. Acad. Sci. USA 2011, 108, 1827-1832.
116. Scott, R.C.; Rosano, J.M.; Ivanov, Z.; Wang, B.; Chong, P.L.; Issekutz, A.C.; Crabbe, D.L.; Kiani, M.F. Targeting VEGF-encapsulated immunoliposomes to MI heart improves vascularity and cardiac function. FASEB J. 2009, 23, 3361-3367.
117. Huang, G.; Rahimtoola, S.H. Prosthetic heart valve. Circulation 2011, 123, 2602-2605.
118. Flanagan, T.C.; Sachweh, J.S.; Frese, J.; Schnoring, H.; Gronloh, N.; Koch, S.; Tolba, R.H.; Schmitz-Rode, T.; Jockenhoevel, S. In vivo remodeling and structural characterization of fibrin-based tissue-engineered heart valves in the adult sheep model. Tissue Eng. A 2009, 15, 2965-2976.
119. Kalfa, D.; Bel, A.; Chen-Tournoux, A.; Della Martina, A.; Rochereau, P.; Coz, C.; Bellamy, V.; Bensalah, M.; Vanneaux, V.; Lecourt, S.; et al. A polydioxanone electrospun valved patch to replace the right ventricular outflow tract in a growing lamb model. Biomaterials 2010, 31, 4056-4063.
120. Aleksieva, G.; Hollweck, T.; Thierfelder, N.; Haas, U.; Koenig, F.; Fano, C.; Dauner, M.; Wintermantel, E.; Reichart, B.; Schmitz, C.; Akra, B. Use of a special bioreactor for the cultivation of a new flexible polyurethane scaffold for aortic valve tissue engineering. Biomed. Eng. Online 2012, 11, 92.
121. Martin, I.; Wendt, D.; Heberer, M. The role of bioreactors in tissue engineering. Trends Biotechnol. 2004, 22, 80-86.
122. Mol, A.; Smits, A.I.; Bouten, C.V.; Baaijens, F.P. Tissue engineering of heart valves: advances and current challenges. Expert Rev. Med. Devices 2009, 6, 259-275.
123. Winter, P.M.; Neubauer, A.M.; Caruthers, S.D.; Harris, T.D.; Robertson, J.D.; Williams, T.A.; Schmieder, A.H.; Hu, G.; Allen, J.S.; Lacy, E.K.; et al. Endothelial alpha(v)beta3 integrintargeted fumagillin nanoparticles inhibit angiogenesis in atherosclerosis. Arterioscler. Thromb. Vasc. Biol. 2006, 26, 2103-2109.
124. Winter, P.M.; Caruthers, S.D.; Zhang, H.; Williams, T.A.; Wickline, S.A.; Lanza, G.M. Antiangiogenic synergism of integrin-targeted fumagillin nanoparticles and atorvastatin in atherosclerosis. JACC Cardiovasc. Imaging 2008, 1, 624-634.
125. Peters, D.; Kastantin, M.; Kotamraju, V.R.; Karmali, P.P.; Gujraty, K.; Tirrell, M.; Ruoslahti, E. Targeting atherosclerosis by using modular, multifunctional micelles. Proc. Natl. Acad. Sci. USA 2009, 106, 9815-9819.
126. Sharma, G.; She, Z.G.; Valenta, D.T.; Stallcup, W.B.; Smith, J.W. Targeting of Macrophage Foam Cells in Atherosclerotic Plaque Using Oligonucleotide-Functionalized Nanoparticles. Nano Life 2010, 1, 207-214.
127. Ji, J.; Ji, S.Y.; Yang, J.A.; He, X.; Yang, X.H.; Ling, W.P.; Chen, X.L. Ultrasound-targeted transfection of tissue-type plasminogen activator gene carried by albumin nanoparticles to dog myocardium to prevent thrombosis after heart mechanical valve replacement. Int. J. Nanomed. 2012, 7, 2911-2919.
128. Acharya, G.; Hopkins, R.A.; Lee, C.H. Advanced polymeric matrix for valvular complications. J. Biomed. Mater. Res. A 2012, 100, 1151-1159.
129. U.S. Food and Drug Administration. The FDA's Drug Review Process: Ensuring Drugs Are Safe and Effective. Avaliable online: http://www.fda.gov/drugs/resourcesforyou/consumers/ucm143534.htm (aceessed on 25 March 2013).
130. ClinicalTrials Home Page. Avaliable online: http://www.clinicaltrials.gov/ (aceessed on 25 March 2013).