Functionalisation of PLLA nanofiber scaffolds using a possible cooperative effect between collagen type I and BMP-2: Impact on colonization and bone formation in vivo

Journal of Materials Science: Materials in Medicine

Volumn 23, Issue 9, 2012, Pages 2227-2233

  Schofer, Markus D ^a   Tünnermann, Lisa ^a   Kaiser, Hendric ^a   Roessler, Philip P ^a   Theisen, Christina ^a   Heverhagen, Johannes T ^a   Hering, Jacqueline ^a   Voelker, Maximilian ^a   Agarwal, Seema ^b   Efe, Turgay ^a   Fuchs Winkelmann, Susanne ^a   Paletta, Jürgen R J ^b  

^a UNIVERSITY HOSPITAL MARBURG   (Germany)

^b PHILIPPS UNIVERSITY MARBURG   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

BONE DEFECT; BONE FORMATION; BONE GRAFT; BONE MORPHOGENETIC PROTEINS; BONE SUBSTITUTION; CHANNEL-LIKE STRUCTURES; COLLAGEN TYPE I; COOPERATIVE EFFECTS; CRITICAL SIZE DEFECT; ELECTROSPUNS; EXTRACELLULAR MATRICES; FOCAL AREA; FUNCTIONALISATION; GROWTH FACTOR; HUMAN MESENCHYMAL STEM CELLS; IN-VIVO; INTEGRINS; LACTIDES; NANOFIBER SCAFFOLD; OSTEOCALCIN; PLLA; SIGNALING PROCESS; SYNTHETIC BIOMATERIALS; TUMOR RESECTION;

BONE; COLLAGEN; COMPUTERIZED TOMOGRAPHY; CYTOLOGY; DEFECTS; NANOFIBERS; STEM CELLS; TISSUE;

SCAFFOLDS (BIOLOGY);

BONE MORPHOGENETIC PROTEIN 2; COLLAGEN TYPE 1; MOLECULAR SCAFFOLD; OSTEOCALCIN; POLYLACTIC ACID; SMAD5 PROTEIN; TISSUE SCAFFOLD;

ANIMAL EUTHANASIA; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CALVARIA; CELL MIGRATION; CELL STRUCTURE; COMPUTER ASSISTED TOMOGRAPHY; CONTROLLED STUDY; HISTOPATHOLOGY; IMMUNOHISTOCHEMISTRY; IN VIVO STUDY; NONHUMAN; OSSIFICATION; PRIORITY JOURNAL; RAT; SKULL DEFECT;

ANIMALS; BONE MORPHOGENETIC PROTEIN 2; BONE SUBSTITUTES; CELL PROLIFERATION; COATED MATERIALS, BIOCOMPATIBLE; COLLAGEN TYPE I; DRUG SYNERGISM; LACTIC ACID; NANOFIBERS; OSTEOGENESIS; POLYMERS; RATS; RATS, SPRAGUE-DAWLEY; SKULL; TISSUE ENGINEERING; TISSUE SCAFFOLDS;

RATTUS;

EID: 84867102642     PISSN: 09574530     EISSN: 15734838     Source Type: Journal    
DOI: 10.1007/s10856-012-4697-0     Document Type: Article

References (41)

1. Kneser U, Schaefer DJ, Polykandriotis E, Horch RE. Tissue engineering of bone: the reconstructive surgeon's point of view. J Cell Mol Med. 2006;10:7.
2. Glowacki J, Mizuno S. Collagen scaffolds for tissue engineering. Biopolymers. 2008;89:338.
3. Khan Y, Yaszemski MJ, Mikos AG, Laurencin CT. Tissue engineering of bone: material and matrix considerations. J Bone Jt Surg Am Volume. 2008;90(Suppl 1):36.
4. Agarwal S, Wendorff J, Greiner A. Use of electrospinning technique for biomedical applications. Polymer. 2008;49:5603.
5. Ashammakhi N, Ndreu A, Yang Y, Ylikauppila H, Nikkola L (2008) Nanofiber-based scaffolds for tissue engineering. European Journal of Plastic Surgery. Eur J Plast Surg. Online first.
6. Zhang Y, Lim CT, Ramakrishna S, Huang ZM. Recent development of polymer nanofibers for biomedical and biotechnological applications. J Mater Sci Mater Med. 2005;16:933.
7. Li WJ, Laurencin CT, Caterson EJ, Tuan RS, Ko FK. Electrospun nanofibrous structure: a novel scaffold for tissue engineering. J Biomed Mater Res. 2002;60:613.
8. Liao S, Li B, Ma Z, Wei H, Chan C, Ramakrishna S. Biomimetic electrospun nanofibers for tissue regeneration. J Biomed Mater. 2006;1:R45.
9. Woo KM, Jun J-H, Chen VJ, et al. Nano-fibrous scaffolding promotes osteoblast differentiation and biomineralization. Biomaterials. 2007;28:335.
10. Zhang R, Ma PX. Synthetic nano-fibrillar extracellular matrices with predesigned macroporous architectures. J Biomed Mater Res. 2000;52:430.
11. WJ Li, JA Cooper, Jr., Mauck RL, Tuan RS (2006) Fabrication and characterization of six electrospun poly(alpha-hydroxy ester)-based fibrous scaffolds for tissue engineering applications. Acta Biomater 2(4):377-85.
12. Schofer MD, Fuchs-Winkelmann S, Gräbedünkel C, et al. Influence of poly(L-Lactic Acid) nanofibers and BMP-2-containing poly(L-Lactic Acid) nanofibers on growth and osteogenic differentiation of human mesenchymal stem cells. ScientificWorld-Journal. 2008;8:1269.
13. Badami AS, Kreke MR, Thompson MS, Riffle JS, Goldstein AS. Effect of fiber diameter on spreading, proliferation, and differentiation of osteoblastic cells on electrospun poly(lactic acid) substrates. Biomaterials. 2006;27:596.
14. Schofer MD, Boudriot U, Wack C, et al. Influence of nanofibers on the growth and osteogenic differentiation of stem cells-A comparison of biological collagen nanofibers and synthetic PLLA fibers. J Mater Sci Mater Med. 2008;20:767.
15. Schofer MD, Boudriot U, Leifeld I, et al. Characterization of a PLLA-collagen I blend nanofiber scaffold with respect to growth and osteogenic differentiation of human mesenchymal stem cells. ScientificWorldJournal. 2009;9:118.
16. Woo KM, Chen VJ, Jung HM, et al. Comparative evaluation of nanofibrous scaffolding for bone regeneration in critical-size calvarial defects. Tissue Eng Part A. 2009;15:2155.
17. Schofer MD, Rößler P, Schäfer J, et al (2011) Electrospun PLLA nanofiber scaffolds and their functionalization with BMP-2 for reconstruction of bone defects. PLos One.
18. Srouji S, Ben-David D, Lotan R, Livne E, Avrahami R, Zussman E. Slow-release human recombinant bone morphogenetic protein-2 embedded within electrospun scaffolds for regeneration of bone defect: in vitro and in vivo evaluation. Tissue Eng Part A. 2011; 17:269.
19. Fu YC, Nie H, Ho ML, Wang CK, Wang CH. Optimized bone regeneration based on sustained release from three-dimensional fibrous PLGA/HAp composite scaffolds loaded with BMP-2. Biotechnol Bioeng. 2008;99:996.
20. Ai-Aql ZS, Alagl AS, Graves DT, Gerstenfeld LC, Einhorn TA. Molecular mechanisms controlling bone formation during fracture healing and distraction osteogenesis. J Dent Res. 2008;87: 107.
21. Gerstenfeld LC, Cullinane DM, Barnes GL, Graves DT, Einhorn TA. Fracture healing as a post-natal developmental process: molecular, spatial, and temporal aspects of its regulation. J Cell Biochem. 2003;88:873.
22. Salasznyk RM, Williams WA, Boskey A, Batorsky A, Plopper GE (2004) Adhesion to vitronectin and collagen I promotes osteogenic differentiation of human mesenchymal stem cells. J Biomed Biotechnol. 1:24-34.
23. Mizuno M, Kuboki Y. Osteoblast-related gene expression of bone marrow cells during the osteoblastic differentiation induced by type I collagen. J Biochem. 2001;129:133.
24. Jikko A, Harris S, Chen D, Mendrick D, Damsky C. Collagen integrin receptors regulate early osteoblast differentiation induced by BMP-2. J Bone Miner Res. 1999;14:1075. doi:10.1359/jbmr. 1999.14.7.1075.
25. Lai C, Cheng S. Alphavbeta integrins play an essential role in BMP-2 induction of osteoblast differentiation. J Bone Miner Res. 2005;20:330. doi:10.1359/JBMR.041013.
26. Sotobori T, Ueda T, Myoui A, et al. Bone morphogenetic protein-2 promotes the haptotactic migration of murine osteoblastic and osteosarcoma cells by enhancing incorporation of integrin beta1 into lipid rafts. Exp Cell Res. 2006;312:3927. doi:10.1016/j. yexcr.2006.08.024.
27. Tamura Y, Takeuchi Y, Suzawa M, et al. Focal adhesion kinase activity is required for bone morphogenetic protein-Smad1 signaling and osteoblastic differentiation in murine MC3T3-E1 cells. J Bone Miner Res. 2001;16:1772. doi:10.1359/jbmr.2001. 16.10.1772.
28. Suzawa M, Tamura Y, Fukumoto S, et al. Stimulation of Smad1 transcriptional activity by Ras-extracellular signal-regulated kinase pathway: a possible mechanism for collagen-dependent osteoblastic differentiation. J Bone Miner Res. 2002;17:240.
29. M Schofer, A Veltum, C Theisen, et al. J Mater Sci Mater Med 1 (2011) Functionalisation of PLLA nanofiber scaffolds using a possible cooperative effect between collagen type I and BMP-2: impact on growth and osteogenic differentiation of human mesenchymal stem cells. J Mater Sci: Mater Med. p 1-10.
30. Ma Z, Kotaki M, Inai R, Ramakrishna S. Potential of nanofiber matrix as tissue-engineering scaffolds. Tissue Eng. 2005;11:101.
31. Itälä AI, Ylänen HO, Ekholm C, Karlsson KH, Aro HT. Pore diameter of more than 100 microm is not requisite for bone ingrowth in rabbits. J Biomed Mater Res. 2001;58:679. 10.1002/jbm.1069. (Pubitemid 33096568)
32. Hulbert SF, Young FA, Mathews RS, Klawitter JJ, Talbert CD, Stelling FH. Potential of ceramic materials as permanently implantable skeletal prostheses. J Biomed Mater Res. 1970;4: 433.
33. Szentivanyi A, Chakradeo T, Zernetsch H, Glasmacher B. Electrospun cellular microenvironments: understanding controlled release and scaffold structure. Adv Drug Deliv Rev. 2011;63:209. doi:10.1016/j.addr.2010.12.002.
34. Park K, Jung H, Kim J-J, Ahn K-D, Han D, Ju Y. Acrylic acidgrafted hydrophilic electrospun nanofibrous poly(L-lactic acid) Scaffold. Macromol Res. 2006;14:552.
35. Schofer MD, Veltum A, Theisen C, et al. Functionalisation of PLLA nanofiber scaffolds using a possible cooperative effect between collagen type I and BMP-2: impact on growth and osteogenic differentiation of human mesenchymal stem cells. J Mater Sci Mater Med. 2011;. doi:10.1007/s10856-011-4341-4.
36. Nam J, Huang Y, Agarwal S, Lannutti J. Improved cellular infiltration in electrospun fiber via engineered porosity. Tissue Eng. 2007;13:2249.
37. Baker BM, Gee AO, Metter RB, et al. The potential to improve cell infiltration in composite fiber-Aligned electrospun scaffolds by the selective removal of sacrificial fibers. Biomaterials. 2008; 29:2348.
38. Guimaraes A, Martins A, Pinho ED, Faria S, Reis RL, Neves NM. Solving cell infiltration limitations of electrospun nanofiber meshes for tissue engineering applications. Nanomedicine. 2010; 5:539.
39. Pham QP, Sharma U, Mikos AG. Electrospun poly(epsilon-caprolactone) microfiber and multilayer nanofiber/microfiber scaffolds: characterization of scaffolds and measurement of cellular infiltration. Biomacromolecules. 2006;7:2796.
40. Simonet M, Schneider OD, Neuenschwander P, Stark WJ. Ultraporous 3D polymer meshes by low-Temperature electrospinning: use of ice crystals as a removable void template. Polym Eng Sci. 2007;47:2020.
41. Paletta JR, Mack F, Schenderlein H, et al. Incorporation of osteoblasts (MG63) into 3D nanofibre matrices by simultaneous electrospinning and spraying in bone tissue engineering. Eur Cell Mater. 2011;15:384.