Porous polycaprolactone/nanohydroxyapatite tissue engineering scaffolds fabricated by combining NaCl and PEG as co-porogens: Structure, property, and chondrocyte-scaffold interaction in vitro

Journal of Biomedical Materials Research - Part B Applied Biomaterials

Volumn 100 B, Issue 4, 2012, Pages 956-966

  Liu, Li ^a   Wang, Yuanyuan ^a   Guo, Shengrong ^a   Wang, Zhenyu ^b   Wang, Wei ^b  

^a SHANGHAI JIAO TONG UNIVERSITY   (China)

^b SHANGHAI JIAO TONG UNIVERSITY SCHOOL OF MEDICINE   (China)

Author keywords

hydroxyapatite; leaching technique; polycaprolactone; porous scaffold

Indexed keywords

CARTILAGE TISSUE ENGINEERING; CELL BINDING; CHONDROCYTES; COMPOSITE SCAFFOLDS; DEGRADATION BEHAVIOR; IN-VITRO; INTERCONNECTIVITY; MACROPORES; MICROPORES; MULTI-MODAL; PHYSICOCHEMICAL PROPERTY; PHYSIO-CHEMICAL; PORE ARCHITECTURE; PORE MORPHOLOGY; POROGENS; POROUS SCAFFOLD; STRUCTURE , PROPERTIES; TISSUE ENGINEERING SCAFFOLD; WATERSOLUBLE POLYMERS;

BIODEGRADATION; BIOMECHANICS; BODY FLUIDS; HYDROXYAPATITE; LEACHING; MECHANICAL PROPERTIES; MORPHOLOGY; POLYCAPROLACTONE; SODIUM CHLORIDE;

SCAFFOLDS (BIOLOGY);

HYDROXYAPATITE; MACROGOL; NANOCOMPOSITE; NANOHYDROXYAPATITE; POLYCAPROLACTONE; TISSUE SCAFFOLD; UNCLASSIFIED DRUG;

ARTICLE; CARTILAGE; CARTILAGE CELL; CELL ADHESION; CELL PROLIFERATION; CELL STRUCTURE; CHEMICAL INTERACTION; CHEMICAL MODIFICATION; DEGRADATION; EXTRACELLULAR MATRIX; IN VITRO STUDY; MELTING POINT; MOLECULAR WEIGHT; NANOFABRICATION; PHYSICAL CHEMISTRY; POROSITY; PURIFICATION; SCANNING ELECTRON MICROSCOPY; STRUCTURE ANALYSIS; TISSUE ENGINEERING;

BIOCOMPATIBLE MATERIALS; CARTILAGE; CHEMISTRY, PHYSICAL; CHONDROCYTES; HUMANS; HYDROXYAPATITES; MICROSCOPY, ELECTRON, SCANNING; MODELS, STATISTICAL; NANOSTRUCTURES; POLYESTERS; POLYETHYLENE GLYCOLS; POROSITY; SODIUM CHLORIDE; STRESS, MECHANICAL; TISSUE ENGINEERING; X-RAY DIFFRACTION;

EID: 84862811826     PISSN: 15524973     EISSN: 15524981     Source Type: Journal    
DOI: 10.1002/jbm.b.32658     Document Type: Article

References (32)

1. Hutmacher DW,. Scaffolds in tissue engineering bone and cartilage. Biomaterials 2000; 21: 2529-2543.
2. Meyer U, Meyer T, Handschel J, Wiesmann HP, Eds. Fundamentals of Tissue Engineering and Regenerative Medicine. 2009; Springer, Leipzig, Germany.
3. Kim H-W, Knowles JC, Kim H-E,. Hydroxyapatite/poly([var epsilon]-caprolactone) composite coatings on hydroxyapatite porous bone scaffold for drug delivery. Biomaterials 2004; 25: 1279-1287.
4. Shor L, Guceri S, Wen X, Gandhi M, Sun W,. Fabrication of three-dimensional polycaprolactone/hydroxyapatite tissue scaffolds and osteoblast-scaffold interactions in vitro. Biomaterials 2007; 28: 5291-5297.
5. Wiria FE, Leong KF, Chua CK, Liu Y,. Poly-[epsilon]-caprolactone/ hydroxyapatite for tissue engineering scaffold fabrication via selective laser sintering. Acta Biomater 2007; 3: 1-12.
6. Zhao J, Guo LY, Yang XB, Weng J,. Preparation of bioactive porous HA/PCL composite scaffolds. Appl Surf Sci 2008; 255 (Part 2): 2942-2946.
7. Garcia-Giralt N, Izquierdo R, Nogués X, Perez-Olmedilla M, Benito P, Gõmez-Ribelles JL, Checa MA, Suay J, Caceres E, Monllau JC,. A porous PCL scaffold promotes the human chondrocytes redifferentiation and hyaline-specific extracellular matrix protein synthesis. J Biomed Mater Res A 2008; 85A: 1082-1089.
8. Chuenjitkuntaworn B, Inrung W, Damrongsri D, Mekaapiruk K, Supaphol P, Pavasant P,. Polycaprolactone/hydroxyapatite composite scaffolds: Preparation, characterization, and in vitro and in vivo biological responses of human primary bone cells. J Biomed Mater Res A 2010; 94A: 241-251.
9. Lam CXF, Hutmacher DW, Schantz J-T, Woodruff MA, Teoh SH,. Evaluation of polycaprolactone scaffold degradation for 6 months in vitro and in vivo. J Biomed Mater Res A 2009; 90A: 906-919.
10. Middleton JC, Tipton AJ,. Synthetic biodegradable polymers as orthopedic devices. Biomaterials 2000; 21: 2335-2346.
11. Jack KS, Velayudhan S, Luckman P, Trau M, GrÃ̧ndahl L, Cooper-White J,. The fabrication and characterization of biodegradable HA/PHBV nanoparticle-polymer composite scaffolds. Acta Biomater 2009; 5: 2657-2667.
12. Hou Q, Grijpma DW, Feijen J,. Porous polymeric structures for tissue engineering prepared by a coagulation, compression moulding and salt leaching technique. Biomaterials 2003; 24: 1937-1947.
13. Zhang Y, Venugopal JR, El-Turki A, Ramakrishna S, Su B, Lim CT,. Electrospun biomimetic nanocomposite nanofibers of hydroxyapatite/chitosan for bone tissue engineering. Biomaterials 2008; 29: 4314-4322.
14. Wei G, Ma PX,. Structure and properties of nano-hydroxyapatite/polymer composite scaffolds for bone tissue engineering. Biomaterials 2004; 25: 4749-4757.
15. Zanetta M, Quirici N, Demarosi F, Tanzi MC, Rimondini L, Far S,. Ability of polyurethane foams to support cell proliferation and the differentiation of MSCs into osteoblasts. Acta Biomater 2009; 5: 1126-1136.
16. 2 antisolvent process. Acta Biomater 2009; 5: 1094-1103.
17. Heo S-J, Kim S-E, Wei J, Hyun Y-T, Yun H-S, Kim D-H, Shin JW, Shin J-W,. Fabrication and characterization of novel nano- and micro-HA/PCL composite scaffolds using a modified rapid prototyping process. J Biomed Mater Res A 2009; 89A: 108-116.
18. Park SA, Lee SH, Kim WD,. Fabrication of porous polycaprolactone/ hydroxyapatite (PCL/HA) blend scaffolds using a 3D plotting system for bone tissue engineering. Bioprocess Biosyst Eng 2011; 34: 505-513.
19. Reignier J, Huneault MA,. Preparation of interconnected poly([epsilon]-caprolactone) porous scaffolds by a combination of polymer and salt particulate leaching. Polymer 2006; 47: 4703-4717.
20. Jones AC, Arns CH, Hutmacher DW, Milthorpe BK, Sheppard AP, Knackstedt MA,. The correlation of pore morphology, interconnectivity and physical properties of 3D ceramic scaffolds with bone ingrowth. Biomaterials 2009; 30: 1440-1451.
21. Griffon DJ, Sedighi MR, Schaeffer DV, Eurell JA, Johnson AL,. Chitosan scaffolds: Interconnective pore size and cartilage engineering. Acta Biomater 2006; 2: 313-320.
22. Izquierdo R, Garcia-Giralt N, Rodriguez MT, Cáceres E, García SJ, Gõmez Ribelles JL, Monleõn M, Monllau JC, Suay J,. Biodegradable PCL scaffolds with an interconnected spherical pore network for tissue engineering. J Biomed Mater Res A 2008; 85A: 25-35.
23. Salerno A, Zeppetelli S, Di Maio E, Iannace S, Netti PA,. Processing/structure/property relationship of multi-scaled PCL and PCL-HA composite scaffolds prepared via gas foaming and NaCl reverse templating. Biotech Bioeng 2011; 108: 963-976.
24. Thein-Han WW, Misra RDK,. Biomimetic chitosan-nanohydroxyapatite composite scaffolds for bone tissue engineering. Acta Biomater 2009; 5: 1182-1197.
25. Petrie Aronin CE, Cooper JA, Jr, Sefcik LS, Tholpady SS, Ogle RC, Botchwey EA,. Osteogenic differentiation of dura mater stem cells cultured in vitro on three-dimensional porous scaffolds of poly([epsilon]-caprolactone) fabricated via co-extrusion and gas foaming. Acta Biomater 2008; 4: 1187-1197.
26. Washburn NR, Simon CG, Tona A, Elgendy HM, Karim A, Amis EJ,. Co-extrusion of biocompatible polymers for scaffolds with co-continuous morphology. J Biomed Mater Res 2002; 60: 20-29.
27. Giesche H,. Mercury Porosimetry. New York: Wiley-VCH; 2002.
28. Buckwalter JA, Mankin HJ,. Articular cartilage repair and transplantation. Arthritis Rheum 1998; 41: 1331-1342.
29. Woodruff MA, Hutmacher DW,. The return of a forgotten polymer - Polycaprolactone in the 21st century. Prog Polym Sci 2011; 35: 1217-1256.
30. Porter AE, Botelho CM, Lopes MA, Santos JD, Best SM, Bonfield W,. Ultrastructural comparison of dissolution and apatite precipitation on hydroxyapatite and silicon-substituted hydroxyapatite in vitro and in vivo. J Biomed Mater Res A 2004; 69A: 1552-4965.
31. Lei Y, Rai B, Ho KH, Teoh SH,. In vitro degradation of novel bioactive polycaprolactone - 20% tricalcium phosphate composite scaffolds for bone engineering. Mater Sci Eng: C 2007; 27: 293-298.
32. Nuernberger S, Cyran N, Albrecht C, Redl H, Vecsei V, Marlovits S,. The influence of scaffold architecture on chondrocyte distribution and behavior in matrix-associated chondrocyte transplantation grafts. Biomaterials 2011; 32: 1032-1040.