A prospective, randomised, controlled trial using a Mg-hydroxyapatite - demineralized bone matrix nanocomposite in tibial osteotomy

Biomaterials

Volumn 33, Issue 1, 2012, Pages 72-79

  Dallari, Dante ^a   Savarino, Lucia ^a   Albisinni, Ugo ^a   Fornasari, Piermaria ^a   Ferruzzi, Alberto ^a   Baldini, Nicola ^a,b   Giannini, Sandro ^a,b  

^a RIZZOLI ORTHOPAEDIC INSTITUTE   (Italy)

^b UNIVERSITY OF BOLOGNA   (Italy)

Author keywords

Bone healing; Demineralized bone matrix; Nano structured Mg hydroxyapatite; Osteotomy

Indexed keywords

BONE BIOPSY; BONE HEALING; CLINICAL TRIAL; CONTROLLED TRIAL; DEMINERALIZED BONE MATRIX; HISTOMORPHOMETRY; IN-VIVO; NANO-STRUCTURED; OSSEOINTEGRATION; OSTEOTOMY; TIBIAL OSTEOTOMY;

APATITE; BIOMIMETICS; COMPUTERIZED TOMOGRAPHY; HYDROXYAPATITE; NANOCOMPOSITES; NANOSTRUCTURES; SURGERY;

BONE;

HYDROXYAPATITE; MAGNESIUM; NANOCOMPOSITE;

ADULT; ARTICLE; BONE BIOPSY; BONE MATRIX; BONE REGENERATION; CLINICAL ARTICLE; COMPUTER ASSISTED TOMOGRAPHY; CONTROLLED STUDY; FEMALE; FOLLOW UP; FRACTURE HEALING; HUMAN; HUMAN TISSUE; IN VIVO STUDY; MALE; MORPHOMETRICS; OUTCOME ASSESSMENT; PRIORITY JOURNAL; PROSPECTIVE STUDY; RANDOMIZED CONTROLLED TRIAL; TIBIA OSTEOTOMY; VARUS DEFORMITY;

ADULT; BONE MATRIX; DURAPATITE; FEMALE; HUMANS; MALE; MIDDLE AGED; NANOCOMPOSITES; OSTEOTOMY; TIBIA; YOUNG ADULT;

EID: 82855161331     PISSN: 01429612     EISSN: 18785905     Source Type: Journal    
DOI: 10.1016/j.biomaterials.2011.09.029     Document Type: Article

References (25)

1. Ito K., Yamada Y., Nagasaka T., Baba S., Ueda M. Osteogenic potential of injectable tissue-engineered bone: a comparison among autogenous bone, bone substitute (Bio-oss), platelet-rich plasma, and tissue-engineered bone with respect to their mechanical properties and histological findings. J Biomed Mater Res A 2005, 73:63-72.
2. De Long W.G., Einhorn T.A., Koval K., McKee M., Smith W., Sanders R., et al. Bone grafts and bone graft substitutes in orthopaedic trauma surgery. A critical analysis. J Bone Jt Surg Am 2007, 89:649-658.
3. Finkemeier C.G. Current concepts review bone-grafting and bone-graft substitutes. J Bone Jt Surg Am 2002, 84:454-464.
4. Mahli A., Coskun D., Altun N.S., Simsek A., Ocal E., Kostekci M. Alcohol neurolysis for persistent pain caused by superior cluneal nerves injury after iliac crest bone graft harvesting in orthopedic surgery: report of four cases and review of the literature. Spine 2002, 15(27):E478-E481.
5. Cricchio G., Lundgren S. Donor site morbidity in two different approaches to anterior iliac crest bone harvesting. Clin Implant Dent Relat Res 2003, 5:161-169.
6. Chris Arts J.J., Verdonschot N., Schreurs B.W., Buma P. The use of a bioresorbable nano-crystalline hydroxyapatite paste in acetabular bone impaction grafting. Biomaterials 2006, 27:1110-1118.
7. Kasaj A., Röhrig B., Zafiropoulos G.G., Willershausen B. Clinical evaluation of nano crystalline hydroxyapatite paste in the treatment of human periodontal bony defects. A randomized controlled clinical trial: 6 month results. J Periodontol 2008, 79:394-400.
8. Thorwarth M., Schultze-Mosgau S., Kessler P., Wiltfang J., Schlegel K.A. Bone regeneration in osseous defects using a resorbable nanoparticular hydroxyapatite. J Oral Maxillofac Surg 2005, 63:1626-1633.
9. Cazalbou S., Eichert D., Ranz X., Drouet C., Combes C., Harmand M.F., et al. Ion exchanges in apatites for biomedical application. J Mater Sci Mater Med 2005, 16:405-409.
10. Bertinetti L., Drouet C., Combes C., Rey C., Tampieri A., Coluccia S., et al. Surface characteristics of nanocrystalline apatites: effect of Mg surface enrichment on morphology, surface hydration species, and cationic environments. Langmuir 2009, 25:5647-5654.
11. Bigi A., Falini G., Foresti E., Gazzano M., Ripamonti A., Roveri N. Magnesium influence on hydroxyapatite crystallization. J Inorg Biochem 1993, 49:69-78.
12. Landi E., Logroscino G., Proietti L., Tampieri A., Sandri M., Sprio S. Biomimetic Mg-substituted hydroxyapatite: from synthesis to in vivo behaviour. J Mater Sci Mater Med 2008, 19:239-247.
13. Checchi V., Savarino L., Montevecchi M., Felice P., Checchi L. Clinical-radiographic and histological evaluation of two hydroxyapatites in human extraction sockets: a pilot study. Int J Oral Maxillofac Surg 2011, 40:526-532.
14. Cancedda R., Mastrogiacomo M., Bianchi G., Derubeis A., Muraglia A., Quarto R. Bone marrow stromal cells and their use in regenerating bone. Novartis Found Symp 2003, 249:133-143.
15. Caplan A.I., Bruder S.P. Mesenchymal stem cells: building blocks for molecular medicine in the 21st century. Trends Mol Med 2001, 7:259-264.
16. Acarturk T.O., Hollinger J.O. Commercially available demineralized bone matrix compositions to regenerate calvarial critical-sized bone defects. Plast Reconstr Surg 2006, 118:862-873.
17. Bender S.A., Rogalski J.B., Mills M.P., Arnold R.M., Cochran D.L., Mellonig J.T. Evaluation of demineralized bone matrix paste and putty in periodontal intraosseous defects. J Periodontol 2005, 76:768-777.
18. Savarino L., Cenni E., Tarabusi C., Dallari D., Stagni C., Cenacchi A., et al. Evaluation of bone healing enhancement by lyophilized bone grafts supplemented with platelet gel: a standardized methodology in patients with tibial osteotomy for genu varus. J Biomed Mater Res B Appl Biomater 2006, 76:364-372.
19. Insall JN, Dorr LD, Scott RD, Scott RD, W. Scott N. Rationale of The Knee Society Clinical Rating System.(last accessed 10/18/2010). http://www.kneesociety.org/web/outcomes.html.
20. Dallari D., Savarino L., Stagni C., Cenni E., Cenacchi A., Fornasari P.M., et al. Enhanced tibial osteotomy healing with use of bone grafts supplemented with platelet gel or platelet gel and bone marrow stromal cells. J Bone Jt Surg Am 2007, 89:2413-2420.
21. Gibson I.R., Bonfield W. Preparation and characterization of magnesium/carbonate co-substituted hydroxyapatites. J Mater Sci Mater Med 2002, 13:685-693.
22. Simpson A.H., Mills L., Noble B. The role of growth factors and related agents in accelerating fracture healing. J Bone Jt Surg Br 2006, 88:701-705.
23. Kassem M., Marie P.J. Senescence-associated intrinsic mechanisms of osteoblast dysfunctions. Aging Cell 2011, 10:191-197.
24. Nagi O.N., Kumar S., Aggarwal S. Combined lateral closing and medial opening-wedge high tibial osteotomy. J Bone Jt Surg Am 2007, 89:542-549.
25. Rothamel D., Schwarz F., Herten M., Engelhardt E., Donath K., Kuehn P., et al. Dimensional ridge alterations following socket preservation using a nanocrystalline hydroxyapatite paste. A histomorphometrical study in dogs. Int J Oral Maxillofac Surg 2008, 37:741-747.