The Synthetic Amphipathic Peptidomimetic LTX109 Is a Potent Fungicide That Disturbs Plasma Membrane Integrity in a Sphingolipid Dependent Manner

PLoS ONE

Volumn 8, Issue 7, 2013, Pages

  Bojsen, Rasmus ^a   Torbensen, Rasmus ^b   Larsen, Camilla Eggert ^b   Folkesson, Anders ^a,c   Regenberg, Birgitte ^b  

^a TECHNICAL UNIVERSITY OF DENMARK   (Denmark)

^b UNIVERSITY OF COPENHAGEN   (Denmark)

^c Denmark   (Denmark)

Author keywords

[No Author keywords available]

Indexed keywords

AMPHOTERICIN B; ANTIFUNGAL AGENT; ARGININE TERTBUTYL TRYPTOPHYLARGINYLPHENYLETHAN; CERAMIDE DERIVATIVE; FLUORESCENT DYE; LYTIXAR; MANNOSYL DI(INOSITOL PHOSPHORYL)CERAMIDE; MANNOSYLINOSITOL PHOSPHORYLCERAMIDE; SPHINGOLIPID; SULFONYLUREA RECEPTOR 1; UNCLASSIFIED DRUG;

AMINO ACID TRANSPORT; ANTIFUNGAL ACTIVITY; ANTIFUNGAL RESISTANCE; ARTICLE; BIOFILM; CELL MEMBRANE PERMEABILITY; CELL VIABILITY; CONTROLLED STUDY; DRUG SCREENING; FEN1 GENE; FUNGAL CELL; FUNGAL GENE; GENE DELETION; GENE IDENTIFICATION; GENE LIBRARY; IPT1 GENE; LIMIT OF DETECTION; MINIMUM INHIBITORY CONCENTRATION; MUTATIONAL ANALYSIS; NONHUMAN; ORM2 GENE; SACCHAROMYCES CEREVISIAE; SENSITIVITY ANALYSIS; SKN1 GENE; SUR1 GENE; SUR2 GENE;

AMINO ACIDS; AMPHOTERICIN B; BIOFILMS; BIOLOGICAL TRANSPORT; CELL MEMBRANE; DRUG RESISTANCE, FUNGAL; FLUORESCENT DYES; FUNGICIDES, INDUSTRIAL; GENE DELETION; MICROBIAL VIABILITY; MUTATION; OLIGOPEPTIDES; POTASSIUM; PROTONS; SACCHAROMYCES CEREVISIAE; SPHINGOLIPIDS;

EID: 84880079835     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0069483     Document Type: Article

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