High interleukin-10 expression within the central nervous system may be important for initiation of recovery of Dark Agouti rats from experimental autoimmune encephalomyelitis

Immunobiology

Volumn 218, Issue 9, 2013, Pages 1192-1199

  Blaževski, Jana ^a   Petković, Filip ^a   Momčilović, Miljana ^a   Jevtic, Bojan ^a   Miljković, Djordje ^a   Mostarica Stojković, Marija ^a  

^a UNIVERSITY OF BELGRADE   (Serbia)

Author keywords

Astrocyte; CXCL12; Experimental autoimmune encephalomyelitis; Interleukin 10; Neuroinflammation; Transforming growth factor

Indexed keywords

INTERLEUKIN 10; METHYLPREDNISOLONE; TRANSFORMING GROWTH FACTOR BETA;

ALLERGIC ENCEPHALOMYELITIS; ALLERGIC GLOMERULONEPHRITIS; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; ASTROCYTE; CELL INFILTRATION; CENTRAL NERVOUS SYSTEM DISEASE; CONTROLLED STUDY; DARK AGOUTI RAT; GLIA CELL; IMMUNOCOMPETENT CELL; NERVOUS SYSTEM INFLAMMATION; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; SPINAL CORD; TISSUE HOMOGENATE;

ALBINO OXFORD; AO; ASTROCYTE; C.S.; CELL FREE SUPERNATANT COLLECTED FROM 48H CULTURE OF RAT SPLENOCYTES STIMULATED WITH CONA; CENTRAL NERVOUS SYSTEM; CFA; CLINICAL SCORE; CNS; COMPLETE FREUND'S ADJUVANT; CONA; CONASN; CONCANAVALINE A; CXCL12; D.P.I.; DA; DARK AGOUTI; DAYS POST IMMUNIZATION; DLN; DLNC; DRAINING LYMPH NODE; DRAINING LYMPH NODE CELLS; EAE; EXPERIMENTAL AUTOIMMUNE ENCEPHALOMYELITIS; HELPER T CELLS; IFA; IFN; IL; INCOMPLETE FREUND'S ADJUVANT; INTERFERON; INTERLEUKIN; INTERLEUKIN-10; MBP; METHYLPREDNISOLONE; MOG; MP; MS; MULTIPLE SCLEROSIS; MYELIN BASIC PROTEIN; MYELIN OLIGODENDROCYTE PROTEIN; NEUROINFLAMMATION; PBMC; PBS; PERIPHERAL BLOOD MONONUCLEAR CELLS; PHOSPHATE BUFFER SALINE; SC; SCH; SPINAL CORD; SPINAL CORD HOMOGENATE; TGF; TH; TRANSFORMING GROWTH FACTOR;

ANIMALS; ASTROCYTES; CELLS, CULTURED; CHEMOKINE CXCL12; CONVALESCENCE; DISEASE PROGRESSION; ENCEPHALOMYELITIS, AUTOIMMUNE, EXPERIMENTAL; GENE EXPRESSION REGULATION; INTERLEUKIN-10; METHYLPREDNISOLONE; RATS; RATS, INBRED STRAINS; SPINAL CORD; TRANSFORMING GROWTH FACTOR BETA;

EID: 84880038556     PISSN: 01712985     EISSN: 18783279     Source Type: Journal    
DOI: 10.1016/j.imbio.2013.04.004     Document Type: Article

References (44)

1. Adikari S.B., Pettersson A., Soderstrom M., Huang Y.M., Link H. Interleukin-10-modulated immature dendritic cells control the proinflammatory environment in multiple sclerosis. Scand. J. Immunol. 2004, 59:600-606.
2. Ambrosini E., Remoli M.E., Giacomini E., Rosicarelli B., Serafini B., Lande R., Aloisi F., Coccia E.M. Astrocytes produce dendritic cell-attracting chemokines in vitro and in multiple sclerosis lesions. J. Neuropathol. Exp. Neurol. 2005, 64:706-715.
3. Aristimuño C., Navarro J., de Andrés C., Martínez-Ginés L., Giménez-Roldán S., Fernández-Cruz E., Sánchez-Ramón S. Expansion of regulatory CD8+ T-lymphocytes and fall of activated CD8+ T-lymphocytes after i.v. methyl-prednisolone for multiple sclerosis relapse. J. Neuroimmunol. 2008, 204:131-135.
4. Beebe A.M., de Cua D.J., Waal Malefyt R. The role of interleukin-10 in autoimmune disease: systemic lupus erythematosus (SLE) and multiple sclerosis (MS). Cytokine Growth Factor Rev. 2002, 13:403-412.
5. Bettelli E., Das M.P., Howard E.D., Weiner H.L., Sobel R.A., Kuchroo V.K. IL-10 is critical in the regulation of autoimmune encephalomyelitis as demonstrated by studies of IL-10- and IL-4-deficient and transgenic mice. J. Immunol. 1998, 161:3299-3306.
6. Boonstra A., Rajsbaum R., Holman M., Marques R., Asselin-Paturel C., Pereira J.P., Bates E.E., Akira S., Vieira P., Liu Y.J., Trinchieri G., O'Garra A. Macrophages and myeloid dendritic cells, but not plasmacytoid dendritic cells, produce IL-10 in response to MyD88- and TRIF-dependent TLR signals, and TLR-independent signals. J. Immunol. 1998, 177:7551-7558.
7. Calcagni E., Elenkov I. Stress system activity, innate and T helper cytokines, and susceptibility to immune-related diseases. Ann. N. Y. Acad. Sci. 2006, 1069:62-76.
8. Calderon T.M., Eugenin E.A., Lopez L., Kumar S.S., Hesselgesser J., Raine C.S., Berman J.W. A role for CXCL12 (SDF-1alpha) in the pathogenesis of multiple sclerosis: regulation of CXCL12 expression in astrocytes by soluble myelin basic protein. J. Neuroimmunol. 2006, 177:27-39.
9. Carbajal K.S., Schaumburg C., Strieter R., Kane J., Lane T.E. Migration of engrafted neural stem cells is mediated by CXCL12 signaling through CXCR4 in a viral model of multiple sclerosis. Proc. Natl. Acad. Sci. U. S. A. 2010, 107:11068-11070.
10. Cautain B., Damoiseaux J., Bernard I., van Straaten H., van Breda Vriesman P., Boneu B., Druet P., Saoudi A. Essential role of TGF-beta in the natural resistance to experimental allergic encephalomyelitis in rats. Eur. J. Immunol. 2001, 31:1132-1140.
11. Cope A., Le Friec G., Cardone J., Kemper C. The Th1 life cycle: molecular control of IFN-γ to IL-10 switching. Trends Immunol. 2011, 32:278-286.
12. Cua D.J., Groux H., Hinton D.R., Stohlman S.A., Coffman R.L. Transgenic interleukin 10 prevents induction of experimental autoimmune encephalomyelitis. J. Exp. Med. 1999, 189:1005-1010.
13. Diab A., Zhu J., Xiao B.G., Mustafa M., Link H. High IL-6 and low IL-10 in the central nervous system are associated with protracted relapsing EAE in DA rats. J. Neuropathol. Exp. Neurol. 1997, 56:641-650.
14. El-behi M., Rostami A., Ciric B. Current views on the roles of Th1 and Th17 cells in experimental autoimmune encephalomyelitis. J. Neuroimmune Pharmacol. 2010, 5:189-197.
15. Fujita S., Seino K., Sato K., Sato Y., Eizumi K., Yamashita N., Taniguchi M., Sato K. Regulatory dendritic cells act as regulators of acute lethal systemic inflammatory response. Blood 2006, 107:3656-3664.
16. Germain R.N. Maintaining system homeostasis: the third law of Newtonian immunology. Nat. Immunol. 2012, 13:902-906.
17. Harris M.G., Fabry Z. Initiation and regulation of CNS autoimmunity: balancing immune surveillance and inflammation in the CNS. Neurosci. Med. 2012, 3:203-224.
18. Issazadeh S., Lorentzen J.C., Mustafa M.I., Höjeberg B., Müssener A., Olsson T. Cytokines in relapsing experimental autoimmune encephalomyelitis in DA rats: persistent mRNA expression of proinflammatory cytokines and absent expression of interleukin-10 and transforming growth factor-beta. J. Neuroimmunol. 1996, 69:103-115.
19. Jander S., Pohl J., D'Urso D., Gillen C., Stoll G. Time course and cellular localization of interleukin-10 mRNA and protein expression in autoimmune inflammation of the rat central nervous system. Am. J. Pathol. 1998, 152:975-982.
20. Jankovic D., Kugler D.G., Sher A. IL-10 production by CD4+ effector T cells: a mechanism for self-regulation. Mucosal. Immunol. 2010, 3:239-246.
21. Johansson A.C., Hansson A.S., Nandakumar K.S., Bäcklund J., Holmdahl R. IL-10-deficient B10Q mice develop more severe collagen-induced arthritis, but are protected from arthritis induced with anti-type II collagen antibodies. J. Immunol. 2001, 167:3505-3512.
22. Laouar Y., Town T., Jeng D., Tran E., Wan Y., Kuchroo V.K., Flavell R.A. TGF-beta signaling in dendritic cells is a prerequisite for the control of autoimmune encephalomyelitis. Proc. Natl. Acad. Sci. U.S.A. 2008, 105:10865-10870.
23. Lenz D.C., Wolf N.A., Swanborg R.H. Strain variation in autoimmunity: attempted tolerization of DA rats results in the induction of experimental autoimmune encephalomyelitis. J. Immunol. 1999, 163:1763-1768.
24. Li M.O., Flavell R.A. Contextual regulation of inflammation: a duet by transforming growth factor-beta and interleukin-10. Immunity 2008, 28:468-476.
25. Li M.O., Flavell R.A. TGF-beta a master of all T cell trades. Cell 2008, 134:392-404.
26. Li M., Ransohoff R.M. Multiple roles of chemokine CXCL12 in the central nervous system: a migration from immunology to neurobiology. Prog. Neurobiol. 2008, 84:116-131.
27. Link H. The cytokine storm in multiple sclerosis. Mult. Scler. 1998, 4:12-15.
28. Lukic M.L., Mensah-Brown E., Galadari S., Shahin A. Lack of apoptosis of infiltrating cells as the mechanism of high susceptibility to EAE in DA rats. Dev. Immunol. 2001, 8:193-200.
29. Markovic M., Miljkovic D., Momcilovic M., Popadic D., Miljkovic Z., Savic E., Ramic Z., Mostarica Stojkovic M. Strain difference in susceptibility to experimental autoimmune encephalomyelitis in rats correlates with TH1 and TH17-inducing cytokine profiles. Mol. Immunol. 2001, 47:141-146.
30. McCarthy K.D., de Vellis J. Preparation of separate astroglial and oligodendroglial cell cultures from rat cerebral tissue. J Cell Biol 1980, 85:890-902.
31. Meiron M., Zohar Y., Anunu R., Wildbaum G., Karin N. CXCL12 (SDF-1alpha) suppresses ongoing experimental autoimmune encephalomyelitis by selecting antigen-specific regulatory T cells. J. Exp. Med. 2008, 205:2643-2655.
32. Miljkovic D., Stosic-Grujicic S., Markovic M., Momcilovic M., Ramic Z., Maksimovic-Ivanic D., Mijatovic S., Popadic D., Cvetkovic I., Mostarica-Stojkovic M. Strain difference in susceptibility to experimental autoimmune encephalomyelitis between Albino Oxford and Dark Agouti rats correlates lack of neurological deficits in AO rats could be a consequence of lower generation of NO by with disparity in production of IL-17, but not nitric oxide. J. Neurosci. Res. 2008, 84:379-388.
33. Miljković D., Stanojević Z., Momcilović M., Odoardi F., Flügel A., Mostarica-Stojković M. CXCL12 expression within the CNS contributes to the resistance against experimental autoimmune encephalomyelitis in Albino Oxford rats. Immunobiology 2008, 216:979-987.
34. Momcilović M., Mostarica-Stojković M., Miljković D. CXCL12 in control of neuroinflammation. Immunol. Res. 2012, 52:53-63.
35. Ouyang W., Rutz S., Crellin N.K., Valdez P.A., Hymowitz S.G. Regulation and functions of the IL-10 family of cytokines in inflammation and disease. Annu Rev Immunol 2011, 29:71-109.
36. Patel J.R., McCandless E.E., Dorsey D., Klein R.S. CXCR4 promotes differentiation of oligodendrocyte progenitors and remyelination. Proc. Natl. Acad. Sci. U. S. A. 2010, 107:11062-11070.
37. Petermann F., Korn T. Cytokines and effector T cell subsets causing autoimmune CNS disease. FEBS Lett. 2010, 585:3747-3757.
38. Peterson R.A. Regulatory T-cells: diverse phenotypes integral to immune homeostasis and suppression. Toxicol. Pathol. 2010, 40:186-204.
39. Rott O., Fleischer B., Cash E. Interleukin-10 prevents experimental allergic encephalomyelitis in rats. Eur. J. Immunol. 2010, 24:1434-1440.
40. Stosic-Grujicic S., Ramic Z., Bumbasirevic V., Harhaji L., Mostarica-Stojkovic M. Induction of experimental autoimmune encephalomyelitis in Dark Agouti rats without adjuvant. Clin. Exp. Immunol. 2010, 136:49-55.
41. Sun D., Hu X.Z., Shah R., Coleclough C. The pattern of cytokine gene expression induced in rat T cells specific for myelin basic protein depends on the type and quality of antigenic stimulus. Cell. Immunol. 2010, 166:1-8.
42. Yaswen L., Kulkarni A.B., Fredrickson T., Mittleman B., Schiffman R., Payne S., Longenecker G., Mozes E., Karlsson S. Autoimmune manifestations in the transforming growth factor-beta 1 knockout mouse. Blood 1996, 87:1439-1445.
43. Zargarova T., Kulakova O., Prassolov V., Zharmukhamedova T., Tsyganova V., Turobov V., Ivanov D., Parfenov M., Sudomoina M., Chernajovsky Y., Favorova O. Prevention of experimental autoimmune encephalomyelitis in DA rats by grafting primary skin fibroblasts engineered to express transforming growth factor-beta1. Clin. Exp. Immunol. 2004, 137:313-319.
44. Zhao J., Zhao J., Fett C., Trandem K., Fleming E., Perlman S. IFN-γ- and IL-10-expressing virus epitope-specific Foxp3(+) T reg cells in the central nervous system during encephalomyelitis. J Exp Med 2011, 208:1571-1577.