Fucoxanthin and its deacetylated product, fucoxanthinol, induce apoptosis of primary effusion lymphomas

Cancer Letters

Volumn 300, Issue 2, 2011, Pages 225-234

  Yamamoto, Kei ^a   Ishikawa, Chie ^a,b   Katano, Harukata ^c   Yasumoto, Takeshi ^d   Mori, Naoki ^a  

^a UNIVERSITY OF THE RYUKYUS   (Japan)

^b Transdisciplinary Research Organization for Subtropics and Island Studies   (Japan)

^c NATIONAL INSTITUTE OF INFECTIOUS DISEASES   (Japan)

^d Okinawa Science and Technology Promotion Center   (Japan)

Author keywords

FX; FXOH; HHV 8; PEL; Proteasome

Indexed keywords

CASPASE; DRUG METABOLITE; FUCOXANTHIN; FUCOXANTHINOL; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; PROTEASOME; PROTEIN KINASE B; TRANSCRIPTION FACTOR AP 1; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; CANCER INHIBITION; CELL CYCLE G1 PHASE; CELL CYCLE REGULATION; CELL VIABILITY; CONTROLLED STUDY; DEACETYLATION; DOSE RESPONSE; DOWN REGULATION; DRUG EFFECT; DRUG MECHANISM; ENZYME ACTIVATION; FEMALE; HUMAN; HUMAN CELL; IN VITRO STUDY; MOUSE; NONHUMAN; PRIMARY EFFUSION LYMPHOMA; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; PROTEIN DEGRADATION; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; SIGNAL TRANSDUCTION;

ANTINEOPLASTIC AGENTS; APOPTOSIS; BETA CAROTENE; BLOTTING, WESTERN; CASPASES; CELL CYCLE; CELL LINE, TUMOR; CELL SURVIVAL; ELECTROPHORETIC MOBILITY SHIFT ASSAY; HUMANS; LYMPHOMA, PRIMARY EFFUSION; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION; XANTHOPHYLLS;

ANIMALIA; HUMAN HERPESVIRUS 8;

EID: 78649629110     PISSN: 03043835     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.canlet.2010.10.016     Document Type: Article

References (51)

1. Knowles D.M., Inghirami G., Ubriaco A., Dalla-Favera R. Molecular genetic analysis of three AIDS-associated neoplasms of uncertain lineage demonstrates their B-cell derivation and the possible pathogenetic role of the Epstein-Barr virus. Blood 1989, 73:792-799.
2. Walts A.E., Shintaku I.P., Said J.W. Diagnosis of malignant lymphoma in effusions from patients with AIDS by gene rearrangement. Am. J. Clin. Pathol. 1990, 94:170-175.
3. Cesarman E., Chang Y., Moore P.S., Said J.W., Knowles D.M. Kaposi's sarcoma-associated herpesvirus-like DNA sequences in AIDS-related body-cavity-based lymphomas. N. Engl. J. Med. 1995, 332:1186-1191.
4. Ansari M.Q., Dawson D.B., Nador R., Rutherford C., Schneider N.R., Latimer M.J., Picker L., Knowles D.M., McKenna R.W. Primary body cavity-based AIDS-related lymphomas. Am. J. Clin. Pathol. 1996, 105:221-229.
5. Boulanger E., Gérard L., Gabarre J., Molina J.-M., Rapp C., Abino J.-F., Cadranel J., Chevret S., Oksenhendler E. Prognostic factors and outcome of human herpesvirus 8-associated primary effusion lymphoma in patients with AIDS. J. Clin. Oncol. 2005, 23:4372-4380.
6. Mesri E.A., Cesarman E., Arvanitakis L., Rafii S., Moore M.A.S., Posnett D.N., Knowles D.M., Asch A.S. Human herpesvirus-8/Kaposi's sarcoma-associated herpesvirus is a new transmissible virus that infects B cells. J. Exp. Med. 1996, 183:2385-2390.
7. Chaudhary P.M., Jasmin A., Eby M.T., Hood L. Modulation of the NF-κB pathway by virally encoded death effector domains-containing proteins. Oncogene 1999, 18:5738-5746.
8. Liu L., Eby M.T., Rathore N., Sinha S.K., Kumar A., Chaudhary P.M. The human herpes virus 8-encoded viral FLICE inhibitory protein physically associates with and persistently activates the IκB kinase complex. J. Biol. Chem. 2002, 277:13745-13751.
9. Field N., Low W., Daniels M., Howell S., Daviet L., Boshoff C., Collins M. KSHV vFLIP binds to IKK-γ to activate IKK. J. Cell. Sci. 2003, 116:3721-3728.
10. Guasparri I., Wu H., Cesarman E. The KSHV oncoprotein vFLIP contains a TRAF-interacting motif and requires TRAF2 and TRAF3 for signaling. EMBO Rep. 2006, 7:114-119.
11. Guasparri I., Keller S.A., Cesarman E. KSHV vFLIP is essential for the survival of infected lymphoma cells. J. Exp. Med. 2004, 199:993-1003.
12. Järviluoma A., Ojala P.M. Cell signaling pathways engaged by KSHV. Biochim. Biophys. Acta 2006, 1766:140-158.
13. Karin M., Lin A. NF-κB at the crossroads of life and death. Nat. Immunol. 2002, 3:221-227.
14. Keller S.A., Schattner E.J., Cesarman E. Inhibition of NF-κB induces apoptosis of KSHV-infected primary effusion lymphoma cells. Blood 2000, 96:2537-2542.
15. Hess J., Angel P., Schorpp-Kistner M. AP-1 subunits: quarrel and harmony among siblings. J. Cell Sci. 2004, 117:5965-5973.
16. An J., Lichtenstein A.K., Brent G., Rettig M.B. The Kaposi sarcoma-associated herpesvirus (KSHV) induces cellular interleukin 6 expression: role of the KSHV latency-associated nuclear antigen and the AP1 response element. Blood 2002, 99:649-654.
17. An J., Sun Y., Sun R., Rettig M.B. Kaposi's sarcoma-associated herpesvirus encoded vFLIP induces cellular IL-6 expression: the role of the NF-κB and JNK/AP1 pathways. Oncogene 2003, 22:3371-3385.
18. An J., Sun Y., Rettig M.B. Transcriptional coactivation of c-Jun by the KSHV-encoded LANA. Blood 2004, 103:222-228.
19. Cannon M.L., Cesarman E. The KSHV G protein-coupled receptor signals via multiple pathways to induce transcription factor activation in primary effusion lymphoma cells. Oncogene 2004, 23:514-523.
20. Cannon M., Philpott N.J., Cesarman E. The Kaposi's sarcoma-associated herpesvirus G protein-coupled receptor has broad signaling effects in primary effusion lymphoma cells. J. Virol. 2003, 77:57-67.
21. Sin S.-H., Roy D., Wang L., Staudt M.R., Fakhari F.D., Patel D.D., Henry D., Harrington W.J., Damania B.A., Dittmer D.P. Rapamycin is efficacious against primary effusion lymphoma (PEL) cell lines in vivo by inhibiting autocrine signaling. Blood 2007, 109:2165-2173.
22. Bhatt A.P., Bhende P.M., Sin S.-H., Roy D., Dittmer D.P., Damania B. Dual inhibition of PI3K and mTOR inhibits autocrine and paracrine proliferative loops in PI3K/Akt/mTOR-addicted lymphomas. Blood 2010, 115:4455-4463.
23. Sodhi A., Chaisuparat R., Hu J., Ramsdell A.K., Manning B.D., Sausville E.A., Sawai E.T., Molinolo A., Gutkind J.S., Montaner S. The TSC2/mTOR pathway drives endothelial cell transformation induced by the Kaposi's sarcoma-associated herpesvirus G protein-coupled receptor. Cancer Cell 2006, 10:133-143.
24. Sodhi A., Montaner S., Patel V., Gómez-Román J.J., Li Y., Sausville E.A., Sawai E.T., Gutkind J.S. Akt plays a central role in sarcomagenesis induced by Kaposi's sarcoma herpesvirus-encoded G protein-coupled receptor. Proc. Natl. Acad. Sci. USA 2004, 101:4821-4826.
25. Tomlinson C.C., Damania B. The K1 protein of Kaposi's sarcoma-associated herpesvirus activates the Akt signaling pathway. J. Virol. 2004, 78:1918-1927.
26. Satomi Y., Nishino H. Fucoxanthin, a natural carotenoid, induces G1 arrest and GADD45 gene expression in human cancer cells. In Vivo 2007, 21:305-309.
27. Shiratori K., Ohgami K., Ilieva I., Jin X.H., Koyama Y., Miyashita K., Yoshida K., Kase S., Ohno S. Effects of fucoxanthin on lipopolysaccharide-induced inflammation in vitro and in vivo. Exp. Eye Res. 2005, 81:422-428.
28. Sachindra N.M., Sato E., Maeda H., Hosokawa M., Niwano Y., Kohno M., Miyashita K. Radical scavenging and singlet oxygen quenching activity of marine carotenoid fucoxanthin and its metabolites. J. Agric. Food Chem. 2007, 55:8516-8522.
29. Beppu F., Niwano Y., Sato E., Kohno M., Tsukui T., Hosokawa M., Miyashita K. In vitro and in vivo evaluation of mutagenicity of fucoxanthin (FX) and its metabolite fucoxanthinol (FXOH). J. Toxicol. Sci. 2009, 34:693-698.
30. Renne R., Zhong W., Herndier B., McGrath M., Abbey N., Kedes D., Ganem D. Lytic growth of Kaposi's sarcoma-associated herpesvirus (human herpesvirus 8) in culture. Nat. Med. 1996, 2:342-346.
31. Katano H., Hoshino Y., Morishita Y., Nakamura T., Satoh H., Iwamoto A., Herndier B., Mori S. Establishing and characterizing a CD30-positive cell line harboring HHV-8 from a primary effusion lymphoma. J. Med. Virol. 1999, 58:394-401.
32. Zhang C., Ao Z., Seth A., Schlossman S.F. A mitochondrial membrane protein defined by a novel monoclonal antibody is preferentially detected in apoptotic cells. J. Immunol. 1996, 157:3980-3987.
33. Antalis T.M., Goldbolt D. Isolation nuclei from hematopoietic cell types. Nucleic Acids Res. 1991, 19:4301.
34. Krishnan H.H., Naranatt P.P., Smith M.S., Zeng L., Bloomer C., Chandran B. Concurrent expression of latent and a limited number of lytic genes with immune modulation and antiapoptotic function by Kaposi's sarcoma-associated herpesvirus early during infection of primary endothelial and fibroblast cells and subsequent decline of lytic gene expression. J. Virol. 2004, 78:3601-3620.
35. Yoo S.M., Zhou F.-C., Ye F.-C., Pan H.-Y., Gao S.-J. Early and sustained expression of latent and host modulating genes in coordinated transcriptional program of KSHV productive primary infection of human primary endothelial cells. Virology 2005, 343:47-64.
36. Bartek J., Bartkova J., Lukas J. The retinoblastoma protein pathway in cell cycle control and cancer. Exp. Cell Res. 1997, 237:1-6.
37. Pahl H.L. Activators and target genes of Rel/NF-κB transcription factors. Oncogene 1999, 18:6853-6866.
38. Huang Y., Ohtani K., Iwanaga R., Matsumura Y., Nakamura M. Direct trans-activation of the human cyclin D2 gene by the oncogene product Tax of human T-cell leukemia virus type I. Oncogene 2001, 20:1094-1102.
39. Iwanaga R., Ohtani K., Hayashi T., Nakamura M. Molecular mechanism of cell cycle progression induced by the oncogene product Tax of human T-cell leukemia virus type I. Oncogene 2001, 20:2055-2067.
40. Zhu L., Fukuda S., Cordis G., Das D.K., Maulik N. Anti-apoptotic protein survivin plays a significant role in tubular morphogenesis of human coronary arteriolar endothelial cells by hypoxic preconditioning. FEBS Lett. 2001, 508:369-374.
41. Stehlik C., de Martin R., Kumabashiri I., Schmid J.A., Binder B.R., Lipp J. Nuclear factor (NF)-κB-regulated X-chromosome-linked iap gene expression protects endothelial cells from tumor necrosis factor alpha-induced apoptosis. J. Exp. Med. 1998, 188:211-216.
42. Manning B.D., Cantley L.C. AKT/PKB signaling: navigating downstream. Cell 2007, 129:1261-1274.
43. Brown H.J., Song M.J., Deng H., Wu T.-T., Cheng G., Sun R. NF-κB inhibits gammaherpesvirus lytic replication. J. Virol. 2003, 77:8532-8540.
44. Arya R., Mallik M., Lakhotia S.C. Heat shock genes-integrating cell survival and death. J. Biosci. 2007, 32:595-610.
45. Pratt W.B. The hsp90-based chaperone system: involvement in signal transduction from a variety of hormone and growth factor receptors. Proc. Soc. Exp. Biol. Med. 1998, 217:420-434.
46. Kamal A., Boehm M.F., Burrows F.J. Therapeutic and diagnostic implications of Hsp90 activation. Trends Mol. Med. 2004, 10:283-290.
47. Zhang H., Burrows F. Targeting multiple signal transduction pathways through inhibition of Hsp90. J. Mol. Med. 2004, 82:488-499.
48. Ma Y., Lakshmikanthan V., Lewis R.W., Kumar M.V. Sensitization of TRAIL-resistant cells by inhibition of heat shock protein 90 with low-dose geldanamycin. Mol. Cancer Ther. 2006, 5:170-178.
49. Li M., Lee H., Yoon D.-W., Albrecht J.-C., Fleckenstein B., Neipel F., Jung J.U. Kaposi's sarcoma-associated herpesvirus encodes a functional cyclin. J. Virol. 1997, 71:1984-1991.
50. Sugawara T., Baskaran V., Tsuzuki W., Nagao A. Brown algae fucoxanthin is hydrolyzed to fucoxanthinol during absorption by Caco-2 human intestinal cells and mice. J. Nutr. 2002, 132:946-951.
51. Asai A., Yonekura L., Nagao A. Low bioavailability of dietary epoxyxanthophylls in humans. Brit. J. Nutr. 2008, 100:273-277.