Endogenous n-3 polyunsaturated fatty acids (PUFAs) mitigate ovariectomy-induced bone loss by attenuating bone marrow adipogenesis in FAT1 transgenic mice

Drug Design, Development and Therapy

Volumn 7, Issue , 2013, Pages 545-552

  Chen, Tian Yu ^a,b   Zhang, Zhong Min ^a,b   Zheng, Xiao Chen ^a,b   Wang, Liang ^a,b   Huang, Min Jun ^a,b   Qin, Si ^c   Chen, Jian ^a,b   Lai, Ping Lin ^d   Yang, Cheng Liang ^a,b   Liu, Jia ^a,b   Dai, Yi Fan ^e   Jin, Da Di ^a,b   Bai, Xiao Chun ^a,b,d  

^a THE THIRD AFFILIATED HOSPITAL OF SOUTHERN MEDICAL UNIVERSITY   (China)

^b Academy of Orthopaedicss   (China)

^c GUANGDONG SECOND PROVINCIAL GENERAL HOSPITAL   (China)

^d SOUTHERN MEDICAL UNIVERSITY   (China)

^e NANJING MEDICAL UNIVERSITY   (China)

Author keywords

Adipogenesis; Antiosteoporosis; Bone marrow; N 3 PUFAs

Indexed keywords

OMEGA 3 FATTY ACID; OMEGA 6 FATTY ACID; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA; TRANSCRIPTION FACTOR RUNX2; CADHERIN; FATH PROTEIN, MOUSE; RUNX2 PROTEIN, MOUSE;

ABDOMINAL FAT; ADIPOCYTE; ADIPOGENESIS; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BODY WEIGHT; BONE DENSITY; BONE MARROW; BONE MASS; BONE MINERAL; CAENORHABDITIS ELEGANS; CELL COUNT; CELL VOLUME; CONTROLLED STUDY; DIET; FAT1 GENE; FEMALE; FEMUR; GENE; GENE OVEREXPRESSION; IMMUNOFLUORESCENCE; IMMUNOHISTOCHEMISTRY; METAPHYSIS; MICRO-COMPUTED TOMOGRAPHY; MOUSE; NONHUMAN; OSTEOLYSIS; OSTEOPOROSIS; OVARIECTOMY; PROTEIN EXPRESSION; TRANSGENIC MOUSE; ANIMAL; C57BL MOUSE; GENETICS; METABOLISM; OBESITY; PHYSIOLOGY;

ADIPOGENESIS; ADIPOSITY; ANIMALS; BONE MARROW; CADHERINS; CORE BINDING FACTOR ALPHA 1 SUBUNIT; FATTY ACIDS, OMEGA-3; FEMALE; IMMUNOHISTOCHEMISTRY; MICE; MICE, INBRED C57BL; MICE, TRANSGENIC; OSTEOPOROSIS; OVARIECTOMY; PPAR GAMMA;

EID: 84879984744     PISSN: 11778881     EISSN: None     Source Type: Journal    
DOI: 10.2147/DDDT.S45263     Document Type: Article

References (45)

1. [No authors listed]. Consensus development conference: diagnosis, prophylaxis, and treatment of osteoporosis. Am J Med. 1993;94:646-650.
2. Meunier P, Aaron J, Edouard C, Vignon G. Osteoporosis and the replacement of cell populations of the marrow by adipose tissue. A quantitative study of 84 iliac bone biopsies. Clin Orthop Relat Res. 1971;80:147-154.
3. Griffth JF, Yeung DK, Antonio GE, et al. Vertebral marrow fat content and diffusion and perfusion indexes in women with varying bone density: MR evaluation. Radiology. 2006;241:831-838.
4. Verma S, Rajaratnam JH, Denton J, Hoyland JA, Byers RJ. Adipocytic proportion of bone marrow is inversely related to bone formation in osteoporosis. J Clin Pathol. 2002;55:693-698.
5. Owen M. Marrow stromal stem cells. J Cell Sci Suppl. 1988;10:63-76.
6. Rodríguez J P, Montecinos L, Ríos S, Reyes P, Martínez J. Mesenchymal stem cells from osteoporotic patients produce a type I collagen-defcient extracellular matrix favoring adipogenic differentiation. J Cell Biochem. 2000;79:557-565.
7. Song L, Tuan RS. Transdifferentiation potential of human mesenchymal stem cells derived from bone marrow. FASEB J. 2004;18:980-982.
8. Muruganandan S, Roman AA, Sinal CJ. Adipocyte differentiation of bone marrow-derived mesenchymal stem cells: cross talk with the osteoblastogenic program. Cell Mol Life Sci. 2009;66:236-253.
9. Beresford JN, Bennett JH, Devlin C, Leboy PS, Owen ME. Evidence for an inverse relationship between the differentiation of adipocytic and osteogenic cells in rat marrow stromal cell cultures. J Cell Sci. 1992;102:341-351.
10. Clabaut A, Delplace S, Chauveau C, Hardouin P, Broux O. Human osteoblasts derived from mesenchymal stem cells express adipogenic markers upon coculture with bone marrow adipocytes. Differentiation. 2010;80:40-45.
11. Maurin AC, Chavassieux PM, Frappart L, Delmas PD, Serre CM, Meunier PJ. Infuence of mature adipocytes on osteoblast proliferation in human primary cocultures. Bone. 2000;26:485-489.
12. Maurin AC, Chavassieux PM, Vericel E, Meunier PJ. Role of polyun-saturated fatty acids in the inhibitory effect of human adipocytes on osteoblastic proliferation. Bone. 2002;31:260-266.
13. Elbaz A, Wu X, Rivas D, Gimble JM, Duque G. Inhibition of fatty acid biosynthesis prevents adipocyte lipotoxicity on human osteoblasts in vitro. J Cell Mol Med. 2010;14:982-991.
14. Sakaguchi K, Morita I, Murota S. Relationship between the ability to support differentiation of osteoclast-like cells and adipogenesis in murine stromal cells derived from bone marrow. Prostaglandins Leukot Essent Fatty Acids. 2000;62:319-327.
15. Zevenbergen H, de Bree A, Zeelenberg M, Laitinen K, van Duijn G, Flöter E. Foods with a high fat quality are essential for healthy diets. Ann Nutr Metab. 2009;54:15-24.
16. Watkins BA, Li Y, Lippman HE, Seifert M F. Omega-3 polyunsaturated fatty acids and skeletal health. Exp Biol Med. 2001;226:485-497.
17. Fernandes G, Lawrence R, Sun D. Protective role of n-3 lipids and soy protein in osteoporosis. Prostaglandins Leukot Essent Fatty Acids. 2003;68:361-372.
18. Watkins BA, Li Y, Lippman HE, Feng S. Modulatory effect of omega-3 polyunsaturated fatty acids on osteoblast function and bone metabolism. Prostaglandins Leukot Essent Fatty Acids. 2003;68: 387-398.
19. Sun D, Krishnan A, Zaman K, Lawrence R, Bhattacharya A, Fernandes G. Dietary n-3 fatty acids decrease osteoclastogenesis and loss of bone mass in ovariectomized mice. J Bone Miner Res. 2003;18:1206-1216.
20. Green KH, Wong SC, Weiler HA. The effect of dietary n-3 long-chain polyunsaturated fatty acids on femur mineral density and biomark-ers of bone metabolism in healthy, diabetic and dietary-restricted growing rats. Prostaglandins Leukot Essent Fatty Acids. 2004;71: 121-130.
21. Watkins BA, Reinwald S, Li Y, Seifert MF. Protective actions of soy isofavones and n-3 PUFAs on bone mass in ovariectomized rats. J Nutr Biochem. 2005;16:479-488.
22. Shen CL, Yeh JK, Rasty J, Li Y, Watkins BA. Protective effect of dietary long-chain n-3 polyunsaturated fatty acids on bone loss in gonad-intact middle-aged male rats. Br J Nutr. 2006;95:462-468.
23. Rahman MM, Bhattacharya A, Banu J, Kang JX, Fernandes G. Endogenous n-3 fatty acids protect ovariectomy induced bone loss by attenuating osteoclastogenesis. J Cell Mol Med. 2009;13:1833-1844.
24. Wood RJ. Vitamin D and adipogenesis: new molecular insights. Nutr Rev. 2008;66:40-46.
25. Moerman EJ, Teng K, Lipschitz DA, Lecka-Czernik B. Aging activates adipogenic and suppresses osteogenic programs in mesenchymal marrow stroma/stem cells: the role of PPAR-gamma2 transcription factor and TGF-beta/BMP signaling pathways. Aging Cell. 2004;3:379-389.
26. Yoshida CA, Furuichi T, Fujita T, et al. Core-binding factor beta interacts with Runx2 and is required for skeletal development. Nat Genet. 2002;32:633-638.
27. Wei D, Li J, Shen M, et al. Cellular production of n-3 PUFAs and reduction of n-6-to-n-3 ratios in the pancreatic beta-cells and islets enhance insulin secretion and confer protection against cytokine-induced cell death. Diabetes. 2010;59:471-478.
28. Elbaz A, Rivas D, Duque G. Effect of estrogens on bone marrow adi-pogenesis and Sirt1 in aging C57BL/6J mice. Biogerontology. 2009;10: 747-755.
29. Syed FA, Oursler MJ, Hefferanm TE, Peterson JM, Riggs BL, Khosla S. Effects of estrogen therapy on bone marrow adipocytes in postmeno-pausal osteoporotic women. Osteoporos Int. 2008;19:1323-1330.
30. Meunier P, Aaron J, Edouard C, Vignon A. Osteoporosis and the replacement of cell populations of the marrow by adipose tissue. Clin Orthop Rel Res. 1971;80:147-154.
31. Justesen J, Stenderup K, Ebbesen EN, Mosekilde L, Steiniche T, Kassem M. Adipocyte tissue volume in bone marrow is increased with aging and in patients with osteoporosis. Biogerontology. 2001;2: 165-171.
32. Kesavalu L, Vasudevan B, Raghu B, et al. Omega-3 fatty acid effect on alveolar bone loss in rats. J Dent Res. 2006;85:648-652.
33. Bhattacharya A, Rahman M, Sun D, Fernandes G. Effect of fsh oil on bone mineral density in aging C57BL/6 female mice. J Nutr Biochem. 2007;18:372-379.
34. Lau BY, Ward WE, Kang JX, Ma DW. Femur EPA and DHA are correlated with femur biomechanical strength in young fat-1 mice. J Nutr Biochem. 2009;20:453-461.
35. Taes YE, Lapauw B, Vanbillemont G, et al. Fat mass is negatively associated with cortical bone size in young healthy male siblings. J Clin Endocrinol Metab. 2009;94:2325-2331.
36. Massiera F, Saint-Marc P, Seydoux J, et al. Arachidonic acid and prostacyclin signaling promote adipose tissue development: a human health concern? J Lipid Res. 2003;44:271-279.
37. Fournier C, Perrier A, Thomas M, et al. Reduction by strontium of the bone marrow adiposity in mice and repression of the adipogenic commitment of multipotent C3H10T1/2 cells. Bone. 2012;50:499-509.
38. Jin J, Wang L, Wang XK, et al. Risedronate inhibits bone marrow mesenchymal stem cell adipogenesis and switches RANKL/OPG ratio to impair osteoclast differentiation. J Surg Res. 2013;180:e21-e29.
39. Fried SK, Bunkin DA, Greenberg AS. Omental and subcutaneous adipose tissues of obese subjects release interleukin-6: depot difference and regulation by glucocorticoid. J Clin Endocrinol Metab. 1998;83: 847-850.
40. Timper K, Grisouard J, Sauter NS, et al. Glucose-dependent insulino-tropic polypeptide induces cytokine expression, lipolysis and insulin resistance in human adipocytes. Am J Physiol Endocrinol Metab. 2013;304:E1-E13.
41. Jilka RL, Hangoc G, Girasole G, et al. Increased osteoclast development after estrogen loss: mediation by interleukin-6. Science. 1992;257: 88-91.
42. Manolagas SC. Role of cytokines in bone resorption. Bone. 1995; 17 (2 Suppl):63S-67S.
43. Lee YM, Fujikado N, Manaka H, Yasuda H, Iwakura Y. IL-1 plays an important role in the bone metabolism under physiological conditions. Int Immunol. 2010;22:805-816.
44. Hashizume M, Mihara M. The roles of interleukin-6 in the pathogenesis of rheumatoid arthritis. Arthritis. 2011;2011:765624.
45. Maurin AC, Chavassieux PM, Frappart L, Delmas PD, Serre CM, Meunier PJ. Influence of mature adipocytes on osteoblast proliferation in human primary cocultures. Bone. 2000;26:485-489.